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Gene: BIK (BCL2 interacting killer) Homo sapiens
Symbol: BIK
Name: BCL2 interacting killer
Description: Involved in positive regulation of protein-containing complex assembly and positive regulation of release of cytochrome c from mitochondria. Predicted to localize to mitochondrial envelope. Implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Biomarker of renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis inducer NBK; apoptosis-inducing NBK; bcl-2-interacting killer; BCL2-interacting killer; BCL2-interacting killer (apoptosis-inducing); BIP1; BP4; natural born killer; NBK
Mus musculus (house mouse) : Bik (BCL2-interacting killer)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bik (BCL2-interacting killer)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bik (BCL2 interacting killer)
Pan paniscus (bonobo/pygmy chimpanzee) : BIK (BCL2 interacting killer)
Canis lupus familiaris (dog) : BIK (BCL2 interacting killer)
Chlorocebus sabaeus (African green monkey) : BIK (BCL2 interacting killer)
Heterocephalus glaber (naked mole-rat) : Bik (BCL2 interacting killer)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2243,110,750 - 43,129,712 (+)EnsemblGRCh38hg38GRCh38
GRCh382243,110,750 - 43,129,712 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,506,754 - 43,525,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,836,701 - 41,855,662 (+)NCBINCBI36hg18NCBI36
Build 342241,831,254 - 41,850,215NCBI
Celera2227,417,143 - 27,436,106 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2226,465,060 - 26,484,115 (+)NCBIHuRef
CHM1_12243,466,350 - 43,485,313 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BIK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347683
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.