Fzd6 (frizzled class receptor 6) - Rat Genome Database

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Gene: Fzd6 (frizzled class receptor 6) Rattus norvegicus
Analyze
Symbol: Fzd6
Name: frizzled class receptor 6
RGD ID: 628816
Description: Predicted to enable Wnt receptor activity; Wnt-protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Predicted to be located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, non-canonical pathway; Wnt signaling, the planar cell polarity pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: frizzled family receptor 6; frizzled homolog 6; frizzled homolog 6 (Drosophila); frizzled-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2770,055,012 - 70,086,781 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,055,068 - 70,086,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,928,131 - 71,959,724 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0774,130,707 - 74,162,300 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0773,998,735 - 74,030,325 (+)NCBIRnor_WKY
Rnor_6.0777,898,329 - 77,931,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,899,322 - 77,931,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0778,317,818 - 78,349,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,562,307 - 74,594,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1774,608,138 - 74,610,532 (+)NCBI
Celera767,111,454 - 67,143,157 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cocaine  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
lithium chloride  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (EXP)
nickel sulfate  (ISO)
paracetamol  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
retinyl acetate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. Golan T, etal., J Biol Chem 2004 Apr 9;279(15):14879-88. Epub 2004 Jan 27.
4. Planar cell polarity signaling in vertebrates. Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
Additional References at PubMed
PMID:10347172   PMID:12399112   PMID:15169958   PMID:15265686   PMID:16495441   PMID:17172440   PMID:17376975   PMID:18606138   PMID:19842188   PMID:19901330   PMID:22575959   PMID:23439395  
PMID:26418459   PMID:31073040  


Genomics

Comparative Map Data
Fzd6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2770,055,012 - 70,086,781 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,055,068 - 70,086,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,928,131 - 71,959,724 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0774,130,707 - 74,162,300 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0773,998,735 - 74,030,325 (+)NCBIRnor_WKY
Rnor_6.0777,898,329 - 77,931,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,899,322 - 77,931,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0778,317,818 - 78,349,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,562,307 - 74,594,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1774,608,138 - 74,610,532 (+)NCBI
Celera767,111,454 - 67,143,157 (+)NCBICelera
Cytogenetic Map7q22NCBI
FZD6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388103,298,494 - 103,332,866 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8103,298,433 - 103,332,866 (+)EnsemblGRCh38hg38GRCh38
GRCh378104,310,722 - 104,345,094 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368104,380,276 - 104,414,270 (+)NCBINCBI36Build 36hg18NCBI36
Build 348104,380,275 - 104,414,268NCBI
Celera8100,497,508 - 100,531,944 (+)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef899,511,909 - 99,546,152 (+)NCBIHuRef
CHM1_18104,351,658 - 104,386,105 (+)NCBICHM1_1
T2T-CHM13v2.08104,426,440 - 104,460,824 (+)NCBIT2T-CHM13v2.0
Fzd6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,869,667 - 38,901,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1538,869,429 - 38,901,583 (+)EnsemblGRCm39 Ensembl
GRCm381539,006,149 - 39,038,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,006,034 - 39,038,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371538,837,826 - 38,869,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361538,836,426 - 38,868,266 (+)NCBIMGSCv36mm8
Celera1539,491,330 - 39,523,038 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.22NCBI
Fzd6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,465,701 - 27,494,790 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,465,730 - 27,493,752 (+)NCBIChiLan1.0ChiLan1.0
FZD6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18102,110,317 - 102,144,363 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8102,110,317 - 102,144,363 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0899,954,523 - 99,989,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FZD6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,732,541 - 4,771,294 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,733,017 - 4,772,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,736,685 - 4,774,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,896,006 - 4,936,859 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,896,040 - 4,936,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,737,532 - 4,775,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,855,495 - 4,893,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,868,139 - 4,906,505 (+)NCBIUU_Cfam_GSD_1.0
Fzd6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530332,990,184 - 33,027,935 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647040,416,014 - 40,454,062 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647040,416,254 - 40,454,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl433,809,809 - 33,844,656 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1433,811,159 - 33,844,556 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2436,662,301 - 36,697,139 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FZD6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1898,154,173 - 98,187,864 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl898,154,196 - 98,188,069 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603942,412,469 - 42,446,650 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476319,861,837 - 19,888,626 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fzd6
191 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:149
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000006195
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat

Markers in Region
RH128010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2770,086,349 - 70,086,532 (+)MAPPERmRatBN7.2
Rnor_6.0777,930,603 - 77,930,785NCBIRnor6.0
Rnor_5.0778,318,067 - 78,318,249UniSTSRnor5.0
RGSC_v3.4774,593,588 - 74,593,770UniSTSRGSC3.4
Celera767,142,731 - 67,142,913UniSTS
Cytogenetic Map7q22UniSTS
Fzd6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2698,100,874 - 98,100,975 (+)MAPPERmRatBN7.2
Rnor_6.06102,478,321 - 102,478,421NCBIRnor6.0
Rnor_5.06115,164,269 - 115,164,369UniSTSRnor5.0
RGSC_v3.46102,071,084 - 102,071,184UniSTSRGSC3.4
Celera696,485,919 - 96,486,019UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map7q22UniSTS
Fzd6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2770,080,140 - 70,080,340 (+)MAPPERmRatBN7.2
Rnor_6.0777,924,394 - 77,924,593NCBIRnor6.0
Rnor_5.0778,324,259 - 78,324,458UniSTSRnor5.0
RGSC_v3.4774,587,379 - 74,587,578UniSTSRGSC3.4
Celera767,136,522 - 67,136,721UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 30 14 6 6 1 1 6 31 35 11 1
Low 2 13 43 35 19 35 7 10 68 4 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006195   ⟹   ENSRNOP00000006195
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl770,055,068 - 70,086,776 (+)Ensembl
Rnor_6.0 Ensembl777,899,322 - 77,931,029 (+)Ensembl
RefSeq Acc Id: NM_001130536   ⟹   NP_001124008
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,068 - 70,086,776 (+)NCBI
Rnor_6.0777,899,322 - 77,931,029 (+)NCBI
Rnor_5.0778,317,818 - 78,349,530 (-)NCBI
RGSC_v3.4774,562,307 - 74,594,014 (+)RGD
Celera767,111,454 - 67,143,157 (+)RGD
Sequence:
RefSeq Acc Id: XM_008765450   ⟹   XP_008763672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,058,298 - 70,086,781 (+)NCBI
Rnor_6.0777,902,600 - 77,931,034 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594684   ⟹   XP_017450173
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,012 - 70,086,781 (+)NCBI
Rnor_6.0777,898,329 - 77,931,034 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594686   ⟹   XP_017450175
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,176 - 70,086,781 (+)NCBI
Rnor_6.0777,899,468 - 77,931,034 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078518   ⟹   XP_038934446
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,067 - 70,086,781 (+)NCBI
RefSeq Acc Id: XM_039078519   ⟹   XP_038934447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,012 - 70,086,781 (+)NCBI
RefSeq Acc Id: XM_039078520   ⟹   XP_038934448
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,012 - 70,086,781 (+)NCBI
RefSeq Acc Id: XM_039078521   ⟹   XP_038934449
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,069 - 70,083,545 (+)NCBI
RefSeq Acc Id: XR_005486551
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,055,069 - 70,083,521 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001124008   ⟸   NM_001130536
- Peptide Label: precursor
- UniProtKB: G3V6L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763672   ⟸   XM_008765450
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017450173   ⟸   XM_017594684
- Peptide Label: isoform X1
- UniProtKB: G3V6L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450175   ⟸   XM_017594686
- Peptide Label: isoform X1
- UniProtKB: G3V6L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006195   ⟸   ENSRNOT00000006195
RefSeq Acc Id: XP_038934447   ⟸   XM_039078519
- Peptide Label: isoform X1
- UniProtKB: G3V6L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934448   ⟸   XM_039078520
- Peptide Label: isoform X1
- UniProtKB: G3V6L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934446   ⟸   XM_039078518
- Peptide Label: isoform X1
- UniProtKB: G3V6L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934449   ⟸   XM_039078521
- Peptide Label: isoform X3
Protein Domains
FZ   G_PROTEIN_RECEP_F2_4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6L1-F1-model_v2 AlphaFold G3V6L1 1-710 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695304
Promoter ID:EPDNEW_R5829
Type:initiation region
Name:Fzd6_1
Description:frizzled class receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,899,251 - 77,899,311EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628816 AgrOrtholog
BioCyc Gene G2FUF-33579 BioCyc
Ensembl Genes ENSRNOG00000004660 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006195 ENTREZGENE
  ENSRNOP00000006195.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006195 ENTREZGENE
  ENSRNOT00000006195.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
InterPro Frizzled UniProtKB/TrEMBL
  Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  FZ6_CRD UniProtKB/TrEMBL
  FZD6 UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
KEGG Report rno:282581 UniProtKB/TrEMBL
NCBI Gene 282581 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  PTHR11309:SF75 UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PharmGKB FZD6 RGD
PhenoGen Fzd6 PhenoGen
PRINTS FRIZZLED UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART FRI UniProtKB/TrEMBL
  Frizzled UniProtKB/TrEMBL
Superfamily-SCOP Frizzled_Cys-rich UniProtKB/TrEMBL
UniProt G3V6L1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Fzd6  frizzled class receptor 6  Fzd6  frizzled family receptor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fzd6  frizzled family receptor 6  Fzd6  frizzled homolog 6 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fzd6  frizzled homolog 6 (Drosophila)      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Fzd6  frizzled homolog 6 (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL