GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | decreases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Berberine results in decreased expression of PPARG mRNA | PMID:26478571 | Pparg | decreases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Berberine results in decreased expression of PPARG mRNA; Berberine results in decreased expression of PPARG protein | PMID:37511356 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Berberine results in increased expression of PPARG mRNA | PMID:29408570 | Pparg | increases response to substance | ISO | PPARG (Homo sapiens) | 6480464 | CTD | PPARG mRNA results in increased susceptibility to Berberine | PMID:29408570 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | 15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein] | PMID:29408570 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein] | PMID:20564506 PMID:37839514 | | ||||||||||||||||||||||
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