Arc (activity-regulated cytoskeleton-associated protein) - Rat Genome Database

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Gene: Arc (activity-regulated cytoskeleton-associated protein) Rattus norvegicus
Analyze
Symbol: Arc
Name: activity-regulated cytoskeleton-associated protein
RGD ID: 62037
Description: Enables mRNA binding activity. Involved in several processes, including learning or memory; positive regulation of AMPA receptor activity; and regulation of synaptic plasticity. Located in several cellular components, including extracellular vesicle; glutamatergic synapse; and postsynaptic endosome. Is active in postsynaptic density membrane. Biomarker of middle cerebral artery infarction and visual epilepsy. Orthologous to human ARC (activity regulated cytoskeleton associated protein); INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-amphetamine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: activity regulated cytoskeletal-associated protein; activity-regulated gene 3.1 protein; ARC/ARG3.1; arg3.1; rg3.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27106,555,968 - 106,559,697 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl7115,907,097 - 115,910,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07115,907,097 - 115,911,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07115,812,499 - 115,815,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,771,937 - 112,775,381 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17112,806,166 - 112,809,611 (-)NCBI
Celera7102,957,256 - 102,960,700 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
26-hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
6-propyl-2-thiouracil  (EXP)
8-OH-DPAT  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bicuculline  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
Citreoviridin  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
desipramine  (EXP)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
disulfiram  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
glufosinate  (ISO)
glycidol  (EXP)
graphite  (EXP)
haloperidol  (EXP)
isoflurane  (EXP)
kainic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
Licochalcone B  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
monosodium L-glutamate  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalenes  (EXP)
nicotine  (ISO)
paracetamol  (ISO)
paroxetine  (EXP)
pentanal  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
poly(I:C)  (EXP)
progesterone  (EXP)
propanal  (ISO)
propofol  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
SCH 23390  (EXP)
scopolamine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SKF 38393  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulfur dioxide  (EXP)
temozolomide  (ISO)
tetradecane  (EXP)
tetrodotoxin  (ISO)
thimerosal  (ISO)
tranylcypromine  (EXP)
triazolam  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
mRNA binding  (IDA)
protein binding  (IPI,ISO)

References

References - curated
1. Chowdhury S, etal., Neuron. 2006 Nov 9;52(3):445-59.
2. Fujiyama K, etal., Synapse 2003 Sep 1;49(3):143-9.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Guzowski JF, etal., J Neurosci. 2000 Jun 1;20(11):3993-4001.
5. Kim KA, etal., J Neurosci Res 2002 Jul 15;69(2):268-77.
6. Lacor PN, etal., J Neurosci. 2004 Nov 10;24(45):10191-200.
7. Li PF, etal., Mol Cell 2002 Aug;10(2):247-58.
8. Link W, etal., Proc Natl Acad Sci U S A 1995 Jun 6;92(12):5734-8.
9. Lyford GL, etal., Neuron 1995 Feb;14(2):433-45.
10. Matsuoka M, etal., Neurosci Lett 2002 Dec 25;335(2):111-4.
11. Mengozzi M, etal., Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9617-22. doi: 10.1073/pnas.1200554109. Epub 2012 May 29.
12. Messaoudi E, etal., J Neurosci. 2007 Sep 26;27(39):10445-55.
13. MGD data from the GO Consortium
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Okuno H, etal., Cell. 2012 May 11;149(4):886-98. doi: 10.1016/j.cell.2012.02.062.
16. OMIM Disease Annotation Pipeline
17. Panford-Walsh R, etal., Mol Pharmacol. 2008 Sep;74(3):595-604. doi: 10.1124/mol.108.046375. Epub 2008 Jun 4.
18. Pastuzyn ED, etal., Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024.
19. Rapanelli M, etal., PLoS One. 2010 Jan 11;5(1):e8656.
20. RGD automated data pipeline
21. RGD automated import pipeline for gene-chemical interactions
22. Song BN, etal., Acta Otolaryngol. 2009 Feb;129(2):142-54. doi: 10.1080/00016480802043949.
23. Stoss O, etal., J Biol Chem 1999 Apr 16;274(16):10951-62.
24. Szyndler J, etal., Pharmacol Rep. 2013;65(2):368-78.
25. Tan J, etal., Neuroscience. 2007 Mar 16;145(2):715-26. Epub 2007 Feb 1.
26. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Vazdarjanova A, etal., J Neurosci 2002 Dec 1;22(23):10067-71.
28. Wu J, etal., Cell. 2011 Oct 28;147(3):615-28. doi: 10.1016/j.cell.2011.09.036.
Additional References at PubMed
PMID:10644725   PMID:10727859   PMID:12787067   PMID:12878684   PMID:14580947   PMID:14969744   PMID:15048929   PMID:15087240   PMID:15147503   PMID:15248288   PMID:15336574   PMID:15659610  
PMID:15716412   PMID:15932597   PMID:16221847   PMID:16367764   PMID:16415163   PMID:16553613   PMID:16871537   PMID:17026535   PMID:17088212   PMID:17088213   PMID:17286278   PMID:17611082  
PMID:17614950   PMID:18062938   PMID:18305102   PMID:18322102   PMID:18419604   PMID:18501523   PMID:18555615   PMID:18798281   PMID:19159662   PMID:19222557   PMID:19262551   PMID:19290048  
PMID:19544747   PMID:19576731   PMID:20189687   PMID:20452974   PMID:20592749   PMID:20599428   PMID:20653942   PMID:20654701   PMID:20675582   PMID:20824728   PMID:20850902   PMID:20865740  
PMID:20942997   PMID:21162918   PMID:21315825   PMID:21319893   PMID:21420441   PMID:21515256   PMID:21549764   PMID:21562269   PMID:21590283   PMID:21737703   PMID:21834987   PMID:21921210  
PMID:22071872   PMID:22179607   PMID:22350812   PMID:22535445   PMID:22573703   PMID:22584581   PMID:22613772   PMID:22617701   PMID:22683463   PMID:22844515   PMID:22871113   PMID:22933785  
PMID:22945419   PMID:22982514   PMID:23079472   PMID:23154938   PMID:23345235   PMID:23426670   PMID:23708554   PMID:23791196   PMID:23843540   PMID:23872190   PMID:23876329   PMID:24103311  
PMID:24671994   PMID:24704997   PMID:24810662   PMID:25239865   PMID:25249385   PMID:25623071   PMID:25646592   PMID:25682931   PMID:25746394   PMID:26219984   PMID:26238574   PMID:26774022  
PMID:26888068   PMID:26895748   PMID:26976088   PMID:27397520   PMID:27474832   PMID:27702572   PMID:28185871   PMID:28472857   PMID:28553222   PMID:28585865   PMID:28630256   PMID:28716957  
PMID:28856239   PMID:29232477   PMID:29264923   PMID:29326059   PMID:29588465   PMID:29723575   PMID:30244496   PMID:30458282   PMID:31151856   PMID:31919348   PMID:32333254   PMID:32861833  


Genomics

Candidate Gene Status
Arc is a candidate Gene for QTL Bp335
Comparative Map Data
Arc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27106,555,968 - 106,559,697 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl7115,907,097 - 115,910,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07115,907,097 - 115,911,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07115,812,499 - 115,815,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,771,937 - 112,775,381 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17112,806,166 - 112,809,611 (-)NCBI
Celera7102,957,256 - 102,960,700 (-)NCBICelera
Cytogenetic Map7q34NCBI
ARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8142,611,049 - 142,614,479 (-)EnsemblGRCh38hg38GRCh38
GRCh388142,611,049 - 142,614,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378143,692,410 - 143,695,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,689,412 - 143,692,835 (-)NCBINCBI36hg18NCBI36
Build 348143,689,411 - 143,692,835NCBI
Celera8140,003,980 - 140,007,899 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8138,948,085 - 138,951,389 (-)NCBIHuRef
CHM1_18143,732,641 - 143,736,069 (-)NCBICHM1_1
Arc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,540,930 - 74,544,419 (-)NCBIGRCm39mm39
GRCm39 Ensembl1574,540,932 - 74,544,419 (-)Ensembl
GRCm381574,669,081 - 74,672,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,669,083 - 74,672,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,499,513 - 74,503,000 (-)NCBIGRCm37mm9NCBIm37
MGSCv361574,496,338 - 74,499,825 (-)NCBImm8
Celera1576,173,822 - 76,177,304 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.25NCBI
Arc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554541,379,998 - 1,383,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554541,379,998 - 1,383,414 (-)NCBIChiLan1.0ChiLan1.0
ARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18142,365,962 - 142,369,309 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,367,995 - 142,369,185 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08139,320,366 - 139,323,802 (-)NCBIMhudiblu_PPA_v0panPan3
ARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,743,027 - 36,744,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,609,093 - 36,612,592 (-)NCBI
ROS_Cfam_1.01337,136,507 - 37,140,000 (-)NCBI
UMICH_Zoey_3.11336,855,275 - 36,858,753 (-)NCBI
UNSW_CanFamBas_1.01336,944,976 - 36,948,432 (-)NCBI
UU_Cfam_GSD_1.01337,366,985 - 37,370,448 (-)NCBI
Arc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,759,046 - 1,762,161 (+)NCBI
SpeTri2.0NW_0049364709,185,145 - 9,188,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,517,980 - 1,521,403 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.141,517,986 - 1,521,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18136,857,402 - 136,860,933 (-)NCBI
ChlSab1.1 Ensembl8136,859,438 - 136,860,628 (-)Ensembl
Vero_WHO_p1.0NW_0236660393,095,686 - 3,099,176 (+)NCBI
Arc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,968,628 - 13,972,026 (+)NCBI

