Grap2 (GRB2-related adaptor protein 2) - Rat Genome Database

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Gene: Grap2 (GRB2-related adaptor protein 2) Rattus norvegicus
Analyze
Symbol: Grap2
Name: GRB2-related adaptor protein 2
RGD ID: 1307605
Description: Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in cytosol; endosome; and nucleus. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2); PARTICIPATES IN T cell receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GRB2-related adapter protein 2; LOC366962; MGC125066
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,997,356 - 114,071,073 (+)NCBIGRCr8
mRatBN7.27112,117,142 - 112,190,880 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,117,142 - 112,190,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,872,662 - 113,946,895 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,096,186 - 116,170,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,065,563 - 116,139,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,791,330 - 121,864,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,841,855 - 121,864,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,781,461 - 121,854,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,856,130 - 118,931,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,882,484 - 118,965,381 (+)NCBI
Celera7108,442,874 - 108,515,048 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
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Reference
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Original Reference(s)
Grap2RatAnaphylaxis amelioratesISORGD:1552736126790488 RGD 
Grap2Rathepatitis C severityISORGD:1316895126790487DNA:SNP:intron: (human)RGD 
Object Symbol
Species
Term
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Reference
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Original Reference(s)
Grap2Ratadenylosuccinase lyase deficiency  ISORGD:13168958554872ClinVar Annotator: match by term: Adenylosuccinate lyase deficiencyClinVarPMID:28492532
Grap2RatRubinstein-Taybi syndrome  ISORGD:13168958554872ClinVar Annotator: match by term: Rubinstein-Taybi syndrome 2ClinVarPMID:28492532

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Object Symbol
Species
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Original Reference(s)
Grap2Rat(-)-demecolcine decreases expressionISORGD:13168956480464Demecolcine results in decreased expression of GRAP2 mRNACTDPMID:23649840
Grap2Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:15527366480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Grap2Rat1-chloro-2,4-dinitrobenzene increases expressionISORGD:15527366480464Dinitrochlorobenzene results in increased expression of GRAP2 mRNACTDPMID:21404309
Grap2Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of GRAP2 mRNACTDPMID:30723492
Grap2Rat17beta-estradiol multiple interactionsISORGD:13168956480464[Estradiol co-treated with TGFB1 protein] results in increased expression of GRAP2 mRNACTDPMID:30165855
Grap2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORGD:15527366480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Grap2Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORGD:15527366480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Grap2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15527366480464Tetrachlorodibenzodioxin affects the expression of GRAP2 mRNACTDPMID:21570461|PMID:24680724
Grap2Rat2,4,4'-trichlorobiphenyl multiple interactionsISORGD:15527366480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Grap2Rat4,4'-sulfonyldiphenol affects expressionISORGD:15527366480464bisphenol S affects the expression of GRAP2 mRNACTDPMID:30951980
Grap2Rat4-(ethoxymethylene)-2-phenyloxazol-5-one increases expressionISORGD:15527366480464Oxazolone results in increased expression of GRAP2 mRNACTDPMID:21404309
Grap2Rataflatoxin B1 increases methylationISORGD:13168956480464Aflatoxin B1 results in increased methylation of GRAP2 intronCTDPMID:30157460
Grap2RatAflatoxin B2 alpha increases methylationISORGD:13168956480464aflatoxin B2 results in increased methylation of GRAP2 intronCTDPMID:30157460
Grap2Rataldehydo-D-glucose multiple interactionsISORGD:15527366480464[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ...CTDPMID:37567420
Grap2Ratalpha-Zearalanol increases expressionEXP 6480464Zeranol results in increased expression of GRAP2 mRNACTDPMID:35163327
Grap2Ratbenzo[a]pyrene affects methylationISORGD:13168956480464Benzo(a)pyrene affects the methylation of GRAP2 intronCTDPMID:30157460
Grap2Ratbenzo[e]pyrene increases methylationISORGD:13168956480464benzo(e)pyrene results in increased methylation of GRAP2 intronCTDPMID:30157460
Grap2Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of GRAP2 mRNACTDPMID:25181051|PMID:30816183|PMID:32528016
Grap2Ratbisphenol A increases expressionISORGD:15527366480464bisphenol A results in increased expression of GRAP2 mRNACTDPMID:38701888
Grap2Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of GRAP2 mRNACTDPMID:32145629

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Biological Process

  
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Original Reference(s)
Grap2Ratregulation of MAPK cascade involved_inIBAFB:FBgn0004638|MGI:95805|PANTHER:PTN0052735741600115GO_REF:0000033GO_CentralGO_REF:0000033
Grap2Ratsignal transduction involved_inIBAFB:FBgn0004638|MGI:95805|PANTHER:PTN005273574|UniProtKB:P62993|WB:WBGene000047741600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component
1 to 18 of 18 rows

  
Object Symbol
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Original Reference(s)
Grap2Ratcytoplasm located_inISORGD:13168951624291 PMID:21179510RGDPMID:21179510
Grap2Ratcytoplasm located_inIEAUniProtKB:O75791|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratcytoplasm is_active_inIBAMGI:95805|PANTHER:PTN005273574|UniProtKB:O75791|UniProtKB:P629931600115GO_REF:0000033GO_CentralGO_REF:0000033
Grap2Ratcytosol located_inISORGD:1316895|UniProtKB:O75791-11624291 RGDGO_REF:0000052
Grap2Ratcytosol located_inIEAUniProtKB:O75791|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratcytosol located_inIEAUniProtKB:Q6FI14|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratendosome located_inISORGD:13168951624291 PMID:21179510RGDPMID:21179510
Grap2Ratendosome located_inIEAUniProtKB:O75791|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratnucleoplasm located_inISORGD:1316895|UniProtKB:O75791-11624291 RGDGO_REF:0000052
Grap2Ratnucleoplasm located_inIEAUniProtKB:Q6FI14|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratnucleoplasm is_active_inIBAPANTHER:PTN005273574|UniProtKB:O75791|UniProtKB:P629931600115GO_REF:0000033GO_CentralGO_REF:0000033
Grap2Ratnucleoplasm located_inIEAUniProtKB:O75791|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratnucleus located_inISORGD:13168951624291 PMID:21179510RGDPMID:21179510
Grap2Ratnucleus located_inIEAUniProtKB:O75791|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratplasma membrane located_inISORGD:1316895|UniProtKB:O75791-11624291 RGDGO_REF:0000052
Grap2Ratplasma membrane located_inIEAUniProtKB:Q6FI14|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratplasma membrane located_inIEAUniProtKB:O75791|ensembl:ENSP000003391861600115GO_REF:0000107EnsemblGO_REF:0000107
Grap2Ratplasma membrane is_active_inIBAFB:FBgn0004638|MGI:95805|PANTHER:PTN005273574|UniProtKB:O75791|UniProtKB:P629931600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function

