Bcl2l1 (Bcl2-like 1) - Rat Genome Database
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Gene: Bcl2l1 (Bcl2-like 1) Rattus norvegicus
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Symbol: Bcl2l1
Name: Bcl2-like 1
RGD ID: 2200
Description: Exhibits several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and positive regulation of transport. Localizes to cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; mental depression; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1); PARTICIPATES IN intrinsic apoptotic pathway; erythropoietin signaling pathway; interleukin-3 signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-carnitine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; bcl-2-like protein 1; bcl-X; Bcl-xl; bcl2-L-1; Bcl2l; Bclx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Bcl2l1-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,253,508 - 141,304,582 (-)NCBI
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Celera3140,002,906 - 140,053,959 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IMP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
brain ischemia  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal adenocarcinoma  (ISO)
cryptorchidism  (ISO)
dilated cardiomyopathy  (IEP)
endometrial cancer  (ISO)
endometriosis  (IDA)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Pancreatitis, Acute  (IEP)
gastric ulcer  (IDA)
Head and Neck Neoplasms  (ISO)
Hearing Loss  (ISO)
hematopoietic system disease  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (ISO)
Hypoxia-Ischemia, Brain  (IDA)
impotence  (IDA,ISO)
leiomyoma  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (IEP)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
Mammary Neoplasms, Experimental  (IDA)
melanoma  (ISO)
mental depression  (IEP)
multiple myeloma  (ISO)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
nephroblastoma  (ISO)
ocular hypertension  (IEP)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell neoplasm  (ISO)
polycythemia vera  (ISO)
prostate carcinoma  (ISO)
pulmonary hypertension  (IDA)
renal cell carcinoma  (ISO)
Retina Reperfusion Injury  (IEP)
status epilepticus  (IEP)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uterus interstitial leiomyoma  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-Salsolinol  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,3-dinitrobenzene  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1-bromopropane  (EXP,ISO)
1-nitropyrene  (ISO)
10-Hydroxycamptothecin  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-Methylenedioxyamphetamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-oxocampestanol  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
[6]-Shogaol  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allicin  (ISO)
alloxan  (EXP)
alpha-Zearalanol  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP,ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
Anacardic acid  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
ANTIMYCIN  (ISO)
antirheumatic drug  (ISO)
AP20187  (ISO)
apigenin  (EXP)
apocynin  (ISO)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arjunolic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
Atranorin  (ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
azilsartan  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
benzothiazoles  (ISO)
Berbamine  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brassinin  (ISO)
brassinolide  (ISO)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cafestol  (ISO)
caffeine  (ISO)
Calcimycin  (EXP)
calciol  (ISO)
calcitriol  (EXP,ISO)
calyculin a  (ISO)
camalexin  (ISO)
camptothecin  (EXP,ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carmustine  (EXP,ISO)
carvedilol  (EXP)
casticin  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
cetrorelix  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysin  (EXP)
chrysin 5,7-dimethyl ether  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
Clivoline  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (EXP)
dactolisib  (ISO)
daidzein  (ISO)
Deguelin  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (ISO)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextromethorphan  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
diazoxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
erdosteine  (ISO)
Erionite  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
finasteride  (EXP)
fisetin  (ISO)
flavonoids  (EXP,ISO)
flubendazole  (ISO)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP)
furan  (EXP)
Fusarenone X  (ISO)
galangin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
glucose  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
GW 6471  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
homoeriodictyol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxyurea  (EXP)
ibrutinib  (ISO)
ibuprofen  (ISO)
idelalisib  (ISO)
Ilimaquinone  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
kurarinol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leptomycin B  (ISO)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP)
lutein  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
metoprolol  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morin  (ISO)
morphine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (EXP,ISO)
nitrobenzenes  (EXP)
nitrofen  (ISO)
nitroprusside  (EXP)
Nodularin  (EXP)
NSC 23766  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
oltipraz  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
paricalcitol  (ISO)
parthenolide  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
pepstatin A  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
pevonedistat  (ISO)
PHA-665752  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
PK-11195  (ISO)
platycodin D  (ISO)
potassium dichromate  (EXP)
Pranoprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (EXP)
promethazine  (ISO)
propiconazole  (ISO)
propofol  (EXP)
propylparaben  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
purine-6-thiol  (ISO)
puromycin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
ritonavir  (ISO)
Ro 31-8220  (EXP)
romidepsin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
rutin  (EXP)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
sarin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
scutellarin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
simazine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sorafenib  (ISO)
spironolactone  (EXP)
stattic  (ISO)
staurosporine  (EXP,ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
Tautomycin  (ISO)
temozolomide  (ISO)
TEMPO  (EXP,ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
Thiotepa  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (ISO)
tin(II) chloride (anhydrous)  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
trimethyltin  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
veliparib  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
apoptotic process  (IEA,IEP)
apoptotic process in bone marrow cell  (ISO)
cell population proliferation  (ISO)
cellular response to alkaloid  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to astaxanthin  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to drug  (IEP)
cellular response to erythropoietin  (IEP)
cellular response to gamma radiation  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to prolactin  (IEP)
cellular response to thapsigargin  (IEP)
cellular response to tumor necrosis factor  (IEP)
cerebral cortex development  (IEP)
defense response to virus  (ISO)
endocytosis  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
fertilization  (ISO)
germ cell development  (ISO)
hepatocyte apoptotic process  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,ISO)
male gonad development  (ISO)
mitochondrion morphogenesis  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IDA,IMP,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of execution phase of apoptosis  (ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle development  (IMP,ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of synaptic vesicle clustering  (IMP)
positive regulation of synaptic vesicle endocytosis  (IMP)
positive regulation of synaptic vesicle exocytosis  (IMP)
regulation of apoptotic process  (IDA,IEA)
regulation of cytokinesis  (ISO,ISS)
regulation of growth  (ISO)
regulation of long-term synaptic depression  (IMP)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to cycloheximide  (ISO)
response to cytokine  (ISO)
response to drug  (IEP)
response to electrical stimulus  (IEP)
response to erythropoietin  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to ischemia  (IDA)
response to lead ion  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to oxidative stress  (IEP)
response to peptide hormone  (IEP)
response to radiation  (ISO)
response to virus  (ISO)
spermatogenesis  (ISO)
suppression by virus of host apoptotic process  (ISO)
synaptic vesicle recycling via endosome  (IMP)

References

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Additional References at PubMed
PMID:7607090   PMID:7650367   PMID:7650488   PMID:7753802   PMID:7828536   PMID:7834748   PMID:8625820   PMID:8798158   PMID:8798452   PMID:8918887   PMID:9096145   PMID:9176392  
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Genomics

Candidate Gene Status
Bcl2l1 is a candidate Gene for QTL Eau4
Comparative Map Data
Bcl2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,253,508 - 141,304,582 (-)NCBI
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Celera3140,002,906 - 140,053,959 (-)NCBICelera
Cytogenetic Map3q41NCBI
BCL2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2031,664,452 - 31,723,989 (-)EnsemblGRCh38hg38GRCh38
GRCh382031,664,452 - 31,723,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,252,255 - 30,311,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,715,922 - 29,774,317 (-)NCBINCBI36hg18NCBI36
Build 342029,715,923 - 29,774,317NCBI
Celera2027,008,611 - 27,067,007 (-)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,040,965 - 27,099,720 (-)NCBIHuRef
CHM1_12030,156,165 - 30,215,683 (-)NCBICHM1_1
Bcl2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,600,652 - 152,675,723 (-)NCBIGRCm39mm39
GRCm39 Ensembl2152,622,588 - 152,673,648 (-)Ensembl
GRCm382152,758,732 - 152,833,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,780,668 - 152,831,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,606,404 - 152,657,418 (-)NCBIGRCm37mm9NCBIm37
MGSCv362152,472,109 - 152,523,123 (-)NCBImm8
Celera2158,596,643 - 158,647,694 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Bcl2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,254,216 - 29,308,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,254,440 - 29,307,104 (+)NCBIChiLan1.0ChiLan1.0
BCL2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12029,088,055 - 29,147,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,088,055 - 29,146,585 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02027,955,688 - 28,015,950 (-)NCBIMhudiblu_PPA_v0panPan3
BCL2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12421,145,214 - 21,209,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bcl2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648518,654,046 - 18,707,324 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,366,141 - 35,415,359 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,366,139 - 35,415,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,303,991 - 40,304,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,059,024 - 36,118,332 (-)NCBI
ChlSab1.1 Ensembl236,058,919 - 36,116,470 (-)Ensembl
Bcl2l1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624741788,445 - 838,513 (+)NCBI

