(Z)-3-butylidenephthalide increases expression ISO RGD:1347683 6480464 butylidenephthalide results in increased expression of BIK protein CTD PMID:23770345 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o, p'-DDT results in increased expression of BIK mRNA CTD PMID:22937105 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression EXP 6480464 o, p'-DDT analog results in decreased expression of BIK mRNA CTD PMID:22937105 17beta-estradiol multiple interactions ISO RGD:1347683 6480464 [Estradiol co-treated with EGF protein] results in decreased expression of BIK mRNA more ... CTD PMID:19619570 more ... 17beta-estradiol affects expression ISO RGD:1347683 6480464 Estradiol affects the expression of BIK mRNA CTD PMID:21826169 17beta-estradiol decreases expression ISO RGD:1347683 6480464 Estradiol results in decreased expression of BIK mRNA CTD PMID:19619570 more ... 17beta-estradiol increases expression ISO RGD:1347683 6480464 Estradiol results in increased expression of BIK mRNA, Estradiol results in increased expression of BIK protein CTD PMID:17638070 , PMID:24481588 1H-pyrazole multiple interactions EXP 6480464 [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA CTD PMID:16610055 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:732887 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1347683 6480464 Tetrachlorodibenzodioxin results in decreased expression of BIK mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1347683 6480464 Tetrachlorodibenzodioxin results in increased expression of BIK mRNA CTD PMID:20106945 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of BIK mRNA CTD PMID:19520675 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1347683 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BIK mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732887 6480464 Tetrachlorodibenzodioxin affects the expression of BIK mRNA CTD PMID:14718646 2-hydroxypropanoic acid increases expression ISO RGD:1347683 6480464 Lactic Acid results in increased expression of BIK mRNA CTD PMID:30851411 3-chloropropane-1,2-diol increases expression ISO RGD:1347683 6480464 alpha-Chlorohydrin results in increased expression of BIK mRNA CTD PMID:28070108 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases expression ISO RGD:1347683 6480464 2-amino-3-methylimidazo(4, 5-f)quinoline results in increased expression of BIK mRNA CTD PMID:26198647 4,4'-diaminodiphenylmethane decreases expression ISO RGD:732887 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of BIK mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:732887 6480464 Fenretinide results in increased expression of BIK mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO RGD:1347683 6480464 Decitabine results in increased expression of BIK protein CTD PMID:17064661 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1347683 6480464 [Decitabine co-treated with Depsipeptides] results in increased expression of BIK mRNA more ... CTD PMID:17064661 , PMID:21095227 5-azacytidine multiple interactions EXP 6480464 [Azacitidine co-treated with entinostat] results in increased expression of BIK mRNA CTD PMID:21224363 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of BIK mRNA CTD PMID:21224363 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of BIK mRNA CTD PMID:24780913 afimoxifene increases expression ISO RGD:1347683 6480464 afimoxifene results in increased expression of BIK mRNA CTD PMID:23373633 aflatoxin B1 affects expression ISO RGD:1347683 6480464 Aflatoxin B1 affects the expression of BIK protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:1347683 6480464 Aflatoxin B1 results in increased expression of BIK mRNA CTD PMID:21641981 , PMID:26198647 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of BIK mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of BIK mRNA CTD PMID:30779732 arsane affects expression ISO RGD:1347683 6480464 Arsenic affects the expression of BIK protein CTD PMID:24675094 arsenic atom affects expression ISO RGD:1347683 6480464 Arsenic affects the expression of BIK protein CTD PMID:24675094 arsenous acid multiple interactions ISO RGD:1347683 6480464 [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of BIK mRNA CTD PMID:24345465 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of BIK mRNA CTD PMID:19730151 arsenous acid increases expression ISO RGD:1347683 6480464 Arsenic Trioxide results in increased expression of BIK mRNA CTD PMID:24345465 benzidine increases expression ISO RGD:1347683 6480464 benzidine results in increased expression of BIK mRNA CTD PMID:26198647 benzo[a]pyrene increases expression ISO RGD:732887 6480464 Benzo(a)pyrene results in increased expression of BIK mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1347683 6480464 Benzo(a)pyrene affects the methylation of BIK 3' UTR, Benzo(a)pyrene affects the methylation of BIK 5' UTR CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:1347683 6480464 Benzo(a)pyrene results in increased methylation of BIK promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1347683 6480464 