Csf2rb (colony stimulating factor 2 receptor subunit beta)

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Gene: Csf2rb (colony stimulating factor 2 receptor subunit beta) Rattus norvegicus

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Symbol:

Csf2rb

Name:

colony stimulating factor 2 receptor subunit beta

RGD ID:

620189

Description:

Predicted to enable coreceptor activity and cytokine receptor activity. Involved in response to lipopolysaccharide. Predicted to be part of granulocyte macrophage colony-stimulating factor receptor complex. Predicted to be active in external side of plasma membrane. Used to study asthma. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-3 signaling pathway; interleukin-5 signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

colony stimulating factor 2 receptor beta common subunit; colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage); colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); Csf2rb1; cytokine receptor common subunit beta; interleukin 3 common beta chain

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,756,950 - 111,782,089 (+)	NCBI		GRCr8
mRatBN7.2	7	109,876,919 - 109,901,589 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,886,425 - 109,904,157 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,626,685 - 111,649,953 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,850,226 - 113,873,488 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,818,844 - 113,842,074 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,554,383 - 119,568,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,554,354 - 119,568,776 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,544,873 - 119,558,539 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,227,239 - 116,271,993 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	116,271,510 - 116,306,223 (+)	NCBI
Celera	7	106,216,478 - 106,238,726 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

asthma (IMP)

autosomal recessive chronic granulomatous disease 3 (ISO)

brain ischemia (IEP)

Emery-Dreifuss muscular dystrophy (ISO)

genetic disease (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

Pulmonary Surfactant Metabolism Dysfunction 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

buta-1,3-diene (ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

carbonyl sulfide (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

clofibrate (ISO)

clopidogrel (ISO)

copper atom (EXP)

copper(0) (EXP)

curcumin (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

Diisodecyl phthalate (ISO)

dioxygen (EXP)

endosulfan (EXP)

ethanol (ISO)

flavonoids (ISO)

folic acid (ISO)

fonofos (ISO)

formaldehyde (ISO)

hexachlorobenzene (EXP)

isoprenaline (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methotrexate (ISO)

monosodium L-glutamate (ISO)

Muraglitazar (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

permethrin (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

tacrolimus hydrate (ISO)

terbufos (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

troglitazone (EXP)

tungsten (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway via JAK-STAT (ISO)

cytokine-mediated signaling pathway (IBA)

granulocyte-macrophage colony-stimulating factor signaling pathway (ISO)

immunoglobulin mediated immune response (IBA)

interleukin-3-mediated signaling pathway (ISO)

interleukin-5-mediated signaling pathway (ISO)

positive regulation of leukocyte proliferation (ISO)

response to lipopolysaccharide (IEP)

Cellular Component

external side of plasma membrane (IBA)

granulocyte macrophage colony-stimulating factor receptor complex (ISO)

plasma membrane (ISO)

Molecular Function

coreceptor activity (ISO)

cytokine receptor activity (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

apoptotic cell death pathway (IEA)

cytokine mediated signaling pathway (IEA)

granulocyte-macrophage colony-stimulating factor signaling pathway (ISO)

interleukin-3 signaling pathway (ISO)

interleukin-5 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Multitargeted approach using antisense oligonucleotides for the treatment of asthma.	Allakhverdi Z, etal., Ann N Y Acad Sci. 2006 Oct;1082:62-73.
2.	Cloning of rat interleukin-3 receptor beta-subunit from cultured microglia and its mRNA expression in vivo.	Appel K, etal., J Neurosci 1995 Aug;15(8):5800-9.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:1695379

Genomics

Comparative Map Data

Csf2rb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,756,950 - 111,782,089 (+)	NCBI		GRCr8
mRatBN7.2	7	109,876,919 - 109,901,589 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,886,425 - 109,904,157 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,626,685 - 111,649,953 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,850,226 - 113,873,488 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,818,844 - 113,842,074 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,554,383 - 119,568,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,554,354 - 119,568,776 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,544,873 - 119,558,539 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,227,239 - 116,271,993 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	116,271,510 - 116,306,223 (+)	NCBI
Celera	7	106,216,478 - 106,238,726 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

