Gene: Mcl1 (MCL1, BCL2 family apoptosis regulator) Rattus norvegicus
Symbol: Mcl1
Name: MCL1, BCL2 family apoptosis regulator
Description: ENCODES a protein that exhibits BH domain binding; protein dimerization activity; protein heterodimerization activity; INVOLVED IN negative regulation of apoptotic process; apoptotic mitochondrial changes (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; hypoxia inducible factor pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Barrett's esophagus (ortholog); cutaneous T cell lymphoma (ortholog); leishmaniasis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
Type: protein-coding
Also known as: BCL2 family apoptosis regulator; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; myeloid cell leukemia 1; myeloid cell leukemia sequence 1
Homo sapiens (human) : MCL1 (MCL1, BCL2 family apoptosis regulator)  HGNC  Alliance
Mus musculus (house mouse) : Mcl1 (myeloid cell leukemia sequence 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcl1 (MCL1, BCL2 family apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : MCL1 (MCL1, BCL2 family apoptosis regulator)
Canis lupus familiaris (dog) : MCL1 (MCL1, BCL2 family apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcl1 (MCL1, BCL2 family apoptosis regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02197,786,212 - 197,788,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,273,158 - 217,275,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,749,995 - 175,752,956 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mcl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620525
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2018-05-29
Status: ACTIVE