Benzo(a)pyrene results in increased expression of BIK mRNA CTD PMID:20106945 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1347683 6480464 7 more ... CTD PMID:19150397 bisphenol A affects expression ISO RGD:1347683 6480464 bisphenol A affects the expression of BIK mRNA CTD PMID:21826169 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of BIK mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1347683 6480464 bisphenol A results in decreased expression of BIK mRNA CTD PMID:24062438 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of BIK mRNA CTD PMID:24066056 bortezomib increases response to substance ISO RGD:1347683 6480464 BIK results in increased susceptibility to Bortezomib CTD PMID:18566236 bortezomib increases expression ISO RGD:1347683 6480464 Bortezomib results in increased expression of BIK protein CTD PMID:18566236 bortezomib increases activity ISO RGD:1347683 6480464 Bortezomib results in increased activity of BIK protein CTD PMID:16446371 butan-1-ol multiple interactions ISO RGD:1347683 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of BIK mRNA CTD PMID:29432896 butanal increases expression ISO RGD:1347683 6480464 butyraldehyde results in increased expression of BIK mRNA CTD PMID:26079696 carbamazepine affects expression ISO RGD:1347683 6480464 Carbamazepine affects the expression of BIK mRNA CTD PMID:25979313 chlorambucil increases expression ISO RGD:1347683 6480464 Chlorambucil results in increased expression of BIK mRNA CTD PMID:26198647 chlorpyrifos decreases expression ISO RGD:1347683 6480464 Chlorpyrifos results in decreased expression of BIK mRNA CTD PMID:26299976 chlorpyrifos decreases response to substance ISO RGD:1347683 6480464 BIK gene mutant form results in decreased susceptibility to Chlorpyrifos CTD PMID:26299976 cholesterol increases expression EXP 6480464 Cholesterol analog results in increased expression of BIK mRNA CTD PMID:19477266 cisplatin increases expression ISO RGD:1347683 6480464 Cisplatin results in increased expression of BIK mRNA CTD PMID:20878077 , PMID:27392435 cisplatin multiple interactions ISO RGD:1347683 6480464 Cisplatin affects the localization of and affects the expression of BIK protein, Y 27632 inhibits the reaction [Cisplatin results in increased expression of BIK mRNA] CTD PMID:20878077 , PMID:26059411 clozapine multiple interactions ISO RGD:1347683 6480464 CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] CTD PMID:16160616 clozapine increases expression ISO RGD:1347683 6480464 Clozapine results in increased expression of BIK mRNA CTD PMID:16160616 cocaine affects expression ISO RGD:732887 6480464 Cocaine affects the expression of BIK mRNA CTD PMID:15681117 copper(II) sulfate increases expression ISO RGD:1347683 6480464 Copper Sulfate results in increased expression of BIK mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1347683 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of BIK mRNA CTD PMID:19167446 cyclophosphamide decreases expression ISO RGD:1347683 6480464 Cyclophosphamide results in decreased expression of BIK mRNA CTD PMID:17403535 cyclosporin A increases expression ISO RGD:1347683 6480464 Cyclosporine results in increased expression of BIK mRNA CTD PMID:25562108 DDE affects expression EXP 6480464 Dichlorodiphenyl Dichloroethylene affects the expression of BIK mRNA CTD PMID:24576310 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of BIK mRNA CTD PMID:23914054 depsipeptide multiple interactions ISO RGD:1347683 6480464 [decitabine co-treated with Depsipeptides] results in increased expression of BIK mRNA, Depsipeptides promotes the reaction [decitabine results in increased expression of BIK protein] CTD PMID:17064661 depsipeptide increases expression ISO RGD:1347683 6480464 Depsipeptides results in increased expression of BIK mRNA, Depsipeptides results in increased expression of BIK protein CTD PMID:17064661 diarsenic trioxide multiple interactions ISO RGD:1347683 6480464 [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of BIK mRNA CTD PMID:24345465 diarsenic trioxide increases expression ISO RGD:1347683 6480464 Arsenic Trioxide results in increased expression of BIK mRNA CTD PMID:24345465 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of BIK mRNA CTD PMID:19730151 diazinon affects expression EXP 6480464 Diazinon affects the expression of BIK mRNA CTD PMID:22546817 dibutyl phthalate increases expression ISO RGD:732887 6480464 Dibutyl Phthalate results in increased expression of BIK mRNA CTD PMID:17361019 , PMID:21266533 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of BIK mRNA CTD PMID:22546817 dinophysistoxin 1 increases expression ISO RGD:1347683 6480464 dinophysistoxin 1 results in increased expression of BIK mRNA CTD PMID:28939011 disodium selenite decreases expression ISO RGD:1347683 6480464 Sodium Selenite results in decreased expression of BIK mRNA CTD PMID:18175754 diuron increases expression EXP 6480464 Diuron results in increased expression of BIK mRNA CTD PMID:25152437 dorsomorphin multiple interactions ISO RGD:1347683 