Bcl2l1 (Bcl2-like 1) - Rat Genome Database

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Gene: Bcl2l1 (Bcl2-like 1) Rattus norvegicus
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Symbol: Bcl2l1
Name: Bcl2-like 1
RGD ID: 2200
Description: Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hormone stimulus; and positive regulation of transport. Located in cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; hepatocellular carcinoma; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1); PARTICIPATES IN intrinsic apoptotic pathway; erythropoietin signaling pathway; interleukin-3 signaling pathway; INTERACTS WITH (R)-carnitine; (R)-lipoic acid; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; bcl-2-like protein 1; bcl-X; Bcl-xl; bcl2-L-1; Bcl2l; Bclx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Bcl2l1-ps1  
Candidate Gene For: Eau4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,253,508 - 141,304,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,253,523 - 141,303,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,158,456 - 145,209,456 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03153,742,281 - 153,793,281 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03151,482,052 - 151,532,840 (-)NCBIRnor_WKY
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Celera3140,002,906 - 140,053,959 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IMP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Hypoxia-Ischemia  (IDA)
brain ischemia  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal adenocarcinoma  (ISO)
cryptorchidism  (ISO)
dilated cardiomyopathy  (IEP)
endometrial cancer  (ISO)
endometriosis  (IDA)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
gastric ulcer  (IDA)
Head and Neck Neoplasms  (ISO)
Hearing Loss  (ISO)
hematopoietic system disease  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
impotence  (IDA,ISO)
leiomyoma  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (IEP)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
melanoma  (ISO)
mental depression  (IEP)
multiple myeloma  (ISO)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
nephroblastoma  (ISO)
ocular hypertension  (IEP)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell neoplasm  (ISO)
polycythemia vera  (ISO)
prostate carcinoma  (ISO)
pulmonary hypertension  (IDA)
renal cell carcinoma  (ISO)
Retina Reperfusion Injury  (IEP)
status epilepticus  (IEP)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uterus interstitial leiomyoma  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-Salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,3-dinitrobenzene  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1-bromopropane  (EXP,ISO)
1-nitropyrene  (ISO)
10-Hydroxycamptothecin  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxyethanol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-Methylenedioxyamphetamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-Aminobenzamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-oxocampestanol  (ISO)
7,8-Diacetoxy-4-methylcoumarin  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
[6]-Shogaol  (ISO)
ABT-737  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
acrylonitrile  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allicin  (ISO)
alloxan  (EXP)
alpha-Solamarine  (ISO)
alpha-Zearalanol  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP,ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
ANTIMYCIN  (ISO)
antirheumatic drug  (ISO)
AP20187  (ISO)
apigenin  (EXP)
apocynin  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
aripiprazole  (ISO)
arjunolic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
Atranorin  (ISO)
atrazine  (EXP,ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
azilsartan  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
benzothiazoles  (ISO)
Berbamine  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
Beta-Solamarine  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (ISO)
brassinin  (ISO)
brassinolide  (ISO)
Bromoenol lactone  (EXP)
Brusatol  (ISO)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cafestol  (ISO)
caffeine  (ISO)
Calcimycin  (EXP)
calciol  (ISO)
calcitriol  (EXP,ISO)
calyculin a  (ISO)
camalexin  (ISO)
camptothecin  (EXP,ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carmustine  (EXP,ISO)
carvedilol  (EXP)
casticin  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
cetrorelix  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
chrysin  (EXP)
chrysin 5,7-dimethyl ether  (EXP)
ciguatoxin CTX1B  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
Clivoline  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (EXP)
dactolisib  (ISO)
daidzein  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
depsipeptide  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextromethorphan  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
diazoxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
erdosteine  (ISO)
Erionite  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
finasteride  (EXP)
fisetin  (ISO)
