Atf4 (activating transcription factor 4) - Rat Genome Database

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Gene: Atf4 (activating transcription factor 4) Rattus norvegicus
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Symbol: Atf4
Name: activating transcription factor 4
RGD ID: 621863
Description: Enables DNA-binding transcription factor binding activity and general transcription initiation factor binding activity. Involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and response to manganese-induced endoplasmic reticulum stress. Located in dendrite membrane. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Endoplasmic Reticulum-associated degradation pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; cyclic AMP-dependent transcription factor ATF-4; rATF-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,684,681 - 113,686,739 (+)NCBIGRCr8
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,558,983 - 113,561,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,782,520 - 115,784,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,751,882 - 115,753,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-amphetamine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
avermectin  (ISO)
azoxystrobin  (ISO)
baicalein  (EXP)
bathocuproine disulfonic acid  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bepridil  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bongkrekic acid  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidin  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
cerium  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cibenzoline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
corilagin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (EXP,ISO)
dapagliflozin  (EXP)
DDE  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydrocapsaicin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxomicin  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (EXP)
esketamine  (ISO)
ethanol  (EXP,ISO)
ethylene glycol  (EXP)
etoposide  (ISO)
fangchinoline  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
ferrostatin-1  (ISO)
flavokawain B  (ISO)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
gadolinium trichloride  (EXP)
galactose  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GSK2656157  (EXP,ISO)
helenalin  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
KN-93  (EXP)
L-1,4-dithiothreitol  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
L-serine  (ISO)
lead diacetate  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP,ISO)
Leonurine  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
MK-2206  (ISO)
montelukast  (ISO)
morphine  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nelfinavir  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
orlistat  (ISO)
oxidopamine  (EXP)
oxycodone  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
Pachymic acid  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
Pendulone  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
Perhexiline maleate  (ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (EXP,ISO)
SB 203580  (ISO)
SB-239063  (ISO)
SCH 23390  (EXP)
scopoletin  (EXP)
selenium atom  (ISO)
sertraline  (ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
triclocarban  (ISO)
triclosan  (ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
umbelliferone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vildagliptin  (EXP)
withaferin A  (ISO)
XAV939  (ISO)
xylitol  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone mineralization  (IEA,ISO,ISS)
cellular response to amino acid starvation  (IEA,ISO,ISS)
cellular response to glucose starvation  (IEA,ISO)
cellular response to hypoxia  (IEP)
cellular response to leucine starvation  (IEA,ISO)
cellular response to oxidative stress  (IEA,IMP,ISO,ISS)
cellular response to UV  (ISS)
circadian regulation of gene expression  (IEA,ISO,ISS)
circadian rhythm  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO,ISS)
endoplasmic reticulum unfolded protein response  (IEA,ISO,ISS)
gamma-aminobutyric acid signaling pathway  (IDA)
gluconeogenesis  (IEA,ISO)
HRI-mediated signaling  (IEA,ISO,ISS)
integrated stress response signaling  (IEA,ISO,ISS)
intracellular calcium ion homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO,ISS)
L-asparagine metabolic process  (IEA,ISO)
lens fiber cell morphogenesis  (IEA,ISO,ISS)
mRNA transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,IMP,ISO)
negative regulation of potassium ion transport  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of translational initiation in response to stress  (ISS)
neuron differentiation  (IEP)
PERK-mediated unfolded protein response  (IEA,ISO,ISS)
positive regulation of biomineral tissue development  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO,ISS)
positive regulation of sodium-dependent phosphate transport  (IEA,ISO)
positive regulation of transcription by RNA polymerase I  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO,ISS)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of osteoblast differentiation  (IEA,ISO,ISS)
regulation of synaptic plasticity  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO,ISS)
response to manganese-induced endoplasmic reticulum stress  (IEP)
response to nutrient levels  (IEA,ISO)
response to toxic substance  (IEP)
rhythmic process  (IEA)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells. Cho YM, etal., Exp Mol Med. 2009 Jun 30;41(6):440-52. doi: 10.3858/emm.2009.41.6.049.
2. Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid. Fujinami Y, etal., Neurochem Int. 2010 Feb;56(3):487-94. doi: 10.1016/j.neuint.2009.12.008. Epub 2009 Dec 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. STAMP2 increases oxidative stress and is critical for prostate cancer. Jin Y, etal., EMBO Mol Med. 2015 Mar;7(3):315-31. doi: 10.15252/emmm.201404181.
6. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, etal., Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5.
7. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. Nehring RB, etal., J Biol Chem 2000 Nov 10;275(45):35185-91.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. Sun X, etal., J Neurosci. 2013 Feb 6;33(6):2398-407. doi: 10.1523/JNEUROSCI.2292-12.2013.
16. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
17. Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Tanaka T, etal., Genes Cells 1998 Dec;3(12):801-10.
18. Effects of ATF4 on PGC1a expression in brown adipose tissue and metabolic responses to cold stress. Wang C, etal., Metabolism. 2013 Feb;62(2):282-9. doi: 10.1016/j.metabol.2012.07.017. Epub 2012 Sep 11.
19. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
20. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
21. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
22. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. Yu S, etal., J Biol Chem. 2008 Feb 29;283(9):5542-53. doi: 10.1074/jbc.M705653200. Epub 2008 Jan 2.
23. EIF2alpha and caspase-12 activation are involved in oxygen-glucose-serum deprivation/restoration-induced apoptosis of spinal cord astrocytes. Zhang A, etal., Neurosci Lett. 2010 Jun 30;478(1):32-6. doi: 10.1016/j.neulet.2010.04.062. Epub 2010 May 2.
24. miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer. Zhang L, etal., Mol Med Rep. 2016 Sep;14(3):2077-84. doi: 10.3892/mmr.2016.5469. Epub 2016 Jul 6.
Additional References at PubMed
PMID:8506317   PMID:10580117   PMID:10602480   PMID:11106749   PMID:11274184   PMID:11478948   PMID:11916968   PMID:11960987   PMID:12749859   PMID:12871976   PMID:14729979   PMID:15013631  
PMID:15277680   PMID:15724149   PMID:15775988   PMID:15788408   PMID:15911876   PMID:16445384   PMID:16682973   PMID:16751105   PMID:18305237   PMID:18617696   PMID:18654882   PMID:18940792  
PMID:19017641   PMID:19061639   PMID:19232401   PMID:19726676   PMID:20873783   PMID:21068199   PMID:21113145   PMID:21159964   PMID:21436843   PMID:21768648   PMID:21821103   PMID:21984568  
PMID:22095285   PMID:22507839   PMID:22915762   PMID:22952236   PMID:22974638   PMID:23663782   PMID:23686245   PMID:24136195   PMID:24939851   PMID:25012492   PMID:26174742   PMID:27233218  
PMID:27484784   PMID:27812542   PMID:27841340   PMID:28188284   PMID:29875265   PMID:31416289   PMID:31787756   PMID:32304741   PMID:35315506   PMID:35403324   PMID:35531910   PMID:35574856  
PMID:36928813   PMID:38879481  


Genomics

Comparative Map Data
Atf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,684,681 - 113,686,739 (+)NCBIGRCr8
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,558,983 - 113,561,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,782,520 - 115,784,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,751,882 - 115,753,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
ATF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,520,559 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,519,695 - 39,522,686 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,916,564 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,308 - 39,877,431 (+)NCBICHM1_1
T2T-CHM13v2.02239,985,692 - 39,993,317 (+)NCBIT2T-CHM13v2.0
Atf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,139,385 - 80,141,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,139,385 - 80,141,742 (+)EnsemblGRCm39 Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,255,184 - 80,257,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBIMGSCv36mm8
Celera1582,372,526 - 82,374,883 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Atf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBIChiLan1.0ChiLan1.0
ATF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,368,664 - 49,369,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,058,755 - 52,061,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,426,743 - 20,428,892 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,246,337 - 38,249,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,248,094 - 38,249,249 (+)Ensemblpanpan1.1panPan2
ATF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,528,880 - 25,531,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,528,874 - 25,530,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,464,741 - 25,466,879 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,280,612 - 26,282,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,280,619 - 26,282,738 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,995,219 - 25,997,329 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,314,765 - 26,316,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,490,223 - 26,492,367 (-)NCBIUU_Cfam_GSD_1.0
Atf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,104,066 - 9,105,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,110,634 - 2,115,996 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,114,478 - 2,115,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,742,967 - 8,745,368 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,742,964 - 8,745,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,042,584 - 6,044,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,092,046 - 22,094,184 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,091,667 - 22,095,230 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,557,595 - 103,561,018 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,822,740 - 8,825,032 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,822,955 - 8,825,019 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atf4
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:124
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000065304
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH127863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,806,076 - 111,806,285 (+)MAPPERmRatBN7.2
Rnor_6.07121,482,401 - 121,482,609NCBIRnor6.0
Rnor_5.07121,470,216 - 121,470,424UniSTSRnor5.0
RGSC_v3.47118,538,623 - 118,538,831UniSTSRGSC3.4
RH 3.4 Map7861.0UniSTS
Cytogenetic Map7q34UniSTS
PMC19934P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,805,777 - 111,806,254 (+)MAPPERmRatBN7.2
Rnor_6.07121,482,102 - 121,482,578NCBIRnor6.0
Rnor_5.07121,469,917 - 121,470,393UniSTSRnor5.0
RGSC_v3.47118,538,324 - 118,538,800UniSTSRGSC3.4
Cytogenetic Map7q34UniSTS
UniSTS:274176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,804,444 - 111,805,676 (+)MAPPERmRatBN7.2
Rnor_6.07121,480,770 - 121,482,000NCBIRnor6.0
Rnor_5.07121,468,585 - 121,469,815UniSTSRnor5.0
RGSC_v3.47118,536,992 - 118,538,222UniSTSRGSC3.4
Cytogenetic Map7q34UniSTS
Atf4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,806,080 - 111,806,329 (+)MAPPERmRatBN7.2
Rnor_6.07121,482,405 - 121,482,653NCBIRnor6.0
Rnor_5.07121,470,220 - 121,470,468UniSTSRnor5.0
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF252627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000065304   ⟹   ENSRNOP00000060302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)Ensembl
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7121,480,735 - 121,481,478 (+)Ensembl
RefSeq Acc Id: NM_024403   ⟹   NP_077379
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,684,681 - 113,686,739 (+)NCBI
mRatBN7.27111,804,398 - 111,806,457 (+)NCBI
Rnor_6.07121,480,723 - 121,482,781 (+)NCBI
Rnor_5.07121,468,275 - 121,470,587 (+)NCBI
RGSC_v3.47118,537,718 - 118,538,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079942   ⟹   XP_038935870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,685,575 - 113,686,730 (+)NCBI
mRatBN7.27111,804,135 - 111,806,448 (+)NCBI
Protein Sequences
Protein RefSeqs NP_077379 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935870 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31732 (Get FASTA)   NCBI Sequence Viewer  
  AAI58589 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060302
  ENSRNOP00000060302.1
GenBank Protein Q9ES19 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077379   ⟸   NM_024403
- UniProtKB: Q9ES19 (UniProtKB/Swiss-Prot),   B0BMW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060302   ⟸   ENSRNOT00000065304
RefSeq Acc Id: XP_038935870   ⟸   XM_039079942
- Peptide Label: isoform X1
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES19-F1-model_v2 AlphaFold Q9ES19 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695496
Promoter ID:EPDNEW_R6021
Type:multiple initiation site
Name:Atf4_1
Description:activating transcription factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07121,480,721 - 121,480,781EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621863 AgrOrtholog
BioCyc Gene G2FUF-32706 BioCyc
Ensembl Genes ENSRNOG00000017801 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065304 ENTREZGENE
  ENSRNOT00000065304.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9098368 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:79255 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187368 IMAGE-MGC_LOAD
NCBI Gene 79255 ENTREZGENE
PANTHER ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 UniProtKB/Swiss-Prot
  CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Atf4 PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017801 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt ATF4_RAT UniProtKB/Swiss-Prot
  B0BMW3 ENTREZGENE, UniProtKB/TrEMBL
  Q9ES19 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Atf4  activating transcription factor 4  Atf4  activating transcription factor 4 (tax-responsive enhancer element B67)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atf4  activating transcription factor 4 (tax-responsive enhancer element B67)  Atf4  activating transcription factor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Atf4  activating transcription factor 4    activating transcription factor ATF-4  Name updated 1299863 APPROVED
2002-08-07 Atf4  activating transcription factor ATF-4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the cAMP response element-binding protein/ATF family 631878