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Gene: Lrrk2 (leucine-rich repeat kinase 2) Rattus norvegicus
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
RGD ID: 1561168
Description: Predicted to have several functions, including cytoskeletal protein binding activity; enzyme regulator activity; and protein kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Localizes to several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
Also known as: leucine-rich repeat serine/threonine-protein kinase 2
Homo sapiens (human) : LRRK2 (leucine rich repeat kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Lrrk2 (leucine-rich repeat kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
Sus scrofa (pig) : LRRK2 (leucine rich repeat kinase 2)
Chlorocebus sabaeus (African green monkey) : LRRK2 (leucine rich repeat kinase 2)
Heterocephalus glaber (naked mole-rat) : Lrrk2 (leucine rich repeat kinase 2)
more info ...
Allele / Splice: Lrrk1em1SageLrrk2em1Sage   Lrrk2em1Sage  
Genetic Models: LE-Lrrk2em1Sage-/- LE-Lrrk2em1Sage LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/- LE-Lrrk1em1SageLrrk2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,857,628 - 133,018,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Lrrk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1561168
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.