Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database

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Gene: Ppara (peroxisome proliferator activated receptor alpha) Rattus norvegicus
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Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 3369
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including behavioral response to nicotine; cellular response to fructose stimulus; and negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; hydrocephalus; hypertension; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (3-phenoxyphenyl)methanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (IEP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (IDA)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (IEP,ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Diabetic Cardiomyopathies  (IDA)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IAGP)
Hepatomegaly  (ISO)
hydrocephalus  (IEP)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (IEP,IMP,ISO)
hypertensive encephalopathy  (IDA)
Hypertensive Nephropathy  (IDA)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (IEP)
Inflammation  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP,ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (IEP,ISO)
periodontitis  (IDA)
Phelan-McDermid syndrome  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (IDA,ISO)
schizophrenia  (ISS)
Sepsis  (ISO)
steatotic liver disease  (IEP,ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(3-phenoxyphenyl)methanol  (EXP)
(9E,11E)-octadecadienoic acid  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dichlorobenzene  (ISO)
1-benzofuran  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
13-HPODE  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Ethylhexanoic acid  (EXP,ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-phenoxybenzoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acadesine  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (EXP,ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
angiotensin II  (EXP)
Ankaflavin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arachidonoyl-CoA  (ISO)
Arctiin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (EXP)
berberine  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bisphenol F diglycidyl ether  (ISO)
bleomycin A2  (ISO)
boron atom  (EXP)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (EXP)
cannabidiol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP)
carbaryl  (EXP)
carbon dioxide  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefuroxime  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chitosan  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (EXP,ISO)
citronellol  (ISO)
Clinofibrate  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cyanamide  (EXP)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
DAPT  (EXP)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofop-methyl  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
difenoconazole  (ISO)
diheptyl phthalate  (ISO)
dihydroartemisinin  (EXP,ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
enalapril  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (ISO)
fentin chloride  (EXP)
flufenamic acid  (ISO)
fluoxetine  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (EXP)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-linolenic acid  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
Gingerenone A  (ISO)
ginsenoside Rf  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine betaine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
gramine  (ISO)
griseofulvin  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 501516  (ISO)
GW 6471  (EXP,ISO)
GW 7647  (EXP,ISO)
HET0016  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (ISO)
ibuprofen  (EXP,ISO)
icariin  (ISO)
idebenone  (EXP)
Ile(5)-angiotensin II  (EXP)
imidacloprid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isosilybin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene B4  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (EXP)
LY294002  (ISO)
lycopene  (ISO)
malathion  (ISO)
malonyl-CoA  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
meldonium  (ISO)
mercury dichloride  (EXP,ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methiocarb  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP)
methylparaben  (EXP)
metoprolol  (EXP)
mevalonic acid  (ISO)
miquelianin  (EXP)
monascin  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (EXP,ISO)
myricetin  (EXP)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-phenylthiourea  (ISO)
nafenopin  (EXP,ISO)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
nefazodone  (ISO)
nicotine  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (EXP)
NMN zwitterion  (ISO)
nonanoic acid  (ISO)
norathyriol  (ISO)
NS-398  (EXP,ISO)
obeticholic acid  (EXP,ISO)
octadecanoic acid  (ISO)
octanoic acid  (ISO)
octocrylene  (ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleoyl ethanolamide  (ISO)
oleoyl-CoA  (ISO)
orotic acid  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
oxazepam  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
palmitoyl ethanolamide  (EXP)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
penconazole  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic acid  (ISO)
phytanic acid  (ISO)
phytol  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
propiconazole  (ISO)
propylparaben  (EXP)
propyzamide  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxal 5'-phosphate  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quizalofop-ethyl  (EXP)
raffinose  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
saccharin  (ISO)
salicylamide  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
Sodium oleate  (ISO)
sphingosine 1-phosphate  (EXP)
spironolactone  (ISO)
stearoyl-CoA  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
Sudan III  (EXP,ISO)
sulfluramid  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tectoridin  (ISO)
tectorigenin  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
testosterone cypionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetradecanoic acid  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolazoline  (ISO)
tolmetin  (ISO)
tomelukast  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ubiquinones  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
voriconazole  (EXP)
WIN 55212-2  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (IDA)
cell differentiation  (IBA)
cellular response to fructose stimulus  (IEP)
cellular response to starvation  (ISO)
circadian regulation of gene expression  (ISO,ISS)
enamel mineralization  (ISO)
epidermis development  (ISO)
fatty acid metabolic process  (IBA,IMP,ISO)
gluconeogenesis  (ISO)
heart development  (IEP)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IEA)
lipoprotein metabolic process  (IMP)
negative regulation of appetite  (ISO,ISS)
negative regulation of blood pressure  (IMP)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cholesterol storage  (IBA,ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein binding  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
nitric oxide metabolic process  (IEP)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of cellular ketone metabolic process  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of DNA-templated transcription  (IDA)
regulation of fatty acid metabolic process  (ISO,TAS)
regulation of gene expression  (ISO)
regulation of lipid storage  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IDA,IEP)
response to insulin  (IMP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
steroid hormone mediated signaling pathway  (IEA)
wound healing  (ISO)

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. Ameen C, etal., J Biol Chem. 2005 Jan 14;280(2):1224-9. Epub 2004 Nov 9.
2. WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease. Archer DC, etal., Clin Exp Immunol. 2007 Nov;150(2):386-96. Epub 2007 Sep 20.
3. Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis. Asano J, etal., Cancer Sci. 2010 Apr;101(4):869-75. Epub 2009 Dec 8.
4. The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains. Ataman ZA, etal., Structure. 2007 Dec;15(12):1603-17. doi: 10.1016/j.str.2007.10.012.
5. PPARalpha contributes to colonic protection in mice with DSS-induced colitis. Azuma YT, etal., Int Immunopharmacol. 2010 Oct;10(10):1261-7. Epub 2010 Jul 31.
6. Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. Bansal T, etal., J Biol Chem. 2017 Oct 6;292(40):16440-16462. doi: 10.1074/jbc.M117.788299. Epub 2017 Aug 18.
7. Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord. Benani A, etal., J Chem Neuroanat 2003 Jan;25(1):29-38.
8. Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, on hepatic ischemia-reperfusion injury in rats. Boshra V and Moustafa AM, J Mol Histol. 2011 Apr;42(2):113-22. Epub 2011 Feb 9.
9. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-alpha PPAR-alpha Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. Briguglio E, etal., PPAR Res. 2010;2010:193019. Epub 2010 Dec 27.
10. Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease. Brune S, etal., J Neural Transm. 2003 Sep;110(9):1041-50.
11. Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury. Chen XR, etal., J Pharmacol Exp Ther. 2008 Sep;326(3):966-74. Epub 2008 Jun 18.
12. Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. Chu R, etal., J Biol Chem 1996 Nov 1;271(44):27670-6.
13. Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection. de Gottardi A, etal., Aliment Pharmacol Ther. 2006 Jan 1;23(1):107-14. doi: 10.1111/j.1365-2036.2006.02729.x.
14. Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection. Dharancy S, etal., Gastroenterology. 2005 Feb;128(2):334-42.
15. Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan. Di Paola R, etal., Shock. 2006 Nov;26(5):477-84.
16. Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability. Eberhardt W, etal., J Biol Chem 2002 Sep 6;277(36):33518-28.
17. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
18. omega-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. Fei J, etal., Atherosclerosis. 2012 Jun;222(2):395-401. doi: 10.1016/j.atherosclerosis.2012.02.040. Epub 2012 Mar 14.
19. Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat. Forcheron F, etal., Cardiovasc Diabetol. 2009 Mar 24;8:16.
20. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. Gardner OS, etal., J Biol Chem. 2003 Nov 21;278(47):46261-9. Epub 2003 Sep 9.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats. Gelosa P, etal., J Pharmacol Exp Ther. 2010 Nov;335(2):324-31. Epub 2010 Jul 29.
23. Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Gilde AJ, etal., Circ Res 2003 Mar 21;92(5):518-24.
24. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
25. Regulation of peroxisome proliferator-activated receptor-alpha by MDM2. Gopinathan L, etal., Toxicol Sci. 2009 Mar;108(1):48-58. Epub 2008 Dec 22.
26. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Gottlicher M, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4653-7.
27. Peroxisome proliferator-activated receptor-alpha agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function. Gray E, etal., Eur J Neurosci. 2011 Apr;33(8):1421-32. doi: 10.1111/j.1460-9568.2011.07637.x. Epub 2011 Mar 7.
28. The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha. Gray JP, etal., Toxicol Sci. 2006 Feb;89(2):535-46. Epub 2005 Nov 9.
29. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
30. Efficacy of combined peroxisome proliferator-activated receptor-alpha ligand and glucocorticoid therapy in a murine model of atopic dermatitis. Hatano Y, etal., J Invest Dermatol. 2011 Sep;131(9):1845-52. doi: 10.1038/jid.2011.144. Epub 2011 Jun 2.
31. Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. Holness MJ, etal., Biochem J 2002 Jun 15;364(Pt 3):687-94.
32. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382.
33. Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Jalouli M, etal., Endocrinology 2003 Jan;144(1):101-9.
34. Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Jamshidi Y, etal., Circulation. 2002 Feb 26;105(8):950-5.
35. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Jeong S and Yoon M, Exp Mol Med. 2009 Jun 30;41(6):397-405.
36. Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Ki SH, etal., Mol Cell Biol. 2005 May;25(10):4150-65.
37. Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-alpha. Koch M, etal., Neurotox Res. 2011 Feb;19(2):330-40. Epub 2010 Mar 11.
38. PPAR-alpha L162V polymorphism in human hepatocellular carcinoma. Koytak ES, etal., Turk J Gastroenterol. 2008 Dec;19(4):245-9.
39. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
40. Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. Lacquemant C, etal., Diabetes Metab. 2000 Nov;26(5):393-401.
41. The PPAR-alpha agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with NASH. Larter CZ, etal., J Gastroenterol Hepatol. 2011 Sep 19. doi: 10.1111/j.1440-1746.2011.06939.x.
42. PPARalpha activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. Le K, etal., Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. Epub 2011 Dec 16.
43. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. Linden D, etal., J Biol Chem 2002 Jun 21;277(25):23044-53.
44. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Mascia P, etal., Biol Psychiatry. 2011 Apr 1;69(7):633-41.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus. Morgan FW, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):273-90.
47. Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression. Mouthiers A, etal., Mol Endocrinol. 2005 May;19(5):1135-46. doi: 10.1210/me.2004-0188. Epub 2005 Jan 20.
48. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
49. Skeletal Muscle Characteristics of Rats with Obesity, Diabetes, Hypertension, and Hyperlipidemia. Nagatomo F, etal., J Atheroscler Thromb. 2009 Sep 18.
50. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Nakajima T, etal., Hepatology. 2004 Oct;40(4):972-80.
51. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
52. Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. Oakes ND, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R938-46.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes. Pawar A and Jump DB, J Biol Chem. 2003 Sep 19;278(38):35931-9. Epub 2003 Jul 9.
55. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
56. Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. Remels AH, etal., Eur Respir J. 2007 Aug;30(2):245-52. Epub 2007 Apr 25.
57. Peroxisome proliferator-activated receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes. Reynders V, etal., Respir Res. 2006 Jul 30;7:104.
58. GOA pipeline RGD automated data pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association. Sjolander A, etal., Neurobiol Aging. 2009 Apr;30(4):666-8. Epub 2007 Sep 11.
62. Reduced PPARalpha Expression is Associated With Decreased Survival and Increased Tissue Bacterial Load in Sepsis. Standage SW, etal., Shock. 2011 Nov 15.
63. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Stavinoha MA, etal., Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E888-95. Epub 2004 Aug 3.
64. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Steinmetz M, etal., Basic Res Cardiol. 2005 May;100(3):263-9. Epub 2005 Mar 9.
65. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.
66. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
67. Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. Tien ES, etal., J Biol Chem. 2004 Jun 4;279(23):24053-63. Epub 2004 Mar 29.
68. Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia. Vohl MC, etal., J Lipid Res. 2000 Jun;41(6):945-52.
69. Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. Williams JM, etal., Hypertension. 2005 Aug;46(2):366-71. Epub 2005 Jun 20.
70. Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation. Wu X, etal., Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E436-E445. doi: 10.1152/ajpendo.00454.2018. Epub 2019 Jun 18.
71. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
72. Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice. Yaacob NS, etal., J Clin Immunol. 2009 Sep;29(5):595-602. Epub 2009 May 27.
73. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
74. Lack of PPARalpha exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress. Yoo SH, etal., Toxicol Lett. 2011 Apr 10;202(1):23-9. Epub 2011 Jan 22.
75. Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. Zak I, etal., Clin Chim Acta. 2005 Dec;362(1-2):110-8. Epub 2005 Jul 25.
