Adcy8 (adenylate cyclase 8) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Adcy8 (adenylate cyclase 8) Rattus norvegicus
Analyze
Symbol: Adcy8
Name: adenylate cyclase 8
RGD ID: 2036
Description: Enables several functions, including calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and cellular response to organonitrogen compound. Located in several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Colocalizes with actin cytoskeleton. Orthologous to human ADCY8 (adenylate cyclase 8); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac8; adenylate cyclase 8 (brain); adenylate cyclase type 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase 8 variant E; adenylyl cyclase 8 variant F; adenylyl cyclase 8 variant G; adenylyl cyclase 8 variant H; ATP pyrophosphate-lyase 8; ca(2+)/calmodulin-activated adenylyl cyclase; type VIII adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2796,417,310 - 96,665,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx798,176,363 - 98,425,655 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07100,377,999 - 100,627,320 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07100,299,283 - 100,548,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07105,353,883 - 105,593,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07105,301,826 - 105,541,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,957,807 - 102,210,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,992,036 - 102,244,576 (-)NCBI
Celera792,997,741 - 93,245,305 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu. Ayling LJ, etal., J Cell Sci. 2012 Feb 15;125(Pt 4):869-86. doi: 10.1242/jcs.091090. Epub 2012 Mar 7.
2. Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. Cali JJ, etal., J Biol Chem 1994 Apr 22;269(16):12190-5.
3. Splice variants of type VIII adenylyl cyclase. Differences in glycosylation and regulation by Ca2+/calmodulin. Cali JJ, etal., J Biol Chem. 1996 Jan 12;271(2):1089-95.
4. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505.
5. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Crossthwaite AJ, etal., Mol Pharmacol. 2006 Feb;69(2):608-17. doi: 10.1124/mol.105.018275. Epub 2005 Oct 28.
6. Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. Delint-Ramirez I, etal., J Biol Chem. 2011 Sep 23;286(38):32962-75. doi: 10.1074/jbc.M111.243899. Epub 2011 Jul 19.
7. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Delmeire D, etal., Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17.
8. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Dou H, etal., Diabetologia. 2015 Feb;58(2):324-33. doi: 10.1007/s00125-014-3437-z. Epub 2014 Nov 9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Dimerization of mammalian adenylate cyclases. Gu C, etal., Eur J Biochem. 2002 Jan;269(2):413-21.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition. Macdougall DA, etal., J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.
14. Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8. Martin AC, etal., Mol Pharmacol. 2009 Apr;75(4):830-42. doi: 10.1124/mol.108.051748. Epub 2009 Jan 26.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry. Pagano M, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C607-19. doi: 10.1152/ajpcell.00488.2008. Epub 2009 Jan 21.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Roger B, etal., Diabetologia. 2011 Feb;54(2):390-402. doi: 10.1007/s00125-010-1955-x. Epub 2010 Nov 3.
24. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
25. Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry. Smith KE, etal., J Biol Chem. 2002 Feb 22;277(8):6025-31. doi: 10.1074/jbc.M109615200. Epub 2001 Dec 13.
26. Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers. Steiner D, etal., J Mol Neurosci. 2005;27(2):195-203.
27. Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Strazzabosco M, etal., Hepatology. 2009 Jul;50(1):244-52.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. Willoughby D, etal., J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.
30. A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex. Willoughby D, etal., J Cell Sci. 2012 Dec 1;125(Pt 23):5850-9. doi: 10.1242/jcs.111427. Epub 2012 Sep 12.
31. Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. Willoughby D, etal., Sci Signal. 2012 Apr 10;5(219):ra29. doi: 10.1126/scisignal.2002299.
