Foxh1 (forkhead box H1) - Rat Genome Database

Name: Foxh1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Foxh1 (forkhead box H1) Rattus norvegicus

Analyze

Symbol:

Foxh1

Name:

forkhead box H1

RGD ID:

1311275

Description:

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and SMAD binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in hepatocyte differentiation. Predicted to be located in nucleus. Predicted to be part of activin responsive factor complex and chromatin. Orthologous to human FOXH1 (forkhead box H1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

forkhead box protein H1; LOC300054

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOXH1 (forkhead box H1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Foxh1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Foxh1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FOXH1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FOXH1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Foxh1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOXH1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FOXH1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Foxh1 (forkhead box H1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FOXH1 (forkhead box H1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Foxh1 (forkhead box H1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	foxh1 (forkhead box H1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	foxh1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	108,387,969 - 108,391,566 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	108,387,969 - 108,390,049 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	110,129,799 - 110,131,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	112,353,375 - 112,355,455 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	112,314,210 - 112,316,290 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	117,730,307 - 117,733,076 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	117,730,307 - 117,732,387 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	117,718,390 - 117,720,470 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	114,717,890 - 114,719,455 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	114,752,036 - 114,753,685 (-)	NCBI
Celera	7	104,737,872 - 104,739,952 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

agnathia-otocephaly complex (ISS)

Brown-Vialetto-Van Laere syndrome 2 (ISO)

Conotruncal Cardiac Defects (ISO)

epidermolysis bullosa simplex with muscular dystrophy (ISO)

genetic disease (ISO)

holoprosencephaly (ISO)

tetralogy of Fallot (ISO)

visceral heterotaxy (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

aflatoxin B1 (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbamazepine (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

panobinostat (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (ISO)

aorta morphogenesis (ISO)

axial mesoderm development (ISO)

cardiac right ventricle morphogenesis (ISO)

cellular response to cytokine stimulus (ISO)

determination of left/right symmetry (ISO)

embryonic heart tube anterior/posterior pattern specification (ISO)

heart looping (ISO)

hepatocyte differentiation (IEP)

negative regulation of androgen receptor signaling pathway (ISO)

negative regulation of intracellular estrogen receptor signaling pathway (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

outflow tract morphogenesis (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

regulation of DNA-templated transcription (ISO)

regulation of transcription by RNA polymerase II (ISO)

secondary heart field specification (ISO)

transforming growth factor beta receptor signaling pathway (IBA,ISO)

ventricular trabecula myocardium morphogenesis (ISO)

Cellular Component

activin responsive factor complex (IBA,ISO)

chromatin (ISO)

nucleus (ISO)

transcription regulator complex (ISO)

Molecular Function

bHLH transcription factor binding (ISO)

co-SMAD binding (ISO)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IBA,ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor binding (ISO)

nuclear androgen receptor binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

R-SMAD binding (ISO)

sequence-specific DNA binding (ISO)

SMAD binding (ISO)

transcription cis-regulatory region binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Smad transcription factors.	Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Hepatic differentiation of rat mesenchymal stem cells by a small molecule.	Ouyang J, etal., ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	How the Smads regulate transcription.	Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
9.	Identification of FOXH1 mutations in patients with sporadic conotruncal heart defect.	Wei W, etal., Clin Genet. 2020 Apr;97(4):576-585. doi: 10.1111/cge.13710. Epub 2020 Feb 12.

Additional References at PubMed

PMID:9389648	PMID:9702197	PMID:9702198	PMID:9858566	PMID:10349617	PMID:11358868	PMID:11358869	PMID:12477932	PMID:12642485	PMID:14671321	PMID:15363409	PMID:16120611
PMID:17438144	PMID:17568773	PMID:18331719	PMID:21828274

Genomics

Comparative Map Data

Foxh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	108,387,969 - 108,391,566 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	108,387,969 - 108,390,049 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	110,129,799 - 110,131,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	112,353,375 - 112,355,455 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	112,314,210 - 112,316,290 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	117,730,307 - 117,733,076 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	117,730,307 - 117,732,387 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	117,718,390 - 117,720,470 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	114,717,890 - 114,719,455 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	114,752,036 - 114,753,685 (-)	NCBI
Celera	7	104,737,872 - 104,739,952 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

FOXH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	144,473,412 - 144,475,849 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	144,473,412 - 144,475,849 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	145,698,795 - 145,701,232 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	145,670,306 - 145,672,526 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	145,670,316 - 145,672,526	NCBI
Celera	8	141,874,214 - 141,876,817 (-)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	140,812,639 - 140,814,791 (-)	NCBI		HuRef
CHM1_1	8	145,737,374 - 145,739,977 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	145,643,152 - 145,645,589 (-)	NCBI		T2T-CHM13v2.0

Foxh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	76,552,029 - 76,554,286 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	76,552,425 - 76,554,148 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	76,667,829 - 76,671,614 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	76,668,225 - 76,669,948 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	76,498,737 - 76,500,303 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	76,495,562 - 76,497,128 (-)	NCBI		MGSCv36	mm8
Celera	15	78,161,919 - 78,163,485 (-)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	36.24	NCBI

Foxh1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	3,094,033 - 3,095,512 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	3,094,015 - 3,096,060 (-)	NCBI	ChiLan1.0	ChiLan1.0

FOXH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	137,494,284 - 137,498,488 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	141,240,691 - 141,244,381 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	144,229,228 - 144,231,829 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	144,225,933 - 144,232,736 (-)	Ensembl	panpan1.1		panPan2

FOXH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,883,554 - 37,887,324 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,882,687 - 37,885,319 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,844,309 - 37,848,077 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	38,357,286 - 38,361,056 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	38,356,419 - 38,358,928 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	38,049,036 - 38,052,801 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	38,157,673 - 38,161,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	38,634,120 - 38,637,890 (-)	NCBI		UU_Cfam_GSD_1.0

Foxh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	361,968 - 365,427 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	7,789,541 - 7,791,039 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936470	7,789,486 - 7,791,067 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOXH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	322,838 - 324,481 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	320,610 - 324,570 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	411,723 - 415,556 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FOXH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	138,685,137 - 138,688,451 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	138,685,626 - 138,687,144 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	1,166,573 - 1,171,132 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Foxh1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	12,386,281 - 12,387,774 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	12,384,728 - 12,388,234 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Foxh1
10 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	247
Count of miRNA genes:	170
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000020696
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	80221299	109401111	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat

Markers in Region

Foxh1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	108,389,162 - 108,389,507 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	117,731,501 - 117,731,845	NCBI	Rnor6.0
Rnor_5.0	7	117,719,584 - 117,719,928	UniSTS	Rnor5.0
RGSC_v3.4	7	114,718,577 - 114,718,921	UniSTS	RGSC3.4
Celera	7	104,739,066 - 104,739,410	UniSTS
Cytogenetic Map	7	q34	UniSTS

AI045836

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	108,388,093 - 108,388,278 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	117,730,432 - 117,730,616	NCBI	Rnor6.0
Rnor_5.0	7	117,718,515 - 117,718,699	UniSTS	Rnor5.0
RGSC_v3.4	7	114,717,508 - 114,717,692	UniSTS	RGSC3.4
Celera	7	104,737,997 - 104,738,181	UniSTS
RH 3.4 Map	7	794.3	UniSTS
Cytogenetic Map	7	q34	UniSTS

PMC313795P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	108,389,162 - 108,389,507 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	117,731,501 - 117,731,845	NCBI	Rnor6.0
Rnor_5.0	7	117,719,584 - 117,719,928	UniSTS	Rnor5.0
RGSC_v3.4	7	114,718,577 - 114,718,921	UniSTS	RGSC3.4
Celera	7	104,739,066 - 104,739,410	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low		4	2	2		2			4		10
Below cutoff	3	4	28	18	11	18	1	1	47	17	20	9	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001130493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000020696 ⟹ ENSRNOP00000020696

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	108,387,969 - 108,390,049 (-)	Ensembl
Rnor_6.0 Ensembl	7	117,730,307 - 117,732,387 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092917 ⟹ ENSRNOP00000075944

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	117,730,307 - 117,732,339 (-)	Ensembl

RefSeq Acc Id:

NM_001130493 ⟹ NP_001123965

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	108,387,969 - 108,390,049 (-)	NCBI
Rnor_6.0	7	117,730,307 - 117,732,387 (-)	NCBI
Rnor_5.0	7	117,718,390 - 117,720,470 (-)	NCBI
Celera	7	104,737,872 - 104,739,952 (-)	NCBI

Sequence:

show sequence

GTCCCAGCATGGCCTCGGGCTGGGACCTGGCCTCAACTTACAGTCCGACTACCCTGAGCCCCCA
GTTGGTCCAGGCTCTGGCCCAGGGCTACATCCCTTGTATGGGGCCTCTCGACAACTCTCAGCTG
AGGCCTCCAGAAGCAGAGTCTCTTTCGAAGACCCCCAAGAGGAGGAAGAAGAGATACCTACGGC
ATGACAAGCCCCCCTACACTTACTTGGCCATGATCGCCTTGGTAATTCAGGCCGCACCCTTCCG
CAGACTGAAACTGGCTCAGATTATCCGTCAGGTCCAGGCAGTGTTCCCCTTCTTCAGGGACGAC
TATGAGGGCTGGAAGGACTCCATCCGCCACAACCTTTCCTCTAACCGGTGCTTCCGTAAGGTGC
CTAAGGACCCTGCAAAGCCCCAGGCCAAGGGCAACTTCTGGGCGGTGGACGTGAGCCTGATTCC
TGCAGAGGCGCTGCGCCTTCAGAACACTGCCCTGTGCCGTCGATGGCAGAACCGGGGCACACAC
AGAGCGTTCGCCAAGGACCTGAGCCCCTATGTGCTCCACGGCCAGCCTTATCGGCCACCCAGTC
CCCCACCACCATCTAGGGAGGATTTCAGCATCAAGTCCCTGCTAGGGGACCCTGGGAAAGCATC
CACATGGCCCCAGCATCCTAGGCTAGCTGGACAGAGCACTCCAGCTCAGGCAAGCACCTTGTCA
AAGGGGGAAGAGGGGATAGGCGCTGGACCCTCTAACGTCTCTGATAAGCCTCTGTGGCCCCTCA
GCTCCCTTCCCAGGCCCACAAGAATAGAGGGGGAGACTTCCCAAGGGGAAGTCATCAGGCCTTC
TCCCGTTTCCTCAGACCAAGGCTCCTGGCCCCTCCACTTACTTCAGGATTCCTCAGATTCCATG
GGAATGTCCAGGAGGGGGAGCAGAGCTTCCTTGTGGGGACAGCTACCCACCTCTTACTTGCCCA
TCTACACGCCCAATGTAGTAATGCCCTTGGCCACGCTACCCCCTACCTCTTGTCCCCGGTGCCC
ATCTTCAGCCAGCCCAGCCTACTGGAGCGTGGGTACTGAATCCCAAGGGTCCCAGGATCTGCTC
TGTGATCTGGACTCCCTCTTCCAGGGAGTACCACCCAACAAGAGCATCTATGATGTGTGGGTCA
GCCACCCTAGGGACCTGGCAGCTCCTGCCCCAGGCTGGCTCCTTTCCTGGTATAGCATGTAATA
TTTTAGGGCAGACAAGGGCTACTTCTCTCTTCCATCCATGAATATCATTTTGATGAACCAGAGC
TAGGAGCACGTCCACTGCAACAGCTTCAAAACACCAGGCACAGCCTTGCTGAAAACCCACAGCT
TTAATTAGGTAACTCCAGAAAGGGTTTTGCCTCTGCTAGATAGGAAGGCCTGGCCAACCGCGCC
TTTGACACTCTCACACACAGGGACCAGATCTGGAGAGCAGGGCTCAACCTAGATAGTGCCTCCT
CTTGATCCCACCTTCTCAGGCCCTCAAGCCATCCATCTATCCATCCCGCTGTCACCATGCCTTC
CTGGCTCCAGGCTGGGGGAGGGAGAGCCAAAAGTGGGTCCAATCTGAAGTCTTGCCCTCTGTCA
ACTGCCTGGGTGGAAGGTAGCACCTTTCAGGGAAAGGGTTAAGAAAGACTGGACCATACATGAT
TTTGGTGTAATGGAAGTCGGGGAGTGATTAACAGTAAAGGAATTTACAACGTTTTAA

hide sequence

RefSeq Acc Id:

XM_008765565 ⟹ XP_008763787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	108,387,969 - 108,391,566 (-)	NCBI
Rnor_6.0	7	117,730,307 - 117,733,076 (-)	NCBI

Sequence:

show sequence

CAAGCACTCTACCACTGAGCTAAATCCCCAACCCCTTCTCAAAAGTTTTTAGTGCCGACGGTCT
TGGATTGTTGACTCTAACACCAATCTCTGCCGTCTGTGCCCTGATTCAGATTCTCAATACAAAC
CTGCCCATTGTAGTAGCCAGGAGAACTTGGGTAAAGTTTAGAACACAGACAGTGACCAGGTCTC
TGTATCCTCCTCTTGTTTCTGGGGACAGACTCTATTCCTTTTTGGTCTAGAAAGTCTGTCAGTC
TGTATGCCCCCTACCTCATTAAGTTCTGGGCAGACTCCCCACCTAGGGCTTGACTTCTTTTGAC
TGCTTTGTCTTGAACTCCTGGGAATTCCCCATCCCTCTCTGGGTAGTTTGGCTGGAGAAGTCAT
TTCCCCTCTGTTAAATGGGAGTTAGAGACCAACCCAGGCAGATACATTACCCTGGGGTAGACTT
CTTTCAAGGGCTTTTCCTTCCAGGTTATAGGGGATACCCAGGCACCCAAAGGCAACTTGAGAGT
GGAGACTGATTTCAAAGGCCACCAAAAGTCCCTACTGGAATCTTTTCTGCCCTTCCCTCCAAGA
TTAACTGAAACCTGCTAATTGTGGCTGCCCACACATGTTCCCCTCCCCCACAGCCTCTTTCTCT
CACCCCTCCCCCTTTCATCAGAATGATAAAGAAAGAGCCTGGCCTCCCTGTCCCAGCATGGCCT
CGGGCTGGGACCTGGCCTCAACTTACAGTCCGACTACCCTGAGCCCCCAGTTGGTCCAGGCTCT
GGCCCAGGGCTACATCCCTTGTATGGGGCCTCTCGACAACTCTCAGCTGAGGCCTCCAGAAGCA
GAGTCTCTTTCGAAGACCCCCAAGAGGAGGAAGAAGAGATACCTACGGCATGACAAGCCCCCCT
ACACTTACTTGGCCATGATCGCCTTGATTATCCGTCAGGTCCAGGCAGTGTTCCCCTTCTTCAG
GGACGACTATGAGGGCTGGAAGGACTCCATCCGCCACAACCTTTCCTCTAACCGGTGCTTCCGT
AAGGTGCCTAAGGACCCTGCAAAGCCCCAGGCCAAGGGCAACTTCTGGGCGGTGGACGTGAGCC
TGATTCCTGCAGAGGCGCTGCGCCTTCAGAACACTGCCCTGTGCCGTCGATGGCAGAACCGGGG
CACACACAGAGCGTTCGCCAAGGACCTGAGCCCCTATGTGCTCCACGGCCAGCCTTATCGGCCA
CCCAGTCCCCCACCACCATCTAGGGAGGATTTCAGCATCAAGTCCCTGCTAGGGGACCCTGGGA
AAGCATCCACATGGCCCCAGCATCCTAGGCTAGCTGGACAGAGCACTCCAGCTCAGGCAAGCAC
CTTGTCAAAGGGGGAAGAGGGGATAGGCGCTGGACCCTCTAACGTCTCTGATAAGCCTCTGTGG
CCCCTCAGCTCCCTTCCCAGGCCCACAAGAATAGAGGGGGAGACTTCCCAAGGGGAAGTCATCA
GGCCTTCTCCCGTTTCCTCAGACCAAGGCTCCTGGCCCCTCCACTTACTTCAGGATTCCTCAGA
TTCCATGGGAATGTCCAGGAGGGGGAGCAGAGCTTCCTTGTGGGGACAGCTACCCACCTCTTAC
TTGCCCATCTACACGCCCAATGTAGTAATGCCCTTGGCCACGCTACCCCCTACCTCTTGTCCCC
GGTGCCCATCTTCAGCCAGCCCAGCCTACTGGAGCGTGGGTACTGAATCCCAAGGGTCCCAGGA
TCTGCTCTGTGATCTGGACTCCCTCTTCCAGGGAGTACCACCCAACAAGAGCATCTATGATGTG
TGGGTCAGCCACCCTAGGGACCTGGCAGCTCCTGCCCCAGGCTGGCTCCTTTCCTGGTATAGCA
TGTAATATTTTAGGGCAGACAAGGGCTACTTCTCTCTTCCATCCATGAATATCATTTTGATGAA
CCAGAGCTAGGAGCACGTCCACTGCAACAGCTTCAAAACACCAGGCACAGCCTTGCTGAAAACC
CACAGCTTTAATTAGGTAACTCCAGAAAGGGTTTTGCCTCTGCTAGATAGGAAGGCCTGGCCAA
CCGCGCCTTTGACACTCTCACACACAGGGACCAGATCTGGAGAGCAGGGCTCAACCTAGATAGT
GCCTCCTCTTGATCCCACCTTCTCAGGCCCTCAAGCCATCCATCTATCCATCCCGCTGTCACCA
TGCCTTCCTGGCTCCAGGCTGGGGGAGGGAGAGCCAAAAGTGGGTCCAATCTGAAGTCTTGCCC
TCTGTCAACTGCCTGGGTGGAAGGTAGCACCTTTCAGGGAAAGGGTTAAGAAAGACTGGACCAT
ACATGATTTTGGTGTAATGGAAGTCGGGGAGTGATTAACAGTAAAGGAATTTACAACGTTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001123965	(Get FASTA)	NCBI Sequence Viewer
	XP_008763787	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58732	(Get FASTA)	NCBI Sequence Viewer
	EDM15950	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020696
	ENSRNOP00000020696.4

RefSeq Acc Id:

NP_001123965 ⟸ NM_001130493

- UniProtKB:

G3V7Y6 (UniProtKB/TrEMBL), A6HSC2 (UniProtKB/TrEMBL), B0BN92 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASGWDLASTYSPTTLSPQLVQALAQGYIPCMGPLDNSQLRPPEAESLSKTPKRRKKRYLRHDK
PPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFRKVPKD
PAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYRPPSPPP
PSREDFSIKSLLGDPGKASTWPQHPRLAGQSTPAQASTLSKGEEGIGAGPSNVSDKPLWPLSSL
PRPTRIEGETSQGEVIRPSPVSSDQGSWPLHLLQDSSDSMGMSRRGSRASLWGQLPTSYLPIYT
PNVVMPLATLPPTSCPRCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHP
RDLAAPAPGWLLSWYSM

hide sequence

RefSeq Acc Id:	XP_008763787 ⟸ XM_008765565
- Peptide Label:	isoform X1
- UniProtKB:	B0BN92 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFPSPTASFSHPSPFHQNDKERAWPPCPSMASGWDLASTYSPTTLSPQLVQALAQGYIPCMGPL DNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALIIRQVQAVFPFFRDDYEGWKDSIR HNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSP YVLHGQPYRPPSPPPPSREDFSIKSLLGDPGKASTWPQHPRLAGQSTPAQASTLSKGEEGIGAG PSNVSDKPLWPLSSLPRPTRIEGETSQGEVIRPSPVSSDQGSWPLHLLQDSSDSMGMSRRGSRA SLWGQLPTSYLPIYTPNVVMPLATLPPTSCPRCPSSASPAYWSVGTESQGSQDLLCDLDSLFQG VPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM hide sequence

RefSeq Acc Id:

ENSRNOP00000075944 ⟸ ENSRNOT00000092917

RefSeq Acc Id:

ENSRNOP00000020696 ⟸ ENSRNOT00000020696

Protein Domains

Fork-head

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7Y6-F1-model_v2	AlphaFold	G3V7Y6	1-401	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311275	AgrOrtholog
BioCyc Gene	G2FUF-32911	BioCyc
Ensembl Genes	ENSRNOG00000015371	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020696	ENTREZGENE
	ENSRNOT00000020696.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9092498	IMAGE-MGC_LOAD
InterPro	FH_FOXH1	UniProtKB/TrEMBL
	TF_fork_head	UniProtKB/TrEMBL
	TF_fork_head_CS_2	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:300054	UniProtKB/TrEMBL
MGC_CLONE	MGC:187890	IMAGE-MGC_LOAD
NCBI Gene	300054	ENTREZGENE
PANTHER	FORKHEAD BOX PROTEIN H1	UniProtKB/TrEMBL
	FORKHEAD BOX PROTEIN H1	UniProtKB/TrEMBL
Pfam	Fork_head	UniProtKB/TrEMBL
PhenoGen	Foxh1	PhenoGen
PRINTS	FORKHEAD	UniProtKB/TrEMBL
PROSITE	FORK_HEAD_2	UniProtKB/TrEMBL
	FORK_HEAD_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015371	RatGTEx
SMART	SM00339	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A6HSC2	ENTREZGENE, UniProtKB/TrEMBL
	B0BN92	ENTREZGENE, UniProtKB/TrEMBL
	G3V7Y6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Foxh1	forkhead box H1	Foxh1_predicted	forkhead box H1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Foxh1_predicted	forkhead box H1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

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