Mb (myoglobin) - Rat Genome Database

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Gene: Mb (myoglobin) Rattus norvegicus
Analyze
Symbol: Mb
Name: myoglobin
RGD ID: 620411
Description: Enables oxygen binding activity. Involved in several processes, including oxygen transport; response to hydrogen peroxide; and slow-twitch skeletal muscle fiber contraction. Predicted to be located in sarcoplasm. Used to study acute kidney failure. Orthologous to human MB (myoglobin); INTERACTS WITH (R,R,R)-alpha-tocopherol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glng; globin g; nitrite reductase MB; pseudoperoxidase MB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mbem6Mcwi  
Genetic Models: WKY-Mbem6Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,640,511 - 110,647,742 (-)NCBIGRCr8
mRatBN7.27108,759,903 - 108,767,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,502,181 - 110,509,413 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,725,771 - 112,733,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,687,217 - 112,694,445 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Celera7105,108,137 - 105,115,366 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carvacrol  (EXP)
cerium trichloride  (ISO)
cerivastatin  (EXP)
CGP 52608  (ISO)
ciprofloxacin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corilagin  (EXP)
corticosterone  (EXP)
CU-O LINKAGE  (EXP)
cumene hydroperoxide  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
entinostat  (ISO)
ethanol  (EXP)
gallic acid  (ISO)
genistein  (EXP,ISO)
glycerol  (EXP)
glyphosate  (EXP)
graphite  (ISO)
Heliotrine  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium dichromate  (ISO)
rosuvastatin calcium  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sinapic acid  (EXP)
sodium arsenite  (ISO)
sodium nitrate  (ISO)
succinylcholine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triamcinolone  (EXP)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
sarcoplasm  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Anwaruddin S, etal., Am J Clin Pathol. 2005 Jan;123(1):140-5.
2. Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. Detweiler CD, etal., Free Radic Biol Med. 2002 Aug 1;33(3):364-9.
3. An observational study on rhabdomyolysis in the intensive care unit. Exploring its risk factors and main complication: acute kidney injury. El-Abdellati E, etal., Ann Intensive Care. 2013 Mar 14;3(1):8. doi: 10.1186/2110-5820-3-8.
4. Contribution of myoglobin-induced increases in vascular resistance to shock decompensation in experimental Crush-syndrome in anesthetized rats. Emig U, etal., Shock. 2003 Jan;19(1):79-84.
5. Role of myoglobin in the antioxidant defense of the heart. Flogel U, etal., FASEB J. 2004 Jul;18(10):1156-8. Epub 2004 May 7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
8. Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle. Giannocco G, etal., Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26.
9. Role of myoglobin as a scavenger of cellular NO in myocardium. Kreutzer U and Jue T, Am J Physiol Heart Circ Physiol 2004 Mar;286(3):H985-91.
10. Myoglobin Translational Diffusion in Myocardium and Its Implication on Intracellular Oxygen Transport. Lin PC, etal., J Physiol. 2006 Oct 12;.
11. The role of myoglobin in retarding oxygen depletion in anoxic heart. Marzouki L, etal., Arch Physiol Biochem. 2002 Dec;110(5):400-7.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. Moore KP, etal., J Biol Chem. 1998 Nov 27;273(48):31731-7.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Myoglobin gene expression attenuates hepatic ischemia reperfusion injury. Nitta T, etal., J Surg Res. 2003 Apr;110(2):322-31.
16. Proteomic analysis of slow- and fast-twitch skeletal muscles. Okumura N, etal., Proteomics. 2005 Jul;5(11):2896-906.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Ruan Q, etal., Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3.
20. Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo. Seiyama A Dyn Med. 2006 Jan 24;5:3.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Evaluation of coronary artery patency using cardiac markers. Tanasijevic MJ J Thromb Thrombolysis. 2005 Feb;19(1):21-4.
23. The contrast of immunohistochemical studies of myocardial fibrinogen and myoglobin in early myocardial ischemia in rats. Xiaohong Z, etal., Leg Med (Tokyo). 2002 Mar;4(1):47-51.
24. The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single-centre, retrospective, observational study in Wuhan. Zhang Y, etal., Diabetes Obes Metab. 2020 May 14. doi: 10.1111/dom.14086.
25. [Effects of myocardial ischemia reperfusion injury on L-arginine/nitric oxide system in rat heart] Zheng HZ, etal., Sheng Li Xue Bao. 1999 Feb;51(1):25-30.
Additional References at PubMed
PMID:11304494   PMID:14656764   PMID:15048578   PMID:15489334   PMID:17218454   PMID:17293481   PMID:18492766   PMID:19308875   PMID:19545623   PMID:23533145   PMID:23608161   PMID:24256333  
PMID:26945066   PMID:27329933   PMID:29476059   PMID:30658240   PMID:35352799  


