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Gene: Pla2g6 (phospholipase A2 group VI) Rattus norvegicus
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Symbol: Pla2g6
Name: phospholipase A2 group VI
Description: Exhibits ATP-dependent protein binding activity; calcium-independent phospholipase A2 activity; and protein kinase binding activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; positive regulation of secretion; and positive regulation of signal transduction. Localizes to the cytosol and mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI); PARTICIPATES IN angiotensin II signaling pathway; alpha-linoleic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4,4',6-tetrachlorobiphenyl; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; caI-PLA2; group VI phospholipase A2; GVI PLA2; intracellular membrane-associated calcium-independent phospholipase A2 beta; iPla2; iPLA2-beta; MGC93880; patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
Orthologs:
Homo sapiens (human) : PLA2G6 (phospholipase A2 group VI)  HGNC  Alliance
Mus musculus (house mouse) : Pla2g6 (phospholipase A2, group VI)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pla2g6 (phospholipase A2 group VI)
Pan paniscus (bonobo/pygmy chimpanzee) : PLA2G6 (phospholipase A2 group VI)
Canis lupus familiaris (dog) : PLA2G6 (phospholipase A2 group VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pla2g6 (phospholipase A2 group VI)
Sus scrofa (pig) : PLA2G6 (phospholipase A2 group VI)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07120,519,479 - 120,559,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,519,467 - 120,559,347 (-)Ensembl
Rnor_5.07120,512,621 - 120,553,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,266,784 - 117,307,172 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17117,301,013 - 117,341,212 (-)NCBI
Celera7107,184,586 - 107,224,721 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pla2g6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628867
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.