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Gene: SOX10 (SRY-box transcription factor 10) Homo sapiens
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Symbol: SOX10
Name: SRY-box transcription factor 10
Description: Exhibits identical protein binding activity. Predicted to be involved in several processes, including nervous system development; neural crest cell migration; and positive regulation of transcription by RNA polymerase II. Localizes to the nucleoplasm. Implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DOM; dominant megacolon, mouse, human homolog of; MGC15649; PCWH; SRY (sex determining region Y)-box 10; SRY box 10; SRY-box 10; sry-box containing gene 10; SRY-related HMG-box gene 10; transcription factor SOX-10; WS2E; WS4; WS4C
Orthologs:
Mus musculus (house mouse) : Sox10 (SRY (sex determining region Y)-box 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox10 (SRY-box transcription factor 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox10 (SRY-box transcription factor 10)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX10 (SRY-box transcription factor 10)
Canis lupus familiaris (dog) : SOX10 (SRY-box transcription factor 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox10 (SRY-box transcription factor 10)
Sus scrofa (pig) : SOX10 (SRY-box transcription factor 10)
Chlorocebus sabaeus (green monkey) : SOX10 (SRY-box transcription factor 10)
Heterocephalus glaber (naked mole-rat) : Sox10 (SRY-box transcription factor 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2237,970,686 - 37,987,422 (-)Ensembl
GRCh382237,972,312 - 37,984,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,368,319 - 38,380,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,698,265 - 36,710,485 (-)NCBINCBI36hg18NCBI36
Build 342236,692,819 - 36,705,039NCBI
Celera2222,170,048 - 22,182,268 (-)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,334,376 - 21,346,534 (-)NCBIHuRef
CHM1_12238,327,060 - 38,339,280 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SOX10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731681
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.