Mcl1 (MCL1 apoptosis regulator, BCL2 family member) - Rat Genome Database

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Gene: Mcl1 (MCL1 apoptosis regulator, BCL2 family member) Rattus norvegicus
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Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
RGD ID: 620525
Description: Enables BH domain binding activity and protein dimerization activity. Involved in negative regulation of apoptotic process. Predicted to be located in several cellular components, including cytosol; mitochondrial matrix; and nucleus. Predicted to be part of Bcl-2 family protein complex. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member); PARTICIPATES IN intrinsic apoptotic pathway; hypoxia inducible factor pathway; interleukin-6 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCL2 family apoptosis regulator; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; MCL1, BCL2 family apoptosis regulator; myeloid cell leukemia 1; myeloid cell leukemia sequence 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,219,137 - 183,235,676 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,219,220 - 183,222,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,884,075 - 190,887,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,679,562 - 188,682,647 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,516,603 - 183,519,688 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02197,786,212 - 197,788,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,273,158 - 217,275,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,749,995 - 175,752,956 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-methylphenanthrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-Nerolidylcatechol  (ISO)
4-nonylphenol  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
ABT-737  (ISO)
acetaldehyde  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-Elemonic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cafestol  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
Cardanol  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cepharanthine  (ISO)
ceritinib  (ISO)
CGP 52608  (ISO)
chloroacetic acid  (ISO)
chloroquine  (ISO)
ciprofloxacin  (ISO)
cirsilineol  (ISO)
cisplatin  (ISO)
clavulone II  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumarins  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-penicillamine  (ISO)
dacarbazine  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
Dictamnine  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
etacrynic acid  (ISO)
etoposide  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
flubendazole  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formononetin  (ISO)
gamma-tocopherol  (ISO)
gentamycin  (EXP)
Geraniin  (ISO)
glycochenodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypol  (ISO)
Heptachlor epoxide  (ISO)
Honokiol  (ISO)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
irinotecan  (ISO)
Isoangustone A  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
jaceosidin  (ISO)
ketoconazole  (ISO)
kurarinol  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
lidocaine  (EXP)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonidamine  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lysophosphatidylethanolamine  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
mercury dichloride  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
MK-2206  (ISO)
monocrotophos  (EXP)
morphine  (ISO)
Myrtucommulone A  (ISO)
N(6)-methyladenosine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-dimethylsphingosine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitroprusside  (ISO)
Nonidet P-40  (ISO)
NORCANTHARIDIN  (ISO)
ochratoxin A  (EXP,ISO)
oltipraz  (ISO)
omacetaxine mepesuccinate  (ISO)
osimertinib  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
PD 0325901  (ISO)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picropodophyllotoxin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
promethazine  (ISO)
propiconazole  (ISO)
propranolol  (ISO)
propylparaben  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
pyrimidines  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinazolines  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
romidepsin  (ISO)
sarin  (ISO)
sepantronium  (ISO)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
staurosporine  (ISO)
sucrose  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tautomycin  (ISO)
tebufenpyrad  (ISO)
TEMPO  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiostrepton  (ISO)
tocopherol  (ISO)
trichostatin A  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Degradation of MCL-1 by bufalin reverses acquired resistance to osimertinib in EGFR-mutant lung cancer. Cao F, etal., Toxicol Appl Pharmacol. 2019 Sep 15;379:114662. doi: 10.1016/j.taap.2019.114662. Epub 2019 Jul 10.
3. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Chen G, etal., Cancer Res. 2019 Dec 15;79(24):6126-6138. doi: 10.1158/0008-5472.CAN-19-0950. Epub 2019 Oct 29.
4. Myeloid cell leukemia-1 protein expression and myeloid cell leukemia-1 gene amplification in non small cell lung cancer. El Jabbour T, etal., Indian J Pathol Microbiol. 2018 Jan-Mar;61(1):27-30. doi: 10.4103/IJPM.IJPM_731_16.
5. FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation. Feng C, etal., Cancer Gene Ther. 2017 Aug;24(8):342-347. doi: 10.1038/cgt.2017.24. Epub 2017 Aug 4.
6. Aberrant expression of deubiquitylating enzyme USP9X predicts poor prognosis in gastric cancer. Fu X, etal., Clin Res Hepatol Gastroenterol. 2017 Dec;41(6):687-692. doi: 10.1016/j.clinre.2017.01.008. Epub 2017 Mar 6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice. Healy ME, etal., Gastroenterology. 2020 Jul;159(1):183-199. doi: 10.1053/j.gastro.2020.03.017. Epub 2020 Mar 14.
9. Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis. Hirsova P, etal., Cell Death Dis. 2020 Feb 3;11(2):80. doi: 10.1038/s41419-020-2283-9.
10. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu SY, etal., Mol Endocrinol 1998 Sep;12(9):1432-40.
11. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
12. The FOXM1-induced resistance to oxaliplatin is partially mediated by its novel target gene Mcl-1 in gastric cancer cells. Hu CJ, etal., Biochim Biophys Acta. 2015 Mar;1849(3):290-9. doi: 10.1016/j.bbagrm.2014.11.008. Epub 2014 Dec 4.
13. Functional regulatory variants of MCL1 contribute to enhanced promoter activity and reduced risk of lung cancer in nonsmokers: implications for context-dependent phenotype of an antiapoptotic and antiproliferative gene in solid tumor. Jiang Y, etal., Cancer. 2012 Apr 15;118(8):2085-95. doi: 10.1002/cncr.26502. Epub 2011 Sep 1.
14. Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells. Kang XH, etal., Cell Physiol Biochem. 2017;41(5):2067-2076. doi: 10.1159/000475438. Epub 2017 Apr 14.
15. Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer. Lee WS, etal., Int J Oncol. 2015 May;46(5):2154-62. doi: 10.3892/ijo.2015.2890. Epub 2015 Feb 10.
16. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Correlation Between BCL2 and Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer. Mhaidat NM, etal., Curr Pharm Biotechnol. 2021;22(5):646-653. doi: 10.2174/1389201021666200703200126.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. MCL1 inhibition enhances the therapeutic effect of MEK inhibitors in KRAS-mutant lung adenocarcinoma cells. Tada M, etal., Lung Cancer. 2019 Jul;133:88-95. doi: 10.1016/j.lungcan.2019.05.014. Epub 2019 May 14.
26. Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines. Wang J, etal., Cell Physiol Biochem. 2013;32(6):1707-19. doi: 10.1159/000356605. Epub 2013 Dec 13.
27. Copy-number variation of MCL1 predicts overall survival of non-small-cell lung cancer in a Southern Chinese population. Yin J, etal., Cancer Med. 2016 Sep;5(9):2171-9. doi: 10.1002/cam4.774. Epub 2016 Jun 5.
28. Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers. Yu H, etal., Cell Death Dis. 2018 Jun 13;9(6):702. doi: 10.1038/s41419-018-0660-4.
29. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. Yu X, etal., J Exp Clin Cancer Res. 2020 Apr 10;39(1):62. doi: 10.1186/s13046-020-01566-2.
Additional References at PubMed
PMID:7896880   PMID:9184696   PMID:10837489   PMID:15489334   PMID:15901672   PMID:15936722   PMID:16513083   PMID:16543145   PMID:17200126   PMID:17289999   PMID:18757878   PMID:19919825  
PMID:20041405   PMID:20189983   PMID:20467439   PMID:20627101   PMID:20921992   PMID:21036904   PMID:21199865   PMID:21660051   PMID:22277751   PMID:23216940   PMID:23553788   PMID:23688351  
PMID:23825534   PMID:23858059   PMID:23926254   PMID:24113155   PMID:25986861   PMID:27220418   PMID:28491238   PMID:31197456   PMID:31257502   PMID:33378038   PMID:36260529  


Genomics

Comparative Map Data
Mcl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,219,137 - 183,235,676 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,219,220 - 183,222,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,884,075 - 190,887,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,679,562 - 188,682,647 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,516,603 - 183,519,688 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02197,786,212 - 197,788,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,273,158 - 217,275,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,749,995 - 175,752,956 (+)NCBICelera
Cytogenetic Map2q34NCBI
MCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,574,558 - 150,579,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,560,895 - 150,579,738 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,547,034 - 150,552,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,813,658 - 148,818,760 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,360,106 - 147,365,209NCBI
Celera1123,662,793 - 123,667,900 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,925,157 - 121,930,349 (-)NCBIHuRef
CHM1_11151,942,802 - 151,947,994 (-)NCBICHM1_1
T2T-CHM13v2.01149,698,578 - 149,703,635 (-)NCBIT2T-CHM13v2.0
Mcl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,564,017 - 95,583,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,566,099 - 95,570,487 (+)EnsemblGRCm39 Ensembl
GRCm38395,656,944 - 95,663,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,658,788 - 95,663,176 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,462,643 - 95,467,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,744,192 - 95,748,584 (+)NCBIMGSCv36mm8
MGSCv36395,942,505 - 95,946,924 (+)NCBIMGSCv36mm8
Celera397,090,304 - 97,094,626 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Mcl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955413238,043 - 243,317 (+)NCBIChiLan1.0ChiLan1.0
MCL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1199,013,464 - 99,018,758 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,918,760 - 125,923,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,566,827 - 129,572,086 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,566,827 - 129,572,086 (-)Ensemblpanpan1.1panPan2
