Gpd1l2 (glycerol-3-phosphate dehydrogenase 1 like 2) - Rat Genome Database

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Gene: Gpd1l2 (glycerol-3-phosphate dehydrogenase 1 like 2) Rattus norvegicus
Analyze
Symbol: Gpd1l2 (Ensembl: AABR07058116.1)
Name: glycerol-3-phosphate dehydrogenase 1 like 2
RGD ID: 1563100
Description: Predicted to enable NAD binding activity; glycerol-3-phosphate dehydrogenase (NAD+) activity; and protein homodimerization activity. Predicted to be involved in NADH oxidation; carbohydrate metabolic process; and glycerol-3-phosphate catabolic process. Predicted to be located in cytoplasm; INTERACTS WITH bisphenol A; metformin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC299964; RGD1563100; similar to KIAA0089
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8793,829,651 - 93,831,530 (+)NCBIGRCr8
mRatBN7.2791,940,258 - 91,942,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl791,940,260 - 91,942,559 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07100,699,866 - 100,701,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07101,278,450 - 101,279,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4797,232,035 - 97,236,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera788,668,182 - 88,670,202 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
metformin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Gpd1l2
14 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000006506   ⟹   ENSRNOP00000078340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl791,940,260 - 91,942,559 (+)Ensembl
Rnor_6.0 Ensembl7100,700,670 - 100,701,725 (+)Ensembl
RefSeq Acc Id: XM_039080203   ⟹   XP_038936131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8793,829,660 - 93,831,530 (+)NCBI
mRatBN7.2791,940,258 - 91,942,125 (+)NCBI
RefSeq Acc Id: XM_039080204   ⟹   XP_038936132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8793,829,651 - 93,831,530 (+)NCBI
mRatBN7.2791,940,258 - 91,942,125 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038936131 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936132 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078340.1
RefSeq Acc Id: XP_038936131   ⟸   XM_039080203
- UniProtKB: A0A8I5ZKP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936132   ⟸   XM_039080204
- UniProtKB: A0A8I5ZKP8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078340   ⟸   ENSRNOT00000006506
Protein Domains
Glycerol-3-phosphate dehydrogenase NAD-dependent C-   Glycerol-3-phosphate dehydrogenase NAD-dependent N-

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-33256 BioCyc
Ensembl Genes ENSRNOG00000004906 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006506.6 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro 6-PGluconate_DH-like_C_sf UniProtKB/TrEMBL
  6PGD_dom2 UniProtKB/TrEMBL
  G3P_DH_NAD-dep UniProtKB/TrEMBL
  G3P_DH_NAD-dep_C UniProtKB/TrEMBL
  G3P_DH_NAD-dep_euk UniProtKB/TrEMBL
  G3P_DH_NAD-dep_N UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene 299964 ENTREZGENE
PANTHER GLYCEROL-3-PHOSPHATE DEHYDROGENASE UniProtKB/TrEMBL
  GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam NAD_Gly3P_dh_C UniProtKB/TrEMBL
  NAD_Gly3P_dh_N UniProtKB/TrEMBL
PhenoGen Gpd1l2 PhenoGen
PIRSF Glycerol-3-P_dh UniProtKB/TrEMBL
PRINTS GPDHDRGNASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004906 RatGTEx
Superfamily-SCOP SSF48179 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8I5ZKP8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Gpd1l2  glycerol-3-phosphate dehydrogenase 1 like 2  RGD1563100  similar to KIAA0089  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1563100  similar to KIAA0089   RGD1563100_predicted  similar to KIAA0089 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563100_predicted  similar to KIAA0089 (predicted)  LOC299964  similar to KIAA0089  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299964  similar to KIAA0089      Symbol and Name status set to provisional 70820 PROVISIONAL