  
Object Symbol
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Original Reference(s)
Grap2Ratphosphotyrosine residue binding enablesIBAFB:FBgn0004638|PANTHER:PTN005273574|RGD:619758|UniProtKB:P629931600115GO_REF:0000033GO_CentralGO_REF:0000033
Grap2Ratprotein binding enablesISORGD:13168951624291UniProtKB:O14672|UniProtKB:O43597|UniProtKB:O95630|UniProtKB:P00533|UniProtKB:P00540|UniProtKB:P04626|UniProtKB:P0CG20|UniProtKB:P10721|UniProtKB:P15622-3|UniProtKB:P30039|UniProtKB:P54646|UniProtKB:Q08460|UniProtKB:Q13094|UniProtKB:Q13480|UniProtKB:Q5T749|UniProtKB:Q7Z783|UniProtKB:Q8IWV1|UniProtKB:Q8IY67|UniProtKB:Q8TBB1|UniProtKB:Q9H3S7|UniProtKB:Q9H706|UniProtKB:Q9H788|UniProtKB:Q9P2F9|UniProtKB:Q9UQC2|UniProtKB:Q9Y5A6 PMID:12359715, PMID:15929943, PMID:16189514, PMID:16273093, PMID:16730941, PMID:17010654, PMID:17065230, PMID:17235283, PMID:20534575, PMID:21179510, PMID:21516116, PMID:24658140, PMID:24728074, more ...RGDPMID:12359715|PMID:15929943|PMID:16189514|PMID:16273093|PMID:16730941|PMID:17010654|PMID:17065230|PMID:17235283|PMID:20534575|PMID:21179510|PMID:21516116|PMID:24658140|PMID:24728074|PMID:25036101|PMID:25241761|PMID:25416956|PMID:25814554|PMID:27107012|PMID:28514442|PMID:29997244|PMID:31467278|PMID:31515488|PMID:31980649|PMID:32296183|PMID:32814053|PMID:33961781|PMID:37398436
Grap2Ratprotein binding enablesISORGD:15527361624291PR:P70218|UniProtKB:Q13094|UniProtKB:Q60787|UniProtKB:Q6PB44|UniProtKB:Q9H3S7 PMID:15100220, PMID:16511262, PMID:17010654, PMID:19523899, PMID:24584089RGDPMID:15100220|PMID:16511262|PMID:17010654|PMID:19523899|PMID:24584089

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Grap2RatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Genetic variations in humans associated with differences in the course of hepatitis C. Saito T, etal., Biochem Biophys Res Commun. 2004 Apr 30;317(2):335-41. doi: 10.1016/j.bbrc.2004.03.056.
9. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. Yamasaki S, etal., Int Immunol. 2008 Oct;20(10):1289-97. doi: 10.1093/intimm/dxn085. Epub 2008 Jul 29.
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PMID:12477932   PMID:21179510  



Grap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,997,356 - 114,071,073 (+)NCBIGRCr8
mRatBN7.27112,117,142 - 112,190,880 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,117,142 - 112,190,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,872,662 - 113,946,895 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,096,186 - 116,170,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,065,563 - 116,139,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,791,330 - 121,864,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,841,855 - 121,864,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,781,461 - 121,854,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,856,130 - 118,931,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,882,484 - 118,965,381 (+)NCBI
Celera7108,442,874 - 108,515,048 (+)NCBICelera
Cytogenetic Map7q34NCBI
GRAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,893,820 - 39,973,721 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,901,084 - 39,973,721 (+)EnsemblGRCh38hg38GRCh38
GRCh372240,297,088 - 40,369,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,627,032 - 38,697,330 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,621,585 - 38,691,884NCBI
Celera2224,099,151 - 24,169,444 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2223,260,094 - 23,330,327 (+)NCBIHuRef
CHM1_12240,256,126 - 40,326,591 (+)NCBICHM1_1
T2T-CHM13v2.02240,364,806 - 40,444,710 (+)NCBIT2T-CHM13v2.0
Grap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,456,798 - 80,537,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,456,795 - 80,537,055 (+)EnsemblGRCm39 Ensembl
GRCm381580,572,597 - 80,652,854 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,572,594 - 80,652,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,453,913 - 80,480,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,450,738 - 80,477,553 (+)NCBIMGSCv36mm8
Celera1582,743,068 - 82,770,161 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.88NCBI
Grap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,691,439 - 25,758,813 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,691,824 - 25,758,461 (+)NCBIChiLan1.0ChiLan1.0
GRAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,740,213 - 49,826,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,431,531 - 52,517,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,831,191 - 20,878,867 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,651,719 - 38,696,566 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,651,719 - 38,696,566 (+)Ensemblpanpan1.1panPan2
GRAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,156,233 - 25,220,106 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,157,841 - 25,220,222 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,092,401 - 25,156,329 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,908,310 - 25,972,290 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,909,919 - 25,972,202 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,619,908 - 25,683,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,942,524 - 26,006,115 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,117,033 - 26,181,059 (-)NCBIUU_Cfam_GSD_1.0
Grap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,745,057 - 8,816,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,759,298 - 1,796,049 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,759,182 - 1,796,049 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,375,762 - 8,445,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,372,920 - 8,445,128 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.255,668,663 - 5,744,087 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,478,744 - 22,548,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,524,851 - 22,552,977 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,050,792 - 103,121,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,458,292 - 8,476,256 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,453,946 - 8,476,256 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Grap2
416 total Variants

