Sox10 (SRY-box transcription factor 10) - Rat Genome Database

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Gene: Sox10 (SRY-box transcription factor 10) Ictidomys tridecemlineatus
Analyze
Symbol: Sox10
Name: SRY-box transcription factor 10
RGD ID: 12562898
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN cell differentiation (ortholog); cell maturation (ortholog); cellular response to progesterone stimulus (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Anosmia (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SRY-box 10; transcription factor SOX-10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,163,344 - 10,174,369 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,173,741 - 3,185,024 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,173,770 - 3,183,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA,ISO)
cell maturation  (IEA,ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
central nervous system myelination  (IEA)
developmental growth  (IEA,ISO)
developmental process  (IEA)
digestive tract morphogenesis  (IEA,ISO)
enteric nervous system development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lacrimal gland development  (IEA,ISO)
melanocyte differentiation  (IEA,ISO)
morphogenesis of a branching epithelium  (IEA,ISO)
morphogenesis of an epithelium  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of Schwann cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neural crest cell migration  (IEA)
neuroblast proliferation  (IEA,ISO)
oligodendrocyte development  (IEA)
oligodendrocyte differentiation  (IEA,ISO)
peripheral nervous system development  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of gliogenesis  (IEA)
positive regulation of myelination  (ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
stem cell differentiation  (ISO)
transcription by RNA polymerase II  (IEA,ISO)
transcription elongation by RNA polymerase II  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Sox10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,163,344 - 10,174,369 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,173,741 - 3,185,024 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,173,770 - 3,183,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOX10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,972,312 - 37,984,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,970,686 - 37,987,422 (-)EnsemblGRCh38hg38GRCh38
GRCh372238,368,319 - 38,380,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,698,265 - 36,710,485 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,692,819 - 36,705,039NCBI
Celera2222,170,048 - 22,182,268 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,334,376 - 21,346,534 (-)NCBIHuRef
CHM1_12238,327,060 - 38,339,280 (-)NCBICHM1_1
T2T-CHM13v2.02238,433,934 - 38,446,177 (-)NCBIT2T-CHM13v2.0
Sox10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,039,113 - 79,048,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,039,108 - 79,049,440 (-)EnsemblGRCm39 Ensembl
GRCm381579,154,913 - 79,164,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,154,908 - 79,165,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,985,343 - 78,994,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,982,168 - 78,992,495 (-)NCBIMGSCv36mm8
Celera1581,267,600 - 81,277,195 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Sox10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,605,721 - 112,615,097 (-)NCBIGRCr8
mRatBN7.27110,725,274 - 110,734,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,725,274 - 110,735,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,473,920 - 112,483,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,697,448 - 114,706,706 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,666,769 - 114,676,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,393,238 - 120,403,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,393,254 - 120,403,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,387,071 - 120,397,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,138,694 - 117,149,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,172,923 - 117,184,169 (-)NCBI
Celera7107,059,767 - 107,070,023 (-)NCBICelera
RH 3.4 Map7839.3RGD
Cytogenetic Map7q34NCBI
Sox10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,311,783 - 24,323,315 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,313,311 - 24,323,112 (-)NCBIChiLan1.0ChiLan1.0
SOX10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,828,983 - 47,841,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,517,348 - 50,529,603 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,885,679 - 18,897,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,712,128 - 36,724,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,713,310 - 36,723,439 (-)Ensemblpanpan1.1panPan2
SOX10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,680,441 - 26,690,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,681,122 - 26,689,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,635,515 - 26,646,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,472,272 - 27,482,931 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,472,118 - 27,482,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,192,256 - 27,202,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,503,817 - 27,514,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,681,016 - 27,691,677 (+)NCBIUU_Cfam_GSD_1.0
SOX10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,891,525 - 9,901,743 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,890,439 - 9,901,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,289,992 - 7,299,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOX10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,673,053 - 20,685,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045105,090,681 - 105,103,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sox10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,965,756 - 9,973,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,965,015 - 9,976,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005322261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000021946   ⟹   ENSSTOP00000017111
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364923,173,741 - 3,185,024 (+)Ensembl
RefSeq Acc Id: XM_005322261   ⟹   XP_005322318
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494510,163,344 - 10,174,369 (+)NCBI
SpeTri2.0NW_0049364923,173,770 - 3,183,423 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005322318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000017111.1
GenBank Protein KAG3290963 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005322318   ⟸   XM_005322261
- UniProtKB: I3MYB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000017111   ⟸   ENSSTOT00000021946
Protein Domains
HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025370 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021946.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  Sox_N UniProtKB/TrEMBL
  SOX_TF UniProtKB/TrEMBL
NCBI Gene Sox10 ENTREZGENE
PANTHER SOX100B UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SOX-10 UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
  Sox_N UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt I3MYB5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-18 Sox10  SRY-box transcription factor 10  Sox10  SRY-box 10  Symbol and/or name change 5135510 APPROVED