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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:6052
Term: isorhamnetin
Definition: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.
Chemical ID: MESH:C047368
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTD3-methylquercetin results in increased expression of PPARG proteinPMID:22992727
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG proteinPMID:22992727
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