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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:81582
Term: 2,4-dibromophenyl 2,4,5-tribromophenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, 5, 2', and 4' positions have been replaced by bromines.
Chemical ID: MESH:C477694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTD2,2',4,4',5-brominated diphenyl ether metabolite binds to PPARG proteinPMID:25314719
Ppargdecreases methylationISOPparg (Mus musculus)6480464CTD2,2',4,4',5-brominated diphenyl ether results in decreased methylation of PPARG promoterPMID:30903904
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of PPARG mRNAPMID:30903904
Ppargincreases expressionISOPparg (Mus musculus)6480464CTD2,2',4,4',5-brominated diphenyl ether results in increased expression of PPARG mRNA; 2,2',4,4',5-brominated diphenyl ether results in increased expression of PPARG proteinPMID:30903904
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD2,2',4,4',5-brominated diphenyl ether promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]PMID:30903904
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