Pparg (peroxisome proliferator-activated receptor gamma) - Rat Genome Database

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Gene: Pparg (peroxisome proliferator-activated receptor gamma) Rattus norvegicus
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
RGD ID: 3371
Description: Enables several functions, including nuclear estrogen receptor binding activity; protein phosphatase binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell differentiation; and response to vitamin. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); pancreatitis; polycystic kidney disease; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma); PARTICIPATES IN DNA modification pathway; Wnt signaling, non-canonical pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor, gamma; peroxisome proliferator activator receptor gamma; peroxisome proliferator activator receptor, gamma; PPAR-gamma; PPARgamma2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ppargem1Mcwi   Ppargm1Kyo  
Genetic Models: SS-Ppargem1Mcwi F344-Ppargm1Kyo
Is Marker For: QTLs:   Coreg2  
Candidate Gene For: Bp116
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84150,095,743 - 150,221,104 (+)NCBIGRCr8
mRatBN7.24148,423,102 - 148,548,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,648,115 - 154,772,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,431,203 - 150,555,814 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,055,023 - 149,179,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,274,055 - 147,399,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,562,928 - 210,688,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,492,220 - 151,617,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,796,047 - 151,862,171 (+)NCBI
Celera4137,316,681 - 137,440,473 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)