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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:81526
Term: endrin
Definition: An organochlorine compound resulting from the epoxidation of the double bond of isodrin. It is the endo, endo stereoisomer of dieldrin. It is an insecticide mainly used on field crops such as cotton and grains and has also been used as a rodenticide to control mice and voles. The product is banned in many countries since it is a persistent organic pollutant.
Chemical ID: MESH:D004732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionISOPparg (Mus musculus)6480464CTDEndrin results in decreased expression of PPARG proteinPMID:10385688
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDEndrin results in increased expression of PPARG mRNAPMID:34801515
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDMK 2206 inhibits the reaction [Endrin results in increased expression of PPARG mRNA]; Sirolimus inhibits the reaction [Endrin results in increased expression of PPARG mRNA]PMID:34801515
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