Additional References at PubMed
PMID:10482244   PMID:10864938   PMID:12206999   PMID:12441059   PMID:14585998   PMID:17335981   PMID:18222416   PMID:18448650   PMID:19029295   PMID:22531884   PMID:22613711   PMID:25403481  
PMID:27234425   PMID:29940197  


Genomics

Comparative Map Data
Adcy8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2796,417,310 - 96,665,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx798,176,363 - 98,425,655 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07100,377,999 - 100,627,320 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07100,299,283 - 100,548,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07105,353,883 - 105,593,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07105,301,826 - 105,541,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,957,807 - 102,210,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,992,036 - 102,244,576 (-)NCBI
Celera792,997,741 - 93,245,305 (-)NCBICelera
Cytogenetic Map7q33NCBI
ADCY8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388130,780,301 - 131,040,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8130,780,301 - 131,040,909 (-)EnsemblGRCh38hg38GRCh38
GRCh378131,792,547 - 132,053,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368131,861,729 - 132,123,854 (-)NCBINCBI36Build 36hg18NCBI36
Build 348131,861,728 - 132,123,854NCBI
Celera8127,969,937 - 128,230,969 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8127,112,105 - 127,216,470 (-)NCBIHuRef
HuRef8127,235,506 - 127,372,263 (-)NCBIHuRef
CHM1_18131,833,662 - 132,093,872 (-)NCBICHM1_1
T2T-CHM13v2.08131,907,547 - 132,167,269 (-)NCBIT2T-CHM13v2.0
Adcy8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391564,570,884 - 64,794,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1564,568,933 - 64,794,145 (-)EnsemblGRCm39 Ensembl
GRCm381564,699,035 - 64,922,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1564,697,084 - 64,922,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv371564,530,597 - 64,753,858 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361564,528,707 - 64,751,833 (-)NCBIMGSCv36mm8
Celera1566,221,302 - 66,448,865 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.03NCBI
Adcy8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554615,497,628 - 5,725,574 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554615,497,708 - 5,725,574 (-)NCBIChiLan1.0ChiLan1.0
ADCY8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan18123,667,241 - 123,929,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08127,418,407 - 127,681,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18130,399,223 - 130,661,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8130,398,288 - 130,661,073 (-)Ensemblpanpan1.1panPan2
ADCY8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11327,723,530 - 27,937,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1327,723,530 - 27,937,734 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1327,690,009 - 27,910,417 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01328,068,919 - 28,289,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1328,068,921 - 28,289,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11327,784,095 - 28,006,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01327,904,105 - 28,118,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01328,205,442 - 28,426,573 (-)NCBIUU_Cfam_GSD_1.0
Adcy8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530310,405,531 - 10,621,769 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647017,831,639 - 18,047,868 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647017,831,644 - 18,047,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl49,645,659 - 9,866,550 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.149,645,398 - 9,867,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.249,777,859 - 9,968,857 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18125,269,396 - 125,535,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8125,269,736 - 125,533,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603914,582,569 - 14,845,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473524,891,583 - 25,149,900 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473524,891,803 - 25,149,817 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy8
958 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:64
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000006789
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat

Markers in Region
AW060868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2796,417,524 - 96,417,616 (+)MAPPERmRatBN7.2
Rnor_6.07105,354,114 - 105,354,205NCBIRnor6.0
Rnor_5.07105,302,057 - 105,302,148UniSTSRnor5.0
RGSC_v3.47101,958,022 - 101,958,113UniSTSRGSC3.4
Celera792,997,954 - 92,998,045UniSTS
Cytogenetic Map7q33UniSTS
UniSTS:546632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2796,665,028 - 96,665,927 (+)MAPPERmRatBN7.2
Rnor_6.07105,591,922 - 105,592,820NCBIRnor6.0
Rnor_5.07105,539,569 - 105,540,467UniSTSRnor5.0
Celera793,244,423 - 93,245,321UniSTS
