DNA MODIFICATION PATHWAY (PW:0001340)

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Description

Epigenetic changes, the modification and remodeling of chromatin, play a key role in the differential expression of genes. Chromatin modification and remodeling directly affect the relative relaxation or compaction of chromatin and thus, the extent to which DNA replication, transcription, damage response and repair, associated RNA processing and splicing are promoted or are silenced, respectively. The basic unit of chromatin is the nucleosome - it consists of 145-147 base pairs of DNA wrapped ar

Pathway Diagram:

Elsevier Inc. 5-methylcytosine cytosine 5-formylcytosine 5-carboxylcytosine 5-hydroxymethylcytosine S-adenosylmethionine histone modification pathway chromatin remodeling pathway Dnmt3b Dnmt3a cytosine ---> 5-methylcytosine S-adenosylmethionine ---> 5-methylcytosine gene expression cytosine ---- non-methylated CpG readers 5-methylcytosine ---> 5-hydroxymethylcytosine 5-hydroxymethylcytosine ---> 5-carboxylcytosine 5-hydroxymethylcytosine ---> 5-formylcytosine 5-methylcytosine ---- MBP proteins 5-hydroxymethylcytosine ---- MBP proteins TET interacting partners ---- TET proteins Dnmt1 TET interacting partners TET proteins MBP proteins cytosine ---> gene expression 5-hydroxymethylcytosine ---> gene expression 5-methylcytosine ---> gene expression non-methylated CpG readers base excision repair pathway 5-carboxylcytosine ---- MBP proteins
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Genes in Pathway:

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DNA modification pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxxc1 CXXC finger protein 1 JBrowse link 18 70,192,520 70,197,871 RGD:9479164
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:8695943
RGD:8695944
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:8695943
RGD:8695944
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:8695943
RGD:8695944
G Kdm2a lysine demethylase 2A JBrowse link 1 219,566,130 219,642,294 RGD:9479164
G Kdm2b lysine demethylase 2B JBrowse link 12 39,021,924 39,161,954 RGD:9479164
G Kmt2a lysine methyltransferase 2A JBrowse link 8 49,110,407 49,185,872 RGD:9479164
G Kmt2c lysine methyltransferase 2C JBrowse link 4
4
82,506
6,083,650
109,986
6,294,413
RGD:9479164
G Mbd1 methyl-CpG binding domain protein 1 JBrowse link 18 70,248,568 70,263,190 RGD:8695954
G Mbd2 methyl-CpG binding domain protein 2 JBrowse link 18 65,814,026 65,885,115 RGD:8695954
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase JBrowse link 4 147,744,673 147,756,462 RGD:8695954
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:8695954
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:8695944
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 71,540,870 71,585,906 RGD:8695944
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:8695944
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:8695944
G Spi1 Spi-1 proto-oncogene JBrowse link 3 79,918,127 79,937,708 RGD:8695944
G Tet1 tet methylcytosine dioxygenase 1 JBrowse link 20 27,359,122 27,438,039 RGD:8695943
RGD:8695944
G Tet2 tet methylcytosine dioxygenase 2 JBrowse link 2 238,719,389 238,802,975 RGD:8695943
RGD:8695944
G Tet3 tet methylcytosine dioxygenase 3 JBrowse link 4 115,060,702 115,160,800 RGD:8695943
RGD:9479164
RGD:8695944
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:8695954
G Uhrf2 ubiquitin like with PHD and ring finger domains 2 JBrowse link 1 248,228,496 248,291,984 RGD:8695954
G Zbtb33 zinc finger and BTB domain containing 33 JBrowse link X 124,319,299 124,326,506 RGD:8695954
G Zbtb38 zinc finger and BTB domain containing 38 JBrowse link 8 104,566,999 104,694,890 RGD:8695954
G Zbtb4 zinc finger and BTB domain containing 4 JBrowse link 10 56,367,586 56,388,296 RGD:8695954
G Zfp57 zinc finger protein 57 JBrowse link 20 2,014,177 2,020,488 RGD:8695954
altered DNA modification pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase JBrowse link 4 147,744,673 147,756,462 RGD:9588971

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the DNA modification pathway

References Associated with the DNA modification pathway:

Ontology Path Diagram:

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