Position Markers
C86064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,556,107 - 106,556,196 (+)MAPPERmRatBN7.2
Rnor_6.07115,907,232 - 115,907,320NCBIRnor6.0
Rnor_5.07115,812,634 - 115,812,722UniSTSRnor5.0
RGSC_v3.47112,772,072 - 112,772,160UniSTSRGSC3.4
Celera7102,957,391 - 102,957,479UniSTS
Cytogenetic Map7q34UniSTS
RH137921  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,556,035 - 106,556,176 (+)MAPPERmRatBN7.2
Rnor_6.07115,907,160 - 115,907,300NCBIRnor6.0
Rnor_5.07115,812,562 - 115,812,702UniSTSRnor5.0
RGSC_v3.47112,772,000 - 112,772,140UniSTSRGSC3.4
Celera7102,957,319 - 102,957,459UniSTS
RH 3.4 Map7764.5UniSTS
Cytogenetic Map7q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)777428105127748511Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)777428234122421148Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)781645773140745067Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)788365265119318087Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)788365265121986709Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)788365265133365265Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)788365265134673427Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)791018361136018361Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)793726906138726906Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)793726906138726906Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)7100160423140335001Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)7102588256116249643Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)7103815550126525386Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)7103867802126080176Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7112429186126525386Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:570
Count of miRNA genes:250
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000067442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19
Low 2 36 22 6 13 6 7 10 55 35 38 7
Below cutoff 1 7 29 29 6 29 1 1 3 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067442   ⟹   ENSRNOP00000063719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7115,907,097 - 115,910,541 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076998   ⟹   ENSRNOP00000068090
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7115,907,097 - 115,910,522 (-)Ensembl
RefSeq Acc Id: NM_019361   ⟹   NP_062234
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27106,555,973 - 106,559,417 (-)NCBI
Rnor_6.07115,907,097 - 115,910,541 (-)NCBI
Rnor_5.07115,812,499 - 115,815,958 (-)NCBI
RGSC_v3.47112,771,937 - 112,775,381 (-)RGD
Celera7102,957,256 - 102,960,700 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595064   ⟹   XP_017450553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27106,555,968 - 106,559,697 (-)NCBI
Rnor_6.07115,907,097 - 115,911,059 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062234 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450553 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA68695 (Get FASTA)   NCBI Sequence Viewer  
  CAA87033 (Get FASTA)   NCBI Sequence Viewer  
  EDM16100 (Get FASTA)   NCBI Sequence Viewer  
  Q63053 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062234   ⟸   NM_019361
- Sequence:
RefSeq Acc Id: XP_017450553   ⟸   XM_017595064
- Peptide Label: isoform X1
- UniProtKB: Q63053 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063719   ⟸   ENSRNOT00000067442
RefSeq Acc Id: ENSRNOP00000068090   ⟸   ENSRNOT00000076998

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695376
Promoter ID:EPDNEW_R5896
Type:single initiation site
Name:Arc_1
Description:activity-regulated cytoskeleton-associated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07115,910,541 - 115,910,601EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62037 AgrOrtholog
Ensembl Genes ENSRNOG00000043465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000063719 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000068090 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000076998 UniProtKB/Swiss-Prot
InterPro Activity-reg_cytoskelet-assoc UniProtKB/Swiss-Prot
  Arc_C UniProtKB/Swiss-Prot
KEGG Report rno:54323 UniProtKB/Swiss-Prot
NCBI Gene 54323 ENTREZGENE
PANTHER PTHR15962 UniProtKB/Swiss-Prot
Pfam Arc_C UniProtKB/Swiss-Prot
PhenoGen Arc PhenoGen
PRINTS ARCARG31 UniProtKB/Swiss-Prot
TIGR TC207326
UniProt ARC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62743 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Arc  activity-regulated cytoskeleton-associated protein  Arc  activity regulated cytoskeletal-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arc  activity regulated cytoskeletal-associated protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hippocampal and neocortical neurons 628408
gene_function immediate-early gene (IEG) encoding an effector protein 628408
gene_process involved as a dynamic response to synaptic activity 628408
gene_process mouse homolog is essential for maintenance of long-term potentiation (LTP) and consolidation of memory for spatial experience; may modify structure and functions of dendrites affecting synaptic efficacy 628408
gene_process capable of modifying synaptic function 628408