Additional References at PubMed
PMID:8041794   PMID:8828512   PMID:9113987   PMID:9488698   PMID:9626662   PMID:9748239   PMID:11514592   PMID:12015306   PMID:12065722   PMID:12083418   PMID:12118155   PMID:12354675  
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PMID:34233552   PMID:36219352   PMID:36401357   PMID:36654276   PMID:37204637  


Genomics

Comparative Map Data
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,150,521 - 46,243,755 (+)EnsemblGRCh38hg38GRCh38
GRCh372246,546,429 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBICelera
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
T2T-CHM13v2.02246,635,225 - 46,728,457 (+)NCBIT2T-CHM13v2.0
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,619,184 - 85,687,020 (+)EnsemblGRCm39 Ensembl
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBIMGSCv36mm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBINHGRI_mPanPan1
PanPan1.12245,218,364 - 45,302,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensemblpanpan1.1panPan2
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,862,969 - 19,928,467 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,667,818 - 20,740,885 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,668,580 - 20,740,947 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,394,544 - 20,460,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,707,323 - 20,772,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,889,156 - 20,954,630 (-)NCBIUU_Cfam_GSD_1.0
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,665,412 - 3,725,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,672,460 - 3,725,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,741 - 3,364,239 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223491
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,614,892 - 28,709,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppara
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppara
473 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:149
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000030082
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat

Markers in Region
D15Rat79  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07126,352,198 - 126,352,352UniSTSRnor5.0
RGSC_v3.47123,751,137 - 123,751,291UniSTSRGSC3.4
RGSC_v3.17123,785,366 - 123,785,521RGD
Celera7113,146,585 - 113,146,739UniSTS
FHH x ACI Map755.57UniSTS
Cytogenetic Map7q34UniSTS
D7Rat233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,854,121 - 116,854,276 (+)MAPPERmRatBN7.2
Rnor_6.07126,640,561 - 126,640,715NCBIRnor6.0
Rnor_5.07126,352,198 - 126,352,352UniSTSRnor5.0
Rnor_5.07126,352,197 - 126,352,352NCBIRnor5.0
Rnor_5.07126,352,196 - 126,352,352NCBIRnor5.0
RGSC_v3.47123,751,136 - 123,751,291RGDRGSC3.4
RGSC_v3.47123,751,137 - 123,751,291UniSTSRGSC3.4
RGSC_v3.17123,785,235 - 123,785,693RGD
Celera7113,146,585 - 113,146,739UniSTS
FHH x ACI Map755.57UniSTS
FHH x ACI Map755.57RGD
Cytogenetic Map7q34UniSTS
D7Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,852,655 - 116,852,895 (+)MAPPERmRatBN7.2
Rnor_6.07126,639,095 - 126,639,334NCBIRnor6.0
Rnor_5.07126,350,732 - 126,350,971UniSTSRnor5.0
RGSC_v3.47123,749,672 - 123,749,912RGDRGSC3.4
RGSC_v3.47123,749,673 - 123,749,912UniSTSRGSC3.4
RGSC_v3.17123,783,902 - 123,784,142RGD
Celera7113,145,123 - 113,145,362UniSTS
Cytogenetic Map7q34UniSTS
D7Uwm22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,836,447 - 116,836,583 (+)MAPPERmRatBN7.2
Rnor_6.07126,622,888 - 126,623,023NCBIRnor6.0
Rnor_5.07126,334,525 - 126,334,660UniSTSRnor5.0
RGSC_v3.47123,733,466 - 123,733,601UniSTSRGSC3.4
RGSC_v3.17123,767,695 - 123,767,831RGD
Celera7113,128,915 - 113,129,050UniSTS
Cytogenetic Map7q34UniSTS
PMC113093P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,894,866 - 116,895,185 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,273 - 126,681,591NCBIRnor6.0
Rnor_5.07126,392,269 - 126,392,587UniSTSRnor5.0
RGSC_v3.47123,806,611 - 123,806,929UniSTSRGSC3.4
Celera7113,186,925 - 113,187,243UniSTS
Cytogenetic Map7q34UniSTS
Ppara  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,160 - 116,895,694 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,567 - 126,682,100NCBIRnor6.0
Rnor_5.07126,392,563 - 126,393,096UniSTSRnor5.0
RGSC_v3.47123,806,905 - 123,807,438UniSTSRGSC3.4
Celera7113,187,219 - 113,187,752UniSTS
Cytogenetic Map7q34UniSTS
RH94816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,167 - 116,895,331 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,574 - 126,681,737NCBIRnor6.0
Rnor_5.07126,392,570 - 126,392,733UniSTSRnor5.0
RGSC_v3.47123,806,912 - 123,807,075UniSTSRGSC3.4
Celera7113,187,226 - 113,187,389UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS
RH94495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,165 - 116,895,327 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,572 - 126,681,733NCBIRnor6.0
Rnor_5.07126,392,568 - 126,392,729UniSTSRnor5.0
RGSC_v3.47123,806,910 - 123,807,071UniSTSRGSC3.4
Celera7113,187,224 - 113,187,385UniSTS
Cytogenetic Map7q34UniSTS
RH140266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,893,729 - 116,893,929 (+)MAPPERmRatBN7.2
Rnor_6.07126,680,136 - 126,680,335NCBIRnor6.0
Rnor_5.07126,391,132 - 126,391,331UniSTSRnor5.0
RGSC_v3.47123,805,474 - 123,805,673UniSTSRGSC3.4
Celera7113,185,788 - 113,185,987UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS
BI282868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,895,168 - 116,895,322 (+)MAPPERmRatBN7.2
Rnor_6.07126,681,575 - 126,681,728NCBIRnor6.0
Rnor_5.07126,392,571 - 126,392,724UniSTSRnor5.0
RGSC_v3.47123,806,913 - 123,807,066UniSTSRGSC3.4
Celera7113,187,227 - 113,187,380UniSTS
RH 3.4 Map7922.4UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 39 30 3 30 13 1 1
Low 3 15 18 11 16 11 8 11 60 22 38 10 8
Below cutoff 14 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM117640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M88592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000030082   ⟹   ENSRNOP00000038651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)Ensembl
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078928   ⟹   ENSRNOP00000074329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7126,641,952 - 126,681,708 (+)Ensembl
RefSeq Acc Id: NM_013196   ⟹   NP_037328
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,607 - 118,775,193 (+)NCBI
mRatBN7.27116,832,756 - 116,895,346 (+)NCBI
Rnor_6.07126,619,196 - 126,681,752 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
RGSC_v3.47123,729,774 - 123,807,090 (+)RGD
Celera7113,125,201 - 113,187,404 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242152   ⟹   XP_006242214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,412 - 118,780,723 (+)NCBI
mRatBN7.27116,832,633 - 116,900,878 (+)NCBI
Rnor_6.07126,619,087 - 126,687,282 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242153   ⟹   XP_006242215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,326 - 118,780,723 (+)NCBI
mRatBN7.27116,832,426 - 116,900,878 (+)NCBI
Rnor_6.07126,618,987 - 126,687,282 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242154   ⟹   XP_006242216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,261 - 118,780,723 (+)NCBI
mRatBN7.27116,832,405 - 116,900,878 (+)NCBI
Rnor_6.07126,618,872 - 126,687,282 (+)NCBI
Rnor_5.07126,330,559 - 126,397,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078501   ⟹   XP_038934429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,712,261 - 118,780,723 (+)NCBI
mRatBN7.27116,832,406 - 116,900,878 (+)NCBI
RefSeq Acc Id: NP_037328   ⟸   NM_013196
- UniProtKB: P37230 (UniProtKB/Swiss-Prot),   A6HTE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242216   ⟸   XM_006242154
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006242215   ⟸   XM_006242153
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006242214   ⟸   XM_006242152
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000038651   ⟸   ENSRNOT00000030082
RefSeq Acc Id: ENSRNOP00000074329   ⟸   ENSRNOT00000078928
RefSeq Acc Id: XP_038934429   ⟸   XM_039078501
- Peptide Label: isoform X2
- UniProtKB: P37230 (UniProtKB/Swiss-Prot),   A6HTE9 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37230-F1-model_v2 AlphaFold P37230 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695568
Promoter ID:EPDNEW_R6092
Type:initiation region
Name:Ppara_1
Description:peroxisome proliferator activated receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07126,619,141 - 126,619,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3369 AgrOrtholog
BioCyc Gene G2FUF-32527 BioCyc
Ensembl Genes ENSRNOG00000021463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055032099 UniProtKB/Swiss-Prot
  ENSRNOG00060023253 UniProtKB/Swiss-Prot
  ENSRNOG00065033228 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000030082 ENTREZGENE
  ENSRNOT00000030082.3 UniProtKB/Swiss-Prot
  ENSRNOT00055055491 UniProtKB/Swiss-Prot
  ENSRNOT00060040199 UniProtKB/Swiss-Prot
  ENSRNOT00065057129 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinoid X Receptor UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPAR-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25747 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25747 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PPARA RGD
PhenoGen Ppara PhenoGen
PRINTS PROXISOMEPAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROXISOMPAAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021463 RatGTEx
  ENSRNOG00055032099 RatGTEx
  ENSRNOG00060023253 RatGTEx
  ENSRNOG00065033228 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear receptor ligand-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC228504
UniProt A6HTE9 ENTREZGENE, UniProtKB/TrEMBL
  P37230 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ppara  Peroxisome proliferator activated receptor alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs agoninst WY14643 stimulated the secretion of apoB-100 in primary hepatocytes 625405
gene_expression enriched in liver, heart, skeletal muscle, kidney, and intestine 729544
gene_process activation decreases triglyceride biosynthesis 625405
gene_process mediates lipid homeostasis, especially fatty acid oxidation and lipoprotein metabolism 625405
gene_process mediates lipid homeostasis, especially fatty acid oxidation and lipoprotein metabolism 729544