Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database

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Gene: Ppara (peroxisome proliferator activated receptor alpha) Rattus norvegicus
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Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 3369
Description: Exhibits several functions, including MDM2/MDM4 family protein binding activity; nuclear receptor activity; and transcription factor binding activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Localizes to nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (3-phenoxyphenyl)methanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27116,832,405 - 116,900,878 (+)NCBI
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (IEP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (IDA)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (IEP,ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISS)
Diabetic Cardiomyopathies  (IDA)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (IEP,ISO)
hepatocellular carcinoma  (IAGP)
Hepatomegaly  (ISO)
hydrocephalus  (IEP)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (IEP,IMP,ISO)
hypertensive encephalopathy  (IDA)
Hypertensive Nephropathy  (IDA)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
periodontitis  (IDA)
Phelan-McDermid syndrome  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (IDA,ISO)
Sepsis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(3-phenoxyphenyl)methanol  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dichlorobenzene  (ISO)
1-benzofuran  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
13-HPODE  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Ethylhexanoic acid  (EXP,ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-phenoxybenzoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9-cis-retinoic acid  (ISO)
9E,11E-octadecadienoic acid  (ISO)
acadesine  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (EXP,ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arachidonoyl-CoA  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (EXP)
berberine  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bisphenol F diglycidyl ether  (ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbaryl  (EXP)
carbon dioxide  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefuroxime  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chitosan  (EXP)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (ISO)
citronellol  (ISO)
Clinofibrate  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cyanamide  (EXP)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
daunorubicin  (EXP)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofop-methyl  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diheptyl phthalate  (ISO)
dihydroartemisinin  (EXP,ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (ISO)
flufenamic acid  (ISO)
fluoxetine  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (EXP)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-linolenic acid  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
ginsenoside Rf  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
griseofulvin  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 501516  (ISO)
GW 6471  (EXP,ISO)
GW 7647  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (ISO)
ibuprofen  (EXP,ISO)
icariin  (ISO)
idebenone  (EXP)
imidacloprid  (ISO)
indometacin  (EXP,ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
leukotriene B4  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (EXP)
LY294002  (ISO)
malathion  (ISO)
malonyl-CoA  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
meldonium  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methiocarb  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP)
methylparaben  (EXP)
metoprolol  (EXP)
miquelianin  (EXP)
monascin  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
myricetin  (EXP)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-phenylthiourea  (ISO)
nafenopin  (EXP,ISO)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
nicotine  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
NMN zwitterion  (ISO)
nonanoic acid  (ISO)
norathyriol  (ISO)
NS-398  (EXP,ISO)
obeticholic acid  (EXP,ISO)
octadecanoic acid  (ISO)
octanoic acid  (ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleoyl ethanolamide  (ISO)
oleoyl-CoA  (ISO)
orotic acid  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
oxazepam  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
palmitoyl ethanolamide  (EXP)
palmitoyl-CoA  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
penconazole  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic acid  (ISO)
phytanic acid  (ISO)
phytol  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
propiconazole  (ISO)
propylparaben  (EXP)
propyzamide  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (EXP)
puerarin  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxal 5'-phosphate  (EXP)
quercetin  (EXP,ISO)
quinoline  (ISO)
quizalofop-ethyl  (EXP)
raffinose  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rotenone  (EXP)
rutin  (EXP)
saccharin  (ISO)
salicylamide  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
sphingosine 1-phosphate  (EXP)
spironolactone  (ISO)
stearoyl-CoA  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
Sudan III  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tectoridin  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
testosterone cypionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetradecanoic acid  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolazoline  (ISO)
tolmetin  (ISO)
tomelukast  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ubiquinones  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (IDA)
cell differentiation  (IBA)
cellular response to starvation  (ISO)
circadian regulation of gene expression  (ISO,ISS)
enamel mineralization  (ISO)
epidermis development  (ISO)
fatty acid metabolic process  (IBA,IMP,ISO)
heart development  (IEP)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IEA)
lipid localization  (IEP)
lipoprotein metabolic process  (IMP)
negative regulation of appetite  (ISO,ISS)
negative regulation of blood pressure  (IMP)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cholesterol storage  (IBA,ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of neuron death  (IDA,IMP)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of protein binding  (IMP)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of viral genome replication  (ISO)
regulation of cellular ketone metabolic process  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of fatty acid metabolic process  (ISO,TAS)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (IBA)
regulation of lipid storage  (IEP)
regulation of transcription, DNA-templated  (IDA)
response to ethanol  (IEP)
response to hypoxia  (IDA)
response to insulin  (IMP)
response to lipid  (IBA)
response to organic cyclic compound  (IEP)
steroid hormone mediated signaling pathway  (IEA)
wound healing  (ISO)

