GRAP2 (GRB2 related adaptor protein 2) - Rat Genome Database

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Gene: GRAP2 (GRB2 related adaptor protein 2) Chlorocebus sabaeus
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Symbol: GRAP2
Name: GRB2 related adaptor protein 2
RGD ID: 18436368
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); INVOLVED IN regulation of MAPK cascade (inferred); signal transduction (inferred); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Anaphylaxis (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GRB2-related adapter protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,478,744 - 22,548,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,524,851 - 22,552,977 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,050,792 - 103,121,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
endosome  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
plasma membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GRAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,478,744 - 22,548,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,524,851 - 22,552,977 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,050,792 - 103,121,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GRAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,893,820 - 39,973,721 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,901,084 - 39,973,721 (+)EnsemblGRCh38hg38GRCh38
GRCh372240,297,088 - 40,369,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,627,032 - 38,697,330 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,621,585 - 38,691,884NCBI
Celera2224,099,151 - 24,169,444 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2223,260,094 - 23,330,327 (+)NCBIHuRef
CHM1_12240,256,126 - 40,326,591 (+)NCBICHM1_1
T2T-CHM13v2.02240,364,806 - 40,444,710 (+)NCBIT2T-CHM13v2.0
Grap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,456,798 - 80,537,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,456,795 - 80,537,055 (+)EnsemblGRCm39 Ensembl
GRCm381580,572,597 - 80,652,854 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,572,594 - 80,652,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,453,913 - 80,480,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,450,738 - 80,477,553 (+)NCBIMGSCv36mm8
Celera1582,743,068 - 82,770,161 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.88NCBI
Grap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,997,356 - 114,071,073 (+)NCBIGRCr8
mRatBN7.27112,117,142 - 112,190,880 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,117,142 - 112,190,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,872,662 - 113,946,895 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,096,186 - 116,170,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,065,563 - 116,139,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,791,330 - 121,864,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,841,855 - 121,864,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,781,461 - 121,854,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,856,130 - 118,931,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,882,484 - 118,965,381 (+)NCBI
Celera7108,442,874 - 108,515,048 (+)NCBICelera
Cytogenetic Map7q34NCBI
Grap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,691,439 - 25,758,813 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,691,824 - 25,758,461 (+)NCBIChiLan1.0ChiLan1.0
GRAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,740,213 - 49,826,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,431,531 - 52,517,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,831,191 - 20,878,867 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,651,719 - 38,696,566 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,651,719 - 38,696,566 (+)Ensemblpanpan1.1panPan2
GRAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,156,233 - 25,220,106 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,157,841 - 25,220,222 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,092,401 - 25,156,329 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,908,310 - 25,972,290 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,909,919 - 25,972,202 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,619,908 - 25,683,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,942,524 - 26,006,115 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,117,033 - 26,181,059 (-)NCBIUU_Cfam_GSD_1.0
Grap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,745,057 - 8,816,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,759,298 - 1,796,049 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,759,182 - 1,796,049 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,375,762 - 8,445,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,372,920 - 8,445,128 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.255,668,663 - 5,744,087 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Grap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,458,292 - 8,476,256 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,453,946 - 8,476,256 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 19
Low 20 1 41
Below cutoff 15 19

Sequence


RefSeq Acc Id: ENSCSAT00000004103   ⟹   ENSCSAP00000002365
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1922,524,851 - 22,552,977 (+)Ensembl
RefSeq Acc Id: XM_007975855   ⟹   XP_007974046
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11922,524,031 - 22,548,829 (+)NCBI
Vero_WHO_p1.0NW_023666045103,050,792 - 103,075,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007975857   ⟹   XP_007974048
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11922,524,578 - 22,548,829 (+)NCBI
Vero_WHO_p1.0NW_023666045103,050,792 - 103,075,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007975859   ⟹   XP_007974050
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11922,478,744 - 22,548,829 (+)NCBI
Vero_WHO_p1.0NW_023666045103,050,792 - 103,121,149 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038007412   ⟹   XP_037863340
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666045103,050,792 - 103,121,116 (-)NCBI
RefSeq Acc Id: XM_038007413   ⟹   XP_037863341
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666045103,050,792 - 103,074,805 (-)NCBI
RefSeq Acc Id: XM_038007414   ⟹   XP_037863342
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666045103,050,792 - 103,061,826 (-)NCBI
RefSeq Acc Id: XP_007974050   ⟸   XM_007975859
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R176 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974046   ⟸   XM_007975855
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007974048   ⟸   XM_007975857
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R176 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000002365   ⟸   ENSCSAT00000004103
RefSeq Acc Id: XP_037863340   ⟸   XM_038007412
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037863341   ⟸   XM_038007413
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037863342   ⟸   XM_038007414
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006067 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004103.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro GRAP2_C_SH3 UniProtKB/TrEMBL
  Grb2-like UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene GRAP2 ENTREZGENE
PANTHER GRB2-RELATED ADAPTER PROTEIN 2 UniProtKB/TrEMBL
  PTHR46037 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9R176 ENTREZGENE, UniProtKB/TrEMBL