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Gene: Irak4 (interleukin-1 receptor-associated kinase 4) Rattus norvegicus
Symbol: Irak4
Name: interleukin-1 receptor-associated kinase 4
Description: Predicted to have interleukin-1 receptor binding activity and protein serine/threonine kinase activity. Involved in JNK cascade; cytokine-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Localizes to the extracellular space. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC300177
Homo sapiens (human) : IRAK4 (interleukin 1 receptor associated kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Irak4 (interleukin-1 receptor-associated kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak4 (interleukin 1 receptor associated kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK4 (interleukin 1 receptor associated kinase 4)
Canis lupus familiaris (dog) : IRAK4 (interleukin 1 receptor associated kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak4 (interleukin 1 receptor associated kinase 4)
Sus scrofa (pig) : IRAK4 (interleukin 1 receptor associated kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07135,803,723 - 135,831,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,803,698 - 135,832,652 (+)Ensembl
Rnor_5.07135,461,296 - 135,487,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,055,185 - 133,081,614 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17133,131,009 - 133,157,870 (+)NCBI
Celera7122,072,276 - 122,098,055 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Irak4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305303
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.