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000024673
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat

1 to 10 of 35 rows
BI277894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,173,694 - 112,173,799 (+)MAPPERmRatBN7.2
Rnor_6.07121,847,849 - 121,847,953NCBIRnor6.0
Rnor_5.07121,837,628 - 121,837,732UniSTSRnor5.0
RGSC_v3.47118,912,401 - 118,912,505UniSTSRGSC3.4
Celera7108,498,465 - 108,498,569UniSTS
Cytogenetic Map7q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024673   ⟹   ENSRNOP00000024673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,117,142 - 112,190,877 (+)Ensembl
Rnor_6.0 Ensembl7121,841,855 - 121,864,679 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095205   ⟹   ENSRNOP00000094684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,117,142 - 112,190,877 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099654   ⟹   ENSRNOP00000079385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,117,142 - 112,189,629 (+)Ensembl
RefSeq Acc Id: NM_001034944   ⟹   NP_001030116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,997,356 - 114,071,073 (+)NCBI
mRatBN7.27112,117,142 - 112,190,880 (+)NCBI
Rnor_6.07121,791,330 - 121,864,835 (+)NCBI
Rnor_5.07121,781,461 - 121,854,021 (+)NCBI
RGSC_v3.47118,856,130 - 118,931,148 (+)RGD
Celera7108,442,874 - 108,515,048 (+)RGD
Sequence:
Protein RefSeqs NP_001030116 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05896 (Get FASTA)   NCBI Sequence Viewer  
  EDM15748 (Get FASTA)   NCBI Sequence Viewer  
  EDM15749 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024673.8
  ENSRNOP00000079385.1
  ENSRNOP00000094684
  ENSRNOP00000094684.1
RefSeq Acc Id: NP_001030116   ⟸   NM_001034944
- UniProtKB: Q3KR57 (UniProtKB/TrEMBL),   D3ZG10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024673   ⟸   ENSRNOT00000024673
Ensembl Acc Id: ENSRNOP00000079385   ⟸   ENSRNOT00000099654
Ensembl Acc Id: ENSRNOP00000094684   ⟸   ENSRNOT00000095205
SH2   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG10-F1-model_v2 AlphaFold D3ZG10 1-327 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32697 BioCyc
Ensembl Genes ENSRNOG00000018316 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024673.8 UniProtKB/TrEMBL
  ENSRNOT00000095205 ENTREZGENE
  ENSRNOT00000095205.1 UniProtKB/TrEMBL
  ENSRNOT00000099654.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380480 IMAGE-MGC_LOAD
InterPro GRAP2_C_SH3 UniProtKB/TrEMBL
  Grb2-like UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  STAM UniProtKB/TrEMBL
KEGG Report rno:366962 UniProtKB/TrEMBL
MGC_CLONE MGC:125066 IMAGE-MGC_LOAD
NCBI Gene 366962 ENTREZGENE
PANTHER JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE UniProtKB/TrEMBL
  JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE UniProtKB/TrEMBL
  PTHR46037 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Grap2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018316 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8I5ZMQ0_RAT UniProtKB/TrEMBL
  A6HSX3_RAT UniProtKB/TrEMBL
  D3ZG10 ENTREZGENE, UniProtKB/TrEMBL
  Q3KR57 ENTREZGENE, UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Grap2  GRB2-related adaptor protein 2  Grap2_predicted  GRB2-related adaptor protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Grap2_predicted  GRB2-related adaptor protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED