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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sun2 | Rat | (-)-demecolcine | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Demecolcine results in increased expression of SUN2 mRNA | CTD | PMID:23649840 | Sun2 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Sun2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SUN2 mRNA | CTD | PMID:36331819 | Sun2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Sun2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of SUN2 mRNA] | CTD | PMID:22206623 | Sun2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SUN2 mRNA | CTD | PMID:22206623 | Sun2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SUN2 mRNA | CTD | PMID:21215274 | Sun2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SUN2 mRNA | CTD | PMID:33387578 | Sun2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sun2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SUN2 mRNA | CTD | PMID:21570461 and PMID:24680724 | Sun2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SUN2 mRNA | CTD | PMID:21632981 | Sun2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SUN2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SUN2 mRNA | CTD | PMID:28628672 | Sun2 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of SUN2 mRNA | CTD | PMID:18648102 | Sun2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SUN2 mRNA | CTD | PMID:28628672 | Sun2 | Rat | 5-aza-2'-deoxycytidine | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Decitabine results in decreased expression of SUN2 mRNA | CTD | PMID:19363521 | Sun2 | Rat | 5-aza-2'-deoxycytidine | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | TP53 protein affects the reaction [Decitabine results in decreased expression of SUN2 mRNA] | CTD | PMID:19363521 | Sun2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SUN2 mRNA | CTD | PMID:30047161 | Sun2 | Rat | acetylsalicylic acid | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Aspirin results in increased expression of SUN2 mRNA | CTD | PMID:11906190 | Sun2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of SUN2 mRNA | CTD | PMID:30047161 | Sun2 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of SUN2 mRNA | CTD | PMID:30779732 | Sun2 | Rat | aristolochic acid A | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SUN2 mRNA and aristolochic acid I results in decreased expression of SUN2 protein | CTD | PMID:33212167 | Sun2 | Rat | benzo[a]pyrene | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SUN2 mRNA | CTD | PMID:22228805 | Sun2 | Rat | benzo[a]pyrene | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SUN2 mRNA | CTD | PMID:32234424 | Sun2 | Rat | benzo[b]fluoranthene | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of SUN2 mRNA | CTD | PMID:26377693 | Sun2 | Rat | bisphenol A | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SUN2 mRNA | CTD | PMID:28628672 | Sun2 | Rat | bisphenol A | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SUN2 protein | CTD | PMID:34186270 | Sun2 | Rat | bisphenol A | decreases methylation | ISO | SUN2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SUN2 gene | CTD | PMID:31601247 | Sun2 | Rat | bisphenol A | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SUN2 mRNA | CTD | PMID:29275510 | Sun2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SUN2 mRNA | CTD | PMID:30816183 and PMID:32145629 | Sun2 | Rat | Bisphenol B | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SUN2 protein | CTD | PMID:34186270 | Sun2 | Rat | buspirone | increases expression | EXP | | 6480464 | Buspirone results in increased expression of SUN2 mRNA | CTD | PMID:24136188 | Sun2 | Rat | butanal | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SUN2 mRNA | CTD | PMID:26079696 | Sun2 | Rat | caffeine | increases phosphorylation | ISO | SUN2 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of SUN2 protein | CTD | PMID:35688186 | Sun2 | Rat | carbon nanotube | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Sun2 | Rat | carbon nanotube | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of SUN2 mRNA | CTD | PMID:25620056 | Sun2 | Rat | chlorpyrifos | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of SUN2 mRNA | CTD | PMID:37019170 | Sun2 | Rat | ciglitazone | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of SUN2 mRNA | CTD | PMID:16197558 | Sun2 | Rat | ciguatoxin CTX1B | affects expression | ISO | Sun2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of SUN2 mRNA | CTD | PMID:18353800 | Sun2 | Rat | cisplatin | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SUN2 mRNA | CTD | PMID:27594783 | Sun2 | Rat | clofibrate | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SUN2 mRNA | CTD | PMID:23811191 | Sun2 | Rat | copper atom | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA | CTD | PMID:24690739 | Sun2 | Rat | copper(0) | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA | CTD | PMID:24690739 | Sun2 | Rat | coumarin | increases phosphorylation | ISO | SUN2 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of SUN2 protein | CTD | PMID:35688186 | Sun2 | Rat | dexamethasone | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SUN2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SUN2 mRNA | CTD | PMID:28628672 | Sun2 | Rat | Dibutyl phosphate | affects expression | ISO | SUN2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SUN2 mRNA | CTD | PMID:37042841 | Sun2 | Rat | disulfiram | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA | CTD | PMID:24690739 | Sun2 | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SUN2 mRNA | CTD | PMID:21551480 | Sun2 | Rat | doxorubicin | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SUN2 mRNA | CTD | PMID:29803840 | Sun2 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of SUN2 mRNA | CTD | PMID:29391264 | Sun2 | Rat | fenamidone | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | fenamidone results in increased expression of SUN2 mRNA | CTD | PMID:27029645 | Sun2 | Rat | folic acid | multiple interactions | ISO | Sun2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of SUN2 mRNA] | CTD | PMID:22206623 | Sun2 | Rat | FR900359 | affects phosphorylation | ISO | SUN2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SUN2 protein | CTD | PMID:37730182 | Sun2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SUN2 mRNA | CTD | PMID:22061828 and PMID:33387578 | Sun2 | Rat | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of SUN2 mRNA | CTD | PMID:24136188 | Sun2 | Rat | indometacin | multiple interactions | ISO | SUN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SUN2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SUN2 mRNA | CTD | PMID:28628672 | Sun2 | Rat | inulin | multiple interactions | ISO | Sun2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SUN2 mRNA | CTD | PMID:36331819 | Sun2 | Rat | ivermectin | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SUN2 protein | CTD | PMID:32959892 | Sun2 | Rat | lead diacetate | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | lead acetate results in increased expression of SUN2 mRNA | CTD | PMID:38568856 | Sun2 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of SUN2 mRNA | CTD | PMID:24136188 | Sun2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of SUN2 mRNA | CTD | PMID:30047161 | Sun2 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of SUN2 mRNA | CTD | PMID:24136188 | Sun2 | Rat | paracetamol | affects expression | ISO | Sun2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SUN2 mRNA | CTD | PMID:17562736 | Sun2 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SUN2 mRNA | CTD | PMID:33387578 | Sun2 | Rat | perfluorononanoic acid | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of SUN2 mRNA | CTD | PMID:25812627 and PMID:38568856 | Sun2 | Rat | perfluorooctane-1-sulfonic acid | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SUN2 mRNA | CTD | PMID:25812627 | Sun2 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sun2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SUN2 mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SUN2 mRNA | CTD | PMID:36331819 | Sun2 | Rat | perfluorooctanoic acid | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of SUN2 mRNA | CTD | PMID:25812627 | Sun2 | Rat | pirinixic acid | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SUN2 mRNA | CTD | PMID:18301758 and PMID:23811191 | Sun2 | Rat | potassium dichromate | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of SUN2 protein | CTD | PMID:23718831 | Sun2 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of SUN2 mRNA | CTD | PMID:30047161 | Sun2 | Rat | propiconazole | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of SUN2 mRNA | CTD | PMID:21278054 | Sun2 | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of SUN2 mRNA | CTD | PMID:28374803 | Sun2 | Rat | silicon dioxide | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SUN2 mRNA | CTD | PMID:25895662 | Sun2 | Rat | sodium arsenite | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SUN2 mRNA | CTD | PMID:34032870 and PMID:38568856 | Sun2 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of SUN2 mRNA | CTD | PMID:30047161 | Sun2 | Rat | sulindac | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Sulindac results in decreased expression of SUN2 mRNA | CTD | PMID:11906190 | Sun2 | Rat | temozolomide | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of SUN2 mRNA | CTD | PMID:31758290 | Sun2 | Rat | testosterone | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of SUN2 mRNA | CTD | PMID:33848595 | Sun2 | Rat | thimerosal | increases expression | ISO | Sun2 (Mus musculus) | 6480464 | Thimerosal results in increased expression of SUN2 mRNA | CTD | PMID:24675092 | Sun2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SUN2 mRNA | CTD | PMID:34492290 | Sun2 | Rat | titanium dioxide | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SUN2 mRNA | CTD | PMID:27760801 | Sun2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SUN2 mRNA | CTD | PMID:33387578 | Sun2 | Rat | troglitazone | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of SUN2 mRNA | CTD | PMID:28973697 | Sun2 | Rat | trovafloxacin | decreases expression | ISO | Sun2 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SUN2 mRNA | CTD | PMID:35537566 | Sun2 | Rat | valproic acid | increases methylation | ISO | SUN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SUN2 gene | CTD | PMID:29154799 | Sun2 | Rat | valproic acid | affects expression | ISO | SUN2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SUN2 mRNA | CTD | PMID:25979313 | Sun2 | Rat | valproic acid | decreases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SUN2 mRNA | CTD | PMID:29154799 | Sun2 | Rat | vincristine | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Vincristine results in increased expression of SUN2 mRNA | CTD | PMID:23649840 | Sun2 | Rat | vitamin E | increases expression | ISO | SUN2 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of SUN2 mRNA | CTD | PMID:19244175 | |