Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database

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Gene: Ppara (peroxisome proliferator activated receptor alpha) Rattus norvegicus
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Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 3369
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including behavioral response to nicotine; cellular response to fructose stimulus; and negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in fibrillar center and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcohol use disorder; hydrocephalus; hypertension; liver disease (multiple); and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (3-phenoxyphenyl)methanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7118,712,412 - 118,780,714 (+)EnsemblGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7120,748,091 - 120,810,877 (+)NCBI
Lyon_Normotensive7121,693,926 - 121,756,763 (+)NCBI
Lyon_Hypertensive7121,819,819 - 121,882,650 (+)NCBI
F344_StmMcwi7120,312,037 - 120,374,844 (+)NCBI
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
alcohol use disorder  (IEP)
alcohol-associated liver disease  (ISO)
alcoholic hepatitis  (IEP)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (IDA)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (IEP,ISO)
clear cell renal cell carcinoma  (ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISS)
Diabetic Cardiomyopathies  (IDA)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
hepatocellular carcinoma  (IAGP)
Hepatomegaly  (ISO)
hydrocephalus  (IEP)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (IEP,IMP,ISO)
hypertensive encephalopathy  (IDA)
Hypertensive Nephropathy  (IDA)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (IEP)
Inflammation  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
melanoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP,ISO)
morbid obesity  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (IEP,ISO)
ovarian serous cystadenocarcinoma  (ISO)
periodontitis  (IDA)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (IDA,ISO)
sarcoma  (ISO)
schizophrenia  (ISS)
Sepsis  (ISO)
steatotic liver disease  (IEP,ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uterine corpus endometrial carcinoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-acanthoic acid  (ISO)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(3-phenoxyphenyl)methanol  (EXP)
(9E,11E)-octadecadienoic acid  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dichlorobenzene  (ISO)
1,8-cineole  (ISO)
1-benzofuran  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
13-HPODE  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Ethylhexanoic acid  (EXP,ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-phenoxybenzoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acadesine  (EXP,ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
Aescin  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (EXP,ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
Ankaflavin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arachidonoyl-CoA  (ISO)
Arctiin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
Azoxymethane  (ISO)
benzalkonium chloride  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (EXP)
berberine  (EXP,ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
betulinic acid  (ISO)
Betulonic acid  (ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) adipate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bisphenol F diglycidyl ether  (ISO)
bleomycin A2  (ISO)
boron atom  (EXP)
bromuconazole  (EXP)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (EXP)
camphor  (ISO)
cannabidiol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP)
carbaryl  (EXP)
carbendazim  (ISO)
carbon dioxide  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefuroxime  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chitosan  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cholic acid  (EXP,ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (EXP,ISO)
citronellol  (ISO)
CL316243  (EXP)
Clinofibrate  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cyanamide  (EXP)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
DAPT  (EXP)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofop-methyl  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
difenoconazole  (ISO)
diheptyl phthalate  (ISO)
dihydroartemisinin  (EXP,ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
enalapril  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etomoxir  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (ISO)
fentin chloride  (EXP)
fipronil  (ISO)
flufenamic acid  (ISO)
fluoxetine  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (EXP)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-linolenic acid  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
Gingerenone A  (ISO)
ginsenoside Rf  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine betaine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gossypetin  (ISO)
gramine  (ISO)
griseofulvin  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 501516  (ISO)
GW 6471  (EXP,ISO)
GW 7647  (EXP,ISO)
HET0016  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (ISO)
ibuprofen  (EXP,ISO)
icariin  (ISO)
idebenone  (EXP)
imidacloprid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isosilybin  (ISO)
ivermectin  (ISO)
Jujuboside A  (ISO)
ketoconazole  (EXP)
L-methionine  (EXP,ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene B4  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (EXP)
LY294002  (ISO)
lycopene  (ISO)
malathion  (ISO)
malonyl-CoA  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
meldonium  (ISO)
mercury dichloride  (EXP,ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methiocarb  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP)
methylparaben  (EXP)
metoprolol  (EXP)
mevalonic acid  (ISO)
miquelianin  (EXP)
monascin  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (EXP,ISO)
myricetin  (EXP)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-phenylthiourea  (ISO)
nafenopin  (EXP,ISO)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
nefazodone  (ISO)
neohesperidin  (ISO)
nicotine  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (EXP)
NMN zwitterion  (ISO)
nonanoic acid  (ISO)
norathyriol  (ISO)
NS-398  (EXP,ISO)
obeticholic acid  (EXP,ISO)
octadecanoic acid  (ISO)
octanoic acid  (ISO)
octocrylene  (ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleoyl ethanolamide  (ISO)
oleoyl-CoA  (ISO)
orotic acid  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
oxazepam  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
palmitoyl ethanolamide  (EXP)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
penconazole  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic acid  (ISO)
phytanic acid  (ISO)
phytol  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pravastatin  (EXP,ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
propiconazole  (ISO)
propylparaben  (EXP)
propyzamide  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxal 5'-phosphate  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quizalofop-ethyl  (EXP)
raffinose  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
sabinene  (ISO)
saccharin  (ISO)
salicylamide  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (ISO)
sevoflurane  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
Sodium oleate  (ISO)
spathulenol  (ISO)
sphingosine 1-phosphate  (EXP)
spironolactone  (ISO)
stearoyl-CoA  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
Sudan III  (EXP,ISO)
sulfluramid  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tectoridin  (ISO)
tectorigenin  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
testosterone cypionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetradecanoic acid  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolazoline  (ISO)
tolmetin  (ISO)
tomelukast  (ISO)
Torularhodin  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
tyloxapol  (ISO)
ubiquinones  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
voriconazole  (EXP)
WIN 55212-2  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (IDA)
cell differentiation  (IBA)
cellular response to fructose stimulus  (IEP)
cellular response to starvation  (IEA,ISO)
circadian regulation of gene expression  (IEA,ISO,ISS)
DNA-templated transcription  (IEA)
enamel mineralization  (ISO)
epidermis development  (ISO)
fatty acid beta-oxidation  (ISO)
fatty acid metabolic process  (IEA,IMP,ISO)
gene expression  (ISO)
heart development  (IEP)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IBA,IEA)
lactation  (IEP)
lipid metabolic process  (ISO)
lipoprotein metabolic process  (IMP)
negative regulation of appetite  (IEA,ISO,ISS)
negative regulation of blood pressure  (IMP)
negative regulation of cardiac muscle hypertrophy  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cholesterol storage  (IEA,ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (IEA,ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of leukocyte cell-cell adhesion  (IEA,ISO)
negative regulation of macrophage derived foam cell differentiation  (IEA,ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein binding  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
nitric oxide metabolic process  (IEP)
nuclear receptor-mediated steroid hormone signaling pathway  (IEA)
peroxisome proliferator activated receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO,ISS)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (IEA,ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
protein ubiquitination  (ISO)
regulation of circadian rhythm  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IDA,IEA)
regulation of fatty acid metabolic process  (IEA,ISO,TAS)
regulation of gene expression  (ISO)
regulation of ketone metabolic process  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to ethanol  (IEP)
response to fatty acid  (ISO)
response to glucose  (ISO)
response to hypoxia  (IDA,IEP)
response to insulin  (IMP)
response to nutrient  (IEP)
response to stress  (IEA)
signal transduction  (IEA)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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36. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Jeong S and Yoon M, Exp Mol Med. 2009 Jun 30;41(6):397-405.
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52. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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57. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
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60. GOA pipeline RGD automated data pipeline
61. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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69. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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74. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
75. Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice. Yaacob NS, etal., J Clin Immunol. 2009 Sep;29(5):595-602. Epub 2009 May 27.
76. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
77. Lack of PPARalpha exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress. Yoo SH, etal., Toxicol Lett. 2011 Apr 10;202(1):23-9. Epub 2011 Jan 22.
78. Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. Zak I, etal., Clin Chim Acta. 2005 Dec;362(1-2):110-8. Epub 2005 Jul 25.