CSF2RB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	36,913,628 - 36,940,439 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	36,913,628 - 36,940,439 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,309,670 - 37,336,481 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,648,168 - 35,664,764 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,642,721 - 35,659,318	NCBI
Celera	22	21,111,014 - 21,137,820 (+)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	20,271,284 - 20,300,485 (+)	NCBI		HuRef
CHM1_1	22	37,269,205 - 37,296,007 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,372,586 - 37,399,383 (+)	NCBI		T2T-CHM13v2.0

Csf2rb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,166,707 - 78,189,921 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,166,707 - 78,189,921 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,282,507 - 78,305,721 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,282,507 - 78,305,721 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,112,940 - 78,136,033 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,109,765 - 78,132,858 (-)	NCBI		MGSCv36	mm8
Celera	15	79,743,456 - 79,766,549 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.22	NCBI

Csf2rb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,449,111 - 23,463,820 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,442,417 - 23,465,093 (+)	NCBI	ChiLan1.0	ChiLan1.0

CSF2RB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,770,999 - 46,797,941 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,462,363 - 49,489,315 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	17,831,313 - 17,858,272 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,666,729 - 35,693,708 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,666,734 - 35,693,701 (+)	Ensembl	panpan1.1		panPan2

CSF2RB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,541,645 - 27,566,907 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,541,647 - 27,567,278 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,496,146 - 27,521,244 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,333,755 - 28,358,851 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,333,760 - 28,358,984 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	28,055,276 - 28,080,375 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,363,777 - 28,388,879 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,542,588 - 28,567,688 (-)	NCBI		UU_Cfam_GSD_1.0

Csf2rb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,919,175 - 10,950,319 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936492	3,929,589 - 3,974,070 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CSF2RB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,816,376 - 10,840,618 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,816,366 - 10,840,613 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,415,807 - 8,439,906 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CSF2RB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,614,719 - 19,642,546 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,624,234 - 19,640,617 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	106,220,245 - 106,247,737 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Csf2rb
199 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	63
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000000203
Prediction methods:	Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ000555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S79263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000203 ⟹ ENSRNOP00000000203

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	109,886,425 - 109,900,287 (+)	Ensembl
Rnor_6.0 Ensembl	7	119,554,354 - 119,568,776 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100294 ⟹ ENSRNOP00000077733

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	109,886,425 - 109,904,157 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112752 ⟹ ENSRNOP00000085691

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	109,886,425 - 109,900,287 (+)	Ensembl

RefSeq Acc Id:

NM_133555 ⟹ NP_598239

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	111,757,617 - 111,780,787 (+)	NCBI
mRatBN7.2	7	109,877,115 - 109,900,287 (+)	NCBI
Rnor_6.0	7	119,554,383 - 119,568,248 (+)	NCBI
Rnor_5.0	7	119,544,873 - 119,558,539 (+)	NCBI
RGSC_v3.4	7	116,227,239 - 116,271,993 (+)	RGD
Celera	7	106,216,478 - 106,238,726 (+)	RGD

Sequence:

show sequence

CGCAAGTACAGAGCACCAGAGGATGCAGACTAGCAGTGAAGAATCACAAGACCTGTAACATGAG
TGCGGCCCAACCCCCAGCCAAGCTTTGACACAGAACCCCAGGACAATGAGGACACCACCCTGCC
CATAGCTCCCTGTGCAGCCACCTAAAGTGCCAAAATGGACCAGCACATGGCATTTATCTGGGGG
CTGTGCTACATGGCCCTGGTGGCTCTCTGCTGGAGACACGGGGTAACAAAGGCAGAAGAAACTG
TCCCTCTGAAGACTCTGCAGTGCTACAACGACTATATCGAGCGCATCATCTGCAGCTGGGCCGA
CACGGAGGACGCCCAGGGGCTCGTTAACCTGACCCTCTATCACTGGCTAGACAAGAAACAGCCA
ATGTCCTGTGAGCTCAGTGAGGACCTCATGTGGTCAGAGTGCCCGTCATCCCACCGCTGTGTGC
CTAGAAGATGTGTCCTCCCCTATACACAGTTTTCCGTCTCAAAAGAAGACTACTACTCACTCCA
GCCGGATCGTGATCTGAGTATCCATCTCGTGGTTCCGCTGGCCCAGCATGTGCAGCCACCACCT
CCCAAGGACATCAGCATCAGCCCCTCTGGGGACCATTTCCTGCTGAAGTGGAGTGTGCCCCTTG
GGGATGCCCAGGTCTCTCTGCTTTCACAAAAGGACATACAGTTTGAGGTGGCTTATAAGCAGCT
TCAGGACTCCTGGGAGGATGCCTCCAGCCTCCACACTTGCAACCTCTGGGTCACTCTCGAGCCA
AAGCTCTTCCTACCCAACAGTATCTATGTGGCCCGCGTGCGCGCTCAGCTAGCCCCAGGTTCGA
GCTTGTCCGGAAGACCCAGCGGATGGAGCCCAGAGGTACACTGGGACTCTCCGACAGAGGACAA
GGCTCGGCCACAGAACCTTCAGTGCTTCTTTGATGGGATCCAGTCCCTCAACTGCTCCTGGGAG
GTGTGGACCAAGGTGACTGACTCTGTTTCCTTTGGGCTCTTCTATAGCTCCAGTCCCAAAGCTG
GGGAGAAGAAATGCTCTCCAGTGGTGAAGGAGCTGCAGGCCAGCCGCTACACCCGGTACCACTG
CAGCCTAAATGTGTCCGACCCCGCTGCACACAGCCAGTACACCGTCTCTGTTAAGCGGCTGGAA
CAAGGGAAGTTCATCGAGAGCTTTAACCACATCCAGATGAATCCTCCAACCCTCAACCTGACCA
AGAACAGAGACAGCTACAGCCTGCATTGGGAGACTCAGAAAATGTCCTATCCATTCATCCAGCA
TGCATTCCAGGTCCAGTACAAGAAGAAACTGGACCGCTGGGAGGACAGCAAGACAGAGAACCTA
AATCATGCCCACAGCATGGACCTGCCACAGCTGGAGCCTGGCACCTCATACTGCGCCAGGGTGA
GGGTCAAGACCATCCCTGAATACAAAGGGCTCTGGAGCGAGTGGAGCAATGAGTGCACCTGGAC
GACTGACTGGGTGATGCCAACATTGTGGATAGTCCTCATCCTGGTCTTCCTCATCCTCACCTTC
CTCCTGGCCCTCCGCTTTGGCTGCATCTATGGGTGCAAGTTGTACAGAAGATGGAAGGAGAAAA
TCCCCAACCCCAGCAAGAGCCTCCTTTTCCAGGATGGAGGTAAAGGACTCTGGCCTCCTGGCAG
CACGGTGACCTTCTCCAGTAAGAACCCCACTCCCCAGGGGCCACAGAACAACCTTTTCTCTGAG
CTACAGGGGGTGTCATATACACATCTGGAGGACAACGAAGTGTCACCTCTCACCATAGAGGACC
CCAACATTATTCGAGATCCATCATCTGGCCCTGATACAACCCCAGCTGCCTCATCTGAACCCAT
GGAGCAGTCTTCCAATGTTCAAGTAGACCCACCAACTCTTTCTGGCAGACCCAGGAAGCAATTA
CCCAGCTTTGACTTCAATGGCCCGTACCTGGGGCCTCCCCAATCCCACTCCCTGCCCGATCTCC
CAGGCCAGCTGGTTTCCCCCCAGGGGGTTGGAAGCCTGAAGCCAGCACTGCCAGGCTCCTTGGA
GTACATGTGTCTGCCCCCTGGAGGGCAAGTGCAACTGGTCCCACTGTCCCAGGTGATGGGGCAG
GGCCGGGATGTGGATGTGCAGTGTGGGTCCAGCCTGGAGACCACAGAGAGCCCTTCCATGGAAT
CAAGGGAGAGCCCTCCAGTTGAGCTGAAGGAGGAGGAACAGGAGCCAAGGGACAACCCAGTGAC
TCTCCCCATAAGCTCTGGAGGCCCCAAAGACAGTAAGGTGGCCTCTGAGTATGTCACACCTGCA
GATCTGGTGCTCACTCTGCCCACAGAGCCCTTGTCTACCTCTCTGGGTCCCTCTCTAGAGGTCT
CCTCAGCCCAAAGCCCCAGTCTCTGTCTCAAGCTGCCCAGGGTCCCTTCTGAAAGTCCAGCTCT
TGCACCAGCAGTGTTTGAAGATTACGTGGAGCTGCCTCCAAGCATGAGCCAGCCTGCCAAGTCC
CTTCCAGGCAATCCTGCTCCTCCTGGGCCAAGCAGCCCCGCAGTGAGCCCAGGAGAGCCCAGGG
AGGAAGTAGGCGCAGCCCCCACACACCCTGAAGGCCTCCTTGTTCTTCAGCAGGTTGGGGACTA
CTGCTTCCTCCCTGGCCTGGGACCCAGCCCCCTCTCACCACCCAGTAAGCCACCCTCTCCGGGC
CTGTGTCTCGAGACTGAGGACCTAGACAAGGACTTGTCTGTCAAAAAGCTTCCCTACCAACCCA
TACCCCAGGTGCCAGCCATTCAGTTTTTCAAGTCCCTAAAGCATCAGGACTACCTGTCACTGCC
CCCTTGGGACAATAGCCAGCCTGGGAAGGTGTGCTGAGTCTCCCCCCTCCCAATCTCACCAGCA
GCCCTGCGCCTCAGCCTGTGGACCT

hide sequence

RefSeq Acc Id:

XM_039078342 ⟹ XP_038934270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	111,756,950 - 111,782,089 (+)	NCBI
mRatBN7.2	7	109,876,919 - 109,901,589 (+)	NCBI

RefSeq Acc Id:

XM_039078343 ⟹ XP_038934271

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	111,757,548 - 111,782,089 (+)	NCBI
mRatBN7.2	7	109,877,058 - 109,901,589 (+)	NCBI

RefSeq Acc Id:

XM_039078344 ⟹ XP_038934272

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	111,757,573 - 111,782,089 (+)	NCBI
mRatBN7.2	7	109,877,073 - 109,901,589 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_598239	(Get FASTA)	NCBI Sequence Viewer
	XP_038934270	(Get FASTA)	NCBI Sequence Viewer
	XP_038934271	(Get FASTA)	NCBI Sequence Viewer
	XP_038934272	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB35068	(Get FASTA)	NCBI Sequence Viewer
	CAA04186	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000203.6
	ENSRNOP00000077733.1
	ENSRNOP00000085691.1

RefSeq Acc Id:	NP_598239 ⟸ NM_133555
- Peptide Label:	precursor
- UniProtKB:	Q78ZF5 (UniProtKB/TrEMBL), A0A8I6GE59 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDQHMAFIWGLCYMALVALCWRHGVTKAEETVPLKTLQCYNDYIERIICSWADTEDAQGLVNLT LYHWLDKKQPMSCELSEDLMWSECPSSHRCVPRRCVLPYTQFSVSKEDYYSLQPDRDLSIHLVV PLAQHVQPPPPKDISISPSGDHFLLKWSVPLGDAQVSLLSQKDIQFEVAYKQLQDSWEDASSLH TCNLWVTLEPKLFLPNSIYVARVRAQLAPGSSLSGRPSGWSPEVHWDSPTEDKARPQNLQCFFD GIQSLNCSWEVWTKVTDSVSFGLFYSSSPKAGEKKCSPVVKELQASRYTRYHCSLNVSDPAAHS QYTVSVKRLEQGKFIESFNHIQMNPPTLNLTKNRDSYSLHWETQKMSYPFIQHAFQVQYKKKLD RWEDSKTENLNHAHSMDLPQLEPGTSYCARVRVKTIPEYKGLWSEWSNECTWTTDWVMPTLWIV LILVFLILTFLLALRFGCIYGCKLYRRWKEKIPNPSKSLLFQDGGKGLWPPGSTVTFSSKNPTP QGPQNNLFSELQGVSYTHLEDNEVSPLTIEDPNIIRDPSSGPDTTPAASSEPMEQSSNVQVDPP TLSGRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLVSPQGVGSLKPALPGSLEYMCLPPGGQVQ LVPLSQVMGQGRDVDVQCGSSLETTESPSMESRESPPVELKEEEQEPRDNPVTLPISSGGPKDS KVASEYVTPADLVLTLPTEPLSTSLGPSLEVSSAQSPSLCLKLPRVPSESPALAPAVFEDYVEL PPSMSQPAKSLPGNPAPPGPSSPAVSPGEPREEVGAAPTHPEGLLVLQQVGDYCFLPGLGPSPL SPPSKPPSPGLCLETEDLDKDLSVKKLPYQPIPQVPAIQFFKSLKHQDYLSLPPWDNSQPGKVC hide sequence

Ensembl Acc Id:

ENSRNOP00000000203 ⟸ ENSRNOT00000000203

RefSeq Acc Id:	XP_038934270 ⟸ XM_039078342
- Peptide Label:	isoform X1
- UniProtKB:	G3V608 (UniProtKB/TrEMBL), A6HSJ2 (UniProtKB/TrEMBL), A0A8I6GE59 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934271 ⟸ XM_039078343
- Peptide Label:	isoform X1
- UniProtKB:	G3V608 (UniProtKB/TrEMBL), A6HSJ2 (UniProtKB/TrEMBL), A0A8I6GE59 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934272 ⟸ XM_039078344
- Peptide Label:	isoform X1
- UniProtKB:	G3V608 (UniProtKB/TrEMBL), A6HSJ2 (UniProtKB/TrEMBL), A0A8I6GE59 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000085691 ⟸ ENSRNOT00000112752

Ensembl Acc Id:

ENSRNOP00000077733 ⟸ ENSRNOT00000100294

Protein Domains

Fibronectin type-III

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V608-F1-model_v2	AlphaFold	G3V608	1-895	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620189	AgrOrtholog
BioCyc Gene	G2FUF-32835	BioCyc
Ensembl Genes	ENSRNOG00000000187	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000203.6	UniProtKB/TrEMBL
	ENSRNOT00000100294.1	UniProtKB/TrEMBL
	ENSRNOT00000112752.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Fibronectin_type3	UniProtKB/TrEMBL
	FN3_sf	UniProtKB/TrEMBL
	Growth/epo_recpt_lig-bind	UniProtKB/TrEMBL
	Hempt_rcpt_S_F1_CS	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	IL3_rcpt_beta	UniProtKB/TrEMBL
	IL3RB_N	UniProtKB/TrEMBL
	Interferon_alpha/beta_rcpt_bsu	UniProtKB/TrEMBL
KEGG Report	rno:171081	UniProtKB/TrEMBL
NCBI Gene	171081	ENTREZGENE
PANTHER	CYTOKINE RECEPTOR	UniProtKB/TrEMBL
	CYTOKINE RECEPTOR COMMON SUBUNIT BETA	UniProtKB/TrEMBL
Pfam	EpoR_lig-bind	UniProtKB/TrEMBL
	IL3Rb_N	UniProtKB/TrEMBL
	Interfer-bind	UniProtKB/TrEMBL
PhenoGen	Csf2rb	PhenoGen
PIRSF	IL3R_beta_c	UniProtKB/TrEMBL
PROSITE	FN3	UniProtKB/TrEMBL
	HEMATOPO_REC_S_F1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000187	RatGTEx
SMART	FN3	UniProtKB/TrEMBL
Superfamily-SCOP	FN_III-like	UniProtKB/TrEMBL
UniProt	A0A8I5Y685_RAT	UniProtKB/TrEMBL
	A0A8I6GE59	ENTREZGENE, UniProtKB/TrEMBL
	A6HSJ2	ENTREZGENE, UniProtKB/TrEMBL
	G3V608	ENTREZGENE, UniProtKB/TrEMBL
	Q78ZF5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-12-06	Csf2rb	colony stimulating factor 2 receptor subunit beta	Csf2rb	colony stimulating factor 2 receptor beta common subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-20	Csf2rb	colony stimulating factor 2 receptor beta common subunit	Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-22	Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Csf2rb1	colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Csf2rb1	colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Csf2rb1	colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression upregulated by lipopolysaccharide	632531

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)