Eif4b (eukaryotic translation initiation factor 4B) - Rat Genome Database

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Gene: Eif4b (eukaryotic translation initiation factor 4B) Rattus norvegicus
Analyze
Symbol: Eif4b
Name: eukaryotic translation initiation factor 4B
RGD ID: 1306479
Description: Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in dendrite and neuronal cell body. Is active in postsynapse. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B); PARTICIPATES IN mTOR signaling pathway; translation initiation pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC300253; MGC94923
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,206,637 - 133,228,436 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx7134,967,947 - 134,989,735 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07137,197,317 - 137,219,105 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07137,176,131 - 137,197,919 (+)NCBIRnor_WKY
Rnor_6.07143,679,656 - 143,701,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,679,617 - 143,701,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,476,183 - 141,497,941 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,814,663 - 140,836,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,891,099 - 140,912,919 (+)NCBI
Celera7129,641,919 - 129,663,721 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clomipramine  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
glafenine  (EXP)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imipramine  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
LY294002  (ISO)
menadione  (ISO)
N,N-diethyl-m-toluamide  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
Tributyltin oxide  (ISO)
valproic acid  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. Eom T, etal., J Cell Biol. 2014 Oct 27;207(2):237-52. doi: 10.1083/jcb.201401005. Epub 2014 Oct 20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Jernigan CS, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1774-9. doi: 10.1016/j.pnpbp.2011.05.010. Epub 2011 May 23.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid. Nicolini C, etal., Acta Neuropathol Commun. 2015 Jan 20;3:3. doi: 10.1186/s40478-015-0184-4.
7. mRNA helicases: the tacticians of translational control. Parsyan A, etal., Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45. doi: 10.1038/nrm3083.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:16751776   PMID:22658674   PMID:22681889   PMID:25002582   PMID:30361391  


Genomics

Comparative Map Data
Eif4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,206,637 - 133,228,436 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx7134,967,947 - 134,989,735 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07137,197,317 - 137,219,105 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07137,176,131 - 137,197,919 (+)NCBIRnor_WKY
Rnor_6.07143,679,656 - 143,701,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,679,617 - 143,701,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,476,183 - 141,497,941 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,814,663 - 140,836,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,891,099 - 140,912,919 (+)NCBI
Celera7129,641,919 - 129,663,721 (+)NCBICelera
Cytogenetic Map7q36NCBI
EIF4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,006,456 - 53,042,215 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1253,006,282 - 53,042,215 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,400,240 - 53,435,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,686,329 - 51,722,260 (+)NCBINCBI36Build 36hg18NCBI36
Build 341251,686,518 - 51,722,259NCBI
Celera1253,047,026 - 53,083,725 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,442,753 - 50,479,145 (+)NCBIHuRef
CHM1_11253,366,781 - 53,402,607 (+)NCBICHM1_1
T2T-CHM13v2.01252,970,957 - 53,006,612 (+)NCBIT2T-CHM13v2.0
Eif4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,982,208 - 102,005,608 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,982,208 - 102,005,608 (+)EnsemblGRCm39 Ensembl
GRCm3815102,073,773 - 102,097,173 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,073,773 - 102,097,173 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,904,204 - 101,927,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,910,020 - 101,925,207 (+)NCBIMGSCv36mm8
Celera15104,229,434 - 104,252,932 (+)NCBICelera
Cytogenetic Map15F2NCBI
Eif4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458296,244 - 325,451 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458296,242 - 325,451 (+)NCBIChiLan1.0ChiLan1.0
EIF4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,495,103 - 36,530,657 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01235,714,260 - 35,749,991 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EIF4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,118,233 - 2,150,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,120,011 - 2,150,336 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,101,792 - 44,134,056 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,119,865 - 2,151,670 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,119,874 - 2,151,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,138,361 - 2,168,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,122,915 - 2,154,675 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,500,659 - 44,532,693 (+)NCBIUU_Cfam_GSD_1.0
Eif4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,794,787 - 62,823,441 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493651210,341,443 - 10,369,385 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,266,732 - 18,297,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,266,471 - 18,298,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,736,356 - 18,739,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,125,177 - 49,161,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,125,362 - 49,159,034 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,905,168 - 196,941,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,074,091 - 1,106,465 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH128420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,227,944 - 133,228,129 (+)MAPPERmRatBN7.2
Rnor_6.07143,700,961 - 143,701,145NCBIRnor6.0
Rnor_5.07141,497,450 - 141,497,634UniSTSRnor5.0
RGSC_v3.47140,835,994 - 140,836,178UniSTSRGSC3.4
Celera7129,663,230 - 129,663,414UniSTS
RH 3.4 Map71062.1UniSTS
Cytogenetic Map7q36UniSTS
RH137009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X57,570,372 - 57,570,574 (+)MAPPERmRatBN7.2
mRatBN7.2X109,595,553 - 109,595,749 (+)MAPPERmRatBN7.2
Rnor_6.0X117,737,876 - 117,738,071NCBIRnor6.0
Rnor_6.0X61,920,084 - 61,920,285NCBIRnor6.0
Rnor_5.0X62,510,292 - 62,510,493UniSTSRnor5.0
Rnor_5.0X117,875,265 - 117,875,460UniSTSRnor5.0
RGSC_v3.4X32,399,357 - 32,399,552UniSTSRGSC3.4
RGSC_v3.4X80,158,477 - 80,158,678UniSTSRGSC3.4
CeleraX58,008,350 - 58,008,551UniSTS
CeleraX108,964,837 - 108,965,033UniSTS
Cytogenetic MapXq14UniSTS
Cytogenetic MapXq22UniSTS
Cytogenetic Map7q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:551
Count of miRNA genes:271
Interacting mature miRNAs:319
Transcripts:ENSRNOT00000014033
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014033   ⟹   ENSRNOP00000014033
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,679,617 - 143,701,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,690,615 - 143,693,627 (+)Ensembl
RefSeq Acc Id: NM_001008324   ⟹   NP_001008325
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27133,206,637 - 133,228,436 (+)NCBI
Rnor_6.07143,679,656 - 143,701,452 (+)NCBI
Rnor_5.07141,476,183 - 141,497,941 (+)NCBI
RGSC_v3.47140,814,663 - 140,836,485 (+)RGD
Celera7129,641,919 - 129,663,721 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008325 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85933 (Get FASTA)   NCBI Sequence Viewer  
  EDL86866 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001008325   ⟸   NM_001008324
- UniProtKB: Q5RKG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014033   ⟸   ENSRNOT00000014033
Protein Domains
C2 tensin-type   Phorbol-ester/DAG-type   Phosphatase tensin-type   RRM   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RKG9-F1-model_v2 AlphaFold Q5RKG9 1-611 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695688
Promoter ID:EPDNEW_R6212
Type:multiple initiation site
Name:Eif4b_1
Description:eukaryotic translation initiation factor 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6213  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,679,642 - 143,679,702EPDNEW
RGD ID:13695702
Promoter ID:EPDNEW_R6213
Type:single initiation site
Name:Eif4b_2
Description:eukaryotic translation initiation factor 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6212  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,690,604 - 143,690,664EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306479 AgrOrtholog
BioCyc Gene G2FUF-31952 BioCyc
Ensembl Genes ENSRNOG00000010103 Ensembl
  ENSRNOG00000010588 UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014033.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014033.6 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112408 IMAGE-MGC_LOAD
InterPro C1-like_sf UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EIF4B UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tensin-like_SH2 UniProtKB/TrEMBL
  Tensin_C2-dom UniProtKB/TrEMBL
  Tensin_phosphatase UniProtKB/TrEMBL
  Tensin_PTB UniProtKB/TrEMBL
KEGG Report rno:300253 UniProtKB/TrEMBL
MGC_CLONE MGC:94923 IMAGE-MGC_LOAD
NCBI Gene 300253 ENTREZGENE
PANTHER PTHR23236:SF42 UniProtKB/TrEMBL
Pfam PTB UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Eif4b PhenoGen
PROSITE C2_TENSIN UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt F7FBH3_RAT UniProtKB/TrEMBL
  Q5RKG9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Eif4b  eukaryotic translation initiation factor 4B  Eif4b_predicted  eukaryotic translation initiation factor 4B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Eif4b_predicted  eukaryotic translation initiation factor 4B (predicted)      Symbol and Name status set to approved 70820 APPROVED