Additional References at PubMed
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PMID:23592661   PMID:23825665   PMID:23933501   PMID:23958344   PMID:24090815   PMID:24092543   PMID:24128860   PMID:24143360   PMID:24244369   PMID:24288751   PMID:24389592   PMID:24521009  
PMID:24562305   PMID:24639097   PMID:24735884   PMID:24876382   PMID:24993341   PMID:25135355   PMID:25186103   PMID:25617357   PMID:25636810   PMID:25658458   PMID:25796423   PMID:25847140  
PMID:25976666   PMID:26092479   PMID:26194065   PMID:26406917   PMID:26508837   PMID:26519879   PMID:26654758   PMID:26875149   PMID:27050838   PMID:27108888   PMID:27224243   PMID:27248050  
PMID:27457507   PMID:27665777   PMID:27665778   PMID:27927051   PMID:28065827   PMID:28385499   PMID:28550910   PMID:28760335   PMID:29339422   PMID:29440279   PMID:29568903   PMID:29740932  
PMID:30635067   PMID:30890453   PMID:31163124   PMID:31402171   PMID:32102354   PMID:32298755   PMID:32558488   PMID:32902936   PMID:32908637   PMID:33278012   PMID:34233552   PMID:36219352  
PMID:36401357   PMID:36654276   PMID:37204637   PMID:38956068  


Genomics

Comparative Map Data
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7118,712,412 - 118,780,714 (+)EnsemblGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7120,748,091 - 120,810,877 (+)NCBI
Lyon_Normotensive7121,693,926 - 121,756,763 (+)NCBI
Lyon_Hypertensive7121,819,819 - 121,882,650 (+)NCBI
F344_StmMcwi7120,312,037 - 120,374,844 (+)NCBI
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,149,924 - 46,243,755 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh372246,546,429 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBICelera
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
T2T-CHM13v2.02246,635,225 - 46,728,457 (+)NCBIT2T-CHM13v2.0
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,618,656 - 85,687,067 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBIMGSCv36mm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBINHGRI_mPanPan1
PanPan1.12245,218,364 - 45,302,970 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1019,862,969 - 19,928,467 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01020,667,818 - 20,740,885 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,668,580 - 20,740,947 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,394,544 - 20,460,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,707,323 - 20,772,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,889,156 - 20,954,630 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap162,892,428 - 2,953,235 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_0244049453,665,412 - 3,725,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,672,460 - 3,725,626 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,741 - 3,364,239 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1194,593,880 - 4,695,280 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11928,614,892 - 28,709,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Ppara
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl52,691,360 - 2,742,512 (-)Ensembl
Ppara
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11255,087,375 - 255,151,125 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Ppara
452 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:149
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000030082
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7118556868125929417Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D15Rat79  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07126,352,198 - 126,352,352UniSTSRnor5.0
RGSC_v3.47123,751,137 - 123,751,291UniSTSRGSC3.4
Celera7113,146,585 - 113,146,739UniSTS
RGSC_v3.17123,785,366 - 123,785,521RGD
FHH x ACI Map755.57UniSTS
Cytogenetic Map7q34UniSTS
D7Rat233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,854,121 - 116,854,276 (+)MAPPERmRatBN7.2
Rnor_6.07126,640,561 - 126,640,715NCBIRnor6.0
Rnor_5.07126,352,198 - 126,352,352UniSTSRnor5.0
Rnor_5.07126,352,197 - 126,352,352NCBIRnor5.0
Rnor_5.07126,352,196 - 126,352,352NCBIRnor5.0
RGSC_v3.47123,751,136 - 123,751,291RGDRGSC3.4
