Acvrl1 (activin A receptor like type 1) - Rat Genome Database

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Gene: Acvrl1 (activin A receptor like type 1) Rattus norvegicus
Analyze
Symbol: Acvrl1
Name: activin A receptor like type 1
RGD ID: 2029
Description: Predicted to have several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in response to hypoxia. Localizes to cell surface; dendrite; and neuronal cell body. Biomarker of pulmonary hypertension and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (activin A receptor like type 1); PARTICIPATES IN activin signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: activin A receptor type II-like 1; activin A receptor type IL; Activin receptor like kinase 1; activin receptor like kinase 1; Alk1; MGC91691; R-3; R3; serine/threonine-protein kinase receptor R3; SETHKIR; SKR3; TGF-B superfamily receptor type I; TSR-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,239,200 - 132,256,592 (+)NCBI
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07142,769,942 - 142,787,336 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07140,571,236 - 140,588,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,873,596 - 139,884,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,944,251 - 139,961,111 (+)NCBI
Celera7128,712,554 - 128,723,633 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IEA)
angiogenesis  (IBA,ISO)
artery development  (ISO)
blood circulation  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (IBA,ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to transforming growth factor beta stimulus  (ISO)
dorsal aorta morphogenesis  (ISO)
dorsal/ventral pattern formation  (IBA)
endocardial cushion morphogenesis  (ISO)
endocardial cushion to mesenchymal transition  (ISO)
endothelial tube morphogenesis  (ISO)
heart development  (IBA)
in utero embryonic development  (ISO)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of gene expression  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein phosphorylation  (IBA,ISO,TAS)
regulation of blood pressure  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to hypoxia  (IEP)
retina vasculature development in camera-type eye  (ISO)
signal transduction  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,ISO)
venous blood vessel development  (ISO)
wound healing, spreading of epidermal cells  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Assis AM, etal., J Hum Genet. 2007;52(3):237-43. Epub 2007 Jan 12.
2. Bossler AD, etal., Hum Mutat. 2006 Jul;27(7):667-75.
3. de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
4. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Girerd B, etal., Am J Respir Crit Care Med. 2010 Apr 15;181(8):851-61. Epub 2010 Jan 7.
7. GOA data from the GO Consortium
8. Harrison RE, etal., J Med Genet. 2003 Dec;40(12):865-71.
9. Konig HG, etal., J Cell Biol. 2005 Mar 28;168(7):1077-86. Epub 2005 Mar 21.
10. Lesca G, etal., Hum Mutat 2004 Apr;23(4):289-99.
11. Levy GG, etal., Nature. 2001 Oct 4;413(6855):488-94.
12. Lu Q, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L755-67. Epub 2010 Mar 12.
13. Luo JW, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Jun;25(3):308-10.
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline
17. Panchenko MP, etal., Am J Physiol 1996 Apr;270(4 Pt 1):L547-58.
18. Pangas SA and Woodruff TK, Trends Endocrinol Metab. 2000 Oct;11(8):309-14.
19. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
21. RGD automated data pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Srinivasan S, etal., Hum Mol Genet. 2003 Mar 1;12(5):473-82.
25. Takahashi K, etal., Pediatr Res. 2007 Apr;61(4):392-7.
26. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Urness LD, etal., Nat Genet 2000 Nov;26(3):328-31.
28. Zakrzewicz A, etal., Eur Respir J. 2007 Mar 28;.
Additional References at PubMed
PMID:8242742   PMID:8395914   PMID:10716993   PMID:12065756   PMID:12393874   PMID:12453878   PMID:12477932   PMID:12941632   PMID:14580334   PMID:15489334   PMID:15702480   PMID:15851468  
PMID:17068149   PMID:17530030   PMID:17911384   PMID:19366699   PMID:19494318   PMID:19592636   PMID:19903896   PMID:20406889   PMID:22783020   PMID:23868260   PMID:25424912   PMID:26176610  
PMID:26540443   PMID:30262595   PMID:31322216  


Genomics

Comparative Map Data
Acvrl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,239,200 - 132,256,592 (+)NCBI
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07142,769,942 - 142,787,336 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07140,571,236 - 140,588,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,873,596 - 139,884,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,944,251 - 139,961,111 (+)NCBI
Celera7128,712,554 - 128,723,633 (+)NCBICelera
Cytogenetic Map7q36NCBI
ACVRL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1251,906,908 - 51,923,361 (+)EnsemblGRCh38hg38GRCh38
GRCh381251,906,913 - 51,923,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371252,301,288 - 52,317,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,587,469 - 50,603,412 (+)NCBINCBI36hg18NCBI36
Build 341250,587,468 - 50,601,120NCBI
Celera1251,103,338 - 51,119,286 (+)NCBI
Cytogenetic Map12q13.13ENTREZGENE
HuRef1249,334,280 - 49,350,228 (+)NCBIHuRef
CHM1_11252,267,590 - 52,283,516 (+)NCBICHM1_1
Acvrl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,026,403 - 101,043,217 (+)NCBIGRCm39mm39
GRCm39 Ensembl15101,026,403 - 101,043,217 (+)Ensembl
GRCm3815101,128,522 - 101,145,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,128,522 - 101,145,336 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,958,968 - 100,975,767 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615100,956,556 - 100,986,456 (+)NCBImm8
Celera15103,276,934 - 103,293,737 (+)NCBICelera
Cytogenetic Map15F1NCBI
Acvrl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,279,042 - 2,294,443 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,278,548 - 2,293,865 (+)NCBIChiLan1.0ChiLan1.0
ACVRL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11237,615,888 - 37,631,691 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,615,888 - 37,631,691 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01236,839,869 - 36,856,351 (-)NCBIMhudiblu_PPA_v0panPan3
ACVRL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,075,373 - 3,090,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,076,124 - 3,092,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,166,746 - 43,181,176 (+)NCBI
ROS_Cfam_1.0273,072,148 - 3,086,549 (-)NCBI
UMICH_Zoey_3.1273,088,717 - 3,103,128 (-)NCBI
UNSW_CanFamBas_1.0273,075,021 - 3,089,444 (-)NCBI
UU_Cfam_GSD_1.02743,565,141 - 43,579,587 (+)NCBI
Acvrl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,786,735 - 63,800,651 (-)NCBI
SpeTri2.0NW_0049365129,364,551 - 9,379,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVRL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,263,907 - 17,286,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,267,483 - 17,284,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,850,783 - 17,871,395 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACVRL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,063,099 - 48,091,705 (+)NCBI
ChlSab1.1 Ensembl1148,082,135 - 48,093,630 (+)Ensembl
Acvrl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624816402,412 - 426,217 (-)NCBI