Position Markers
D3Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03148,291,418 - 148,291,550NCBIRnor6.0
Rnor_5.03154,694,410 - 154,694,542UniSTSRnor5.0
RGSC_v3.43143,157,804 - 143,157,937RGDRGSC3.4
RGSC_v3.43143,157,805 - 143,157,937UniSTSRGSC3.4
RGSC_v3.13143,063,427 - 143,063,559RGD
Celera3140,031,529 - 140,031,661UniSTS
RH 3.4 Map31253.4RGD
RH 3.4 Map31253.4UniSTS
RH 2.0 Map3852.1RGD
Cytogenetic Map3q41.2UniSTS
BM383754  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03148,260,624 - 148,260,801NCBIRnor6.0
Rnor_6.01167,764,587 - 167,764,764NCBIRnor6.0
Rnor_5.03154,663,616 - 154,663,793UniSTSRnor5.0
Rnor_5.01173,950,019 - 173,950,196UniSTSRnor5.0
RGSC_v3.43143,130,117 - 143,130,294UniSTSRGSC3.4
RGSC_v3.41160,253,614 - 160,253,791UniSTSRGSC3.4
Celera1155,108,435 - 155,108,612UniSTS
Celera3140,003,936 - 140,004,113UniSTS
RH 3.4 Map11288.3UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC196230P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01167,765,020 - 167,765,555NCBIRnor6.0
Rnor_5.01173,950,452 - 173,950,987UniSTSRnor5.0
RGSC_v3.41160,254,047 - 160,254,582UniSTSRGSC3.4
Celera1155,108,868 - 155,109,403UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC316415P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01167,765,044 - 167,765,267NCBIRnor6.0
Rnor_5.01173,950,476 - 173,950,699UniSTSRnor5.0
RGSC_v3.41160,254,071 - 160,254,294UniSTSRGSC3.4
Celera1155,108,892 - 155,109,115UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC123054P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01167,765,230 - 167,765,648NCBIRnor6.0
Rnor_6.03148,311,851 - 148,312,269NCBIRnor6.0
Rnor_5.03154,714,843 - 154,715,261UniSTSRnor5.0
Rnor_5.01173,950,662 - 173,951,080UniSTSRnor5.0
RGSC_v3.43143,178,240 - 143,178,658UniSTSRGSC3.4
RGSC_v3.41160,254,257 - 160,254,675UniSTSRGSC3.4
Celera3140,052,000 - 140,052,418UniSTS
Celera1155,109,078 - 155,109,496UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
PMC20354P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03148,311,672 - 148,311,928NCBIRnor6.0
Rnor_5.03154,714,664 - 154,714,920UniSTSRnor5.0
RGSC_v3.43143,178,061 - 143,178,317UniSTSRGSC3.4
Celera3140,051,821 - 140,052,077UniSTS
Cytogenetic Map3q41.2UniSTS
PMC262691P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03148,311,633 - 148,311,814NCBIRnor6.0
Rnor_5.03154,714,625 - 154,714,806UniSTSRnor5.0
RGSC_v3.43143,178,022 - 143,178,203UniSTSRGSC3.4
Celera3140,051,782 - 140,051,963UniSTS
Cytogenetic Map3q41.2UniSTS
UniSTS:224427  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03148,260,761 - 148,260,914NCBIRnor6.0
Rnor_6.01167,764,724 - 167,764,877NCBIRnor6.0
Rnor_5.03154,663,753 - 154,663,906UniSTSRnor5.0
Rnor_5.01173,950,156 - 173,950,309UniSTSRnor5.0
RGSC_v3.43143,130,254 - 143,130,407UniSTSRGSC3.4
RGSC_v3.41160,253,751 - 160,253,904UniSTSRGSC3.4
Celera3140,004,073 - 140,004,226UniSTS
Celera1155,108,572 - 155,108,725UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
Bcl2l  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01167,765,017 - 167,765,591NCBIRnor6.0
Rnor_5.01173,950,449 - 173,951,023UniSTSRnor5.0
RGSC_v3.41160,254,044 - 160,254,618UniSTSRGSC3.4
Celera1155,108,865 - 155,109,439UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS
Bcl2l1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01167,765,159 - 167,765,527NCBIRnor6.0
Rnor_5.01173,950,591 - 173,950,959UniSTSRnor5.0
Celera1155,109,007 - 155,109,375UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3q41.2UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3126575595153412619Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3147072047154807958Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:238
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000010762, ENSRNOT00000024954, ENSRNOT00000047416
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 35 37 28 19 28 74 35 41 11
Low 1 8 20 13 13 8 11 8
Below cutoff

Sequence