Enables several functions, including ATP-dependent protein binding activity; calcium-independent phospholipase A2 activity; and long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including cardiolipin acyl-chain remodeling; positive regulation of protein kinase C signaling; and positive regulation of secretion. Predicted to be located in several cellular components, including extracellular space; microtubule cytoskeleton; and nuclear speck. Predicted to be active in mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI); PARTICIPATES IN angiotensin II signaling pathway; alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
PLA2G6 protein promotes the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]]
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium]
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium] and [Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium] and [Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G6 protein] which results in increased susceptibility to Calcium] more ...
PLA2G6 protein promotes the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]]
PLA2G6 protein promotes the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of PLA2G6 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of PLA2G6 mRNA
NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLA2G6 mRNA] and NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of PLA2G6 mRNA]
PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PLA2G6 mRNA] and PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLA2G6 mRNA]
PLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA] and UCN protein inhibits the reaction [Thapsigargin results in increased activity of PLA2G6 protein]
Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.
Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.
Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin.
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.
Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
Proinflammatory treatment of astrocytes with lipopolysaccharide results in augmented Ca2+ signaling through increased expression of via phospholipase A2 (iPLA2).
Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles.