GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | increases activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Tetradecanoylphorbol Acetate results in increased activity of PPARG protein | PMID:15707588 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | Tetradecanoylphorbol Acetate results in increased expression of PPARG mRNA; Tetradecanoylphorbol Acetate results in increased expression of PPARG protein | PMID:12044893 PMID:16945329 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of troglitazone]; [Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] affects the expression of PPARG mRNA; [Tetradecanoylphorbol Acetate results in increased expression of PPARG] which affects the susceptibility to troglitazone; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; MAP2K1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; Reactive Oxygen Species affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein] | PMID:16945329 PMID:21511917 | |
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