GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | affects binding | EXP | | 6480464 | CTD | pirinixic acid binds to PPARG protein | PMID:35752307 | Pparg | increases expression | EXP | | 6480464 | CTD | pirinixic acid results in increased expression of PPARG mRNA | PMID:22539621 | Pparg | affects binding | ISO | PPARG (Homo sapiens) | 6480464 | CTD | pirinixic acid binds to PPARG protein | PMID:35752307 | Pparg | increases activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | pirinixic acid results in increased activity of PPARG protein | PMID:16386710 PMID:26135921 | Pparg | increases activity | ISO | Pparg (Mus musculus) | 6480464 | CTD | pirinixic acid results in increased activity of PPARG protein | PMID:12401884 PMID:9703482 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | pirinixic acid results in increased expression of PPARG mRNA | PMID:11840453 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [pirinixic acid results in increased expression of PPARG mRNA]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PPARG mRNA]; pirinixic acid analog binds to and affects the activity of PPARG protein; pirinixic acid analog binds to and results in increased activity of PPARG protein; pirinixic acid binds to and results in increased activity of PPARG protein; pirinixic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; pirinixic acid promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA] | PMID:11840453 PMID:12604364 PMID:17610302 PMID:18275039 PMID:20307981 PMID:9013583 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [pirinixic acid results in increased activity of PPARG protein] which results in increased expression of NFKBIA mRNA; pirinixic acid promotes the reaction [PPARG protein binds to NFKBIA promoter]; pirinixic acid results in increased activity of [PPARG protein co-treated with RXRA protein] | PMID:19438714 PMID:8700121 | | ||||||||||||||||||||||
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