Acvrl1 (activin A receptor like type 1) - Rat Genome Database

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Gene: Acvrl1 (activin A receptor like type 1) Ictidomys tridecemlineatus
Analyze
Symbol: Acvrl1
Name: activin A receptor like type 1
RGD ID: 12708623
Description: ENCODES a protein that exhibits activin binding (ortholog); activin receptor activity, type I (ortholog); ATP binding (ortholog); INVOLVED IN angiogenesis (ortholog); artery development (ortholog); blood circulation (ortholog); PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH arteriovenous malformation (ortholog); COVID-19 (ortholog); Epistaxis (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase receptor R3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,786,735 - 63,800,651 (-)NCBI
SpeTri2.0NW_0049365129,364,551 - 9,379,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
artery development  (ISO)
blood circulation  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardial cushion to mesenchymal transition  (ISO)
endothelial tube morphogenesis  (ISO)
in utero embryonic development  (ISO)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of gene expression  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein phosphorylation  (ISO)
regulation of blood pressure  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to hypoxia  (ISO)
retina vasculature development in camera-type eye  (ISO)
signal transduction  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
venous blood vessel development  (ISO)
wound healing, spreading of epidermal cells  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Acvrl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,786,735 - 63,800,651 (-)NCBI
SpeTri2.0NW_0049365129,364,551 - 9,379,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVRL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1251,906,908 - 51,923,361 (+)EnsemblGRCh38hg38GRCh38
GRCh381251,906,913 - 51,923,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371252,301,288 - 52,317,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,587,469 - 50,603,412 (+)NCBINCBI36hg18NCBI36
Build 341250,587,468 - 50,601,120NCBI
Celera1251,103,338 - 51,119,286 (+)NCBI
Cytogenetic Map12q13.13ENTREZGENE
HuRef1249,334,280 - 49,350,228 (+)NCBIHuRef
CHM1_11252,267,590 - 52,283,516 (+)NCBICHM1_1
Acvrl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,026,403 - 101,043,217 (+)NCBIGRCm39mm39
GRCm39 Ensembl15101,026,403 - 101,043,217 (+)Ensembl
GRCm3815101,128,522 - 101,145,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,128,522 - 101,145,336 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,958,968 - 100,975,767 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615100,956,556 - 100,986,456 (+)NCBImm8
Celera15103,276,934 - 103,293,737 (+)NCBICelera
Cytogenetic Map15F1NCBI
Acvrl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,239,200 - 132,256,592 (+)NCBI
Rnor_6.0 Ensembl7142,776,252 - 142,787,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07142,769,942 - 142,787,336 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07140,571,236 - 140,588,083 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,873,596 - 139,884,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,944,251 - 139,961,111 (+)NCBI
Celera7128,712,554 - 128,723,633 (+)NCBICelera
Cytogenetic Map7q36NCBI
Acvrl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,279,042 - 2,294,443 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,278,548 - 2,293,865 (+)NCBIChiLan1.0ChiLan1.0
ACVRL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11237,615,888 - 37,631,691 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,615,888 - 37,631,691 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01236,839,869 - 36,856,351 (-)NCBIMhudiblu_PPA_v0panPan3
ACVRL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,075,373 - 3,090,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,076,124 - 3,092,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,166,746 - 43,181,176 (+)NCBI
ROS_Cfam_1.0273,072,148 - 3,086,549 (-)NCBI
UMICH_Zoey_3.1273,088,717 - 3,103,128 (-)NCBI
UNSW_CanFamBas_1.0273,075,021 - 3,089,444 (-)NCBI
UU_Cfam_GSD_1.02743,565,141 - 43,579,587 (+)NCBI
ACVRL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,263,907 - 17,286,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,267,483 - 17,284,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,850,783 - 17,871,395 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACVRL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,063,099 - 48,091,705 (+)NCBI
ChlSab1.1 Ensembl1148,082,135 - 48,093,630 (+)Ensembl
Vero_WHO_p1.0NW_023666037197,998,886 - 198,027,294 (-)NCBI
Acvrl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624816402,412 - 426,217 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005324974   ⟹   XP_005325031
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494563,786,735 - 63,800,651 (-)NCBI
SpeTri2.0NW_0049365129,364,551 - 9,379,131 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040280618   ⟹   XP_040136552
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494563,786,735 - 63,800,635 (-)NCBI
RefSeq Acc Id: XM_040280619   ⟹   XP_040136553
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494563,786,735 - 63,800,600 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005325031 (Get FASTA)   NCBI Sequence Viewer  
  XP_040136552 (Get FASTA)   NCBI Sequence Viewer  
  XP_040136553 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005325031   ⟸   XM_005324974
- UniProtKB: I3LWQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040136552   ⟸   XM_040280618
RefSeq Acc Id: XP_040136553   ⟸   XM_040280619


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000477 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000000427 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000475 UniProtKB/TrEMBL
InterPro GS_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
NCBI Gene Acvrl1 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS51256 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00467 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3LWQ1 ENTREZGENE, UniProtKB/TrEMBL