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:8041794   PMID:8828512   PMID:9113987   PMID:9488698   PMID:9626662   PMID:9748239   PMID:11514592   PMID:12015306   PMID:12065722   PMID:12083418   PMID:12118155   PMID:12354675  
PMID:12425954   PMID:12485431   PMID:12700342   PMID:12730403   PMID:12802337   PMID:12914523   PMID:12941763   PMID:12955147   PMID:12962497   PMID:14871557   PMID:15007068   PMID:15123613  
PMID:15232616   PMID:15237213   PMID:15253107   PMID:15254779   PMID:15313227   PMID:15459119   PMID:15528772   PMID:15585952   PMID:15639194   PMID:15838301   PMID:15838320   PMID:15878969  
PMID:16079133   PMID:16271724   PMID:16328010   PMID:16341933   PMID:16484294   PMID:16563274   PMID:16571721   PMID:16584836   PMID:16595700   PMID:16887056   PMID:17011512   PMID:17130498  
PMID:17164430   PMID:17164438   PMID:17234604   PMID:17326204   PMID:17352811   PMID:17431031   PMID:17451160   PMID:17597616   PMID:17610352   PMID:17643263   PMID:17644405   PMID:17683485  
PMID:17963722   PMID:17970749   PMID:17991720   PMID:18079124   PMID:18079279   PMID:18098300   PMID:18202540   PMID:18205750   PMID:18239634   PMID:18283099   PMID:18301758   PMID:18304850  
PMID:18374665   PMID:18375207   PMID:18434116   PMID:18543250   PMID:18665039   PMID:18696335   PMID:18701451   PMID:18703563   PMID:18704104   PMID:18783396   PMID:18818403   PMID:18836674  
PMID:18989661   PMID:19080338   PMID:19114110   PMID:19151258   PMID:19154956   PMID:19304987   PMID:19320717   PMID:19345745   PMID:19403437   PMID:19403796   PMID:19570670   PMID:19596004  
PMID:19699196   PMID:19878707   PMID:19955185   PMID:20159955   PMID:20211032   PMID:20385772   PMID:20567977   PMID:20570248   PMID:20644547   PMID:20837115   PMID:20923527   PMID:21076970  
PMID:21092650   PMID:21205480   PMID:21282101   PMID:21323895   PMID:21540177   PMID:21554431   PMID:21618160   PMID:21636785   PMID:21813270   PMID:22066269   PMID:22083161   PMID:22245887  
PMID:22249025   PMID:22674675   PMID:22722259   PMID:22837722   PMID:22917842   PMID:23041501   PMID:23209793   PMID:23223967   PMID:23394525   PMID:23468969   PMID:23505321   PMID:23525500  
PMID:23592661   PMID:23825665   PMID:23933501   PMID:23958344   PMID:24090815   PMID:24092543   PMID:24128860   PMID:24143360   PMID:24244369   PMID:24288751   PMID:24389592   PMID:24521009  
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PMID:27248050   PMID:27457507   PMID:27665777   PMID:27665778   PMID:27927051   PMID:28065827   PMID:28385499   PMID:28550910   PMID:28760335   PMID:28821620   PMID:29339422   PMID:29440279  
PMID:29568903   PMID:29740932   PMID:30635067   PMID:30890453   PMID:31163124   PMID:31402171   PMID:32102354  


Genomics

Comparative Map Data
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27116,832,405 - 116,900,878 (+)NCBI
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2246,150,521 - 46,243,756 (+)EnsemblGRCh38hg38GRCh38
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372246,546,429 - 46,639,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBINCBI36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBI
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39mm39
GRCm39 Ensembl1585,619,184 - 85,687,020 (+)Ensembl
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBImm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12245,218,364 - 45,302,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensemblpanpan1.1panPan2
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,862,969 - 19,928,467 (-)NCBI
ROS_Cfam_1.01020,667,818 - 20,740,885 (-)NCBI
UMICH_Zoey_3.11020,394,544 - 20,460,174 (-)NCBI
UNSW_CanFamBas_1.01020,707,323 - 20,772,988 (-)NCBI
UU_Cfam_GSD_1.01020,889,156 - 20,954,630 (-)NCBI
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,665,412 - 3,725,573 (-)NCBI
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,708 - 3,366,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223491
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,614,892 - 28,709,272 (+)NCBI
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)Ensembl
Ppara
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBI

Position Markers
D15Rat79  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07126,352,198 - 126,352,352UniSTSRnor5.0
RGSC_v3.47123,751,137 - 123,751,291UniSTSRGSC3.4
RGSC_v3.17123,785,366 - 123,785,521RGD
Celera7113,146,585 - 113,146,739UniSTS
FHH x ACI Map755.57UniSTS
Cytogenetic Map7q34UniSTS
D7Rat233  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,640,561 - 126,640,715NCBIRnor6.0
Rnor_5.07126,352,197 - 126,352,352NCBIRnor5.0
Rnor_5.07126,352,198 - 126,352,352UniSTSRnor5.0
Rnor_5.07126,352,196 - 126,352,352NCBIRnor5.0
RGSC_v3.47123,751,137 - 123,751,291UniSTSRGSC3.4
RGSC_v3.47123,751,136 - 123,751,291RGDRGSC3.4
RGSC_v3.17123,785,235 - 123,785,693RGD
Celera7113,146,585 - 113,146,739UniSTS
FHH x ACI Map755.57RGD
FHH x ACI Map755.57UniSTS
Cytogenetic Map7q34UniSTS
D7Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,639,095 - 126,639,334NCBIRnor6.0
Rnor_5.07126,350,732 - 126,350,971UniSTSRnor5.0
RGSC_v3.47123,749,672 - 123,749,912RGDRGSC3.4
RGSC_v3.47123,749,673 - 123,749,912UniSTSRGSC3.4
RGSC_v3.17123,783,902 - 123,784,142RGD
Celera7113,145,123 - 113,145,362UniSTS
Cytogenetic Map7q34UniSTS
D7Uwm22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,622,888 - 126,623,023NCBIRnor6.0
Rnor_5.07126,334,525 - 126,334,660UniSTSRnor5.0
RGSC_v3.47123,733,466 - 123,733,601UniSTSRGSC3.4
RGSC_v3.17123,767,695 - 123,767,831RGD
Celera7113,128,915 - 113,129,050UniSTS
Cytogenetic Map7q34UniSTS
PMC113093P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,681,273 - 126,681,591NCBIRnor6.0
Rnor_5.07126,392,269 - 126,392,587UniSTSRnor5.0
RGSC_v3.47123,806,611 - 123,806,929UniSTSRGSC3.4
Celera7113,186,925 - 113,187,243UniSTS
Cytogenetic Map7q34UniSTS
Ppara  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,681,567 - 126,682,100NCBIRnor6.0
Rnor_5.07126,392,563 - 126,393,096UniSTSRnor5.0
RGSC_v3.47123,806,905 - 123,807,438UniSTSRGSC3.4
Celera7113,187,219 - 113,187,752UniSTS
Cytogenetic Map7q34UniSTS
RH94816  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,681,574 - 126,681,737NCBIRnor6.0
Rnor_5.07126,392,570 - 126,392,733UniSTSRnor5.0
RGSC_v3.47123,806,912 - 123,807,075UniSTSRGSC3.4
Celera7113,187,226 - 113,187,389UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS
RH94495  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,681,572 - 126,681,733NCBIRnor6.0
Rnor_5.07126,392,568 - 126,392,729UniSTSRnor5.0
RGSC_v3.47123,806,910 - 123,807,071UniSTSRGSC3.4
Celera7113,187,224 - 113,187,385UniSTS
Cytogenetic Map7q34UniSTS
RH140266  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,680,136 - 126,680,335NCBIRnor6.0
Rnor_5.07126,391,132 - 126,391,331UniSTSRnor5.0
RGSC_v3.47123,805,474 - 123,805,673UniSTSRGSC3.4
Celera7113,185,788 - 113,185,987UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS
BI282868  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,681,575 - 126,681,728NCBIRnor6.0
Rnor_5.07126,392,571 - 126,392,724UniSTSRnor5.0
RGSC_v3.47123,806,913 - 123,807,066UniSTSRGSC3.4
Celera7113,187,227 - 113,187,380UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies