Bik (BCL2-interacting killer) - Rat Genome Database

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Gene: Bik (BCL2-interacting killer) Rattus norvegicus
Symbol: Bik
Name: BCL2-interacting killer
RGD ID: 621547
Description: Enables BH domain binding activity. Predicted to be involved in several processes, including apoptotic mitochondrial changes; male gonad development; and positive regulation of cellular component organization. Predicted to act upstream of or within spermatogenesis. Predicted to be located in mitochondrial envelope. Predicted to be part of Bcl-2 family protein complex. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: bcl-2-interacting killer; BCL2-interacting killer (apoptosis-inducing); Bcl2-interacting killer-like; Biklk; Blk
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr87116,552,303 - 116,571,317 (+)NCBIGRCr8
mRatBN7.27114,672,277 - 114,691,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,427,023 - 116,446,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,652,801 - 118,671,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,622,267 - 118,641,107 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,390,924 - 124,410,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,379,878 - 124,399,142 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,377,004 - 121,396,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17121,411,233 - 121,430,839 (-)NCBI
Celera7110,985,150 - 111,004,412 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
depsipeptide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
dinophysistoxin 1  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (EXP,ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flavonoids  (EXP)
fonofos  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
menadione  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
ochratoxin A  (EXP)
olanzapine  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP,ISO)
urethane  (EXP,ISO)
valproic acid  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
3. BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. Isaian A, etal., J Clin Immunol. 2010 Jan;30(1):132-7. doi: 10.1007/s10875-009-9340-6. Epub 2009 Nov 7.
4. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
5. Mutant Bik gene transferred by cationic liposome inhibits peritoneal disseminated murine colon cancer. Lan KL, etal., Clin Exp Metastasis. 2007;24(6):461-70. doi: 10.1007/s10585-007-9083-9. Epub 2007 Jul 18.
6. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
7. Enhancement of Bik antitumor effect by Bik mutants. Li YM, etal., Cancer Res. 2003 Nov 15;63(22):7630-3.
8. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Sturm I, etal., Cell Death Differ. 2006 Apr;13(4):619-27. doi: 10.1038/sj.cdd.4401782.
13. Amplification of D22S283 as a favorable prognostic indicator in liver fluke related cholangiocarcinoma. Thanasai J, etal., World J Gastroenterol. 2006 Jul 21;12(27):4338-44.
Additional References at PubMed
PMID:9525867   PMID:16270031   PMID:21041309   PMID:27262843   PMID:34517787  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr87116,552,303 - 116,571,317 (+)NCBIGRCr8
mRatBN7.27114,672,277 - 114,691,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,427,023 - 116,446,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,652,801 - 118,671,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,622,267 - 118,641,107 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,390,924 - 124,410,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,379,878 - 124,399,142 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,377,004 - 121,396,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17121,411,233 - 121,430,839 (-)NCBI
Celera7110,985,150 - 111,004,412 (+)NCBICelera
Cytogenetic Map7q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382243,110,750 - 43,129,712 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,110,750 - 43,129,712 (+)EnsemblGRCh38hg38GRCh38
GRCh372243,506,756 - 43,525,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,836,701 - 41,855,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,831,254 - 41,850,215NCBI
Celera2227,417,143 - 27,436,106 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2226,465,060 - 26,484,115 (+)NCBIHuRef
CHM1_12243,466,350 - 43,485,313 (+)NCBICHM1_1
T2T-CHM13v2.02243,591,916 - 43,610,878 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391583,410,992 - 83,428,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,411,063 - 83,428,835 (+)EnsemblGRCm39 Ensembl
GRCm381583,526,790 - 83,544,635 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,526,862 - 83,544,634 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,357,292 - 83,375,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361584,321,217 - 84,338,990 (+)NCBIMGSCv36mm8
MGSCv361583,354,628 - 83,372,401 (+)NCBIMGSCv36mm8
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495541328,277,727 - 28,294,032 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22352,933,764 - 52,952,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,626,663 - 55,646,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,994,256 - 24,014,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12242,194,353 - 42,213,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,207,149 - 42,213,022 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11022,417,374 - 22,433,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,354,097 - 22,370,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,161,992 - 23,178,391 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11022,881,118 - 22,897,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,200,499 - 23,217,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,376,192 - 23,391,652 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049456,050,452 - 6,065,650 (-)NCBIHiC_Itri_2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11925,632,837 - 25,658,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,652,945 - 25,658,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604599,781,400 - 99,808,922 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247525,839,422 - 5,856,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bik
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:43
Interacting mature miRNAs:46
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 18 6 6 8
Low 3 22 27 17 13 17 3 4 55 35 33 11 3
Below cutoff 3 22 22 22 5 7 17 5


RefSeq Acc Id: ENSRNOT00000013977   ⟹   ENSRNOP00000013977
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)Ensembl
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113031   ⟹   ENSRNOP00000085980
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7114,672,671 - 114,691,296 (+)Ensembl
RefSeq Acc Id: NM_053704   ⟹   NP_446156
Rat AssemblyChrPosition (strand)Source
GRCr87116,552,303 - 116,571,317 (+)NCBI
mRatBN7.27114,672,277 - 114,691,296 (+)NCBI
Rnor_6.07124,391,432 - 124,410,447 (+)NCBI
Rnor_5.07124,379,878 - 124,399,142 (+)NCBI
RGSC_v3.47121,377,004 - 121,396,609 (-)RGD
Celera7110,985,150 - 111,004,412 (+)RGD
Protein Sequences
Protein RefSeqs NP_446156 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK53820 (Get FASTA)   NCBI Sequence Viewer  
  EDM15624 (Get FASTA)   NCBI Sequence Viewer  
  EDM15625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013977
RefSeq Acc Id: NP_446156   ⟸   NM_053704
- UniProtKB: Q925D2 (UniProtKB/TrEMBL),   A6HT97 (UniProtKB/TrEMBL),   A0A8I6GEH5 (UniProtKB/TrEMBL),   A6HT98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013977   ⟸   ENSRNOT00000013977
RefSeq Acc Id: ENSRNOP00000085980   ⟸   ENSRNOT00000113031

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925D2-F1-model_v2 AlphaFold Q925D2 1-158 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621547 AgrOrtholog
BioCyc Gene G2FUF-32600 BioCyc
Ensembl Genes ENSRNOG00000010359 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013977 ENTREZGENE
  ENSRNOT00000013977.3 UniProtKB/TrEMBL
  ENSRNOT00000113031.1 UniProtKB/TrEMBL
InterPro Bcl2-int_killer UniProtKB/TrEMBL
KEGG Report rno:114496 UniProtKB/TrEMBL
  PTHR15018 UniProtKB/TrEMBL
Pfam bcl-2I13 UniProtKB/TrEMBL
PhenoGen Bik PhenoGen
RatGTEx ENSRNOG00000010359 RatGTEx
UniProt Secondary Q925D2 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Bik  BCL2-interacting killer  Bik  BCL2-interacting killer (apoptosis-inducing)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bik  BCL2-interacting killer (apoptosis-inducing)  Bik  Bcl2-interacting killer  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Bik  Bcl2-interacting killer  Biklk  Bcl2-interacting killer-like  Symbol and Name updated 1299863 APPROVED
2005-01-20 Biklk  Bcl2-interacting killer-like      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Biklk  Bcl2-interacting killer-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a BH3 domain 631874