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Gene: Sox10 (SRY-box transcription factor 10) Rattus norvegicus
Symbol: Sox10
Name: SRY-box transcription factor 10
RGD ID: 3735
Description: Exhibits several functions, including DNA-binding transcription activator activity; promoter-specific chromatin binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to progesterone stimulus; regulation of nervous system development; and regulation of transcription, DNA-templated. Localizes to cytoplasm and nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-trans,6-trans,10-trans-geranylgeranyl diphosphate.
Type: protein-coding
Also known as: SRY (sex determining region Y)-box 10; SRY box 10; SRY-box containing gene 10; transcription factor SOX-10
Homo sapiens (human) : SOX10 (SRY-box transcription factor 10)  HGNC  Alliance
Mus musculus (house mouse) : Sox10 (SRY (sex determining region Y)-box 10)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox10 (SRY-box transcription factor 10)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX10 (SRY-box transcription factor 10)
Canis lupus familiaris (dog) : SOX10 (SRY-box transcription factor 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox10 (SRY-box transcription factor 10)
Sus scrofa (pig) : SOX10 (SRY-box transcription factor 10)
Chlorocebus sabaeus (African green monkey) : SOX10 (SRY-box transcription factor 10)
Heterocephalus glaber (naked mole-rat) : Sox10 (SRY-box transcription factor 10)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07120,393,238 - 120,403,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,387,071 - 120,397,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,138,694 - 117,149,939 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17117,172,923 - 117,184,169 (-)NCBI
Celera7107,059,767 - 107,070,023 (-)NCBICelera
Cytogenetic Map7q34NCBI
RH 3.4 Map7839.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sox10
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3735
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.