Esr2 (estrogen receptor 2) - Rat Genome Database

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Gene: Esr2 (estrogen receptor 2) Rattus norvegicus
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Symbol: Esr2
Name: estrogen receptor 2
RGD ID: 2582
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen response element binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Located in several cellular components, including cilium; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN estrogen signaling pathway; bisphenol A response pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ER-beta; Erb2; ERbeta; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Esr2em1Soar  
Genetic Models: SD-Esr2em1Soar
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoma  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (IDA)
aortic valve stenosis  (ISO)
asthma  (IEP)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Blast Crisis  (ISO)
brain ischemia  (IEP)
breast cancer  (IDA,ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cocaine-Related Disorders  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
colon cancer  (IDA)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cystitis  (IEP)
Deafness  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Arthritis  (IDA)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Melanoma  (ISO)
Female Infertility  (IMP,ISO)
glomerulosclerosis  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IDA)
Hot Flashes  (IDA)
Hyperalgesia  (IDA,ISO)
hypertension  (IMP,ISO)
hypospadias  (ISO)
in situ carcinoma  (ISO)
inflammatory bowel disease  (IDA)
interstitial cystitis  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lithiasis  (ISO)
Lung Injury  (IDA)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (IDA,IEP,ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
mental depression  (IDA)
myasthenia gravis  (ISO)
myeloid leukemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (IDA)
osteoarthritis  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IEP,ISO)
ovarian dysgenesis 8  (ISO)
Parkinson's disease  (ISO)
peritonitis  (IDA)
Pituitary Neoplasms  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IDA,ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IDA)
Spinal Cord Injuries  (IEP)
Splenomegaly  (ISO)
Stroke  (IDA)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IMP)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (IDA)
Varicose Ulcer  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
10H-phenothiazine  (ISO)
16-Ketoestrone  (ISO)
17alpha-estradiol  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Androstenediol  (EXP)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (ISO)
4-hydroxy-17beta-estradiol  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-nitrophenol  (EXP)
4-nitrotoluene  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-Propylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5alpha-androstane-3alpha,17beta-diol  (EXP)
5alpha-androstane-3beta,17beta-diol  (EXP)
6-oxocampestanol  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9,9-bis(4-hydroxyphenyl)fluorene  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetochlor  (ISO)
acetophenone  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
afimoxifene  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (EXP,ISO)
androstane-3,17-diol  (EXP,ISO)
anilines  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzophenone  (ISO)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
beta-tocopherol  (EXP)
beta-Zearalanol  (EXP)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butylbenzene  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (ISO)
cedrol  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloropropylate  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clomiphene  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumaphos  (ISO)
coumestrol  (EXP,IPI,ISO)
Cuprizon  (EXP)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (ISO)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
dienestrol  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
diniconazole  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (EXP,ISO)
EPN  (ISO)
equilin  (ISO)
equol  (ISO)
estradiol  (EXP)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (EXP)
ethanol  (EXP)
ethion  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycitein  (EXP,ISO)
glycitin  (EXP)
glyphosate  (EXP,ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexestrol  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ICI-164384  (EXP)
indinavir  (ISO)
indoles  (ISO)
ipriflavone  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobutylparaben  (EXP,ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
kaempferol  (EXP,ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lasofoxifene  (EXP)
leptophos  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
luteolin  (ISO)
lycopene  (ISO)
M1  (ISO)
mancozeb  (ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (EXP)
methimazole  (ISO)
methiocarb  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
Methyl palmitate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
Moxestrol  (EXP)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
n-propyl gallate  (ISO)
Nafoxidine  (EXP)
nandrolone  (EXP)
Nandrolone decanoate  (EXP)
napropamide  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Nonylphenol  (ISO)
norethisterone  (ISO)
Norethynodrel  (EXP)
notoginsenoside R1  (EXP)
nuarimol  (ISO)
O-Desmethylangolensin  (ISO)
octocrylene  (ISO)
ormeloxifene  (EXP)
oryzalin  (ISO)
Osajin  (ISO)
Oxadiazon  (ISO)
oxybenzone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
parathion-methyl  (ISO)
pendimethalin  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenothrin  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Pomiferin  (ISO)
potassium dichromate  (EXP)
prallethrin  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhapontigenin  (ISO)
rifapentine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
royal jelly  (ISO)
rubitecan  (ISO)
rutin  (EXP)
salicylates  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
sodium arsenite  (ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (EXP,ISO)
staurosporine  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetralin  (ISO)
tetramethrin  (EXP)
tibolone  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (ISO)
toxaphene  (EXP,ISO)
trans-piceid  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
trilostane  (ISO)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (ISO)
triticonazole  (ISO)
undecan-2-one  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vinyl carbamate  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (IEP)
behavioral fear response  (IDA)
brain development  (ISO)
cellular response to estradiol stimulus  (IEA,IEP,ISO)
cellular response to magnetism  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebellum development  (IEP)
epithelial cell maturation involved in prostate gland development  (ISO)
estrous cycle  (IMP)
female gonad development  (IEP)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (IEP)
intracellular estrogen receptor signaling pathway  (IEA,ISO,TAS)
intracellular steroid hormone receptor signaling pathway  (IBA,IDA)
learning or memory  (IMP)
male gonad development  (IEP)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of behavior  (IDA)
negative regulation of cell death  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IDA,ISO)
negative regulation of feeding behavior  (IMP)
negative regulation of neuron death  (IDA)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
neuron migration  (ISO)
ovarian follicle development  (IEP,ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO,ISS)
positive regulation of epidermal growth factor receptor signaling pathway  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription, DNA-templated  (IDA,IEA,ISO)
prostate gland development  (IEP)
prostate gland epithelium morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of neuron apoptotic process  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
response to activity  (IEP)
response to bisphenol A  (IEP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to genistein  (IEP)
response to hormone  (IEP)
response to human chorionic gonadotropin  (IEP)
response to insecticide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to salt  (IEP)
response to testosterone  (IEP,IMP)
response to water deprivation  (IEP)
response to xenobiotic stimulus  (IEP)
Sertoli cell development  (IEP)
Sertoli cell proliferation  (IMP)
steroid hormone mediated signaling pathway  (IEA)
uterus development  (ISO)
vagina development  (ISO)
vasodilation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

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PMID:20096765   PMID:20136693   PMID:20138435   PMID:20160663   PMID:20347696   PMID:20381466   PMID:20424134   PMID:20460386   PMID:20554652   PMID:20584107   PMID:20702577   PMID:20810711  
PMID:20875808   PMID:20926581   PMID:20926671   PMID:20969598   PMID:21182203   PMID:21243777   PMID:21311134   PMID:21392135   PMID:21484804   PMID:21606911   PMID:21628965   PMID:21774811  
PMID:21777515   PMID:21782536   PMID:21808025   PMID:21884022   PMID:21951318   PMID:21972199   PMID:21981044   PMID:21981076   PMID:21995903   PMID:22142178   PMID:22152882   PMID:22169964  
PMID:22192617   PMID:22248091   PMID:22278942   PMID:22330348   PMID:22366496   PMID:22428062   PMID:22541803   PMID:22562172   PMID:22713467   PMID:22778216   PMID:23020785   PMID:23515287  
PMID:23515288   PMID:23749762   PMID:23911387   PMID:24033289   PMID:24188094   PMID:24347325   PMID:24352099   PMID:24390426   PMID:24718039   PMID:25211590   PMID:25217305   PMID:25486578  
PMID:25612677   PMID:25869617   PMID:26408543   PMID:26440063   PMID:26987957   PMID:27004961   PMID:27130032   PMID:27182159   PMID:27321970   PMID:27594441   PMID:27832635   PMID:28362134  
PMID:28542730   PMID:28863192   PMID:28919414   PMID:29030963   PMID:29127073   PMID:29261182   PMID:29394091   PMID:29421437   PMID:30113650   PMID:30277501   PMID:30296306   PMID:30447304  
PMID:30731078   PMID:30790128   PMID:30887585   PMID:31115535   PMID:31250245   PMID:31708494   PMID:31877966   PMID:31931041   PMID:33400952   PMID:34638689  


Genomics

Candidate Gene Status
Esr2 is a candidate Gene for QTL Schws8
Comparative Map Data
Esr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
Celera693,284,596 - 93,334,744 (-)NCBICelera
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
ESR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1464,084,232 - 64,338,112 (-)EnsemblGRCh38hg38GRCh38
GRCh381464,226,707 - 64,338,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBINCBI36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBI
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
Esr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)Ensembl
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBImm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
Esr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,575,088 - 5,638,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,587,003 - 5,644,765 (+)NCBIChiLan1.0ChiLan1.0
ESR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11463,064,397 - 63,175,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,064,402 - 63,131,303 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01444,807,875 - 44,919,780 (-)NCBIMhudiblu_PPA_v0panPan3
ESR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,645,917 - 38,715,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,645,430 - 38,702,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,338,303 - 38,407,225 (-)NCBI
ROS_Cfam_1.0838,869,013 - 38,937,387 (-)NCBI
UMICH_Zoey_3.1838,489,186 - 38,557,866 (-)NCBI
UNSW_CanFamBas_1.0838,561,325 - 38,629,870 (-)NCBI
UU_Cfam_GSD_1.0838,921,461 - 38,990,144 (-)NCBI
Esr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,173,041 - 66,235,531 (+)NCBI
SpeTri2.0NW_0049364957,956,168 - 8,018,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,722,164 - 193,906,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,823,666 - 193,907,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,715,909 - 215,788,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,426,333 - 41,513,802 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,447,224 - 41,512,486 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605329,619,854 - 29,688,619 (-)NCBIVero_WHO_p1.0
Esr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473436,742,913 - 36,862,993 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D6Rat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,876,831 - 94,877,020 (+)MAPPERmRatBN7.2
Rnor_6.0699,182,033 - 99,182,221NCBIRnor6.0
Rnor_5.06108,593,793 - 108,593,981UniSTSRnor5.0
RGSC_v3.4698,742,972 - 98,743,161RGDRGSC3.4
RGSC_v3.4698,742,973 - 98,743,161UniSTSRGSC3.4
RGSC_v3.1698,746,429 - 98,746,617RGD
Celera693,302,793 - 93,302,965UniSTS
RH 3.4 Map6677.0RGD
RH 3.4 Map6677.0UniSTS
SHRSP x BN Map656.7498UniSTS
SHRSP x BN Map656.7498RGD
FHH x ACI Map668.02RGD
Cytogenetic Map6q24UniSTS
RH94710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,859,175 - 94,859,351 (+)MAPPERmRatBN7.2
Rnor_6.0699,164,641 - 99,164,816NCBIRnor6.0
Rnor_5.06108,576,715 - 108,576,890UniSTSRnor5.0
RGSC_v3.4698,691,449 - 98,691,624UniSTSRGSC3.4
Celera693,284,878 - 93,285,053UniSTS
RH 3.4 Map6686.1UniSTS
Cytogenetic Map6q24UniSTS
Esr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,898,051 - 94,899,380 (+)MAPPERmRatBN7.2
Rnor_6.0699,203,253 - 99,204,581NCBIRnor6.0
Rnor_5.06108,615,013 - 108,616,341UniSTSRnor5.0
RGSC_v3.4698,764,193 - 98,765,521UniSTSRGSC3.4
Celera693,323,998 - 93,325,324UniSTS
Cytogenetic Map6q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat


Genetic Models
This gene Esr2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:912
Count of miRNA genes:211
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000007109, ENSRNOT00000041872, ENSRNOT00000042682, ENSRNOT00000043602
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 6 7 26 18 1
Below cutoff 3 18 7 4 10 4 5 5 34 19 14 10 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB012721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB190769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB190770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB530987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF161187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007109   ⟹   ENSRNOP00000007109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0 Ensembl699,164,875 - 99,204,590 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000041872   ⟹   ENSRNOP00000041339
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0 Ensembl699,164,875 - 99,204,590 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000042682   ⟹   ENSRNOP00000040505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043602   ⟹   ENSRNOP00000043144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl694,859,125 - 94,899,624 (-)Ensembl
Rnor_6.0 Ensembl699,164,590 - 99,204,825 (-)Ensembl
RefSeq Acc Id: NM_012754   ⟹   NP_036886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2694,858,894 - 94,908,919 (-)NCBI
Rnor_6.0699,164,359 - 99,214,116 (-)NCBI
Rnor_5.06108,576,398 - 108,626,196 (-)NCBI
RGSC_v3.4698,691,167 - 98,775,299 (-)RGD
Celera693,284,596 - 93,334,744 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240221   ⟹   XP_006240283
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2694,858,438 - 94,909,630 (-)NCBI
Rnor_6.0699,163,953 - 99,214,710 (-)NCBI
Rnor_5.06108,576,398 - 108,626,196 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036886   ⟸   NM_012754
- Sequence:
RefSeq Acc Id: XP_006240283   ⟸   XM_006240221
- Peptide Label: isoform X1
- UniProtKB: Q59IV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043144   ⟸   ENSRNOT00000043602
RefSeq Acc Id: ENSRNOP00000041339   ⟸   ENSRNOT00000041872
RefSeq Acc Id: ENSRNOP00000007109   ⟸   ENSRNOT00000007109
RefSeq Acc Id: ENSRNOP00000040505   ⟸   ENSRNOT00000042682