RGSC_v3.47123,751,137 - 123,751,291UniSTSRGSC3.4
Celera7113,146,585 - 113,146,739UniSTS
RGSC_v3.17123,785,235 - 123,785,693RGD
FHH x ACI Map755.57UniSTS
FHH x ACI Map755.57RGD
Cytogenetic Map7q34UniSTS
D7Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87118,732,505 - 118,732,745 (+)Marker Load Pipeline
mRatBN7.27116,852,655 - 116,852,895 (+)MAPPERmRatBN7.2
Rnor_6.07126,639,095 - 126,639,334NCBIRnor6.0
Rnor_5.07126,350,732 - 126,350,971UniSTSRnor5.0
RGSC_v3.47123,749,673 - 123,749,912UniSTSRGSC3.4
RGSC_v3.47123,749,672 - 123,749,912RGDRGSC3.4
Celera7113,145,123 - 113,145,362UniSTS
RGSC_v3.17123,783,902 - 123,784,142RGD
Cytogenetic Map7q34UniSTS
D7Uwm22  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87118,716,298 - 118,716,434 (+)Marker Load Pipeline
mRatBN7.27116,836,447 - 116,836,583 (+)MAPPERmRatBN7.2
Rnor_6.07126,622,888 - 126,623,023NCBIRnor6.0
Rnor_5.07126,334,525 - 126,334,660UniSTSRnor5.0
RGSC_v3.47123,733,466 - 123,733,601UniSTSRGSC3.4
Celera7113,128,915 - 113,129,050UniSTS
RGSC_v3.17123,767,695 - 123,767,831RGD
Cytogenetic Map7q34UniSTS
PMC113093P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,894,866 - 116,895,185 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,273 - 126,681,591NCBIRnor6.0
Rnor_5.07126,392,269 - 126,392,587UniSTSRnor5.0
RGSC_v3.47123,806,611 - 123,806,929UniSTSRGSC3.4
Celera7113,186,925 - 113,187,243UniSTS
Cytogenetic Map7q34UniSTS
Ppara  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,160 - 116,895,694 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,567 - 126,682,100NCBIRnor6.0
Rnor_5.07126,392,563 - 126,393,096UniSTSRnor5.0
RGSC_v3.47123,806,905 - 123,807,438UniSTSRGSC3.4
Celera7113,187,219 - 113,187,752UniSTS
Cytogenetic Map7q34UniSTS
RH94816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,167 - 116,895,331 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,574 - 126,681,737NCBIRnor6.0
Rnor_5.07126,392,570 - 126,392,733UniSTSRnor5.0
RGSC_v3.47123,806,912 - 123,807,075UniSTSRGSC3.4
Celera7113,187,226 - 113,187,389UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS
RH94495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,165 - 116,895,327 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,572 - 126,681,733NCBIRnor6.0
Rnor_5.07126,392,568 - 126,392,729UniSTSRnor5.0
RGSC_v3.47123,806,910 - 123,807,071UniSTSRGSC3.4
Celera7113,187,224 - 113,187,385UniSTS
Cytogenetic Map7q34UniSTS
RH140266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,893,729 - 116,893,929 (+)MAPPERmRatBN7.2
Rnor_6.07126,680,136 - 126,680,335NCBIRnor6.0
Rnor_5.07126,391,132 - 126,391,331UniSTSRnor5.0
RGSC_v3.47123,805,474 - 123,805,673UniSTSRGSC3.4
Celera7113,185,788 - 113,185,987UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS
BI282868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,168 - 116,895,322 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,575 - 126,681,728NCBIRnor6.0
Rnor_5.07126,392,571 - 126,392,724UniSTSRnor5.0
RGSC_v3.47123,806,913 - 123,807,066UniSTSRGSC3.4
Celera7113,187,227 - 113,187,380UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
276 154 728 1589 4011 1011 1722 128 874 471 856 154 5360 2563 437 3925 37 1390 731 902 160 158

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M88592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000030082   ⟹   ENSRNOP00000038651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7118,712,534 - 118,780,714 (+)Ensembl
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)Ensembl
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078928   ⟹   ENSRNOP00000074329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7126,641,952 - 126,681,708 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136133   ⟹   ENSRNOP00000112415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7118,712,412 - 118,780,714 (+)Ensembl
RefSeq Acc Id: NM_013196   ⟹   NP_037328
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,607 - 118,775,193 (+)NCBI
mRatBN7.27116,832,756 - 116,895,346 (+)NCBI
Dahl_SR_JrHsd7120,748,091 - 120,810,877 (+)NCBI
Lyon_Normotensive7121,693,926 - 121,756,763 (+)NCBI
Lyon_Hypertensive7121,819,819 - 121,882,650 (+)NCBI
