Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects bindingEXP 6480464CTDperfluorooctane sulfonic acid binds to PPARG proteinPMID:35752307
Ppargdecreases acetylationEXP 6480464CTDperfluorooctane sulfonic acid results in decreased acetylation of PPARG proteinPMID:28973641
Ppargincreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of PPARG mRNAPMID:23500012
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDperfluorooctane sulfonic acid binds to PPARG proteinPMID:35752307
Ppargaffects expressionISOPPARG (Homo sapiens)6480464CTDperfluorooctane sulfonic acid affects the expression of PPARG mRNAPMID:30738844
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of PPARG mRNAPMID:32790152
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased activity of PPARG proteinPMID:24998974
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of PPARG mRNAPMID:22269386 PMID:26548598 PMID:28558994 PMID:35337807
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of PPARG mRNAPMID:23500012 PMID:26548598
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDperfluorooctane sulfonic acid binds to and results in increased activity of PPARG proteinPMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD[Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of PPARG mRNA; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PPARG mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of PPARG mRNA; perfluorooctane sulfonic acid binds to and results in increased activity of PPARG proteinPMID:32979393 PMID:33049310 PMID:36331819
Go Back to source page   Continue to Ontology report