flavonoids  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (ISO)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP)
furan  (EXP)
Fusarenone X  (ISO)
galangin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
GW 6471  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
homoeriodictyol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxyurea  (EXP)
ibrutinib  (ISO)
ibuprofen  (ISO)
idelalisib  (ISO)
Idoxifene  (EXP)
Ilimaquinone  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (ISO)
kurarinol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leptomycin B  (ISO)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP)
lutein  (ISO)
luteolin  (ISO)
Luteolin 7-methyl ether  (EXP)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
metoprolol  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morin  (ISO)
morphine  (EXP)
morusin  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (EXP,ISO)
nitrobenzenes  (EXP)
nitrofen  (ISO)
nitroprusside  (EXP)
Nodularin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
oltipraz  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
paricalcitol  (ISO)
parthenolide  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
pepstatin A  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
pevonedistat  (ISO)
PHA-665752  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
PK-11195  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
potassium dichromate  (EXP)
Pranoprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (EXP)
promethazine  (ISO)
propiconazole  (ISO)
propofol  (EXP)
propylparaben  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
Psymberin  (ISO)
pterostilbene  (ISO)
purine-6-thiol  (ISO)
puromycin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
ritonavir  (ISO)
Ro 31-8220  (EXP)
romidepsin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
rutin  (EXP)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
sarin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
scutellarin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
simazine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sorafenib  (ISO)
spironolactone  (EXP)
stattic  (ISO)
staurosporine  (EXP,ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tartrazine  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
Tautomycin  (ISO)
temozolomide  (ISO)
TEMPO  (EXP,ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
Thiotepa  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (ISO)
tin(II) chloride (anhydrous)  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
trimethyltin  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
veliparib  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
Xanthorrhizol  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
apoptotic process  (IEA,IEP,ISO)
apoptotic process in bone marrow cell  (ISO)
cell population proliferation  (ISO)
cellular response to alkaloid  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to astaxanthin  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to erythropoietin  (IEP)
cellular response to gamma radiation  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to nitric oxide  (IEP)
cellular response to prolactin  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex development  (IEP)
defense response to virus  (ISO)
dendritic cell apoptotic process  (ISO)
dendritic cell proliferation  (ISO)
ectopic germ cell programmed cell death  (ISO)
endocytosis  (IEA)
epithelial cell proliferation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
fertilization  (ISO)
germ cell development  (ISO)
gonad development  (IEA)
hepatocyte apoptotic process  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,ISO)
male gonad development  (ISO)
mitochondrion morphogenesis  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IDA,IMP,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of developmental process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of execution phase of apoptosis  (ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of reproductive process  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle development  (IMP,ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of mononuclear cell proliferation  (ISO)
positive regulation of synaptic vesicle clustering  (IMP)
positive regulation of synaptic vesicle endocytosis  (IMP)
positive regulation of synaptic vesicle exocytosis  (IMP)
regulation of apoptotic process  (IDA,IEA)
regulation of cytokinesis  (ISO,ISS)
regulation of growth  (ISO)
regulation of long-term synaptic depression  (IMP)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to cycloheximide  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (IEP)
response to endoplasmic reticulum stress  (IEP)
response to erythropoietin  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to ischemia  (IDA)
response to lead ion  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to oxidative stress  (IEP)
response to peptide hormone  (IEP)
response to radiation  (ISO)
response to virus  (ISO)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (ISO)
suppression by virus of host apoptotic process  (ISO)
synaptic vesicle recycling via endosome  (IMP)