F344_StmMcwi7120,312,037 - 120,374,844 (+)NCBI
Rnor_6.07126,619,196 - 126,681,752 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
RGSC_v3.47123,729,774 - 123,807,090 (+)RGD
Celera7113,125,201 - 113,187,404 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242152   ⟹   XP_006242214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,412 - 118,780,723 (+)NCBI
mRatBN7.27116,832,633 - 116,900,878 (+)NCBI
Rnor_6.07126,619,087 - 126,687,282 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242153   ⟹   XP_006242215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,326 - 118,780,723 (+)NCBI
mRatBN7.27116,832,426 - 116,900,878 (+)NCBI
Rnor_6.07126,618,987 - 126,687,282 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242154   ⟹   XP_006242216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,261 - 118,780,723 (+)NCBI
mRatBN7.27116,832,405 - 116,900,878 (+)NCBI
Rnor_6.07126,618,872 - 126,687,282 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078501   ⟹   XP_038934429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,261 - 118,780,723 (+)NCBI
mRatBN7.27116,832,406 - 116,900,878 (+)NCBI
RefSeq Acc Id: NP_037328   ⟸   NM_013196
- UniProtKB: P37230 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242216   ⟸   XM_006242154
- Peptide Label: isoform X1
- UniProtKB: A0ACJ1LUF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242215   ⟸   XM_006242153
- Peptide Label: isoform X1
- UniProtKB: A0ACJ1LUF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242214   ⟸   XM_006242152
- Peptide Label: isoform X1
- UniProtKB: A0ACJ1LUF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038651   ⟸   ENSRNOT00000030082
Ensembl Acc Id: ENSRNOP00000074329   ⟸   ENSRNOT00000078928
RefSeq Acc Id: XP_038934429   ⟸   XM_039078501
- Peptide Label: isoform X2
- UniProtKB: P37230 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000112415   ⟸   ENSRNOT00000136133
Protein Domains
NR LBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37230-F1-model_v2 AlphaFold P37230 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695568
Promoter ID:EPDNEW_R6092
Type:initiation region
Name:Ppara_1
Description:peroxisome proliferator activated receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07126,619,141 - 126,619,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3369 AgrOrtholog
BioCyc Gene G2FUF-32527 BioCyc
Ensembl Genes ENSRNOG00000021463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055032099 UniProtKB/Swiss-Prot
  ENSRNOG00060023253 UniProtKB/Swiss-Prot
  ENSRNOG00065033228 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000030082 ENTREZGENE
  ENSRNOT00000136133 ENTREZGENE
  ENSRNOT00000136133.1 UniProtKB/Swiss-Prot
  ENSRNOT00055055491 UniProtKB/Swiss-Prot
  ENSRNOT00060040199 UniProtKB/Swiss-Prot
  ENSRNOT00065057129 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro 1Cnucl_rcpt UniProtKB/Swiss-Prot
  NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR1 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  PPAR-alpha UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:25747 UniProtKB/Swiss-Prot
NCBI Gene 25747 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB PPARA RGD
PhenoGen Ppara PhenoGen
PRINTS PROXISOMEPAR UniProtKB/Swiss-Prot
  PROXISOMPAAR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021463 RatGTEx
  ENSRNOG00055032099 RatGTEx
  ENSRNOG00060023253 RatGTEx
  ENSRNOG00065033228 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC228504
UniProt A0ACJ1LUF8 ENTREZGENE, UniProtKB/TrEMBL
  P37230 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ppara  Peroxisome proliferator activated receptor alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs agoninst WY14643 stimulated the secretion of apoB-100 in primary hepatocytes 625405
gene_expression enriched in liver, heart, skeletal muscle, kidney, and intestine 729544
gene_process activation decreases triglyceride biosynthesis 625405
gene_process mediates lipid homeostasis, especially fatty acid oxidation and lipoprotein metabolism 625405
gene_process mediates lipid homeostasis, especially fatty acid oxidation and lipoprotein metabolism 729544