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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:28909
Term: iprodione
Definition: An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.
Chemical ID: MESH:C033148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDiprodione results in increased activity of PPARG proteinPMID:20143881
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDiprodione binds to and results in increased activity of PPARG proteinPMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDiprodione binds to and results in increased activity of PPARG proteinPMID:33049310
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