Pparg (peroxisome proliferator activated receptor gamma) - Rat Genome Database

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Gene: Pparg (peroxisome proliferator activated receptor gamma) Chinchilla lanigera
Analyze
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
RGD ID: 8779373
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); arachidonic acid binding (ortholog); chromatin binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); animal organ regeneration (ortholog); BMP signaling pathway (ortholog); PARTICIPATES IN DNA modification pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor gamma
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
alcoholic cardiomyopathy  (ISO)
Alzheimer's disease  (ISO)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Carotid Intimal Medial Thickness 1  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (ISO)
Chronobiology Disorders  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Burns  (ISO)
Eye Injuries  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 3  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
Follicular Thyroid Cancer  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Graves Ophthalmopathy  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hyperandrogenism  (ISO)
hypertension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
ischemia  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukostasis  (ISO)
lipid storage disease  (ISO)
lipodystrophy  (ISO)
Liver Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
pituitary-dependent Cushing's disease  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
proliferative diabetic retinopathy  (ISO)
psoriasis  (ISO)
RASopathy  (ISO)
Reperfusion Injury  (ISO)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (ISO)
T-Cell Lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
animal organ regeneration  (ISO)
BMP signaling pathway  (ISO)
brown fat cell differentiation  (ISO)
cell fate commitment  (ISO)
cell maturation  (ISO)
cell population proliferation  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lithium ion  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to prostaglandin stimulus  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to vitamin E  (ISO)
cold-induced thermogenesis  (ISO)
diet induced thermogenesis  (ISO)
epithelial cell differentiation  (ISO)
epithelial cell proliferation  (ISO)
fat cell differentiation  (ISO)
fatty acid oxidation  (ISO)
glucose homeostasis  (ISO)
heart development  (ISO)
lipoprotein transport  (ISO)
long-chain fatty acid transport  (ISO)
macrophage derived foam cell differentiation  (ISO)
monocyte differentiation  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular response to insulin stimulus  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of connective tissue replacement involved in inflammatory response wound healing  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interferon-gamma-mediated signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of miRNA-mediated gene silencing  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of pancreatic stellate cell proliferation  (ISO)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of peptide hormone secretion  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of telomerase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
peroxisome proliferator activated receptor signaling pathway  (ISO)
placenta development  (ISO)
positive regulation of adiponectin secretion  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intracellular cholesterol transport  (ISO)
positive regulation of low-density lipoprotein receptor activity  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to cold  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of circadian rhythm  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to caffeine  (ISO)
response to cold  (ISO)
response to dietary excess  (ISO)
response to estrogen  (ISO)
response to food  (ISO)
response to immobilization stress  (ISO)
response to light stimulus  (ISO)
response to lipid  (ISO)
response to mechanical stimulus  (ISO)
response to metformin  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
retinoic acid receptor signaling pathway  (ISO)
signal transduction  (ISO)
white fat cell differentiation  (ISO)
wound healing involved in inflammatory response  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Pparg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBIChiLan1.0ChiLan1.0
PPARG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,287,368 - 12,434,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl312,287,368 - 12,434,356 (+)EnsemblGRCh38hg38GRCh38
GRCh37312,328,867 - 12,475,843 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,304,349 - 12,450,855 (+)NCBINCBI36hg18NCBI36
Build 34312,304,423 - 12,450,840NCBI
Celera312,266,744 - 12,413,226 (+)NCBI
Cytogenetic Map3p25.2NCBI
HuRef312,263,090 - 12,409,169 (+)NCBIHuRef
CHM1_1312,279,448 - 12,425,942 (+)NCBICHM1_1
Pparg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,337,840 - 115,467,365 (+)NCBIGRCm39mm39
GRCm39 Ensembl6115,337,912 - 115,467,360 (+)Ensembl
GRCm386115,360,879 - 115,490,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,360,951 - 115,490,399 (+)EnsemblGRCm38mm10GRCm38
MGSCv376115,311,239 - 115,440,419 (+)NCBIGRCm37mm9NCBIm37
MGSCv366115,387,692 - 115,456,020 (+)NCBImm8
Celera6117,199,637 - 117,329,691 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.41NCBI
Pparg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24148,423,102 - 148,548,471 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)Ensembl
Rnor_6.04147,274,055 - 147,399,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,562,928 - 210,688,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,492,220 - 151,617,331 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14151,796,047 - 151,862,171 (+)NCBI
Celera4137,316,681 - 137,440,473 (+)NCBICelera
Cytogenetic Map4q42NCBI
PPARG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1312,560,670 - 12,705,060 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,622,397 - 12,705,060 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0312,215,322 - 12,361,669 (+)NCBIMhudiblu_PPA_v0panPan3
PPARG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,134,618 - 6,265,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,050,357 - 6,207,981 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,170,697 - 6,244,070 (-)NCBI
ROS_Cfam_1.0206,163,453 - 6,294,865 (-)NCBI
ROS_Cfam_1.0 Ensembl206,163,453 - 6,236,837 (-)Ensembl
UMICH_Zoey_3.1205,878,834 - 5,952,191 (-)NCBI
UNSW_CanFamBas_1.0206,232,700 - 6,306,060 (-)NCBI
UU_Cfam_GSD_1.0206,208,181 - 6,281,750 (-)NCBI
Pparg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,541,121 - 17,706,796 (+)NCBI
SpeTri2.0NW_0049366021,230,907 - 1,368,588 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,302,655 - 68,433,947 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,301,566 - 68,433,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,515,515 - 75,650,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,262,743 - 48,407,415 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,275,600 - 48,407,418 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041118,092,724 - 118,237,828 (-)NCBIVero_WHO_p1.0
Pparg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462495684,673 - 207,176 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021746   ⟹   ENSCLAP00000021543
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542914,873,908 - 14,937,387 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021747   ⟹   ENSCLAP00000021544
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542914,875,680 - 14,936,710 (+)Ensembl
RefSeq Acc Id: XM_005387017   ⟹   XP_005387074
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005387018   ⟹   XP_005387075
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542914,814,690 - 14,936,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005387019   ⟹   XP_005387076
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542914,814,693 - 14,936,869 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005387074 (Get FASTA)   NCBI Sequence Viewer  
  XP_005387075 (Get FASTA)   NCBI Sequence Viewer  
  XP_005387076 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005387074   ⟸   XM_005387017
- Sequence:
RefSeq Acc Id: XP_005387075   ⟸   XM_005387018
- Sequence:
RefSeq Acc Id: XP_005387076   ⟸   XM_005387019
- Sequence:
RefSeq Acc Id: ENSCLAP00000021544   ⟸   ENSCLAT00000021747
RefSeq Acc Id: ENSCLAP00000021543   ⟸   ENSCLAT00000021746


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000021543 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAP00000021544 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021746 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAT00000021747 UniProtKB/TrEMBL
NCBI Gene Pparg ENTREZGENE
UniProt A0A8C2VW58_CHILA UniProtKB/TrEMBL
  A0A8C2VWJ8_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Pparg  peroxisome proliferator activated receptor gamma    peroxisome proliferator-activated receptor gamma  Symbol and/or name change 5135510 APPROVED