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BIK mRNA CTD PMID:27188386 doxorubicin increases response to substance ISO RGD:1347683 6480464 BIK protein results in increased susceptibility to Doxorubicin CTD PMID:16007125 doxorubicin increases expression ISO RGD:1347683 6480464 Doxorubicin results in increased expression of BIK mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:1347683 6480464 Doxorubicin results in decreased expression of BIK mRNA CTD PMID:16705698 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of BIK mRNA CTD PMID:29391264 entinostat multiple interactions EXP 6480464 [Azacitidine co-treated with entinostat] results in increased expression of BIK mRNA CTD PMID:21224363 entinostat increases expression ISO RGD:1347683 6480464 entinostat results in increased expression of BIK mRNA CTD PMID:27188386 ethanol multiple interactions EXP 6480464 [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA CTD PMID:16610055 ethanol multiple interactions ISO RGD:1347683 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of BIK mRNA CTD PMID:29432896 etoposide increases response to substance ISO RGD:1347683 6480464 BIK protein results in increased susceptibility to Etoposide CTD PMID:16007125 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of BIK mRNA CTD PMID:18035473 fonofos increases methylation ISO RGD:1347683 6480464 Fonofos results in increased methylation of BIK promoter CTD PMID:22847954 furan increases expression EXP 6480464 furan results in increased expression of BIK mRNA CTD PMID:20562052 more ... furan decreases expression ISO RGD:732887 6480464 furan results in decreased expression of BIK mRNA CTD PMID:24183702 furosemide affects expression EXP 6480464 Furosemide affects the expression of BIK mRNA CTD PMID:17497460 hydrogen peroxide affects expression ISO RGD:1347683 6480464 Hydrogen Peroxide affects the expression of BIK mRNA CTD PMID:23410634 hydrogen peroxide increases expression ISO RGD:1347683 6480464 Hydrogen Peroxide results in increased expression of BIK protein CTD PMID:31313457 hydrogen peroxide multiple interactions ISO RGD:1347683 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BIK protein] more ... CTD PMID:26059411 , PMID:31313457 hydrogen peroxide affects localization ISO RGD:1347683 6480464 Hydrogen Peroxide affects the localization of BIK protein CTD PMID:26059411 hydroxyurea increases expression ISO RGD:732887 6480464 Hydroxyurea results in increased expression of BIK mRNA CTD PMID:27208086 iron(III) nitrilotriacetate increases expression EXP 6480464 ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 isobutanol multiple interactions ISO RGD:1347683 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of BIK mRNA CTD PMID:29432896 leflunomide increases expression ISO RGD:1347683 6480464 leflunomide results in increased expression of BIK mRNA CTD PMID:28988120 , PMID:29427785 maneb increases expression ISO RGD:1347683 6480464 Maneb results in increased expression of BIK mRNA, Maneb results in increased expression of BIK protein CTD PMID:18266926 maneb multiple interactions ISO RGD:1347683 6480464 [Paraquat co-treated with Maneb] results in increased expression of BIK protein CTD PMID:18266926 menadione increases expression ISO RGD:1347683 6480464 Vitamin K 3 results in increased expression of BIK mRNA CTD PMID:23410634 methotrexate multiple interactions ISO RGD:1347683 6480464 [Methotrexate co-treated with CDKN1A protein] results in decreased expression of BIK mRNA CTD PMID:18483502 methotrexate increases expression ISO RGD:1347683 6480464 Methotrexate results in increased expression of BIK mRNA CTD PMID:18483502 N-acetyl-L-cysteine multiple interactions ISO RGD:1347683 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BIK protein] CTD PMID:31313457 N-methyl-4-phenylpyridinium increases expression ISO RGD:1347683 6480464 1-Methyl-4-phenylpyridinium results in increased expression of BIK mRNA, 1-Methyl-4-phenylpyridinium results in increased expression of BIK protein CTD PMID:18266926 N-nitrosodiethylamine multiple interactions ISO RGD:732887 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BIK mRNA CTD PMID:24535843 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of BIK mRNA CTD PMID:22546817 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of BIK mRNA CTD PMID:23208426 , PMID:23358140 olanzapine increases expression ISO RGD:1347683 6480464 olanzapine results in increased expression of BIK mRNA CTD PMID:16160616 p-chloromercuribenzoic acid increases expression ISO RGD:1347683 6480464 p-Chloromercuribenzoic Acid results in increased expression of BIK mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1347683 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BIK mRNA CTD PMID:27188386 p-menthan-3-ol increases expression ISO RGD:1347683 6480464 Menthol results in increased expression of BIK mRNA CTD PMID:26760959 pamidronate increases response to substance ISO RGD:1347683 6480464 BIK protein results in increased susceptibility to pamidronate CTD PMID:16007125 paracetamol increases expression ISO RGD:1347683 6480464 Acetaminophen results in increased expression of BIK mRNA CTD PMID:25704631 , PMID:29067470 paraquat increases expression ISO RGD:1347683 6480464 Paraquat results in increased expression of BIK mRNA CTD PMID:18836921 paraquat multiple interactions ISO RGD:1347683 6480464 [Paraquat co-treated with Maneb] results in increased expression of BIK protein CTD PMID:18266926 parathion increases methylation ISO RGD:1347683 6480464 Parathion results in increased methylation of BIK promoter CTD PMID:22847954 pentanal increases expression ISO RGD:1347683 6480464 pentanal results in increased expression of BIK mRNA CTD PMID:26079696 phenobarbital multiple interactions ISO RGD:732887 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BIK mRNA CTD PMID:24535843 phenobarbital increases expression ISO RGD:732887 6480464 Phenobarbital results in increased expression of BIK mRNA CTD PMID:19482888 , PMID:23091169 phorbol 13-acetate 12-myristate increases expression ISO RGD:1347683 6480464 Tetradecanoylphorbol Acetate results in increased expression of BIK mRNA CTD PMID:26198647 pirinixic acid increases expression ISO RGD:732887 6480464 pirinixic acid results in increased expression of BIK mRNA CTD PMID:23811191 propanal increases expression ISO RGD:1347683 6480464 propionaldehyde results in increased expression of BIK mRNA CTD PMID:26079696 propiconazole decreases expression ISO RGD:732887 6480464 propiconazole results in decreased expression of BIK mRNA CTD PMID:21278054 propylparaben increases expression ISO RGD:1347683 6480464 propylparaben results in increased expression of BIK mRNA CTD PMID:24481588 quercetin increases expression ISO RGD:1347683 6480464 Quercetin results in increased expression of BIK mRNA CTD PMID:21632981 rac-lactic acid increases expression ISO RGD:1347683 6480464 Lactic Acid results in increased expression of BIK mRNA CTD PMID:30851411 resveratrol multiple interactions ISO RGD:1347683 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of BIK mRNA CTD PMID:19167446 sanguinarine multiple interactions ISO RGD:1347683 6480464 [sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA CTD PMID:24345465 SB 431542 multiple interactions ISO RGD:1347683 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BIK mRNA CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1347683 6480464 Silicon Dioxide analog results in increased expression of BIK mRNA CTD PMID:23806026 , PMID:25895662 sunitinib decreases expression ISO RGD:1347683 6480464 Sunitinib results in decreased expression of BIK mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO RGD:1347683 6480464 ESR2 protein promotes the reaction [Tamoxifen results in increased expression of BIK protein] CTD PMID:17638070 terbufos increases methylation ISO RGD:1347683 6480464 terbufos results in increased methylation of BIK promoter CTD PMID:22847954 tert-butyl hydroperoxide increases expression ISO RGD:1347683 6480464 tert-Butylhydroperoxide results in increased expression of BIK mRNA CTD PMID:23410634 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of BIK mRNA CTD PMID:21515302 tetrachloromethane multiple interactions EXP 6480464 [Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA CTD PMID:16610055 titanium dioxide decreases expression ISO RGD:732887 6480464 titanium dioxide results in decreased expression of BIK mRNA CTD PMID:23409001 Tributyltin oxide decreases expression ISO RGD:1347683 6480464 bis(tri-n-butyltin)oxide results in decreased expression of BIK mRNA CTD PMID:26198647 trichostatin A increases expression ISO RGD:1347683 6480464 trichostatin A results in increased expression of BIK mRNA CTD PMID:24935251 trimellitic anhydride decreases expression ISO RGD:732887 6480464 trimellitic anhydride results in decreased expression of BIK mRNA CTD PMID:19042947 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of BIK mRNA CTD PMID:21515302 troglitazone decreases expression ISO RGD:732887 6480464 troglitazone results in decreased expression of BIK mRNA CTD PMID:28973697 urethane increases expression EXP 6480464 Urethane results in increased expression of BIK mRNA CTD PMID:16978161 urethane increases expression ISO RGD:1347683 6480464 Urethane results in increased expression of BIK mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1347683 6480464 Valproic Acid affects the expression of BIK mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1347683 6480464 Valproic Acid results in increased expression of BIK mRNA CTD PMID:23179753 more ... Y-27632 decreases expression ISO RGD:1347683 6480464 Y 27632 results in decreased expression of BIK mRNA CTD PMID:20878077 Y-27632 multiple interactions ISO RGD:1347683 6480464 Y 27632 inhibits the reaction [Cisplatin results in increased expression of BIK mRNA] CTD PMID:20878077 zinc atom increases expression ISO RGD:1347683 6480464 Zinc deficiency results in increased expression of BIK mRNA CTD PMID:22171008 zinc(0) increases expression ISO RGD:1347683 6480464 Zinc deficiency results in increased expression of BIK mRNA CTD PMID:22171008
Gene-Chemical Interaction Annotations