MCL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,759,605 - 59,763,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,759,605 - 59,763,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,205,905 - 59,209,411 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,773,751 - 60,778,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,773,753 - 60,778,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,605,427 - 59,608,935 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,689,378 - 59,692,878 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,416,999 - 60,420,508 (-)NCBIUU_Cfam_GSD_1.0
Mcl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,772,943 - 21,777,059 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580804,903 - 806,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580803,452 - 806,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,534,812 - 98,567,006 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,562,092 - 98,567,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,809,204 - 107,814,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,707,472 - 12,712,711 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,289,509 - 18,319,033 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,287,587 - 18,292,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcl1
34 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir29arno-miR-29a-3pMirtarbaseexternal_infoWestern blotFunctional MTI20164119

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
RH137008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,222,040 - 183,222,243 (+)MAPPERmRatBN7.2
Rnor_6.02197,788,728 - 197,788,930NCBIRnor6.0
Rnor_5.02217,275,666 - 217,275,868UniSTSRnor5.0
Celera2175,752,692 - 175,752,894UniSTS
Cytogenetic Map2q34UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000109758   ⟹   ENSRNOP00000097988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,219,220 - 183,222,303 (+)Ensembl
RefSeq Acc Id: NM_021846   ⟹   NP_068618
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22183,219,220 - 183,222,305 (+)NCBI
Rnor_6.02197,786,212 - 197,788,992 (+)NCBI
Rnor_5.02217,273,158 - 217,275,930 (+)NCBI
Celera2175,749,995 - 175,752,956 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103018   ⟹   XP_038958946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22183,219,137 - 183,235,676 (+)NCBI
RefSeq Acc Id: NP_068618   ⟸   NM_021846
- UniProtKB: Q6AYY5 (UniProtKB/Swiss-Prot),   Q9R289 (UniProtKB/Swiss-Prot),   Q9Z1P3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038958946   ⟸   XM_039103018
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000097988   ⟸   ENSRNOT00000109758
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1P3-F1-model_v2 AlphaFold Q9Z1P3 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620525 AgrOrtholog
BioCyc Gene G2FUF-52083 BioCyc
Ensembl Genes ENSRNOG00000063678 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055031621 UniProtKB/Swiss-Prot
  ENSRNOG00060013230 UniProtKB/Swiss-Prot
  ENSRNOG00065023492 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000109758 ENTREZGENE
  ENSRNOT00000109758.1 UniProtKB/Swiss-Prot
  ENSRNOT00055054756 UniProtKB/Swiss-Prot
  ENSRNOT00060022547 UniProtKB/Swiss-Prot
  ENSRNOT00065040157 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121699 IMAGE-MGC_LOAD
InterPro Apop_reg_Mc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
KEGG Report rno:60430 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93459 IMAGE-MGC_LOAD
NCBI Gene 60430 ENTREZGENE
PANTHER BCL-2 RELATED UniProtKB/TrEMBL
  INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 UniProtKB/TrEMBL
  PTHR11256 UniProtKB/Swiss-Prot
  PTHR11256:SF46 UniProtKB/Swiss-Prot
Pfam Bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcl1 PhenoGen
PRINTS APOPREGMCL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCL2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000063678 RatGTEx
  ENSRNOG00055031621 RatGTEx
  ENSRNOG00060013230 RatGTEx
  ENSRNOG00065023492 RatGTEx
SMART BCL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Bcl-2 inhibitors of programmed cell death UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6K304_RAT UniProtKB/TrEMBL
  MCL1_RAT UniProtKB/Swiss-Prot
  Q6AYY5 ENTREZGENE
  Q9R289 ENTREZGENE
  Q9Z1P3 ENTREZGENE
UniProt Secondary Q6AYY5 UniProtKB/Swiss-Prot
  Q9R289 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Mcl1  MCL1 apoptosis regulator, BCL2 family member  Mcl1  MCL1, BCL2 family apoptosis regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-29 Mcl1  MCL1, BCL2 family apoptosis regulator  Mcl1  BCL2 family apoptosis regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-22 Mcl1  BCL2 family apoptosis regulator  Mcl1  myeloid cell leukemia 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-04 Mcl1  myeloid cell leukemia 1  Mcl1  myeloid cell leukemia sequence 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mcl1  myeloid cell leukemia sequence 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mcl1  myeloid cell leukemia sequence 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains Bcl-2 homology domains BH1, BH2, and BH3 633263
gene_physical_interaction interacts with proapoptotic Bcl-2 family proteins (Bax, Bak, Bok/Mtd, Bik, and BOD/Bim) 633263