Genomics

Comparative Map Data
Mb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,640,511 - 110,647,742 (-)NCBIGRCr8
mRatBN7.27108,759,903 - 108,767,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,502,181 - 110,509,413 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,725,771 - 112,733,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,687,217 - 112,694,445 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Celera7105,108,137 - 105,115,366 (-)NCBICelera
Cytogenetic Map7q34NCBI
MB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,606,764 - 35,623,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,606,764 - 35,637,951 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,002,811 - 36,019,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,332,757 - 34,349,347 (-)NCBINCBI36Build 36hg18NCBI36
Build 342234,327,310 - 34,338,055NCBI
Celera2219,806,063 - 19,822,655 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,963,313 - 18,979,770 (-)NCBIHuRef
CHM1_12235,961,646 - 35,978,237 (-)NCBICHM1_1
T2T-CHM13v2.02236,065,732 - 36,082,323 (-)NCBIT2T-CHM13v2.0
Mb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,899,687 - 76,934,868 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,899,687 - 76,934,870 (-)EnsemblGRCm39 Ensembl
GRCm381577,015,487 - 77,050,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,015,487 - 77,050,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,845,917 - 76,881,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,842,742 - 76,877,923 (-)NCBIMGSCv36mm8
Celera1578,503,595 - 78,538,817 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.36NCBI
Mb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,215,007 - 43,222,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,215,404 - 43,221,606 (-)NCBIChiLan1.0ChiLan1.0
MB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,546,697 - 45,557,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,243,165 - 48,253,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,612,519 - 16,645,333 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,452,451 - 34,485,581 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,452,451 - 34,463,224 (-)Ensemblpanpan1.1panPan2
MB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,573,819 - 28,583,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,552,749 - 28,583,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,513,611 - 28,523,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,360,185 - 29,369,892 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,356,425 - 29,369,888 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,085,598 - 29,095,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,394,667 - 29,404,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,575,155 - 29,584,857 (+)NCBIUU_Cfam_GSD_1.0
Mb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,880,637 - 11,887,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,890,871 - 4,897,665 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,890,871 - 4,897,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MB
(Sus scrofa - pig)
No map positions available.
MB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,369,234 - 18,385,922 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,369,174 - 18,380,270 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,562,452 - 107,578,780 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750259,041 - 266,238 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750259,559 - 266,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mb
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:50
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000006184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH134536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,759,948 - 108,760,150 (+)MAPPERmRatBN7.2
Rnor_6.07118,101,679 - 118,101,880NCBIRnor6.0
Rnor_5.07118,094,437 - 118,094,638UniSTSRnor5.0
RGSC_v3.47115,087,604 - 115,087,805UniSTSRGSC3.4
Celera7105,108,183 - 105,108,384UniSTS
RH 3.4 Map7800.0UniSTS
Cytogenetic Map7q34UniSTS
MB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,761,978 - 108,762,175 (+)MAPPERmRatBN7.2
Rnor_6.07118,103,709 - 118,103,905NCBIRnor6.0
Rnor_5.07118,096,467 - 118,096,663UniSTSRnor5.0
RGSC_v3.47115,089,634 - 115,089,830UniSTSRGSC3.4
Celera7105,110,213 - 105,110,409UniSTS
Cytogenetic Map7q34UniSTS


Genetic Models
This gene Mb is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 29 7 10 7
Medium 14 17 8 6 8 1 1 2 3 9 1
Low 1 9 2 11 2 11 15 20 2
Below cutoff 1 10 10 2 10 4 16 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF197916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF278533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000006184   ⟹   ENSRNOP00000006184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,759,904 - 108,767,350 (-)Ensembl
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116985   ⟹   ENSRNOP00000092328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)Ensembl
RefSeq Acc Id: NM_021588   ⟹   NP_067599
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,640,511 - 110,647,742 (-)NCBI
mRatBN7.27108,759,903 - 108,767,134 (-)NCBI
Rnor_6.07118,101,633 - 118,108,864 (-)NCBI
Rnor_5.07118,094,391 - 118,101,622 (-)NCBI
RGSC_v3.47115,087,558 - 115,094,789 (-)RGD
Celera7105,108,137 - 105,115,366 (-)RGD
Sequence:
RefSeq Acc Id: NP_067599   ⟸   NM_021588
- UniProtKB: Q9QZ76 (UniProtKB/Swiss-Prot),   A0A1K0FUB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006184   ⟸   ENSRNOT00000006184
RefSeq Acc Id: ENSRNOP00000092328   ⟸   ENSRNOT00000116985
Protein Domains
GLOBIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ76-F1-model_v2 AlphaFold Q9QZ76 1-154 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695443
Promoter ID:EPDNEW_R5968
Type:single initiation site
Name:Mb_1
Description:myoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07118,108,894 - 118,108,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620411 AgrOrtholog
BioCyc Gene G2FUF-32892 BioCyc
Ensembl Genes ENSRNOG00000004583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026647 UniProtKB/Swiss-Prot
  ENSRNOG00060027625 UniProtKB/Swiss-Prot
  ENSRNOG00065030753 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006184 ENTREZGENE
  ENSRNOT00000006184.7 UniProtKB/Swiss-Prot
  ENSRNOT00000116985.1 UniProtKB/TrEMBL
  ENSRNOT00055046010 UniProtKB/Swiss-Prot
  ENSRNOT00060047953 UniProtKB/Swiss-Prot
  ENSRNOT00065053008 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.2100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.2110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103504 IMAGE-MGC_LOAD
InterPro Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91707 IMAGE-MGC_LOAD
NCBI Gene 59108 ENTREZGENE
PANTHER MYOGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47132 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mb PhenoGen
PRINTS MYOGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004583 RatGTEx
  ENSRNOG00055026647 RatGTEx
  ENSRNOG00060027625 RatGTEx
  ENSRNOG00065030753 RatGTEx
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1K0FUB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHY4_RAT UniProtKB/TrEMBL
  MYG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mb  myoglobin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mb  myoglobin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may act as a scavenger of cellular Nitric Oxide in the myocardium 1300476