Dcstamp (dendrocyte expressed seven transmembrane protein) - Rat Genome Database

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Gene: Dcstamp (dendrocyte expressed seven transmembrane protein) Rattus norvegicus
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Symbol: Dcstamp
Name: dendrocyte expressed seven transmembrane protein
RGD ID: 1310435
Description: Involved in cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; and mononuclear cell differentiation. Predicted to be located in endosome membrane. Predicted to be active in cell surface and endoplasmic reticulum membrane. Orthologous to human DCSTAMP (dendrocyte expressed seven transmembrane protein); INTERACTS WITH bisphenol A; dioxygen; paraquat.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dendritic cell-specific transmembrane protein; LOC103690326; LOC299889; Tm7sf4; transmembrane 7 superfamily member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8772,692,364 - 72,706,983 (+)NCBIGRCr8
mRatBN7.2770,807,455 - 70,822,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,807,581 - 70,822,078 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0778,725,173 - 78,756,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,649,875 - 78,650,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,732,904 - 78,741,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,597,411 - 77,598,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4775,318,788 - 75,336,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1775,349,840 - 75,357,112 (+)NCBI
Celera767,860,809 - 67,891,645 (+)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, etal., PLoS One. 2012;7(10):e47930. doi: 10.1371/journal.pone.0047930. Epub 2012 Oct 24.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11169400   PMID:15452179   PMID:15601667   PMID:16061724   PMID:16937266   PMID:17164993   PMID:17713547   PMID:18653699   PMID:20546900   PMID:22865856   PMID:23980096  


Genomics

Comparative Map Data
Dcstamp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8772,692,364 - 72,706,983 (+)NCBIGRCr8
mRatBN7.2770,807,455 - 70,822,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,807,581 - 70,822,078 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0778,725,173 - 78,756,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,649,875 - 78,650,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,732,904 - 78,741,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,597,411 - 77,598,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4775,318,788 - 75,336,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1775,349,840 - 75,357,112 (+)NCBI
Celera767,860,809 - 67,891,645 (+)NCBICelera
Cytogenetic Map7q31NCBI
DCSTAMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388104,339,796 - 104,356,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8104,339,087 - 104,356,689 (+)EnsemblGRCh38hg38GRCh38
GRCh378105,352,024 - 105,368,917 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,421,230 - 105,438,092 (+)NCBINCBI36Build 36hg18NCBI36
Build 348105,421,229 - 105,438,092NCBI
Celera8101,538,720 - 101,555,582 (+)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef8100,553,073 - 100,569,966 (+)NCBIHuRef
CHM1_18105,392,829 - 105,409,722 (+)NCBICHM1_1
T2T-CHM13v2.08105,466,609 - 105,484,210 (+)NCBIT2T-CHM13v2.0
Dcstamp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,609,326 - 39,624,334 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1539,609,326 - 39,624,334 (+)EnsemblGRCm39 Ensembl
GRCm381539,745,930 - 39,760,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,745,930 - 39,760,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv371539,577,478 - 39,592,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361539,576,006 - 39,591,008 (+)NCBIMGSCv36mm8
Celera1540,229,920 - 40,244,989 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.51NCBI
Dcstamp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,155,842 - 28,168,049 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541728,156,046 - 28,169,481 (+)NCBIChiLan1.0ChiLan1.0
DCSTAMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27121,690,535 - 121,709,115 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1897,223,284 - 97,231,562 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08100,967,757 - 100,985,384 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18103,121,332 - 103,138,223 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,121,332 - 103,138,223 (+)Ensemblpanpan1.1panPan2
DCSTAMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,542,474 - 5,559,433 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,542,425 - 5,571,968 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha135,550,114 - 5,580,387 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0135,789,666 - 5,820,024 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,789,570 - 5,806,821 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,558,282 - 5,588,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,677,761 - 5,708,007 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,699,620 - 5,729,895 (+)NCBIUU_Cfam_GSD_1.0
Dcstamp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530332,237,463 - 32,245,440 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647039,664,511 - 39,671,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647039,664,573 - 39,671,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCSTAMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,913,152 - 32,928,235 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1432,912,320 - 32,928,323 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,670,769 - 35,685,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCSTAMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,174,778 - 99,193,539 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl899,185,423 - 99,193,058 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603941,377,453 - 41,386,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcstamp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476320,589,668 - 20,601,641 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476320,588,635 - 20,602,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dcstamp
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:57
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000006243
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
17 17 16 6 6 6 3 20 11 9 3 13 10

Sequence


Ensembl Acc Id: ENSRNOT00000006243   ⟹   ENSRNOP00000006243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl770,807,581 - 70,822,078 (+)Ensembl
Rnor_6.0 Ensembl778,649,875 - 78,650,906 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088433   ⟹   ENSRNOP00000071033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl778,732,904 - 78,741,588 (+)Ensembl
RefSeq Acc Id: XM_008765472   ⟹   XP_008763694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,692,370 - 72,706,983 (+)NCBI
mRatBN7.2770,807,463 - 70,822,067 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765474   ⟹   XP_008763696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,692,364 - 72,706,983 (+)NCBI
mRatBN7.2770,807,455 - 70,822,067 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080168   ⟹   XP_038936096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8772,692,375 - 72,706,983 (+)NCBI
mRatBN7.2770,807,468 - 70,822,067 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419173 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763694 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763696 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936096 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006243
  ENSRNOP00000006243.7
  ENSRNOP00000105491
Ensembl Acc Id: ENSRNOP00000006243   ⟸   ENSRNOT00000006243
Ensembl Acc Id: ENSRNOP00000071033   ⟸   ENSRNOT00000088433
RefSeq Acc Id: XP_008763696   ⟸   XM_008765474
- Peptide Label: isoform X2
- UniProtKB: A6HR82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763694   ⟸   XM_008765472
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038936096   ⟸   XM_039080168
- Peptide Label: isoform X3
Protein Domains
Dendritic cell-specific transmembrane protein-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVC2-F1-model_v2 AlphaFold D3ZVC2 1-344 view protein structure
AF-A0A0G2JZG1-F1-model_v2 AlphaFold A0A0G2JZG1 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310435 AgrOrtholog
Ensembl Genes ENSRNOG00000004704 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000057189 Ensembl
Ensembl Transcript ENSRNOT00000006243 ENTREZGENE
  ENSRNOT00000006243.7 UniProtKB/TrEMBL
  ENSRNOT00000167674 ENTREZGENE
InterPro CSR-E3_Ligase_Protein UniProtKB/TrEMBL
  DC_STAMP-like UniProtKB/TrEMBL
KEGG Report rno:103690326 UniProtKB/TrEMBL
NCBI Gene Dcstamp ENTREZGENE
PANTHER DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN UniProtKB/TrEMBL
  DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN UniProtKB/TrEMBL
Pfam DC_STAMP UniProtKB/TrEMBL
PhenoGen Dcstamp PhenoGen
RatGTEx ENSRNOG00000004704 RatGTEx
  ENSRNOG00000057189 RatGTEx
UniProt A6HR82 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVC2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dcstamp  dendrocyte expressed seven transmembrane protein  LOC103690326  dendritic cell-specific transmembrane protein  Data merged from RGD:9418155 737654 PROVISIONAL
2014-08-25 LOC103690326  dendritic cell-specific transmembrane protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-10-16 Dcstamp  dendrocyte expressed seven transmembrane protein  Tm7sf4  transmembrane 7 superfamily member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tm7sf4  transmembrane 7 superfamily member 4   Tm7sf4_predicted  transmembrane 7 superfamily member 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tm7sf4_predicted  transmembrane 7 superfamily member 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED