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Gene: Pla2g6 (phospholipase A2 group VI) Rattus norvegicus
Symbol: Pla2g6
Name: phospholipase A2 group VI
RGD ID: 628867
Description: Exhibits several functions, including ATP-dependent protein binding activity; calcium-independent phospholipase A2 activity; and palmitoyl-CoA hydrolase activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; positive regulation of secretion; and positive regulation of signal transduction. Localizes to cytosol and mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI); PARTICIPATES IN angiotensin II signaling pathway; alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid; 2,2',4,4'-Tetrabromodiphenyl ether; 2,4,4',6-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; caI-PLA2; group VI phospholipase A2; GVI PLA2; intracellular membrane-associated calcium-independent phospholipase A2 beta; iPla2; iPLA2-beta; MGC93880; palmitoyl-CoA hydrolase; patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
Homo sapiens (human) : PLA2G6 (phospholipase A2 group VI)  HGNC  Alliance
Mus musculus (house mouse) : Pla2g6 (phospholipase A2, group VI)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pla2g6 (phospholipase A2 group VI)
Pan paniscus (bonobo/pygmy chimpanzee) : PLA2G6 (phospholipase A2 group VI)
Canis lupus familiaris (dog) : PLA2G6 (phospholipase A2 group VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pla2g6 (phospholipase A2 group VI)
Sus scrofa (pig) : PLA2G6 (phospholipase A2 group VI)
Chlorocebus sabaeus (African green monkey) : PLA2G6 (phospholipase A2 group VI)
Heterocephalus glaber (naked mole-rat) : Pla2g6 (phospholipase A2 group VI)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07120,519,479 - 120,559,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,519,467 - 120,559,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,512,621 - 120,553,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,266,784 - 117,307,172 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17117,301,013 - 117,341,212 (-)NCBI
Celera7107,184,586 - 107,224,721 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pla2g6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628867
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.