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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Fzd6 | Rat | nonsyndromic congenital nail disorder 1 | | ISO | FZD6 (Homo sapiens) | 7240710 | | OMIM | | |
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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Fzd6 | Rat | nonsyndromic congenital nail disorder 1 | | ISO | FZD6 (Homo sapiens) | 7240710 | | OMIM | | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
3. | The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. | Golan T, etal., J Biol Chem 2004 Apr 9;279(15):14879-88. Epub 2004 Jan 27. |
4. | Planar cell polarity signaling in vertebrates. | Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32. |
5. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
6. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
7. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
8. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
9. | GOA pipeline | RGD automated data pipeline |
10. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
12. | Comprehensive gene review and curation | RGD comprehensive gene curation |
13. | The Wnt Homepage | Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA |
PMID:10347172 | PMID:12399112 | PMID:15169958 | PMID:15265686 | PMID:16495441 | PMID:17172440 | PMID:17376975 | PMID:18606138 | PMID:19842188 | PMID:19901330 | PMID:22575959 | PMID:23439395 |
PMID:26418459 | PMID:31073040 | PMID:38710294 |
Fzd6 (Rattus norvegicus - Norway rat) |
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FZD6 (Homo sapiens - human) |
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Fzd6 (Mus musculus - house mouse) |
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Fzd6 (Chinchilla lanigera - long-tailed chinchilla) |
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FZD6 (Pan paniscus - bonobo/pygmy chimpanzee) |
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FZD6 (Canis lupus familiaris - dog) |
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Fzd6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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FZD6 (Sus scrofa - pig) |
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FZD6 (Chlorocebus sabaeus - green monkey) |
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Fzd6 (Heterocephalus glaber - naked mole-rat) |
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Variants in Fzd6
208 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH128010 |
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Fzd6 |
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Fzd6 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 11 | 49 | 113 | 91 | 90 | 59 | 25 | 59 | 6 | 218 | 97 | 93 | 45 | 60 | 31 |
RefSeq Transcripts | NM_001130536 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_017594684 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017594685 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017594686 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078519 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078520 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063263073 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063263074 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063263075 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_005486551 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC121173 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AC126589 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AF481948 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473950 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000006195 ⟹ ENSRNOP00000006195 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001130536 ⟹ NP_001124008 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017594684 ⟹ XP_017450173 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017594686 ⟹ XP_017450175 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039078519 ⟹ XP_038934447 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039078520 ⟹ XP_038934448 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063263073 ⟹ XP_063119143 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063263074 ⟹ XP_063119144 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063263075 ⟹ XP_063119145 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_005486551 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_001124008 | (Get FASTA) | NCBI Sequence Viewer |
XP_017450173 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017450175 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934447 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934448 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063119143 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063119144 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063119145 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAN51981 | (Get FASTA) | NCBI Sequence Viewer |
EDM16356 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000006195.5 |
RefSeq Acc Id: | NP_001124008 ⟸ NM_001130536 |
- Peptide Label: | precursor |
- UniProtKB: | A6HR66 (UniProtKB/TrEMBL), G3V6L1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017450173 ⟸ XM_017594684 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6HR66 (UniProtKB/TrEMBL), G3V6L1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017450175 ⟸ XM_017594686 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6HR66 (UniProtKB/TrEMBL), G3V6L1 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000006195 ⟸ ENSRNOT00000006195 |
RefSeq Acc Id: | XP_038934447 ⟸ XM_039078519 |
- Peptide Label: | isoform X1 |
- UniProtKB: | G3V6L1 (UniProtKB/TrEMBL), A6HR66 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038934448 ⟸ XM_039078520 |
- Peptide Label: | isoform X1 |
- UniProtKB: | G3V6L1 (UniProtKB/TrEMBL), A6HR66 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063119143 ⟸ XM_063263073 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A6HR66 (UniProtKB/TrEMBL), G3V6L1 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063119144 ⟸ XM_063263074 |
- Peptide Label: | isoform X2 |
RefSeq Acc Id: | XP_063119145 ⟸ XM_063263075 |
- Peptide Label: | isoform X3 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-G3V6L1-F1-model_v2 | AlphaFold | G3V6L1 | 1-710 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13695304 | ||||||||
Promoter ID: | EPDNEW_R5829 | ||||||||
Type: | initiation region | ||||||||
Name: | Fzd6_1 | ||||||||
Description: | frizzled class receptor 6 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:628816 | AgrOrtholog |
BioCyc Gene | G2FUF-33579 | BioCyc |
Ensembl Genes | ENSRNOG00000004660 | Ensembl, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000006195.6 | UniProtKB/TrEMBL |
Gene3D-CATH | 1.10.2000.10 | UniProtKB/TrEMBL |
Rhodopsin 7-helix transmembrane proteins | UniProtKB/TrEMBL | |
InterPro | Frizzled | UniProtKB/TrEMBL |
Frizzled/SFRP | UniProtKB/TrEMBL | |
Frizzled_dom | UniProtKB/TrEMBL | |
Frizzled_dom_sf | UniProtKB/TrEMBL | |
FZ6_CRD | UniProtKB/TrEMBL | |
FZD6_TM | UniProtKB/TrEMBL | |
GPCR_2-like | UniProtKB/TrEMBL | |
KEGG Report | rno:282581 | UniProtKB/TrEMBL |
NCBI Gene | 282581 | ENTREZGENE |
PANTHER | PTHR11309 | UniProtKB/TrEMBL |
PTHR11309:SF75 | UniProtKB/TrEMBL | |
Pfam | Frizzled | UniProtKB/TrEMBL |
PF01392 | UniProtKB/TrEMBL | |
PharmGKB | FZD6 | RGD |
PhenoGen | Fzd6 | PhenoGen |
PRINTS | FRIZZLED | UniProtKB/TrEMBL |
PROSITE | G_PROTEIN_RECEP_F2_4 | UniProtKB/TrEMBL |
PS50038 | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000004660 | RatGTEx |
SMART | FRI | UniProtKB/TrEMBL |
Frizzled | UniProtKB/TrEMBL | |
Superfamily-SCOP | Frizzled_Cys-rich | UniProtKB/TrEMBL |
UniProt | A6HR66 | ENTREZGENE, UniProtKB/TrEMBL |
G3V6L1 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2014-02-06 | Fzd6 | frizzled class receptor 6 | Fzd6 | frizzled family receptor 6 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2011-08-02 | Fzd6 | frizzled family receptor 6 | Fzd6 | frizzled homolog 6 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-01-20 | Fzd6 | frizzled homolog 6 (Drosophila) | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2003-02-27 | Fzd6 | frizzled homolog 6 (Drosophila) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |