C1ql4 (complement C1q like 4) - Rat Genome Database

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Gene: C1ql4 (complement C1q like 4) Rattus norvegicus
Analyze
Symbol: C1ql4
Name: complement C1q like 4
RGD ID: 1565968
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Orthologous to human C1QL4 (complement C1q like 4); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adik; adiponectin k; complement C1q-like protein 4; complement component 1, q subcomponent-like 4; LOC300220; RGD1565968; similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,243,606 - 130,246,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,243,606 - 130,246,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,053,810 - 132,056,883 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,279,384 - 134,282,457 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,191,891 - 134,194,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,766,517 - 140,771,415 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,767,737 - 140,770,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,271,464 - 115,276,272 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,861,471 - 137,864,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7126,728,345 - 126,731,417 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23449976  


Genomics

Comparative Map Data
C1ql4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,243,606 - 130,246,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,243,606 - 130,246,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,053,810 - 132,056,883 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,279,384 - 134,282,457 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,191,891 - 134,194,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,766,517 - 140,771,415 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,767,737 - 140,770,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,271,464 - 115,276,272 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,861,471 - 137,864,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7126,728,345 - 126,731,417 (-)NCBICelera
Cytogenetic Map7q36NCBI
C1QL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,332,409 - 49,337,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,332,409 - 49,337,188 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,726,192 - 49,730,971 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,012,467 - 48,017,238 (-)NCBINCBI36Build 36hg18NCBI36
Celera1248,519,505 - 48,524,276 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,756,631 - 46,761,375 (-)NCBIHuRef
CHM1_11249,691,897 - 49,696,668 (-)NCBICHM1_1
T2T-CHM13v2.01249,294,599 - 49,299,378 (-)NCBIT2T-CHM13v2.0
C1ql4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,981,967 - 98,988,555 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,981,967 - 98,985,698 (-)EnsemblGRCm39 Ensembl
GRCm381599,084,086 - 99,090,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,084,086 - 99,087,817 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,915,185 - 98,918,159 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,912,788 - 98,915,762 (-)NCBIMGSCv36mm8
Celera15101,239,028 - 101,242,002 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1555.84NCBI
C1QL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11244,844,875 - 44,849,663 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,414,635 - 39,419,422 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,301,076 - 40,304,503 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,301,076 - 40,304,503 (+)Ensemblpanpan1.1panPan2
C1QL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,278,347 - 5,281,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,278,360 - 5,281,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,974,923 - 40,978,405 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,329,710 - 5,333,186 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,329,725 - 5,333,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,295,089 - 5,298,570 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,284,610 - 5,288,086 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,368,031 - 41,371,513 (-)NCBIUU_Cfam_GSD_1.0
C1ql4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,071,440 - 66,077,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,087,110 - 7,091,343 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365127,087,116 - 7,091,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1QL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,308,210 - 15,311,915 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,308,307 - 15,311,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,714,740 - 15,718,176 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C1QL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,560,805 - 45,569,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,561,448 - 45,564,888 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,562,838 - 200,567,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C1ql4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,849,484 - 2,853,069 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,848,774 - 2,853,070 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C1ql4
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000003152
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21
Low 22 19 6
Below cutoff 1 9 11 8 7 8 1 1 27 12 20 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081784   ⟹   ENSRNOP00000069930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,243,606 - 130,246,678 (-)Ensembl
Rnor_6.0 Ensembl7140,767,737 - 140,770,647 (-)Ensembl
RefSeq Acc Id: NM_001271242   ⟹   NP_001258171
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27130,243,606 - 130,246,678 (-)NCBI
Rnor_6.07140,767,664 - 140,770,736 (-)NCBI
Rnor_5.0X115,271,464 - 115,276,272 (-)NCBI
Celera7126,728,345 - 126,731,417 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87002 (Get FASTA)   NCBI Sequence Viewer  
  SOR70295 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001258171   ⟸   NM_001271242
- Peptide Label: precursor
- UniProtKB: D3ZMN4 (UniProtKB/TrEMBL),   A6KCE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069930   ⟸   ENSRNOT00000081784
Protein Domains
C1q

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMN4-F1-model_v2 AlphaFold D3ZMN4 1-238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565968 AgrOrtholog
BioCyc Gene G2FUF-32086 BioCyc
Ensembl Genes ENSRNOG00000060020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069930 ENTREZGENE
  ENSRNOP00000069930.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081784 ENTREZGENE
  ENSRNOT00000081784.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro C1q UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:300220 UniProtKB/TrEMBL
NCBI Gene 300220 ENTREZGENE
PANTHER CEREBELLIN-RELATED UniProtKB/TrEMBL
  COMPLEMENT C1Q-LIKE PROTEIN 4 UniProtKB/TrEMBL
Pfam C1q UniProtKB/TrEMBL
PhenoGen C1ql4 PhenoGen
PRINTS COMPLEMNTC1Q UniProtKB/TrEMBL
PROSITE C1Q UniProtKB/TrEMBL
SMART C1Q UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A6KCE0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMN4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 C1ql4  complement C1q like 4  C1ql4  complement component 1, q subcomponent-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 C1ql4  complement component 1, q subcomponent-like 4   C1ql4_predicted  complement component 1, q subcomponent-like 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 C1ql4_predicted  complement component 1, q subcomponent-like 4 (predicted)  RGD1565968_predicted  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-10 RGD1565968_predicted  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1) (predicted)      Name updated 1299863 APPROVED
2006-03-07 RGD1565968_predicted  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1) (predicted)  LOC300220  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300220  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1)      Symbol and Name status set to provisional 70820 PROVISIONAL