Cela1 (chymotrypsin like elastase 1) - Rat Genome Database

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Gene: Cela1 (chymotrypsin like elastase 1) Rattus norvegicus
Analyze
Symbol: Cela1 (Ensembl: Bin2)
Name: chymotrypsin like elastase 1 (Ensembl:bridging integrator 2)
RGD ID: 2547
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including elastin catabolic process; exocrine pancreas development; and regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including extracellular region; phagocytic cup; and podosome. Predicted to be active in extracellular space. Orthologous to human CELA1 (chymotrypsin like elastase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chymotrypsin-like elastase family member 1; chymotrypsin-like elastase family, member 1; Ela1; ELAI1; elastase 1; elastase 1, pancreatic; elastase-1; RATELAI1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,651,939 - 133,665,136 (-)NCBIGRCr8
mRatBN7.27131,773,161 - 131,786,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,575,294 - 133,588,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,800,881 - 135,814,013 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,714,422 - 135,727,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,305,337 - 142,318,621 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,305,338 - 142,318,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,110,478 - 140,123,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,439,589 - 139,452,717 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,515,742 - 139,529,176 (-)NCBI
Celera7128,249,427 - 128,262,461 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
L-methionine  (ISO)
mercaptopurine  (EXP)
methamphetamine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
oxaliplatin  (EXP)
p-toluidine  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
purine-6-thiol  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
3. Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences. MacDonald RJ, etal., Biochemistry 1982 Mar 16;21(6):1453-63.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Structure of the two related elastase genes expressed in the rat pancreas. Swift GH, etal., J Biol Chem 1984 Nov 25;259(22):14271-8.
Additional References at PubMed
PMID:6555050   PMID:14631510   PMID:14631512   PMID:17222338   PMID:24793170  


Genomics

Comparative Map Data
Cela1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,651,939 - 133,665,136 (-)NCBIGRCr8
mRatBN7.27131,773,161 - 131,786,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,575,294 - 133,588,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,800,881 - 135,814,013 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,714,422 - 135,727,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,305,337 - 142,318,621 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,305,338 - 142,318,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,110,478 - 140,123,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,439,589 - 139,452,717 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,515,742 - 139,529,176 (-)NCBI
Celera7128,249,427 - 128,262,461 (-)NCBICelera
Cytogenetic Map7q36NCBI
CELA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,328,442 - 51,346,679 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,328,442 - 51,346,679 (-)EnsemblGRCh38hg38GRCh38
GRCh371251,722,226 - 51,740,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,008,494 - 50,026,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 341250,008,493 - 50,026,730NCBI
Celera1250,523,712 - 50,541,944 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1248,755,149 - 48,773,386 (-)NCBIHuRef
CHM1_11251,688,462 - 51,705,900 (-)NCBICHM1_1
T2T-CHM13v2.01251,291,249 - 51,309,485 (-)NCBIT2T-CHM13v2.0
Cela1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,572,303 - 100,585,801 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,572,302 - 100,585,802 (-)EnsemblGRCm39 Ensembl
GRCm3815100,674,422 - 100,687,920 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,674,421 - 100,687,921 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715100,504,853 - 100,518,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,502,459 - 100,515,952 (-)NCBIMGSCv36mm8
Celera15102,827,643 - 102,841,149 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.38NCBI
Cela1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,810,670 - 1,824,409 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555471,810,680 - 1,823,938 (-)NCBIChiLan1.0ChiLan1.0
CELA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,839,742 - 42,859,679 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,836,504 - 42,856,441 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,407,189 - 37,425,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,291,831 - 38,310,331 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,292,562 - 38,310,197 (+)Ensemblpanpan1.1panPan2
CELA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,542,327 - 3,560,777 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,542,309 - 3,560,777 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,697,240 - 42,715,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,587,196 - 3,605,707 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,536,169 - 3,605,707 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,554,804 - 3,573,236 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,541,322 - 3,559,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,094,493 - 43,113,139 (-)NCBIUU_Cfam_GSD_1.0
Cela1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,244,890 - 64,263,156 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,905,339 - 8,919,819 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,901,674 - 8,919,819 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CELA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2517,250,142 - 17,279,128 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CELA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,526,354 - 47,545,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,526,365 - 47,544,726 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,550,809 - 198,569,559 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cela1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816906,121 - 939,696 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816906,103 - 939,252 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cela1
117 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:47
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000006351
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,786,627 - 131,786,744 (+)MAPPERmRatBN7.2
Rnor_6.07142,318,964 - 142,319,080NCBIRnor6.0
Rnor_5.07140,123,788 - 140,123,904UniSTSRnor5.0
RGSC_v3.47139,453,081 - 139,453,198RGDRGSC3.4
RGSC_v3.47139,453,082 - 139,453,198UniSTSRGSC3.4
RGSC_v3.17139,529,518 - 139,529,635RGD
Celera7128,262,804 - 128,262,920UniSTS
RH 3.4 Map71066.9UniSTS
RH 3.4 Map71066.9RGD
RH 2.0 Map7793.1RGD
Cytogenetic Map7q36UniSTS
D7Mit26  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87133,665,376 - 133,665,591 (+)Marker Load Pipeline
mRatBN7.27131,786,600 - 131,786,815 (+)MAPPERmRatBN7.2
Rnor_6.07142,318,937 - 142,319,151NCBIRnor6.0
Rnor_5.07140,123,761 - 140,123,975UniSTSRnor5.0
RGSC_v3.47139,453,054 - 139,453,269RGDRGSC3.4
RGSC_v3.47139,453,055 - 139,453,269UniSTSRGSC3.4
RGSC_v3.17139,529,491 - 139,529,706RGD
Celera7128,262,777 - 128,262,991UniSTS
RH 3.4 Map71065.9RGD
RH 3.4 Map71065.9UniSTS
RH 2.0 Map7790.8RGD
Cytogenetic Map7q36UniSTS
D7Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,786,607 - 131,786,854 (+)MAPPERmRatBN7.2
Rnor_6.07142,318,944 - 142,319,190NCBIRnor6.0
Rnor_5.07140,123,768 - 140,124,014UniSTSRnor5.0
RGSC_v3.47139,453,061 - 139,453,308RGDRGSC3.4
RGSC_v3.47139,453,062 - 139,453,308UniSTSRGSC3.4
RGSC_v3.17139,529,498 - 139,529,745RGD
Celera7128,262,784 - 128,263,030UniSTS
RH 3.4 Map71070.6UniSTS
RH 3.4 Map71070.6RGD
RH 2.0 Map7794.8RGD
SHRSP x BN Map788.4599RGD
FHH x ACI Map773.51RGD
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 29 109 91 90 59 25 59 6 194 73 89 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006351   ⟹   ENSRNOP00000006351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,773,163 - 131,786,285 (-)Ensembl
Rnor_6.0 Ensembl7142,305,338 - 142,318,620 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048262   ⟹   ENSRNOP00000039630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,742,002 - 131,768,308 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097496   ⟹   ENSRNOP00000079003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,745,813 - 131,761,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103654   ⟹   ENSRNOP00000084036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)Ensembl
RefSeq Acc Id: NM_012552   ⟹   NP_036684
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,651,941 - 133,665,061 (-)NCBI
mRatBN7.27131,773,163 - 131,786,285 (-)NCBI
Rnor_6.07142,305,337 - 142,318,621 (-)NCBI
Rnor_5.07140,110,478 - 140,123,423 (-)NCBI
RGSC_v3.47139,439,589 - 139,452,717 (-)RGD
Celera7128,249,427 - 128,262,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063262977   ⟹   XP_063119047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,652,838 - 133,665,136 (-)NCBI
RefSeq Acc Id: XM_063262978   ⟹   XP_063119048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,651,939 - 133,665,027 (-)NCBI
RefSeq Acc Id: XM_063262979   ⟹   XP_063119049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,652,838 - 133,665,134 (-)NCBI
RefSeq Acc Id: NP_036684   ⟸   NM_012552
- Peptide Label: precursor
- UniProtKB: P00773 (UniProtKB/Swiss-Prot),   A0A0G2JSI5 (UniProtKB/TrEMBL),   A6KCL6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006351   ⟸   ENSRNOT00000006351
Ensembl Acc Id: ENSRNOP00000039630   ⟸   ENSRNOT00000048262
Ensembl Acc Id: ENSRNOP00000084036   ⟸   ENSRNOT00000103654
Ensembl Acc Id: ENSRNOP00000079003   ⟸   ENSRNOT00000097496
RefSeq Acc Id: XP_063119048   ⟸   XM_063262978
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119047   ⟸   XM_063262977
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119049   ⟸   XM_063262979
- Peptide Label: isoform X3
Protein Domains
BAR   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00773-F1-model_v2 AlphaFold P00773 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695664
Promoter ID:EPDNEW_R6188
Type:single initiation site
Name:Cela1_1
Description:chymotrypsin-like elastase family, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,318,621 - 142,318,681EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2547 AgrOrtholog
BioCyc Gene G2FUF-32011 BioCyc
Ensembl Genes ENSRNOG00000004725 Ensembl
  ENSRNOG00000031930 Ensembl
  ENSRNOG00000080453 ENTREZGENE
Ensembl Transcript ENSRNOT00000006351 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_Elastase_sf UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:24331 UniProtKB/Swiss-Prot
NCBI Gene 24331 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/Swiss-Prot
  CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1 UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Cela1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004725 RatGTEx
  ENSRNOG00000031930 RatGTEx
  ENSRNOG00000080453 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A0G2JSI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM51_RAT UniProtKB/TrEMBL
  A0A8I5ZY98_RAT UniProtKB/TrEMBL
  A6KCL6 ENTREZGENE, UniProtKB/TrEMBL
  CELA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Cela1  chymotrypsin like elastase 1  Cela1  chymotrypsin-like elastase family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-18 Cela1  chymotrypsin-like elastase family, member 1  Ela1  elastase 1, pancreatic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ela1  elastase 1, pancreatic    elastase 1  Name updated 1299863 APPROVED
2002-06-10 Ela1  Elastase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 4.2 fold in SHR compared with WKY rats 1357414