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Gene: Adcy8 (adenylate cyclase 8) Rattus norvegicus
Symbol: Adcy8
Name: adenylate cyclase 8
RGD ID: 2036
Description: Exhibits several functions, including calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular chemical homeostasis; and cellular response to organonitrogen compound. Localizes to several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Colocalizes with actin cytoskeleton. Orthologous to human ADCY8 (adenylate cyclase 8); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: Ac8; adenylate cyclase 8 (brain); adenylate cyclase type 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase 8 variant E; adenylyl cyclase 8 variant F; adenylyl cyclase 8 variant G; adenylyl cyclase 8 variant H; ATP pyrophosphate-lyase 8; ca(2+)/calmodulin-activated adenylyl cyclase; type VIII adenylyl cyclase
Homo sapiens (human) : ADCY8 (adenylate cyclase 8)  HGNC  Alliance
Mus musculus (house mouse) : Adcy8 (adenylate cyclase 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adcy8 (adenylate cyclase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : ADCY8 (adenylate cyclase 8)
Canis lupus familiaris (dog) : ADCY8 (adenylate cyclase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adcy8 (adenylate cyclase 8)
Sus scrofa (pig) : ADCY8 (adenylate cyclase 8)
Chlorocebus sabaeus (African green monkey) : ADCY8 (adenylate cyclase 8)
Heterocephalus glaber (naked mole-rat) : Adcy8 (adenylate cyclase 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07105,353,883 - 105,593,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07105,301,826 - 105,541,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,957,807 - 102,210,346 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17101,992,036 - 102,244,576 (-)NCBI
Celera792,997,741 - 93,245,305 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adcy8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2036
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.