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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDOzone results in decreased expression of PPARG mRNAPMID:33524448
Ppargincreases expressionEXP 6480464CTDOzone results in increased expression of PPARG mRNAPMID:16716893 PMID:29329427
Ppargmultiple interactionsEXP 6480464CTD[[Air Pollutants results in increased abundance of Ozone] which co-treated with Dietary Fats] results in increased expression of PPARG mRNA; Fish Oils inhibits the reaction [Ozone results in increased expression of PPARG mRNA]PMID:29329427 PMID:36412511
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of PPARG mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of PPARG mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of and results in increased oxidation of PPARG mRNAPMID:32699268
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