Ccn4 (cellular communication network factor 4)

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Gene: Ccn4 (cellular communication network factor 4) Rattus norvegicus

Analyze

Symbol:

Ccn4

Name:

cellular communication network factor 4

RGD ID:

69431

Description:

Predicted to have heparin binding activity and integrin binding activity. Involved in positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Predicted to localize to cytosol; extracellular matrix; and extracellular space. Orthologous to human CCN4 (cellular communication network factor 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

CCN family member 4; ELM-1; MGC93340; WISP-1; Wisp1; WNT1 inducible signaling pathway protein 1; WNT1-inducible-signaling pathway protein 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	98,645,238 - 98,677,253 (+)	NCBI
Rnor_6.0 Ensembl	7	107,695,215 - 107,723,772 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	107,695,227 - 107,723,759 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	107,644,976 - 107,673,508 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	104,263,089 - 104,291,621 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	104,297,318 - 104,325,846 (+)	NCBI
Celera	7	95,196,524 - 95,225,037 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Airway Remodeling (IMP)

Charcot-Marie-Tooth disease type 4 (ISO)

Experimental Liver Cirrhosis (IEP)

Hyperoxia (IEP)

Neoplasm Metastasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

carmustine (ISO)

chloroprene (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cycloheximide (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

fenvalerate (EXP)

folic acid (ISO)

graphite (EXP)

homocysteine (ISO)

indometacin (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (ISO)

nitroprusside (ISO)

ochratoxin A (ISO)

oxaliplatin (EXP)

pentane-2,3-dione (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

silver atom (ISO)

silver(0) (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

troglitazone (ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone development (IEA,ISO)

cell adhesion (IBA)

glucose homeostasis (IEA,ISO)

negative regulation of cell death (IBA)

negative regulation of chondrocyte differentiation (IEA,ISO)

negative regulation of fat cell differentiation (IEA,ISO)

osteoblast differentiation (IEA,ISO)

osteoclast differentiation (IEA,ISO)

positive regulation of cell growth involved in cardiac muscle cell development (IMP)

positive regulation of inflammatory response (IEA,ISO)

positive regulation of osteoblast differentiation (IEA,ISO)

positive regulation of smooth muscle cell migration (IMP)

positive regulation of smooth muscle cell proliferation (IMP)

positive regulation of Wnt signaling pathway (IEA,ISO)

positive regulation of wound healing (IEA,ISO)

regulation of cytokine production (IEA,ISO)

signal transduction (IBA,IEA)

Wnt signaling pathway (IEA)

Cellular Component

cellular_component (ND)

cytoplasm (ISO,ISS)

cytosol (IEA,ISO)

extracellular matrix (IBA)

extracellular region (IEA)

extracellular space (IEA,ISO,ISS)

Molecular Function

heparin binding (IBA)

insulin-like growth factor binding (IEA)

integrin binding (IBA)

molecular_function (ND)

protein binding (ISO)

References

References - curated


1.	Alapati D, etal., Pediatr Res. 2013 Jun;73(6):719-25. doi: 10.1038/pr.2013.42. Epub 2013 Mar 12.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Jian YC, etal., Clin Lab. 2014;60(1):29-35.
5.	Liu H, etal., Mol Cells. 2013 Aug;36(2):112-8. doi: 10.1007/s10059-013-0012-2. Epub 2013 Jun 25.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	RGD automated data pipeline
9.	RGD automated import pipeline for gene-chemical interactions
10.	RGD comprehensive gene curation
11.	Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
12.	Sleeman MA, etal., Genomics 2000 Oct 15;69(2):214-24.
13.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Tanaka S, etal., Oncogene 2001 Sep 6;20(39):5525-32.
15.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	Yang M, etal., Int Immunopharmacol. 2013 Oct;17(2):350-7. doi: 10.1016/j.intimp.2013.06.011. Epub 2013 Jul 8.

Additional References at PubMed

PMID:15331410	PMID:17616748	PMID:20684029	PMID:22272766	PMID:22475393	PMID:24006456	PMID:25281430	PMID:25864198	PMID:26242865	PMID:26627308	PMID:28496206	PMID:29319180
PMID:29330021	PMID:30556898

Genomics

Comparative Map Data

Ccn4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	98,645,238 - 98,677,253 (+)	NCBI
Rnor_6.0 Ensembl	7	107,695,215 - 107,723,772 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	107,695,227 - 107,723,759 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	107,644,976 - 107,673,508 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	104,263,089 - 104,291,621 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	104,297,318 - 104,325,846 (+)	NCBI
Celera	7	95,196,524 - 95,225,037 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

CCN4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	133,191,039 - 133,231,690 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	133,190,907 - 133,231,690 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	134,203,282 - 134,243,933 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	134,272,494 - 134,310,753 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	134,272,493 - 134,309,234	NCBI
Celera	8	130,380,567 - 130,419,496 (+)	NCBI
Cytogenetic Map	8	q24.22	NCBI
HuRef	8	129,522,987 - 129,563,677 (+)	NCBI		HuRef
CHM1_1	8	134,244,050 - 134,284,955 (+)	NCBI		CHM1_1

Ccn4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	66,763,218 - 66,795,054 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	15	66,763,169 - 66,795,050 (+)	Ensembl
GRCm38	15	66,891,369 - 66,923,201 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	66,891,320 - 66,923,201 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	66,722,955 - 66,754,761 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	15	66,721,062 - 66,752,868 (+)	NCBI			mm8
Celera	15	68,424,047 - 68,455,874 (+)	NCBI		Celera
Cytogenetic Map	15	D2	NCBI
cM Map	15	29.3	NCBI

Ccn4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955461	7,748,005 - 7,780,427 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955461	7,748,399 - 7,780,359 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCN4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	132,818,397 - 132,858,861 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	132,818,397 - 132,858,861 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	129,842,580 - 129,884,528 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CCN4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	29,648,720 - 29,683,822 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	29,648,639 - 29,679,732 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	29,622,701 - 29,661,265 (+)	NCBI
ROS_Cfam_1.0	13	30,004,803 - 30,043,373 (+)	NCBI
UMICH_Zoey_3.1	13	29,731,434 - 29,769,975 (+)	NCBI
UNSW_CanFamBas_1.0	13	29,830,792 - 29,869,352 (+)	NCBI
UU_Cfam_GSD_1.0	13	30,180,453 - 30,219,020 (+)	NCBI

Ccn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_ltri_2	NW_024405303	8,682,581 - 8,708,143 (-)	NCBI
SpeTri2.0	NW_004936470	16,110,492 - 16,134,065 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCN4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	8,078,156 - 8,110,829 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	8,078,163 - 8,110,906 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	8,188,614 - 8,216,061 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCN4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	127,620,635 - 127,658,132 (+)	NCBI
ChlSab1.1 Ensembl	8	127,642,598 - 127,661,462 (+)	Ensembl

Ccn4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	22,789,784 - 22,819,527 (-)	NCBI

Position Markers

BE117857

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	107,723,549 - 107,723,698	NCBI	Rnor6.0
Rnor_5.0	7	107,673,298 - 107,673,447	UniSTS	Rnor5.0
RGSC_v3.4	7	104,291,411 - 104,291,560	UniSTS	RGSC3.4
Celera	7	95,224,827 - 95,224,976	UniSTS
RH 3.4 Map	7	681.1	UniSTS
Cytogenetic Map	7	q33	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	48118835	128611831	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	50704769	128085642	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	51251919	118477612	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	51251919	145729302	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	51252005	111589099	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	55072862	123602998	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	55072862	123602998	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	55072862	123602998	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	61047589	113228378	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	68518460	113518460	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	69399586	111043530	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	69399586	111043530	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	70421228	115421228	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	71448715	145729302	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	77428105	127748511	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	77428234	122421148	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	81645773	140745067	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	85595369	130595369	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	85595369	130595369	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	88365265	119318087	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	88365265	121986709	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	88365265	133365265	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	88365265	134673427	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	91018361	136018361	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	91832949	145158140	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	91832949	145158140	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	93726906	138726906	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	93726906	138726906	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	96630946	141630946	Rat
10450828	Scl79	Serum cholesterol level QTL 79	3.5	0.001	blood HDL cholesterol amount (VT:0000184)	blood low density lipoprotein cholesterol level (CMO:0000053)	7	98200188	111043530	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	100028953	145729302	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	100160423	140335001	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	100192194	145192194	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	102588256	116249643	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	103815550	126525386	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	103867802	126080176	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	106564316	145729302	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	71
Count of miRNA genes:	55
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000009673
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		4								10	9
Low	3	23	13	10	2	10	6	9	50	25	24	9	6
Below cutoff		15	31	18	17	18	2	2	20		5	2	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC091481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF228049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ236871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000009673 ⟹ ENSRNOP00000009673

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	107,695,227 - 107,723,764 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093628 ⟹ ENSRNOP00000076326

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	107,695,215 - 107,723,772 (+)	Ensembl

RefSeq Acc Id:

NM_031716 ⟹ NP_113904

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	98,645,542 - 98,674,073 (+)	NCBI
Rnor_6.0	7	107,695,227 - 107,723,759 (+)	NCBI
Rnor_5.0	7	107,644,976 - 107,673,508 (+)	NCBI
RGSC_v3.4	7	104,263,089 - 104,291,621 (+)	RGD
Celera	7	95,196,524 - 95,225,037 (+)	RGD

Sequence:

show sequence

GGCACGAGGCCTGACGTCAGATGTCGCTTTGACAAACGCCCCCGGGGGCTGAGGAAGGCTCTCC
GCTGCTCTGATGGGCCAGCCCAGTCGTGGCCCAGCTCCCTGGAGAGGCACCGGCATCCTCTGGG
CTGAGCTGTAGCTCCTGTGACGCTGACTTCCAGGCATGAGGTGGCTCCTGCCCTGGACGCTGGC
AGCCGTGGCAGTCCTGATGGTGGGCAACATCCTGGCCACGGCCCTCTCTCCAACCCCCACAACC
ATGACCTTCACCCCAGCACCACTGGAGGAAACGATTACACGGCCGGAATTCTGCAAGTGGCCGT
GTGAGTGCCCACAAGCCCCACCTCGCTGCCCACTGGGTGTCAGCCTAATCACAGATGGCTGTGA
ATGCTGTAAGATATGTGCCCAGCAGCTTGGGGACAACTGCACAGAGGCTGCCGTCTGTGACCCA
CACCGGGGCCTCTACTGCGATTACAGTGGGGACCGCCCGAGGTACGCAATAGGAGTGTGTGCAC
AGGTGGTCGGTGTGGGCTGTGTCCTGGATGGCGTGCGCTACACCAATGGAGAGTCCTTCCAACC
CAACTGCAGGTACAACTGCACCTGTATTGATGGCACCGTGGGCTGCACACCACTGTGCCTGAGC
CCCAGGCCCCCACGCCTCTGGTGCCGCCAGCCCCGTCACGTGAGAGTCCCTGGCCAGTGCTGTG
AACAATGGGTATGTGATGATGATGCCAGGAGGCCACGCCAGACTGCACTGCTGGACACCAGAGC
CTTTGCAGCTTCGGGTGCAGTGGAGCAACGGTATGAGAACTGCATAGCCTACACTAGCCCCTGG
AGTCCCTGCTCAACAACCTGTGGCCTAGGTATCTCGACTCGCATCTCTAATGTCAATGCGCGGT
GCTGGCCAGAGCAGGAAAGTCGCCTCTGCAACCTGCGGCCATGTGATGTGGACATCCGACCACA
CATCAAGGCAGGGAAGAAATGCCTGGCTGTGTACCAGCCAGAGGAGGCCACGAACTTCACTCTC
GCAGGCTGTGTCAGCACACGCACCTACCGACCCAAGTACTGTGGAGTCTGTACTGACAATAGGT
GTTGCATCCCCTACAAGTCTAAGACCATCAGTGTTGATTTCCAGTGTCCAGAGGGGCCGGGTTT
CTCTCGGCAGGTCCTATGGATTAATGCTTGCTTCTGCAACCTGAGCTGCAGGAATCCTAATGAT
ATCTTTGCTGACTTGGAATCTTACCCTGACTTTGCAGAGATTGCCAACTAGGTAGGTGTGTGGC
TTGGAGAACAGCTCCATGTTGCAAAGCAGTCAGCCCTCTGTGGCCCAGGACTTCACAATTGAGC
CTTATTTCATCTACTTCCTCCTCAATTCTGCATTCCCTGACCCTGACCCTCAGTTTCTGTTCCT
ATTTTGACCGTTCCAATGGCCCAGGAAAGTGCTGCTCAGGCTCAGACAATGGGTCCCTCCTTTG
GGACATTCTATATCACTCCAAGGAAAACACCTCTCTGAACTGTTCACAATGAAAGCCAAGCCTG
ACCCCAGCCAGTCTGGCTCCAACCTGTGCAAGTTGTCAGAAATCCTAATGGGACAGTCCAAGGA
AAAAACAGCAACTGAAGAACCAGAATCACAGACTCCCTCTTCAGATGCCCAGCCTGAGGATGTT
GAGATCCTTTCAGACACATGGATGGGATTGGGGGAACGGGAATAAGCTATCATCCCTTACCAAA
TGATACTATCCTGGGAATTTCTGCCCACAACATACCAAAAGTGCTCTTATTCCAAAGATCTATG
TATCACAAGTCACCAAACATGTTCTAGGTGAGGAAAATACTTGCACCATTTTGATTTGAAATTG
AAAATCATATTTAAAAGAAGAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039079864 ⟹ XP_038935792

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	98,645,238 - 98,677,253 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113904	(Get FASTA)	NCBI Sequence Viewer
	XP_038935792	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78787	(Get FASTA)	NCBI Sequence Viewer
	AAK00729	(Get FASTA)	NCBI Sequence Viewer
	CAB41995	(Get FASTA)	NCBI Sequence Viewer
	EDM16148	(Get FASTA)	NCBI Sequence Viewer
	EDM16149	(Get FASTA)	NCBI Sequence Viewer
	EDM16150	(Get FASTA)	NCBI Sequence Viewer
	EDM16151	(Get FASTA)	NCBI Sequence Viewer
	Q99PP0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_113904 ⟸ NM_031716

- Peptide Label:

precursor

- Sequence:

show sequence

MRWLLPWTLAAVAVLMVGNILATALSPTPTTMTFTPAPLEETITRPEFCKWPCECPQAPPRCPL
GVSLITDGCECCKICAQQLGDNCTEAAVCDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGV
RYTNGESFQPNCRYNCTCIDGTVGCTPLCLSPRPPRLWCRQPRHVRVPGQCCEQWVCDDDARRP
RQTALLDTRAFAASGAVEQRYENCIAYTSPWSPCSTTCGLGISTRISNVNARCWPEQESRLCNL
RPCDVDIRPHIKAGKKCLAVYQPEEATNFTLAGCVSTRTYRPKYCGVCTDNRCCIPYKSKTISV
DFQCPEGPGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFAEIAN

hide sequence

RefSeq Acc Id:

ENSRNOP00000076326 ⟸ ENSRNOT00000093628

RefSeq Acc Id:

ENSRNOP00000009673 ⟸ ENSRNOT00000009673

RefSeq Acc Id:	XP_038935792 ⟸ XM_039079864
- Peptide Label:	isoform X1

Protein Domains

CTCK IGFBP N-terminal TSP type-1 VWFC

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695365

Promoter ID:

EPDNEW_R5890

Type:

initiation region

Name:

Wisp1_1

Description:

WNT1 inducible signaling pathway protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	107,695,305 - 107,695,365	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69431	AgrOrtholog
Ensembl Genes	ENSRNOG00000007078	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000009673	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000076326	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009673	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000093628	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131232	IMAGE-MGC_LOAD
InterPro	Cys_knot_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hormone_CN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBP-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBP_CNN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin_GF-bd_Cys-rich_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_CCN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWF_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65154	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93340	IMAGE-MGC_LOAD
NCBI Gene	65154	ENTREZGENE
Pfam	Cys_knot	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_CCN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ccn4	PhenoGen
PIRSF	IGFBP_rP_CNN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CTCK_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CTCK_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBP_N_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBP_N_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWFC_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWFC_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00041	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00121	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VWC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57184	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF82895	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC206062
UniProt	A0A1W2Q6N9_RAT	UniProtKB/TrEMBL
	G3V6X0_RAT	UniProtKB/TrEMBL
	Q99PP0	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q9WUW4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-10-23	Ccn4	cellular communication network factor 4	Wisp1	WNT1 inducible signaling pathway protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Wisp1	WNT1 inducible signaling pathway protein 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD