Krt85 (keratin 85) - Rat Genome Database

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Gene: Krt85 (keratin 85) Rattus norvegicus
Analyze
Symbol: Krt85
Name: keratin 85
RGD ID: 1303149
Description: Human ortholog(s) of this gene implicated in ectodermal dysplasia 4. Orthologous to human KRT85 (keratin 85); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kb25; keratin 85, type II; keratin, type II cuticular Hb5; type II keratin Kb25
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,630,184 - 132,637,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,630,058 - 132,637,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,432,081 - 134,439,034 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,661,601 - 136,668,554 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,571,414 - 136,578,217 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,160,480 - 143,167,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,161,235 - 143,167,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,961,712 - 140,968,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,261,522 - 140,267,924 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,337,958 - 140,344,361 (-)NCBI
Celera7129,093,458 - 129,099,922 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18420582   PMID:23580065  


Genomics

Comparative Map Data
Krt85
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,630,184 - 132,637,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,630,058 - 132,637,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,432,081 - 134,439,034 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,661,601 - 136,668,554 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,571,414 - 136,578,217 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,160,480 - 143,167,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,161,235 - 143,167,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,961,712 - 140,968,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,261,522 - 140,267,924 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,337,958 - 140,344,361 (-)NCBI
Celera7129,093,458 - 129,099,922 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT85
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,360,006 - 52,367,481 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,360,006 - 52,367,481 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,753,790 - 52,761,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,040,057 - 51,047,576 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,040,058 - 51,047,576NCBI
Celera1252,399,944 - 52,407,463 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,797,342 - 49,804,861 (-)NCBIHuRef
CHM1_11252,720,439 - 52,727,956 (-)NCBICHM1_1
T2T-CHM13v2.01252,323,918 - 52,331,392 (-)NCBIT2T-CHM13v2.0
Krt85
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,413,569 - 101,422,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,413,801 - 101,422,054 (-)EnsemblGRCm39 Ensembl
MGSCv3715101,261,432 - 101,360,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,259,035 - 101,390,433 (-)NCBIMGSCv36mm8
Cytogenetic Map15F2NCBI
KRT85
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,706,246 - 2,713,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,706,246 - 2,713,688 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,540,082 - 43,547,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,705,580 - 2,713,022 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,705,580 - 2,713,022 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,722,350 - 2,729,799 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,708,276 - 2,715,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,938,333 - 43,945,782 (-)NCBIUU_Cfam_GSD_1.0
LOC100524022
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,679,199 - 17,690,711 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,679,196 - 17,686,714 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,028,801 - 18,036,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT85
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,506,232 - 48,516,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,508,290 - 48,514,827 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,577,755 - 197,585,259 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt85
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:65
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000011374
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium
Low 1 1 1 4 8 1
Below cutoff 10 5 2 4 2 1 1 10 12 16 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011374   ⟹   ENSRNOP00000011374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,630,447 - 132,637,049 (-)Ensembl
Rnor_6.0 Ensembl7143,161,235 - 143,167,772 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094891   ⟹   ENSRNOP00000080826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,630,520 - 132,637,049 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097854   ⟹   ENSRNOP00000078048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,630,058 - 132,637,049 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112723   ⟹   ENSRNOP00000091586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,630,447 - 132,636,988 (-)Ensembl
RefSeq Acc Id: NM_001008811   ⟹   NP_001008811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,630,184 - 132,637,061 (-)NCBI
Rnor_6.07143,161,308 - 143,167,772 (-)NCBI
Rnor_5.07140,961,712 - 140,968,249 (-)NCBI
RGSC_v3.47140,261,522 - 140,267,924 (-)RGD
Celera7129,093,458 - 129,099,922 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401219   ⟹   NP_001388148
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,630,184 - 132,637,061 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001008811   ⟸   NM_001008811
- Peptide Label: isoform 2
- UniProtKB: Q6IG09 (UniProtKB/TrEMBL),   A0A8I5ZSZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011374   ⟸   ENSRNOT00000011374
RefSeq Acc Id: ENSRNOP00000078048   ⟸   ENSRNOT00000097854
RefSeq Acc Id: ENSRNOP00000080826   ⟸   ENSRNOT00000094891
RefSeq Acc Id: ENSRNOP00000091586   ⟸   ENSRNOT00000112723
RefSeq Acc Id: NP_001388148   ⟸   NM_001401219
- Peptide Label: isoform 1
- UniProtKB: A7M777 (UniProtKB/TrEMBL),   F7FIJ1 (UniProtKB/TrEMBL)
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A7M777-F1-model_v2 AlphaFold A7M777 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695676
Promoter ID:EPDNEW_R6201
Type:single initiation site
Name:Krt85_1
Description:keratin 85
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,167,845 - 143,167,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303149 AgrOrtholog
BioCyc Gene G2FUF-31980 BioCyc
Ensembl Genes ENSRNOG00000008436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000032859 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011374.6 UniProtKB/TrEMBL
  ENSRNOT00000094891 ENTREZGENE
  ENSRNOT00000094891.1 UniProtKB/TrEMBL
  ENSRNOT00000097854 ENTREZGENE
  ENSRNOT00000097854.1 UniProtKB/TrEMBL
  ENSRNOT00000108728.1 UniProtKB/TrEMBL
  ENSRNOT00000112723.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
KEGG Report rno:407762 UniProtKB/TrEMBL
NCBI Gene 407762 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN, TYPE II CUTICULAR 87 UniProtKB/TrEMBL
  KERATIN, TYPE II CUTICULAR HB5 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PhenoGen Krt85 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008436 RatGTEx
  ENSRNOG00000032859 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
  Prefoldin UniProtKB/TrEMBL
UniProt A0A8I5ZSZ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFH1_RAT UniProtKB/TrEMBL
  A7M777 ENTREZGENE, UniProtKB/TrEMBL
  F7FIJ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6IG09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Krt85  keratin 85  Krt85  keratin 85, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt85  keratin 85, type II  Krt85  keratin 85  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt85  keratin 85  Kb25  type II keratin Kb25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Kb25  type II keratin Kb25      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Kb25  type II keratin Kb25      Symbol and Name status set to provisional 70820 PROVISIONAL