Cellular Component

References

References - curated
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95. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. Vukosavic S, etal., J Neurochem. 1999 Dec;73(6):2460-8.
96. Suppression of Bcl-xL expression by a novel tumor-specific RNA interference system inhibits proliferation and enhances radiosensitivity in prostatic carcinoma cells. Wang R, etal., Cancer Chemother Pharmacol. 2007 Jul 26;.
97. Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium. Wang Y, etal., Hum Psychopharmacol. 2011 Mar;26(2):95-101. doi: 10.1002/hup.1177. Epub 2011 Feb 9.
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99. Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation. Wu GJ, etal., Arch Toxicol. 2016 Apr;90(4):905-16. doi: 10.1007/s00204-015-1491-z. Epub 2015 Mar 1.
100. Loss of anti-apoptotic genes in aging rat crura. Yamanaka M, etal., J Urol. 2002 Nov;168(5):2296-300.
101. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Yang J, etal., Mol Ther. 2003 Mar;7(3):341-53.
102. Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. Yang YY, etal., Liver Transpl. 2012 Nov;18(11):1371-83. doi: 10.1002/lt.23520.
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104. Delayed apoptosis by neutrophils from COPD patients is associated with altered Bak, Bcl-xl, and Mcl-1 mRNA expression. Zhang J, etal., Diagn Pathol. 2012 Jun 11;7:65. doi: 10.1186/1746-1596-7-65.
105. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Zhuang L, etal., Mod Pathol. 2007 Apr;20(4):416-26.
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PMID:12011449   PMID:12115603   PMID:12477932   PMID:12496370   PMID:12667443   PMID:12785016   PMID:12931191   PMID:12967636   PMID:14517295   PMID:14532118   PMID:14651853   PMID:14676192  
PMID:14999001   PMID:15006356   PMID:15121179   PMID:15131699   PMID:15149850   PMID:15231831   PMID:15545017   PMID:15574729   PMID:15596800   PMID:15720830   PMID:15901672   PMID:16085054  
PMID:16111822   PMID:16133871   PMID:16205321   PMID:16301318   PMID:16428456   PMID:16603546   PMID:16608847   PMID:16723699   PMID:16815550   PMID:17052454   PMID:17073802   PMID:17132701  
PMID:17267035   PMID:17289999   PMID:17428862   PMID:17600519   PMID:17644076   PMID:18053090   PMID:18163394   PMID:18221257   PMID:18347331   PMID:18497705   PMID:18923682   PMID:18980715  
PMID:19082728   PMID:19339209   PMID:19767770   PMID:19862336   PMID:19885947   PMID:19938943   PMID:20106970   PMID:20457187   PMID:20499358   PMID:20671748   PMID:20673843   PMID:21041309  
PMID:21199865   PMID:21567405   PMID:21639858   PMID:21710144   PMID:21740920   PMID:21840391   PMID:21856303   PMID:21861389   PMID:21863631   PMID:21926988   PMID:22292018   PMID:22294442  
PMID:22366758   PMID:22424444   PMID:22871113   PMID:23015448   PMID:23530063   PMID:23731686   PMID:24096434   PMID:24326522   PMID:24444606   PMID:24787232   PMID:25681439   PMID:26109654  
PMID:26254736   PMID:26582200   PMID:27815660   PMID:27830683   PMID:28320275   PMID:28320276   PMID:28478796   PMID:28597245   PMID:29507230   PMID:33340237  


Genomics

Comparative Map Data
Bcl2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,253,508 - 141,304,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,253,523 - 141,303,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,158,456 - 145,209,456 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03153,742,281 - 153,793,281 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03151,482,052 - 151,532,840 (-)NCBIRnor_WKY
Rnor_6.03148,259,594 - 148,314,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,259,596 - 148,313,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,662,586 - 154,716,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,129,087 - 143,180,199 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,082,602 - 143,084,431 (-)NCBI
Celera3140,002,906 - 140,053,959 (-)NCBICelera
Cytogenetic Map3q41NCBI
BCL2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,664,452 - 31,723,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2031,664,452 - 31,723,989 (-)EnsemblGRCh38hg38GRCh38
GRCh372030,252,255 - 30,311,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,715,922 - 29,774,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 342029,715,923 - 29,774,317NCBI
Celera2027,008,611 - 27,067,007 (-)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,040,965 - 27,099,720 (-)NCBIHuRef
CHM1_12030,156,171 - 30,214,537 (-)NCBICHM1_1
T2T-CHM13v2.02033,388,711 - 33,448,575 (-)NCBIT2T-CHM13v2.0
Bcl2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,600,652 - 152,675,723 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,622,588 - 152,673,648 (-)EnsemblGRCm39 Ensembl
GRCm382152,758,732 - 152,833,803 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,780,668 - 152,831,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,606,404 - 152,657,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,472,109 - 152,523,123 (-)NCBIMGSCv36mm8
Celera2158,596,643 - 158,647,694 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Bcl2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,254,216 - 29,308,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,254,440 - 29,307,104 (+)NCBIChiLan1.0ChiLan1.0
BCL2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12029,088,055 - 29,147,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,088,055 - 29,146,585 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02027,955,688 - 28,015,950 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BCL2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,145,214 - 21,209,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,145,215 - 21,196,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,792,367 - 20,843,516 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,828,012 - 21,896,118 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,831,867 - 21,896,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,109,822 - 21,160,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,214,910 - 21,266,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,645,527 - 21,696,882 (-)NCBIUU_Cfam_GSD_1.0
Bcl2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,222,682 - 170,275,934 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648518,654,046 - 18,707,324 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,366,143 - 35,414,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,366,139 - 35,415,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,303,991 - 40,304,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,059,024 - 36,118,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,058,919 - 36,116,470 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,796,126 - 90,855,484 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741789,355 - 839,507 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741788,445