Cytogenetic Map7q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38
Low 1 6 4 4 4 36 16 25
Below cutoff 1 14 19 8 3 8 7 7 2 9 7 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006789   ⟹   ENSRNOP00000006789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)Ensembl
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096414   ⟹   ENSRNOP00000085627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098906   ⟹   ENSRNOP00000086009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)Ensembl
RefSeq Acc Id: NM_017142   ⟹   NP_058838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,310 - 96,665,911 (-)NCBI
Rnor_6.07105,353,899 - 105,592,804 (-)NCBI
Rnor_5.07105,301,826 - 105,541,014 (-)NCBI
RGSC_v3.47101,957,807 - 102,210,346 (-)RGD
Celera792,997,741 - 93,245,305 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241703   ⟹   XP_006241765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,388 - 96,665,135 (-)NCBI
Rnor_6.07105,353,883 - 105,593,372 (-)NCBI
Rnor_5.07105,301,826 - 105,541,014 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241704   ⟹   XP_006241766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,388 - 96,665,135 (-)NCBI
Rnor_6.07105,353,883 - 105,593,372 (-)NCBI
Rnor_5.07105,301,826 - 105,541,014 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078563   ⟹   XP_038934491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_039078564   ⟹   XP_038934492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_039078565   ⟹   XP_038934493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_039078567   ⟹   XP_038934495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058838   ⟸   NM_017142
- UniProtKB: P40146 (UniProtKB/Swiss-Prot),   A6HRQ4 (UniProtKB/TrEMBL),   G3V6N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241766   ⟸   XM_006241704
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3U3 (UniProtKB/TrEMBL),   A6HRQ4 (UniProtKB/TrEMBL),   G3V6N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241765   ⟸   XM_006241703
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GDK4 (UniProtKB/TrEMBL),   A6HRQ4 (UniProtKB/TrEMBL),   G3V6N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006789   ⟸   ENSRNOT00000006789
RefSeq Acc Id: XP_038934495   ⟸   XM_039078567
- Peptide Label: isoform X6
- UniProtKB: A0A2Z4LIN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934493   ⟸   XM_039078565
- Peptide Label: isoform X5
- UniProtKB: A0A2Z4LIN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934492   ⟸   XM_039078564
- Peptide Label: isoform X4
- UniProtKB: A0A2Z4LIN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934491   ⟸   XM_039078563
- Peptide Label: isoform X3
- UniProtKB: A0A2Z4LIM7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086009   ⟸   ENSRNOT00000098906
RefSeq Acc Id: ENSRNOP00000085627   ⟸   ENSRNOT00000096414
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P40146-F1-model_v2 AlphaFold P40146 1-1248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2036 AgrOrtholog
BioCyc Gene G2FUF-33140 BioCyc
Ensembl Genes ENSRNOG00000004890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006789 ENTREZGENE
  ENSRNOP00000006789.4 UniProtKB/TrEMBL
  ENSRNOP00000085627 ENTREZGENE
  ENSRNOP00000085627.1 UniProtKB/TrEMBL
  ENSRNOP00000086009 ENTREZGENE
  ENSRNOP00000086009.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006789 ENTREZGENE
  ENSRNOT00000006789.7 UniProtKB/TrEMBL
  ENSRNOT00000096414 ENTREZGENE
  ENSRNOT00000096414.1 UniProtKB/TrEMBL
  ENSRNOT00000098906 ENTREZGENE
  ENSRNOT00000098906.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29241 UniProtKB/Swiss-Prot
NCBI Gene 29241 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADCY8 RGD
PhenoGen Adcy8 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207966
UniProt A0A2Z4LIM7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z4LIN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z4LIN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z4LIN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GDK4 ENTREZGENE, UniProtKB/TrEMBL
  A6HRQ3_RAT UniProtKB/TrEMBL
  A6HRQ4 ENTREZGENE, UniProtKB/TrEMBL
  ADCY8_RAT UniProtKB/Swiss-Prot
  G3V6N0 ENTREZGENE, UniProtKB/TrEMBL
  P40146 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Adcy8  adenylate cyclase 8  Adcy8  adenylate cyclase 8 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy8  adenylate cyclase 8 (brain)  Adcy8  adenylate cyclase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adcy8  adenylate cyclase 8    adenylyl cyclase 8  Name updated 1299863 APPROVED
2002-06-10 Adcy8  adenylyl cyclase 8      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in several regions in brain 69741
gene_function has adenylyl cyclase activity that is induced by intracellular calcium/calmodulin 69741
gene_process may play a role in intracellular signaling and long term potentiation 69741
gene_regulation activity is induced by calcuim/calmodulin 69741
gene_regulation induction by calcium/calmodulin is enhanced by addition of Gs alpha 69741
gene_transcript mRNA transcripts of 4.4 and 5.5 kB are detected 69741