Position Markers
RH133448  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07142,787,056 - 142,787,250NCBIRnor6.0
Rnor_5.07140,587,803 - 140,587,997UniSTSRnor5.0
RGSC_v3.47139,884,395 - 139,884,589UniSTSRGSC3.4
Celera7128,723,353 - 128,723,547UniSTS
RH 3.4 Map71063.0UniSTS
Cytogenetic Map7q36UniSTS
BE100434  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07142,769,050 - 142,769,212NCBIRnor6.0
Rnor_5.07140,569,802 - 140,569,964UniSTSRnor5.0
RGSC_v3.47139,866,394 - 139,866,556UniSTSRGSC3.4
Celera7128,705,352 - 128,705,514UniSTS
RH 3.4 Map71065.1UniSTS
Cytogenetic Map7q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7121986439143965591Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7120746024145692398Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7129412003145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7122421276143965415Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7121654760145729302Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:148
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000008673
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 23 1 12 1 3 1 28 30 11 1
Low 1 20 56 41 7 41 7 8 73 7 11 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008673   ⟹   ENSRNOP00000008673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081047   ⟹   ENSRNOP00000072526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7142,776,580 - 142,787,335 (+)Ensembl
RefSeq Acc Id: NM_022441   ⟹   NP_071886
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,245,511 - 132,256,592 (+)NCBI
Rnor_6.07142,776,252 - 142,787,336 (+)NCBI
Rnor_5.07140,571,236 - 140,588,083 (+)NCBI
RGSC_v3.47139,873,596 - 139,884,675 (+)RGD
Celera7128,712,554 - 128,723,633 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242303   ⟹   XP_006242365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,200 - 132,256,592 (+)NCBI
Rnor_6.07142,769,942 - 142,787,336 (+)NCBI
Rnor_5.07140,571,236 - 140,588,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242304   ⟹   XP_006242366
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,775,137 - 142,787,336 (+)NCBI
Rnor_5.07140,571,236 - 140,588,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242305   ⟹   XP_006242367
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,774,329 - 142,787,336 (+)NCBI
Rnor_5.07140,571,236 - 140,588,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765673   ⟹   XP_008763895
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,774,329 - 142,787,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594667   ⟹   XP_017450156
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,770,350 - 142,787,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594668   ⟹   XP_017450157
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,770,350 - 142,787,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078441   ⟹   XP_038934369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078443   ⟹   XP_038934371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078444   ⟹   XP_038934372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078445   ⟹   XP_038934373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078446   ⟹   XP_038934374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078447   ⟹   XP_038934375
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078448   ⟹   XP_038934376
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,239,236 - 132,256,592 (+)NCBI
RefSeq Acc Id: XM_039078449   ⟹   XP_038934377
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,246,733 - 132,256,592 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_071886   ⟸   NM_022441
- Peptide Label: precursor
- UniProtKB: P80203 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242365   ⟸   XM_006242303
- Peptide Label: isoform X1
- UniProtKB: P80203 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242366   ⟸   XM_006242304
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006242367   ⟸   XM_006242305
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763895   ⟸   XM_008765673
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450157   ⟸   XM_017594668
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450156   ⟸   XM_017594667
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000008673   ⟸   ENSRNOT00000008673
RefSeq Acc Id: ENSRNOP00000072526   ⟸   ENSRNOT00000081047
RefSeq Acc Id: XP_038934375   ⟸   XM_039078447
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934369   ⟸   XM_039078441
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934371   ⟸   XM_039078443
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934374   ⟸   XM_039078446
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934373   ⟸   XM_039078445
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934372   ⟸   XM_039078444
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934376   ⟸   XM_039078448
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934377   ⟸   XM_039078449
- Peptide Label: isoform X2
Protein Domains
GS   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2029 AgrOrtholog
Ensembl Genes ENSRNOG00000028713 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008673 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072526 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008673 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081047 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098096 IMAGE-MGC_LOAD
InterPro GS_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:25237 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91691 IMAGE-MGC_LOAD
NCBI Gene 25237 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  TGF_beta_GS UniProtKB/Swiss-Prot
PhenoGen Acvrl1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS51256 UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
  SM00467 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC209468
UniProt ACVL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63559 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvrl1  activin A receptor like type 1  Acvrl1  activin A receptor type IL  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-11 Acvrl1  activin A receptor type IL  Acvrl1  activin A receptor type II-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acvrl1  activin A receptor type II-like 1    Activin receptor like kinase 1  Name updated 629478 APPROVED
2002-06-10 Acvrl1  Activin receptor like kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pulmonary and other blood vessel endothelium 631799
gene_expression expressed in macrophages and lymphoid tissues of spleen 631799
gene_expression expressed in fetal lung blood vessels 631799
gene_product member of the family of type I receptor serine-threonine kinases 631799