Mb (myoglobin) - Rat Genome Database

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Gene: Mb (myoglobin) Rattus norvegicus
Analyze
Symbol: Mb
Name: myoglobin
RGD ID: 620411
Description: Enables oxygen binding activity. Involved in several processes, including oxygen transport; response to hydrogen peroxide; and slow-twitch skeletal muscle fiber contraction. Used to study acute kidney failure. Orthologous to human MB (myoglobin); INTERACTS WITH (+)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Glng; globin g
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mbem6Mcwi  
Genetic Models: WKY-Mbem6Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,759,903 - 108,767,134 (-)NCBI
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Celera7105,108,137 - 105,115,366 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetamiprid  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
carvacrol  (EXP)
cerium trichloride  (ISO)
cerivastatin  (EXP)
ciprofloxacin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
cumene hydroperoxide  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
genistein  (EXP,ISO)
glycerol  (EXP)
glyphosate  (EXP)
graphite  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
methapyrilene  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium dichromate  (ISO)
rosuvastatin calcium  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sinapic acid  (EXP)
sodium arsenite  (ISO)
sodium nitrate  (ISO)
succinylcholine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triamcinolone  (EXP)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (EXP)
vitamin E  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
1. Anwaruddin S, etal., Am J Clin Pathol. 2005 Jan;123(1):140-5.
2. Detweiler CD, etal., Free Radic Biol Med. 2002 Aug 1;33(3):364-9.
3. El-Abdellati E, etal., Ann Intensive Care. 2013 Mar 14;3(1):8. doi: 10.1186/2110-5820-3-8.
4. Emig U, etal., Shock. 2003 Jan;19(1):79-84.
5. Flogel U, etal., FASEB J. 2004 Jul;18(10):1156-8. Epub 2004 May 7.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
8. Giannocco G, etal., Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26.
9. Kreutzer U and Jue T, Am J Physiol Heart Circ Physiol 2004 Mar;286(3):H985-91.
10. Lin PC, etal., J Physiol. 2006 Oct 12;.
11. Marzouki L, etal., Arch Physiol Biochem. 2002 Dec;110(5):400-7.
12. MGD data from the GO Consortium
13. Moore KP, etal., J Biol Chem. 1998 Nov 27;273(48):31731-7.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Nitta T, etal., J Surg Res. 2003 Apr;110(2):322-31.
16. Okumura N, etal., Proteomics. 2005 Jul;5(11):2896-906.
17. RGD automated data pipeline
18. RGD automated import pipeline for gene-chemical interactions
19. Ruan Q, etal., Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3.
20. Seiyama A Dyn Med. 2006 Jan 24;5:3.
21. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tanasijevic MJ J Thromb Thrombolysis. 2005 Feb;19(1):21-4.
23. Xiaohong Z, etal., Leg Med (Tokyo). 2002 Mar;4(1):47-51.
24. Zhang Y, etal., Diabetes Obes Metab. 2020 May 14. doi: 10.1111/dom.14086.
25. Zheng HZ, etal., Sheng Li Xue Bao. 1999 Feb;51(1):25-30.
Additional References at PubMed
PMID:11304494   PMID:14656764   PMID:15048578   PMID:15489334   PMID:17218454   PMID:17293481   PMID:18492766   PMID:19308875   PMID:19545623   PMID:23533145   PMID:23608161   PMID:24256333  
PMID:26945066   PMID:27329933   PMID:29476059   PMID:30658240  


