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Gene: Acvrl1 (activin A receptor, type II-like 1) Mus musculus
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Symbol: Acvrl1
Name: activin A receptor, type II-like 1
Description: Predicted to have several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in several processes, including regulation of endothelial cell differentiation; regulation of transcription by RNA polymerase II; and vasculature development. Predicted to localize to several cellular components, including the BMP receptor complex; dendrite; and neuronal cell body. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human ACVRL1 (activin A receptor like type 1); PARTICIPATES IN activin signaling pathway; INTERACTS WITH 3,3',5-triiodo-L-thyronine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activin receptor-like kinase 1; activin receptor-like kinase-1; Acvrlk1; AI115505; AI427544; Alk1; serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I
Orthologs:
Homo sapiens (human) : ACVRL1 (activin A receptor like type 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Acvrl1 (activin A receptor like type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acvrl1 (activin A receptor like type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACVRL1 (activin A receptor like type 1)
Canis lupus familiaris (dog) : ACVRL1 (activin A receptor like type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acvrl1 (activin A receptor like type 1)
Sus scrofa (pig) : ACVRL1 (activin A receptor like type 1)
Chlorocebus sabaeus (African green monkey) : ACVRL1 (activin A receptor like type 1)
Heterocephalus glaber (naked mole-rat) : Acvrl1 (activin A receptor like type 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl15101,128,522 - 101,145,336 (+)Ensembl
GRCm3815101,128,522 - 101,145,336 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3715100,958,968 - 100,975,767 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615100,956,556 - 100,986,456 (+)NCBImm8
Celera15103,276,919 - 103,293,737 (+)NCBICelera
Cytogenetic Map15 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Acvrl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10079
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.