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Gene: Lrrk2 (leucine-rich repeat kinase 2) Rattus norvegicus
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
Description: Predicted to have several functions, including cytoskeletal protein binding activity; enzyme regulator activity; and kinase activity. Involved in several processes, including nervous system development; positive regulation of microglial cell activation; and positive regulation of transport. Localizes to several cellular components, including the cytoplasm; neuron projection; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; autosomal dominant Parkinson's disease 8; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH (RS)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: leucine-rich repeat serine/threonine-protein kinase 2
Homo sapiens (human) : LRRK2 (leucine rich repeat kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Lrrk2 (leucine-rich repeat kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
Sus scrofa (pig) : LRRK2 (leucine rich repeat kinase 2)
more info ...
Allele / Splice: Lrrk1em1SageLrrk2em1Sage   Lrrk2em1Sage  
Genetic Models: LE-Lrrk2em1Sage-/- LE-Lrrk2em1Sage LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/- LE-Lrrk1em1SageLrrk2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Lrrk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1561168
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-10-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.