Genomics

Comparative Map Data
Mb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,759,903 - 108,767,134 (-)NCBI
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Celera7105,108,137 - 105,115,366 (-)NCBICelera
Cytogenetic Map7q34NCBI
MB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2235,606,764 - 35,637,951 (-)EnsemblGRCh38hg38GRCh38
GRCh382235,606,764 - 35,623,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372236,002,811 - 36,019,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,332,757 - 34,349,347 (-)NCBINCBI36hg18NCBI36
Build 342234,327,310 - 34,338,055NCBI
Celera2219,806,063 - 19,822,655 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2218,963,313 - 18,979,770 (-)NCBIHuRef
CHM1_12235,961,646 - 35,978,237 (-)NCBICHM1_1
Mb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,899,687 - 76,934,868 (-)NCBIGRCm39mm39
GRCm39 Ensembl1576,899,687 - 76,934,870 (-)Ensembl
GRCm381577,015,487 - 77,050,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,015,487 - 77,050,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,845,917 - 76,881,098 (-)NCBIGRCm37mm9NCBIm37
MGSCv361576,842,742 - 76,877,923 (-)NCBImm8
Celera1578,503,595 - 78,538,817 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.36NCBI
Mb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,215,007 - 43,222,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,215,404 - 43,221,606 (-)NCBIChiLan1.0ChiLan1.0
MB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12234,452,451 - 34,485,581 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,452,451 - 34,463,224 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02216,612,519 - 16,645,333 (-)NCBIMhudiblu_PPA_v0panPan3
MB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,573,819 - 28,583,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,552,749 - 28,583,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,513,611 - 28,523,318 (+)NCBI
ROS_Cfam_1.01029,360,185 - 29,369,892 (+)NCBI
UMICH_Zoey_3.11029,085,598 - 29,095,292 (+)NCBI
UNSW_CanFamBas_1.01029,394,667 - 29,404,374 (+)NCBI
UU_Cfam_GSD_1.01029,575,155 - 29,584,857 (+)NCBI
Mb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,880,637 - 11,887,251 (+)NCBI
SpeTri2.0NW_0049364924,890,871 - 4,897,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MB
(Sus scrofa - pig)
No map positions available.
MB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,369,234 - 18,385,922 (-)NCBI
ChlSab1.1 Ensembl1918,369,174 - 18,380,270 (-)Ensembl
Vero_WHO_p1.0NW_023666045107,562,452 - 107,578,780 (+)NCBI
Mb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624750259,559 - 266,124 (+)NCBI

Position Markers
RH134536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,759,948 - 108,760,150 (+)MAPPER
Rnor_6.07118,101,679 - 118,101,880NCBIRnor6.0
Rnor_5.07118,094,437 - 118,094,638UniSTSRnor5.0
RGSC_v3.47115,087,604 - 115,087,805UniSTSRGSC3.4
Celera7105,108,183 - 105,108,384UniSTS
RH 3.4 Map7800.0UniSTS
Cytogenetic Map7q34UniSTS
MB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,761,978 - 108,762,175 (+)MAPPER
Rnor_6.07118,103,709 - 118,103,905NCBIRnor6.0
Rnor_5.07118,096,467 - 118,096,663UniSTSRnor5.0
RGSC_v3.47115,089,634 - 115,089,830UniSTSRGSC3.4
Celera7105,110,213 - 105,110,409UniSTS
Cytogenetic Map7q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)777428105127748511Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)777428234122421148Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)781645773140745067Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)788365265119318087Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)788365265121986709Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)788365265133365265Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)788365265134673427Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)791018361136018361Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)793726906138726906Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)793726906138726906Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)7100160423140335001Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)7103815550126525386Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)7103867802126080176Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7112429186126525386Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat


Genetic Models
This gene Mb is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:50
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000006184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 35 7 10 7
Medium 14 17 8 6 8 1 1 2 3 9 1
Low 1 9 2 11 2 11 15 20 2
Below cutoff 1 10 10 2 10 4 16 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF197916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF278533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000006184   ⟹   ENSRNOP00000006184
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)Ensembl
RefSeq Acc Id: NM_021588   ⟹   NP_067599
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,759,903 - 108,767,134 (-)NCBI
Rnor_6.07118,101,633 - 118,108,864 (-)NCBI
Rnor_5.07118,094,391 - 118,101,622 (-)NCBI
RGSC_v3.47115,087,558 - 115,094,789 (-)RGD
Celera7105,108,137 - 105,115,366 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067599   ⟸   NM_021588
- UniProtKB: Q9QZ76 (UniProtKB/Swiss-Prot),   A0A1K0FUB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006184   ⟸   ENSRNOT00000006184
Protein Domains
GLOBIN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695443
Promoter ID:EPDNEW_R5968
Type:single initiation site
Name:Mb_1
Description:myoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07118,108,894 - 118,108,954EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620411 AgrOrtholog
Ensembl Genes ENSRNOG00000004583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000006184 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006184 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103504 IMAGE-MGC_LOAD
InterPro Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin/Proto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91707 IMAGE-MGC_LOAD
NCBI Gene 59108 ENTREZGENE
PANTHER PTHR47132 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mb PhenoGen
PRINTS MYOGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1K0FUB2 ENTREZGENE, UniProtKB/TrEMBL
  MYG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mb  myoglobin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mb  myoglobin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may act as a scavenger of cellular Nitric Oxide in the myocardium 1300476