Pparg (peroxisome proliferator-activated receptor gamma) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pparg (peroxisome proliferator-activated receptor gamma) Rattus norvegicus
Analyze
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
RGD ID: 3371
Description: Enables several functions, including nuclear estrogen receptor binding activity; protein phosphatase binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to hyperoxia; positive regulation of cell differentiation; and positive regulation of metabolic process. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); glomerulosclerosis; pancreatitis; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma); PARTICIPATES IN DNA modification pathway; Wnt signaling, non-canonical pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor, gamma; peroxisome proliferator activator receptor gamma; peroxisome proliferator activator receptor, gamma; PPAR-gamma; PPARgamma2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ppargem1Mcwi   Ppargm1Kyo  
Genetic Models: SS-Ppargem1Mcwi F344-Ppargm1Kyo
Is Marker For: QTLs:   Coreg2  
Candidate Gene For: Bp116
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,095,743 - 150,221,104 (+)NCBIGRCr8
mRatBN7.24148,423,102 - 148,548,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,648,115 - 154,772,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,431,203 - 150,555,814 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,055,023 - 149,179,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,274,055 - 147,399,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,562,928 - 210,688,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,492,220 - 151,617,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,796,047 - 151,862,171 (+)NCBI
Celera4137,316,681 - 137,440,473 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISS)
acute kidney failure  (IDA,ISO)
Acute Lung Injury  (IEP,ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
alcoholic cardiomyopathy  (IEP)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (ISO)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (IDA)
atherosclerosis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Carotid Intimal Medial Thickness 1  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (ISO)
Chronobiology Disorders  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital generalized lipodystrophy type 2  (ISS)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic encephalopathy  (IEP)
Diabetic Nephropathies  (IMP,ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,IMP)
Eye Burns  (IEP)
Eye Injuries  (ISO)
familial partial lipodystrophy  (ISO,ISS)
familial partial lipodystrophy type 3  (ISO)
Fetal Growth Retardation  (IEP)
Fibrosis  (IMP,ISO)
Follicular Thyroid Cancer  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA)
Graves ophthalmopathy  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hyperandrogenism  (IEP)
hypertension  (IDA,IEP,IMP,ISO)
Inflammation  (IMP,ISO)
Insulin Resistance  (ISO)
ischemia  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (IMP)
leukostasis  (ISO)
lipid storage disease  (ISO)
lipodystrophy  (ISO)
Liver Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IDA,ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (IEP,ISO)
osteoarthritis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (IMP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (IMP)
Perennial Allergic Rhinitis  (ISO)
pituitary-dependent Cushing's disease  (ISO)
polycystic kidney disease  (IDA)
pre-eclampsia  (ISO)
primary pulmonary hypertension  (ISS)
proliferative diabetic retinopathy  (ISO)
psoriasis  (ISO)
Reperfusion Injury  (ISO)
steatotic liver disease  (IEP)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISS)
T-cell non-Hodgkin lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (IEP,IMP)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(3-phenoxyphenyl)methanol  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(9E,11E)-octadecadienoic acid  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,4-thiadiazole  (EXP)
1,3-thiazolidine-2,4-dione  (EXP,ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-phenylenediamine  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
10H-phenothiazine  (ISO)
13-HPODE  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,5-di-tert-butylbenzene-1,4-diol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-arachidonoylglycerol  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-bromohexadecanoic acid  (EXP)
2-deoxy-D-glucose  (ISO)
2-Ethylhexanoic acid  (EXP)
2-Ethylhexyl acrylate  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dimethylbenzidine  (ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3,6-diaminoacridine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-aminobenzamide  (EXP)
3-iodoprop-2-yn-1-yl butylcarbamate  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-methylglutaric acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Methyl-3-penten-2-one, 9CI  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
8-Br-cAMP  (EXP)
9,10-epoxy-12-octadecenoic acid  (ISO)
9,11,13-octadecatrienoic acid  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (EXP,ISO)
9-HODE  (ISO)
9-phenanthrol  (ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
acetochlor  (ISO)
acetophenone  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
adenine  (EXP)
Aescin  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
AL 8810  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (ISO)
allyl isothiocyanate  (EXP)
Aloe emodin  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amentoflavone  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony(0)  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
Aurothioglucose  (ISO)
avobenzone  (ISO)
azinphos-methyl  (ISO)
Azoxymethane  (ISO)
baicalein  (ISO)
baicalin  (EXP)
Bardoxolone methyl  (ISO)
Bavachinin  (ISO)
bazedoxifene  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
Benzyl parahydroxybenzoate  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP,ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
beta-tocopherol  (EXP)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bismuth atom  (ISO)
bismuthane  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bisphenol F diglycidyl ether  (ISO)
bleomycin A2  (ISO)
bongkrekic acid  (ISO)
boric acid  (ISO)
bosentan  (ISO)
Bromadiolone  (ISO)
bromuconazole  (EXP,ISO)
bucladesine  (ISO)
buspirone  (EXP)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP,ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carotenoid  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium  (ISO)
cerulenin  (ISO)
ceruletide  (ISO)
chalcone  (ISO)
Chebulagic acid  (EXP)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chloroacetaldehyde  (ISO)
Chlorobenzilate  (ISO)
chlorogenic acid  (ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (ISO)
cholesterol  (ISO)
choline  (ISO)
chrysin  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP,ISO)
cilnidipine  (ISO)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP)
citronellol  (ISO)
CL316243  (EXP)
Clinofibrate  (ISO)
clodronic acid  (ISO)
clofazimine  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corilagin  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
coumaphos  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyanamide  (ISO)
cyanocob(III)alamin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
decanoic acid  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethomorph  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diniconazole  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
Diphenolic acid  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
Dithiopyr  (ISO)
diuron  (EXP,ISO)
dodecylamine  (ISO)
doramapimod  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
endrin  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
epoxomicin  (ISO)
equilin  (ISO)
esculetin  (EXP,ISO)
Ethalfluralin  (ISO)
ethanol  (EXP,ISO)
ethyl 3,4-dihydroxybenzoate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
farglitazar  (EXP,ISO)
farnesol  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenchone  (ISO)
fenitrothion  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (ISO)
fenthion  (ISO)
fentin chloride  (EXP,ISO)
fentin hydroxide  (ISO)
ferulic acid  (ISO)
finasteride  (ISO)
fipronil  (ISO)
flavanone  (ISO)
flavonoids  (EXP)
fluconazole  (EXP)
fludioxonil  (ISO)
flufenamic acid  (ISO)
Flumetralin  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
fluoxetine  (EXP,ISO)
fluprostenol  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
flutolanil  (ISO)
folic acid  (EXP,ISO)
fomepizole  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B2  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gadobutrol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (EXP,ISO)
gallocatechin  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycerol 2-phosphate  (ISO)
glycine  (ISO)
glycycoumarin  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (ISO)
gossypetin  (ISO)
griseofulvin  (ISO)
GW 1929  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 501516  (ISO)
GW 7647  (ISO)
gypenoside LXXV  (EXP,ISO)
harmine  (ISO)
hesperetin  (ISO)
hesperidin  (EXP,ISO)
HET0016  (EXP)
hexadecanoic acid  (EXP,ISO)
hispidulin  (ISO)
Honokiol  (ISO)
hydrazine  (EXP)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyflutamide  (ISO)
hydroxysafflor yellow A  (EXP)
hydroxytyrosol  (ISO)
ibuprofen  (EXP,ISO)
Icaritin  (ISO)
idarubicin  (ISO)
ifosfamide  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
Ingenol 3,20-dibenzoate  (ISO)
insulin  (ISO)
iohexol  (ISO)
iprodione  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (EXP)
iron(0)  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isophorone  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lacidipine  (ISO)
lactucin  (ISO)
lamotrigine  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
letrozole  (EXP)
Licarin A  (ISO)
linoleamide  (ISO)
linoleic acid  (EXP,ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
lithium chloride  (ISO)
loliolide  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
luteolin  (ISO)
luzindole  (ISO)
LY294002  (EXP)
lycopene  (ISO)
m-xylene  (EXP)
Magnolol  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mangiferin  (EXP,ISO)
manidipine  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP,ISO)
mesalamine  (ISO)
metconazole  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl laurate  (ISO)
methyl oleate  (ISO)
methylglyoxal  (EXP)
methylisothiazolinone  (ISO)
methylparaben  (ISO)
metolachlor  (ISO)
mevalonic acid  (EXP)
mifepristone  (EXP,ISO)
miquelianin  (ISO)
Mitotane  (ISO)
MitoTEMPO  (ISO)
MK-2206  (ISO)
monascin  (EXP,ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
Muraglitazar  (EXP,ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
napropamide  (ISO)
naproxen  (EXP)
naringin  (EXP,ISO)
nevirapine  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
Niflumic acid  (ISO)
nilutamide  (ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP,ISO)
Nivalenol  (ISO)
NMN zwitterion  (ISO)
nonanedioic acid  (ISO)
Nonylphenol  (EXP,ISO)
norathyriol  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
o-cresol  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (EXP)
octanoic acid  (EXP,ISO)
Octicizer  (ISO)
octocrylene  (ISO)
olanzapine  (ISO)
oleamide  (ISO)
oleic acid  (EXP,ISO)
oleoyl-CoA  (ISO)
oleuropein  (EXP)
orientin  (ISO)
orlistat  (ISO)
oryzalin  (ISO)
Osajin  (ISO)
osthole  (ISO)
Oxadiazon  (ISO)
oxaliplatin  (EXP)
oxaprozin  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-tolualdehyde  (ISO)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
paricalcitol  (ISO)
PCB138  (ISO)
PD 0325901  (ISO)
penconazole  (ISO)
pendimethalin  (ISO)
pentachloronitrobenzene  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (EXP,ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perindopril  (EXP)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
Phenylamil  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (ISO)
phosphatidylcholine  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phoxim  (ISO)
phthalic acid  (ISO)
phytanic acid  (ISO)
picoxystrobin  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
Pomiferin  (ISO)
potassium chromate  (ISO)
prallethrin  (ISO)
Pranoprofen  (ISO)
pravastatin  (ISO)
prednisone  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP)
propamocarb  (ISO)
propanil  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
propyzamide  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin J2  (EXP,ISO)
protein kinase inhibitor  (ISO)
psoralen  (EXP)
puerarin  (EXP,ISO)
pyocyanine  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quinolinic acid  (EXP)
quinoxyfen  (ISO)
quizalofop-ethyl  (ISO)
raloxifene  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resmethrin  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
rifaximin  (ISO)
rimonabant  (ISO)
risperidone  (ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
Rosavin  (ISO)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (EXP)
Salmeterol xinafoate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
selenic acid  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
serotonin  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium fluoride  (ISO)
Sodium oleate  (ISO)
Sorbitan monooleate  (ISO)
splitomicin  (ISO)
stavudine  (ISO)
stearoyl-CoA  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilben-4-ol  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulfasalazine  (EXP,ISO)
sulfluramid  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
tebuconazole  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbufos  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP,ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachlorvinphos  (ISO)
tetrahydropalmatine  (EXP)
tetramethylpyrazine  (EXP,ISO)
theophylline  (ISO)
thiamine(1+) chloride  (EXP)
thiazolidinediones  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
thyroxine  (ISO)
tideglusib  (ISO)
tiratricol  (ISO)
titanium dioxide  (ISO)
tolclofos-methyl  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomelukast  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trans-caffeic acid  (ISO)
trans-chalcone  (ISO)
trans-cinnamic acid  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triflumizole  (ISO)
trifluralin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
triticonazole  (ISO)
troglitazone  (EXP,ISO)
tuberostemonine  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (ISO)
umbelliferone  (EXP)
Urolithin A  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP,ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanillic acid  (ISO)
vinclozolin  (ISO)
Vinpocetine  (EXP)
vitamin D  (ISO)
vitamin E  (EXP)
wogonin  (EXP)
wortmannin  (EXP)
Y-27632  (EXP,ISO)
yttrium chloride  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
BMP signaling pathway  (ISO)
brown fat cell differentiation  (ISO)
cell differentiation  (IBA)
cell fate commitment  (ISO)
cell maturation  (ISO)
cell population proliferation  (ISO)
cellular response to hyperoxia  (IEP)
cellular response to hypoxia  (IDA)
cellular response to insulin stimulus  (ISO,ISS)
cellular response to lithium ion  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (IEP)
cellular response to prostaglandin stimulus  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to vitamin E  (IEP)
cold-induced thermogenesis  (ISO)
diet induced thermogenesis  (ISO)
epithelial cell differentiation  (ISO)
epithelial cell proliferation  (ISO)
fat cell differentiation  (ISO)
fatty acid metabolic process  (IBA,TAS)
fatty acid oxidation  (IMP)
glucose homeostasis  (ISO)
heart development  (IEP)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IBA)
lipoprotein transport  (ISO)
long-chain fatty acid transport  (ISO)
monocyte differentiation  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of acute inflammatory response  (IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (IDA)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of cellular response to insulin stimulus  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of cholesterol storage  (IBA,ISO)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of connective tissue replacement involved in inflammatory response wound healing  (IDA)
negative regulation of cytokine production  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of gene expression  (IGI,ISO)
negative regulation of inflammatory response  (IBA)
negative regulation of lipid storage  (IDA,ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of pancreatic stellate cell proliferation  (IMP)
negative regulation of peptide hormone secretion  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (IGI,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of type II interferon-mediated signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
peroxisome proliferator activated receptor signaling pathway  (ISO,ISS)
placenta development  (ISO)
positive regulation of adiponectin secretion  (IDA)
positive regulation of adipose tissue development  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol transport  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of fat cell differentiation  (IMP,ISO)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of intracellular cholesterol transport  (ISO)
positive regulation of low-density lipoprotein receptor activity  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of oligodendrocyte differentiation  (IMP)
positive regulation of phagocytosis, engulfment  (IMP)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of DNA-templated transcription  (ISO)
regulation of fat cell differentiation  (IDA)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (IMP)
regulation of protein localization to plasma membrane  (ISO)
regulation of transcription by RNA polymerase II  (IEP,IMP,ISO,ISS)
response to caffeine  (IEP)
response to dietary excess  (ISO)
response to estrogen  (IEP)
response to food  (ISO)
response to immobilization stress  (IEP)
response to light stimulus  (ISO)
response to linoleic acid  (IEP)
response to lipid  (IEP,ISO)
response to mechanical stimulus  (IEP)
response to starvation  (IEP)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEP)
retinoic acid receptor signaling pathway  (ISO,ISS)
rhythmic process  (IEA)
signal transduction  (ISO)
white fat cell differentiation  (ISO)
wound healing involved in inflammatory response  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells. Ahdjoudj S, etal., Exp Cell Res. 2005 Feb 1;303(1):138-47.
2. Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis. Al-Shali KZ, etal., Stroke. 2004 Sep;35(9):2036-40. Epub 2004 Jul 29.
3. Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Bao Y, etal., Mol Cell Biochem. 2008 Oct;317(1-2):189-96. Epub 2008 Jul 4.
4. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Barroso I, etal., Nature. 1999 Dec 23-30;402(6764):880-3.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
7. Additive Inhibitory Effect of Experimentally Induced Hepatic Cirrhosis by Agonists of Peroxisome Proliferator Activator Receptor gamma and Retinoic Acid Receptor. Bruck R, etal., Dig Dis Sci. 2008 Jul 2.
8. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Caglayan E, etal., Diabetes. 2008 Sep;57(9):2470-9. Epub 2008 May 28.
9. Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. Capobianco E, etal., Mol Hum Reprod. 2008 Aug;14(8):491-9. Epub 2008 Jul 11.
10. Oral intake of rosiglitazone promotes a central antihypertensive effect via upregulation of peroxisome proliferator-activated receptor-gamma and alleviation of oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. Chan SH, etal., Hypertension. 2010 Jun;55(6):1444-53. Epub 2010 Apr 19.
11. Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock. Chima RS, etal., Crit Care Med. 2008 Oct;36(10):2849-57.
12. Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. Churi SB, etal., J Pain. 2008 Jul;9(7):639-49. Epub 2008 Apr 3.
13. Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy. Costa V, etal., J Biomed Biotechnol. 2009;2009:126917. doi: 10.1155/2009/126917. Epub 2008 Dec 25.
14. Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes. Davies GF, etal., J Pharmacol Exp Ther. 2002 Jan;300(1):72-7.
15. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
16. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Dong CP, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Aug;25(4):447-51.
17. Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. Dong YW, etal., World J Gastroenterol. 2009 Jan 28;15(4):441-8.
18. PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. Du J, etal., Biochem Biophys Res Commun. 2009 Jun 12;383(4):485-90. doi: 10.1016/j.bbrc.2009.04.047. Epub 2009 Apr 19.
19. Early and prolonged intake of partially hydrogenated fat alters the expression of genes in rat adipose tissue. Duque-Guimaraes DE, etal., Nutrition. 2009 Jul-Aug;25(7-8):782-9. doi: 10.1016/j.nut.2008.12.004. Epub 2009 Feb 28.
20. Photoreceptor phagocytosis selectively activates PPARgamma expression in retinal pigment epithelial cells. Ershov AV and Bazan NG, J Neurosci Res. 2000 May 1;60(3):328-37.
21. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Escher P, etal., Endocrinology 2001 Oct;142(10):4195-202.
22. Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemia. Eurlings PM, etal., Mol Genet Metab. 2003 Nov;80(3):296-301.
23. Peroxisome proliferator-activated receptor gamma and early folliculogenesis during an acute hyperandrogenism condition. Faut M, etal., Fertil Steril. 2011 Jan;95(1):333-7. doi: 10.1016/j.fertnstert.2010.07.1083.
24. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Feng AW, etal., Fitoterapia. 2011 May 27.
25. Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot study. Fesinmeyer MD, etal., Pancreas. 2009 Aug;38(6):631-7.
26. Pioglitazone improves aortic wall elasticity in a rat model of elastocalcinotic arteriosclerosis. Gaillard V, etal., Hypertension. 2005 Aug;46(2):372-9. Epub 2005 Jun 20.
27. Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells. Gao Y, etal., J Pharm Pharmacol. 2008 Dec;60(12):1695-700. doi: 10.1211/jpp.60/12.0017.
28. Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. Garcia-Bueno B, etal., Biol Psychiatry. 2005 Apr 15;57(8):885-94.
29. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
30. Peroxisome proliferator-activated receptor-gamma and retinoid X receptor-alpha expression in pancreatic ductal adenocarcinoma: association with clinicopathological parameters, tumor proliferative capacity, and patients' survival. Giaginis C, etal., Med Sci Monit. 2009 May;15(5):BR148-56.
31. Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis. Giaginis C, etal., Med Sci Monit. 2011 Jul;17(7):CR381-91.
32. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
33. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. Gressner OA, etal., J Hepatol. 2008 Nov;49(5):758-67. Epub 2008 Apr 30.
34. miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1. Gu C, etal., Sci Rep. 2016 Dec 2;6:38491. doi: 10.1038/srep38491.
35. Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. Guardiola-Diaz HM, etal., J Biol Chem 1999 Aug 13;274(33):23368-77.
36. Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats. Gumbilai V, etal., Diabetes. 2016 Oct;65(10):2954-65. doi: 10.2337/db15-1422. Epub 2016 Jul 5.
37. Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Guo C, etal., Circulation. 2008 Apr 29;117(17):2253-61. Epub 2008 Apr 21.
38. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Halabi CM, etal., Cell Metab. 2008 Mar;7(3):215-26.
39. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Hamilton G, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16.
40. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
41. Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease. Helisalmi S, etal., Neurosci Lett. 2008 Aug 22;441(2):233-6. Epub 2008 Jun 17.
42. Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. Hong JT, etal., J Toxicol Environ Health A. 2002 Mar;65(5-6):407-18.
43. Effect of Chlamydia pneumoniae infection and hyperlipidaemia on the expression of PPARgamma, P50 and c-Fos in aortic endothelial cells in C57bL/6J mice. Huang B, etal., Acta Cardiol. 2005 Feb;60(1):43-9.
44. Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Hyong A, etal., Brain Res. 2008 Jun 18;1215:218-24. Epub 2008 Apr 22.
45. Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells. Jaster R, etal., J Cell Mol Med. 2005 Jul-Sep;9(3):670-82.
46. Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis. Jia S, etal., Cell Physiol Biochem. 2015;37(6):2085-100. doi: 10.1159/000438567. Epub 2015 Nov 25.
47. PPARγ/RAD21 alleviates peripheral secondary brain injury in rat cerebral hemorrhage model through promoting M2 polarization of microglial cells. Jiao Y, etal., Int Immunopharmacol. 2023 Jan;114:109572. doi: 10.1016/j.intimp.2022.109572. Epub 2022 Dec 18.
48. Expression of Renin-Angiotensin System and Peroxisome Proliferator-Activated Receptors in Alcoholic Cardiomyopathy. Jing L, etal., Alcohol Clin Exp Res. 2008 Sep 9.
49. The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy. Jorsal A, etal., Mol Genet Metab. 2008 Jul;94(3):347-51. Epub 2008 May 7.
50. IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPARgamma gene in male and female rat lungs during alveolarization. Joss-Moore LA, etal., Birth Defects Res A Clin Mol Teratol. 2011 Aug;91(8):672-81. doi: 10.1002/bdra.20783. Epub 2011 Mar 21.
51. Dehydroepiandrosterone down-regulates the expression of peroxisome proliferator-activated receptor gamma in adipocytes. Kajita K, etal., Endocrinology 2003 Jan;144(1):253-9.
52. Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis. Kang HJ, etal., Arch Otolaryngol Head Neck Surg. 2006 Nov;132(11):1196-200.
53. Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs. Kasai S, etal., J Pharmacol Sci. 2008 Sep;108(1):40-8. Epub 2008 Sep 6.
54. Rosiglitazone improves insulin sensitivity with increased serum leptin levels in patients with type 2 diabetes mellitus. Kim HJ, etal., Diabetes Res Clin Pract. 2008 Jul;81(1):42-9. Epub 2008 Apr 3.
55. Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Ko GJ, etal., Nephrol Dial Transplant. 2008 Sep;23(9):2750-60. Epub 2008 Apr 3.
56. Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats. Kobayashi N, etal., Am J Hypertens. 2008 May;21(5):576-81. Epub 2008 Mar 20.
57. PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Laplante M, etal., Diabetes 2003 Feb;52(2):291-9.
58. Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism. Laplante M, etal., Diabetes. 2006 Oct;55(10):2771-8.
59. PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation. Legchenko E, etal., Sci Transl Med. 2018 Apr 25;10(438). pii: 10/438/eaao0303. doi: 10.1126/scitranslmed.aao0303.
60. A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. Leisewitz AV, etal., J Cell Physiol. 2008 Nov;217(2):367-76.
61. MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. Lennon AM, etal., J Biol Chem 2002 Aug 16;277(33):29681-5.
62. Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms. Li F, etal., Eur J Pharmacol. 2017 Nov 5;814:324-334. doi: 10.1016/j.ejphar.2017.08.045. Epub 2017 Sep 1.
63. Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats. Lim S, etal., Atherosclerosis. 2009 Oct;206(2):411-7. doi: 10.1016/j.atherosclerosis.2009.02.031. Epub 2009 Mar 11.
64. Decreased expression of peroxisome proliferator-activated receptor gamma in endotoxin-induced acute lung injury. Liu D, etal., Physiol Res. 2006;55(3):291-9. Epub 2005 Aug 5.
65. Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. Liu YW, etal., Pharmacol Biochem Behav. 2014 Feb;117:128-36. doi: 10.1016/j.pbb.2013.11.027. Epub 2013 Dec 1.
66. Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. Lubet RA, etal., Int J Cancer. 2008 Nov 15;123(10):2254-9.
67. Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Ma LJ, etal., Kidney Int. 2001 May;59(5):1899-910.
68. Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor gamma with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development. Mansour MM, etal., PPAR Res. 2008;2008:651419.
69. Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women. Meirhaeghe A, etal., Diabetes. 2005 Oct;54(10):3043-8.
70. Rosiglitazone is cardioprotective in a murine model of myocardial I/R. Mersmann J, etal., Shock. 2008 Jul;30(1):64-8.
71. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
72. Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-gamma). Miana M, etal., J Physiol Pharmacol. 2011 Feb;62(1):87-94.
73. Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1. Miard S, etal., Aging Cell. 2009 Aug;8(4):449-59. Epub 2009 May 22.
74. Peroxisome proliferator-activated receptor-gamma gene expression in orbital adipose/connective tissues is increased during the active stage of Graves' ophthalmopathy. Mimura LY, etal., Thyroid. 2003 Sep;13(9):845-50.
75. The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals. Montagnana M, etal., Diabet Med. 2008 Aug;25(8):902-8.
76. Effects of peroxisome proliferator-activated receptor gamma and its ligand on blood-retinal barrier in a streptozotocin-induced diabetic model. Muranaka K, etal., Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4547-52.
77. Pioglitazone, a thiazolidinedione derivative, attenuates left ventricular hypertrophy and fibrosis in salt-sensitive hypertension. Nakamoto M, etal., Hypertens Res. 2008 Feb;31(2):353-61.
78. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
79. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
80. Activation of peroxisome proliferator-activated receptor-gamma inhibits tumor growth by negatively regulating nuclear factor-κB activation in patients with hepatocellular carcinoma. Nojima H, etal., J Hepatobiliary Pancreat Sci. 2016 Sep;23(9):574-84. doi: 10.1002/jhbp.378. Epub 2016 Aug 16.
81. Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. Oakes ND, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R938-46.
82. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Ogawa D, etal., Circ Res. 2006 Apr 14;98(7):e50-9. Epub 2006 Mar 23.
83. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
84. Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short- and medium-term fasting and refeeding. Palou M, etal., J Nutr Biochem. 2010 Jan;21(1):23-33. doi: 10.1016/j.jnutbio.2008.10.001. Epub 2009 Jan 20.
85. Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. Patzer A, etal., Eur J Neurosci. 2008 Nov;28(9):1786-94.
86. [Effects of peroxisome proliferators-activated receptor-gamma on the function of the vital organs in rats with pancreatitis] Pei HH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jun;28(6):1025-7.
87. Role of adipogenic and thermogenic genes in susceptibility or resistance to develop diet-induced obesity in rats. Perez-Echarri N, etal., J Physiol Biochem. 2007 Dec;63(4):317-27.
88. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
89. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
90. Synergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young rats. Redonnet A, etal., Br J Nutr. 2008 Oct;100(4):722-30. Epub 2008 Apr 3.
91. Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Revelo MP, etal., Nephrol Dial Transplant. 2005 Dec;20(12):2812-9. Epub 2005 Oct 12.
92. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
93. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
94. Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus. Ringel J, etal., Biochem Biophys Res Commun. 1999 Jan 19;254(2):450-3.
95. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. Ristow M, etal., N Engl J Med. 1998 Oct 1;339(14):953-9.
96. Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension. Rodriguez-Esparragon FJ, etal., J Hypertens. 2003 Sep;21(9):1649-55.
97. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
98. Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice. Saika S, etal., Am J Physiol Cell Physiol. 2007 Jul;293(1):C75-86.
99. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. Sanghera DK, etal., BMC Med Genet. 2008 Jul 3;9:59.
100. Loss-of-function mutations in PPAR gamma associated with human colon cancer. Sarraf P, etal., Mol Cell. 1999 Jun;3(6):799-804.
101. Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel. Sato N, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G616-23. Epub 2005 Oct 27.
102. Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Sato N, etal., Shock. 2005 Nov;24(5):462-9.
103. Digenic inheritance of severe insulin resistance in a human pedigree. Savage DB, etal., Nat Genet. 2002 Aug;31(4):379-84. Epub 2002 Jul 15.
104. Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain. Schmerbach K, etal., Brain Res. 2008 May 7;1208:225-33. Epub 2008 Mar 4.
105. Ciglitazone, a PPAR{gamma} agonist ameliorates diabetic nephropathy, in part, through homocysteine clearance. Sen U, etal., Am J Physiol Endocrinol Metab. 2008 Sep 9.
106. Rosiglitazone and delayed onset of proliferative diabetic retinopathy. Shen LQ, etal., Arch Ophthalmol. 2008 Jun;126(6):793-9.
107. Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Shimizu K, etal., Gastroenterology. 2005 Jun;128(7):2105-18.
108. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Steinmetz M, etal., Basic Res Cardiol. 2005 May;100(3):263-9. Epub 2005 Mar 9.
109. Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Sugawara A, etal., Hypertens Res 2003 Aug;26(8):623-8.
110. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells. Sugawara A, etal., J Biol Chem 2002 Mar 22;277(12):9676-83.
111. Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway. Sugimoto K, etal., J Hypertens. 2008 Jun;26(6):1209-15.
112. Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. Sun H, etal., Int J Dev Neurosci. 2008 Aug;26(5):505-15. Epub 2008 Mar 29.
113. Peroxisome proliferator-activated receptor-gamma gene polymorphism and risk of cardiovascular disease in patients with diabetic nephropathy. Szeto CC, etal., Am J Nephrol. 2008;28(5):715-22. Epub 2008 Apr 17.
114. Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy. Tariq K, etal., Mol Vis. 2013;19:710-7. Epub 2013 Mar 21.
115. Suppression of Retinal Peroxisome Proliferator Activated Receptor-gamma in Experimental Diabetes and Oxygen-Induced Retinopathy: Role of NADPH Oxidase. Tawfik A, etal., Invest Ophthalmol Vis Sci. 2008 Sep 20.
116. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes. Treuter E, etal., J Biol Chem. 1999 Mar 5;274(10):6667-77.
117. An ophthalmic solution of a peroxisome proliferator-activated receptor gamma agonist prevents corneal inflammation in a rat alkali burn model. Uchiyama M, etal., Mol Vis. 2013 Nov 1;19:2135-50. eCollection 2013.
118. Circulating activators of peroxisome proliferator-activated receptors are reduced in preeclamptic pregnancy. Waite LL, etal., J Clin Endocrinol Metab. 2005 Feb;90(2):620-6. Epub 2004 Nov 23.
119. Tissue-specific expression of PPAR mRNAs in diabetic rats and divergent effects of cilostazol. Wang F, etal., Can J Physiol Pharmacol. 2008 Jul;86(7):465-71.
120. [Correlation between PPARgamma and VEGF-C expression in extrahepatic cholangioadenocarcinoma (EHCAC) and their prognostic significance] Wang WB, etal., Zhonghua Zhong Liu Za Zhi. 2009 Oct;31(10):773-7.
121. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Way JM, etal., Endocrinology 2001 Mar;142(3):1269-77.
122. The PPAR-gamma Pro12Ala polymorphism and risk of cognitive impairment in a longitudinal study. West NA, etal., Neurobiol Aging. 2008 Jul 16.
123. Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. Wu JS, etal., Circulation. 2009 Mar 3;119(8):1124-34. doi: 10.1161/CIRCULATIONAHA.108.812537. Epub 2009 Feb 16.
124. The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Xiang Q, etal., Pharmacology. 2010;86(2):117-24. doi: 10.1159/000315065. Epub 2010 Aug 6.
125. Impaired expression of PPAR gamma protein contributes to the exaggerated growth of vascular smooth muscle cells in spontaneously hypertensive rats. Xiong C, etal., Life Sci. 2005 Oct 28;77(24):3037-48. Epub 2005 Jun 20.
126. Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. Yamamoto Y, etal., J Gastroenterol Hepatol. 2008 Jun;23(6):930-7.
127. Suppression of injury-induced conjunctiva scarring by peroxisome proliferator-activated receptor gamma gene transfer in mice. Yamanaka O, etal., Invest Ophthalmol Vis Sci. 2009 Jan;50(1):187-93. doi: 10.1167/iovs.08-2282. Epub 2008 Jul 24.
128. Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPARgamma and NF-kappaB. Yang H, etal., World J Gastroenterol. 2012 Apr 14;18(14):1680-8. doi: 10.3748/wjg.v18.i14.1680.
129. Telmisartan but not valsartan inhibits TGF-beta-mediated accumulation of extracellular matrix via activation of PPARgamma. Yao Y, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Oct;28(5):543-8. Epub 2008 Oct 10.
130. PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. Yoshihara D, etal., Am J Physiol Renal Physiol. 2011 Feb;300(2):F465-74. doi: 10.1152/ajprenal.00460.2010. Epub 2010 Dec 8.
131. Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure. Yousefipour Z, etal., J Pharmacol Exp Ther. 2007 Aug;322(2):461-8. Epub 2007 May 9.
132. Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. Yuan Z, etal., Heart. 2005 Sep;91(9):1203-8. Epub 2005 Mar 17.
133. Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells. Yuan Z, etal., J Cardiovasc Pharmacol. 2004 Jun;43(6):868-75.
134. Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-gamma. Zeng Y, etal., Brain Res. 2012 May 3;1452:140-50. doi: 10.1016/j.brainres.2012.02.063. Epub 2012 Mar 6.
135. Peroxisome proliferator activated receptor-gamma in pathogenesis of experimental fatty liver disease. Zhao CY, etal., World J Gastroenterol. 2004 May 1;10(9):1329-32.
136. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Zhou JY, etal., Biol Pharm Bull. 2008 Jun;31(6):1169-76.
137. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Zhou XR, etal., Growth Horm IGF Res. 2008 Oct;18(5):361-8. Epub 2008 Mar 4.
Additional References at PubMed
PMID:8041794   PMID:8943212   PMID:8953045   PMID:9030579   PMID:9113987   PMID:9568715   PMID:9568716   PMID:10937998   PMID:11387233   PMID:11710539   PMID:11996104   PMID:12037571  
PMID:12039952   PMID:12055200   PMID:12083418   PMID:12097321   PMID:12163159   PMID:12370429   PMID:12456800   PMID:12502791   PMID:12699904   PMID:12700342   PMID:12706490   PMID:12885795  
PMID:12914523   PMID:12941763   PMID:12966092   PMID:14592449   PMID:14600076   PMID:14744933   PMID:14749268   PMID:14766236   PMID:14871416   PMID:15033806   PMID:15055257   PMID:15164767  
PMID:15170673   PMID:15175325   PMID:15232616   PMID:15253107   PMID:15304320   PMID:15358182   PMID:15474499   PMID:15483210   PMID:15518707   PMID:15527799   PMID:15528772   PMID:15558556  
PMID:15561927   PMID:15563986   PMID:15618443   PMID:15632188   PMID:15649892   PMID:15673614   PMID:15681609   PMID:15684432   PMID:15687259   PMID:15713687   PMID:15728361   PMID:15733374  
PMID:15737646   PMID:15767042   PMID:15878969   PMID:15993383   PMID:16096283   PMID:16099986   PMID:16127449   PMID:16132694   PMID:16180333   PMID:16213464   PMID:16239304   PMID:16259921  
PMID:16266488   PMID:16329595   PMID:16344371   PMID:16484294   PMID:16530456   PMID:16554032   PMID:16563274   PMID:16574311   PMID:16580578   PMID:16670091   PMID:16815847   PMID:16939881  
PMID:16959952   PMID:17072978   PMID:17101152   PMID:17170230   PMID:17317771   PMID:17362636   PMID:17394460   PMID:17409529   PMID:17435078   PMID:17461532   PMID:17463056   PMID:17484875  
PMID:17589386   PMID:17595322   PMID:17601490   PMID:17611579   PMID:17627264   PMID:17643263   PMID:17643887   PMID:17667812   PMID:17669705   PMID:17905753   PMID:17937915   PMID:17947702  
PMID:17965419   PMID:17966466   PMID:17989144   PMID:18041089   PMID:18047631   PMID:18074385   PMID:18157544   PMID:18274641   PMID:18283099   PMID:18289512   PMID:18293083   PMID:18332871  
PMID:18421861   PMID:18466197   PMID:18471812   PMID:18492766   PMID:18562038   PMID:18566389   PMID:18625072   PMID:18696335   PMID:18815186   PMID:18845632   PMID:18971352   PMID:19041764  
PMID:19043829   PMID:19066220   PMID:19080338   PMID:19114110   PMID:19143008   PMID:19168033   PMID:19211718   PMID:19262292   PMID:19280879   PMID:19281808   PMID:19324970   PMID:19365232  
PMID:19377624   PMID:19408657   PMID:19452630   PMID:19524138   PMID:19570670   PMID:19576043   PMID:19609456   PMID:19666838   PMID:19689083   PMID:19808645   PMID:19808779   PMID:19893245  
PMID:19926821   PMID:19932685   PMID:19940035   PMID:19942298   PMID:19968884   PMID:20018750   PMID:20045920   PMID:20164119   PMID:20212046   PMID:20221786   PMID:20364582   PMID:20465636  
PMID:20498072   PMID:20622039   PMID:20630681   PMID:20644547   PMID:20663865   PMID:20663893   PMID:20668686   PMID:20705243   PMID:20732852   PMID:20884641   PMID:20948513   PMID:20959535  
PMID:21029595   PMID:21035761   PMID:21060836   PMID:21109018   PMID:21162229   PMID:21162800   PMID:21190014   PMID:21221986   PMID:21268089   PMID:21295034   PMID:21440907   PMID:21455100  
PMID:21487070   PMID:21501116   PMID:21532595   PMID:21600121   PMID:21602449   PMID:21669876   PMID:21763752   PMID:21793336   PMID:21835234   PMID:21926264   PMID:21996045   PMID:22014456  
PMID:22019459   PMID:22033706   PMID:22038624   PMID:22094441   PMID:22126757   PMID:22163051   PMID:22219595   PMID:22226965   PMID:22249025   PMID:22253423   PMID:22253428   PMID:22271545  
PMID:22282354   PMID:22292086   PMID:22351778   PMID:22464285   PMID:22466807   PMID:22467681   PMID:22554584   PMID:22561360   PMID:22595559   PMID:22706027   PMID:22714093   PMID:22792090  
PMID:22842585   PMID:22849356   PMID:22917842   PMID:23104384   PMID:23108648   PMID:23122950   PMID:23208382   PMID:23239524   PMID:23275342   PMID:23292098   PMID:23296834   PMID:23323617  
PMID:23372643   PMID:23468969   PMID:23499423   PMID:23500012   PMID:23500774   PMID:23520555   PMID:23526219   PMID:23632742   PMID:23656243   PMID:23775123   PMID:23788637   PMID:23794089  
PMID:23830318   PMID:23840343   PMID:23874818   PMID:24011919   PMID:24039778   PMID:24143360   PMID:24244369   PMID:24244514   PMID:24259663   PMID:24287039   PMID:24321547   PMID:24389592  
PMID:24413708   PMID:24481447   PMID:24521009   PMID:24612634   PMID:24703703   PMID:24717912   PMID:24722948   PMID:24729976   PMID:24771068   PMID:24816434   PMID:24833547   PMID:24960162  
PMID:24993341   PMID:25132338   PMID:25177938   PMID:25252250   PMID:25318873   PMID:25359573   PMID:25391250   PMID:25409419   PMID:25530507   PMID:25542160   PMID:25605873   PMID:25609649  
PMID:25619160   PMID:25633415   PMID:25656735   PMID:25661292   PMID:25795136   PMID:25824615   PMID:26020612   PMID:26047949   PMID:26119485   PMID:26130252   PMID:26194065   PMID:26255201  
PMID:26275398   PMID:26279448   PMID:26406917   PMID:26427354   PMID:26446277   PMID:26467845   PMID:26495791   PMID:26510582   PMID:26519036   PMID:26522682   PMID:26629404   PMID:26654758  
PMID:26674985   PMID:26679939   PMID:26739391   PMID:26826429   PMID:26875149   PMID:26927377   PMID:27046338   PMID:27145370   PMID:27149161   PMID:27175924   PMID:27184517   PMID:27194472  
PMID:27224243   PMID:27422606   PMID:27435855   PMID:27505464   PMID:27519769   PMID:27538526   PMID:27607022   PMID:27663184   PMID:27716232   PMID:27718123   PMID:27725163   PMID:27843299  
PMID:27871858   PMID:28177765   PMID:28277542   PMID:28336108   PMID:28375162   PMID:28432465   PMID:28433567   PMID:28445772   PMID:28484848   PMID:28522568   PMID:28529269   PMID:28550910  
PMID:28566713   PMID:28627661   PMID:28760678   PMID:28838346   PMID:28845215   PMID:28973641   PMID:28978936   PMID:29183319   PMID:29187585   PMID:29241675   PMID:29287795   PMID:29393373  
PMID:29480285   PMID:29488613   PMID:29519872   PMID:29522763   PMID:29550470   PMID:29568896   PMID:29604590   PMID:29761875   PMID:30119293   PMID:30132829   PMID:30194582   PMID:30197006  
PMID:30291215   PMID:30376839   PMID:30398029   PMID:30404040   PMID:30412727   PMID:30488141   PMID:30506990   PMID:30612469   PMID:30623541   PMID:31010302   PMID:31163124   PMID:31386893  
PMID:31479752   PMID:31485635   PMID:31538845   PMID:31707284   PMID:31781338   PMID:31968546   PMID:32102354   PMID:32246423   PMID:32568773   PMID:32775443   PMID:32902936   PMID:33003644  
PMID:33253762   PMID:33394189   PMID:33398367   PMID:33551999   PMID:33636289   PMID:33654147   PMID:33844974   PMID:34329667   PMID:34431454   PMID:34448677   PMID:34592314   PMID:34890588  
PMID:34973951   PMID:35380292   PMID:35550883   PMID:35599576   PMID:35678781   PMID:35689861   PMID:35777809   PMID:35883192   PMID:35900650   PMID:35934252   PMID:36359788   PMID:36611836  
PMID:37010494   PMID:37024064   PMID:37129843   PMID:37231189   PMID:37468053   PMID:37620972   PMID:37644373   PMID:37740176   PMID:37832237   PMID:37971567   PMID:37986543   PMID:38237016  
PMID:38594496   PMID:38648706   PMID:38770649  


Genomics

Comparative Map Data
Pparg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,095,743 - 150,221,104 (+)NCBIGRCr8
mRatBN7.24148,423,102 - 148,548,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,648,115 - 154,772,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,431,203 - 150,555,814 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,055,023 - 149,179,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,274,055 - 147,399,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,562,928 - 210,688,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,492,220 - 151,617,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,796,047 - 151,862,171 (+)NCBI
Celera4137,316,681 - 137,440,473 (+)NCBICelera
Cytogenetic Map4q42NCBI
PPARG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,287,368 - 12,434,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,287,368 - 12,434,356 (+)EnsemblGRCh38hg38GRCh38
GRCh37312,328,867 - 12,475,843 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,304,349 - 12,450,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 34312,304,423 - 12,450,840NCBI
Celera312,266,744 - 12,413,226 (+)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,263,090 - 12,409,169 (+)NCBIHuRef
CHM1_1312,279,448 - 12,425,942 (+)NCBICHM1_1
T2T-CHM13v2.0312,285,564 - 12,432,191 (+)NCBIT2T-CHM13v2.0
Pparg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,337,828 - 115,467,365 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,337,912 - 115,467,360 (+)EnsemblGRCm39 Ensembl
GRCm386115,360,879 - 115,490,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,360,951 - 115,490,399 (+)EnsemblGRCm38mm10GRCm38
MGSCv376115,311,239 - 115,440,419 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,387,692 - 115,456,020 (+)NCBIMGSCv36mm8
Celera6117,199,637 - 117,329,691 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.41NCBI
Pparg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBIChiLan1.0ChiLan1.0
PPARG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,275,725 - 12,421,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,280,497 - 12,426,762 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,215,322 - 12,361,669 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,560,670 - 12,705,060 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,622,397 - 12,705,060 (+)Ensemblpanpan1.1panPan2
PPARG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,134,618 - 6,265,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,050,357 - 6,207,981 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,170,697 - 6,244,070 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,163,453 - 6,294,865 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,163,453 - 6,236,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1205,878,834 - 5,952,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,232,700 - 6,306,060 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,208,181 - 6,281,750 (-)NCBIUU_Cfam_GSD_1.0
Pparg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,541,121 - 17,706,796 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,230,907 - 1,304,743 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,230,907 - 1,368,588 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,302,322 - 68,433,944 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,301,566 - 68,433,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,515,515 - 75,650,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,262,743 - 48,407,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,275,600 - 48,407,418 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041118,092,724 - 118,237,828 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pparg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462495683,842 - 149,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462495684,673 - 207,176 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pparg
375 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:108
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000012137, ENSRNOT00000051858
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
D4Rat198  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84150,142,731 - 150,143,031 (+)Marker Load Pipeline
mRatBN7.24148,470,094 - 148,470,394 (+)MAPPERmRatBN7.2
Rnor_6.04147,321,008 - 147,321,307NCBIRnor6.0
Rnor_5.04210,609,867 - 210,610,166UniSTSRnor5.0
RGSC_v3.44151,539,121 - 151,539,420UniSTSRGSC3.4
RGSC_v3.44151,539,069 - 151,539,451RGDRGSC3.4
RGSC_v3.14151,783,962 - 151,784,261RGD
Celera4137,363,561 - 137,363,860UniSTS
RH 3.4 Map4958.6UniSTS
RH 3.4 Map4958.6RGD
SHRSP x BN Map472.5099RGD
SHRSP x BN Map472.5099UniSTS
Cytogenetic Map4q42UniSTS
D4Got123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,519,843 - 148,520,091 (+)MAPPERmRatBN7.2
Rnor_6.04147,370,756 - 147,371,003NCBIRnor6.0
Rnor_5.04210,659,952 - 210,660,199UniSTSRnor5.0
RGSC_v3.44151,588,605 - 151,588,853RGDRGSC3.4
RGSC_v3.44151,588,606 - 151,588,853UniSTSRGSC3.4
RGSC_v3.14151,833,446 - 151,833,694RGD
Celera4137,411,908 - 137,412,154UniSTS
RH 3.4 Map4950.4UniSTS
RH 3.4 Map4950.4RGD
RH 2.0 Map4963.2RGD
Cytogenetic Map4q42UniSTS
AI453959  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,548,047 - 148,548,230 (+)MAPPERmRatBN7.2
Rnor_6.04147,398,960 - 147,399,142NCBIRnor6.0
Rnor_5.04210,688,162 - 210,688,344UniSTSRnor5.0
RGSC_v3.44151,616,911 - 151,617,093UniSTSRGSC3.4
Celera4137,440,053 - 137,440,235UniSTS
RH 3.4 Map4950.8UniSTS
Cytogenetic Map4q42UniSTS
AI229983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,431,745 - 148,431,949 (+)MAPPERmRatBN7.2
Rnor_6.04147,282,658 - 147,282,861NCBIRnor6.0
Rnor_5.04210,571,517 - 210,571,720UniSTSRnor5.0
RGSC_v3.44151,500,771 - 151,500,974UniSTSRGSC3.4
Celera4137,325,215 - 137,325,418UniSTS
RH 3.4 Map4950.81UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Pparg is modified in the following models/strains:
SS-Ppargem1Mcwi     F344-Ppargm1Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 93 91 90 59 25 59 6 218 97 73 45 59 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB011365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB019561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF246457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF246458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012137   ⟹   ENSRNOP00000012137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,482,143 - 148,548,468 (+)Ensembl
Rnor_6.0 Ensembl4147,333,056 - 147,399,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051858   ⟹   ENSRNOP00000045012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4147,275,334 - 147,399,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082969   ⟹   ENSRNOP00000073235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)Ensembl
Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)Ensembl
RefSeq Acc Id: NM_001145366   ⟹   NP_001138838
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,097,058 - 150,221,104 (+)NCBI
mRatBN7.24148,424,421 - 148,548,468 (+)NCBI
Rnor_6.04147,275,334 - 147,399,380 (+)NCBI
Rnor_5.04210,562,928 - 210,688,585 (+)NCBI
RGSC_v3.44151,492,220 - 151,617,331 (+)RGD
Celera4137,317,890 - 137,440,473 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001145367   ⟹   NP_001138839
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,095,831 - 150,221,104 (+)NCBI
mRatBN7.24148,423,194 - 148,548,468 (+)NCBI
Rnor_6.04147,274,107 - 147,399,380 (+)NCBI
Rnor_5.04210,562,928 - 210,688,585 (+)NCBI
RGSC_v3.44151,492,220 - 151,617,331 (+)RGD
Celera4137,316,681 - 137,440,473 (+)RGD
Sequence:
RefSeq Acc Id: NM_013124   ⟹   NP_037256
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,154,772 - 150,221,104 (+)NCBI
mRatBN7.24148,482,135 - 148,548,468 (+)NCBI
Rnor_6.04147,333,048 - 147,399,380 (+)NCBI
Rnor_5.04210,562,928 - 210,688,585 (+)NCBI
RGSC_v3.44151,492,220 - 151,617,331 (+)RGD
Celera4137,375,601 - 137,440,473 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237009   ⟹   XP_006237071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,095,743 - 150,221,104 (+)NCBI
mRatBN7.24148,423,102 - 148,548,471 (+)NCBI
Rnor_6.04147,274,055 - 147,399,383 (+)NCBI
Rnor_5.04210,562,928 - 210,688,585 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107130   ⟹   XP_038963058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,095,744 - 150,221,104 (+)NCBI
mRatBN7.24148,423,105 - 148,548,471 (+)NCBI
RefSeq Acc Id: XM_063285619   ⟹   XP_063141689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,183,569 - 150,221,104 (+)NCBI
RefSeq Acc Id: NP_037256   ⟸   NM_013124
- Peptide Label: isoform 1
- UniProtKB: Q9QWG0 (UniProtKB/Swiss-Prot),   Q9R197 (UniProtKB/Swiss-Prot),   O88275 (UniProtKB/Swiss-Prot),   A6IKY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138839   ⟸   NM_001145367
- Peptide Label: isoform 2
- UniProtKB: A6IKY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138838   ⟸   NM_001145366
- Peptide Label: isoform 2
- UniProtKB: A6IKY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237071   ⟸   XM_006237009
- Peptide Label: isoform X1
- UniProtKB: A6IKY4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073235   ⟸   ENSRNOT00000082969
Ensembl Acc Id: ENSRNOP00000012137   ⟸   ENSRNOT00000012137
Ensembl Acc Id: ENSRNOP00000045012   ⟸   ENSRNOT00000051858
RefSeq Acc Id: XP_038963058   ⟸   XM_039107130
- Peptide Label: isoform X1
- UniProtKB: A6IKY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141689   ⟸   XM_063285619
- Peptide Label: isoform X2
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88275-F1-model_v2 AlphaFold O88275 1-505 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693320
Promoter ID:EPDNEW_R3845
Type:initiation region
Name:Pparg_1
Description:peroxisome proliferator-activated receptor gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3846  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,274,157 - 147,274,217EPDNEW
RGD ID:13693321
Promoter ID:EPDNEW_R3846
Type:single initiation site
Name:Pparg_2
Description:peroxisome proliferator-activated receptor gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3845  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,275,395 - 147,275,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3371 AgrOrtholog
BioCyc Gene G2FUF-43322 BioCyc
Ensembl Genes ENSRNOG00000008839 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012137.6 UniProtKB/Swiss-Prot
  ENSRNOT00000082969.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinoid X Receptor UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPAR-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPARgamma_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25664 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25664 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPARgamma_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PPARG RGD
PhenoGen Pparg PhenoGen
PRINTS PROXISOMEPAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROXISOMPAGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008839 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear receptor ligand-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IKY3 ENTREZGENE, UniProtKB/TrEMBL
  A6IKY4 ENTREZGENE, UniProtKB/TrEMBL
  O88275 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9QWG0 ENTREZGENE
  Q9R197 ENTREZGENE
UniProt Secondary Q9QWG0 UniProtKB/Swiss-Prot
  Q9R197 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-15 Pparg  peroxisome proliferator-activated receptor gamma  Pparg  peroxisome proliferator activated receptor gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pparg  peroxisome proliferator activated receptor, gamma    peroxisome proliferator activator receptor, gamma  Name updated 629478 APPROVED
2002-06-10 Pparg  peroxisome proliferator activator receptor, gamma      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in adipose tissue 727277
gene_process plays a role in fat cell differentiation 67996
gene_process plays a role in fat cell differentiation 619549