Ncoa1 (nuclear receptor coactivator 1) - Rat Genome Database

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Gene: Ncoa1 (nuclear receptor coactivator 1) Rattus norvegicus
Analyze
Symbol: Ncoa1
Name: nuclear receptor coactivator 1
RGD ID: 1309046
Description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear estrogen receptor binding activity; and nuclear retinoid X receptor binding activity. Involved in several processes, including brain development; estrous cycle; and lactation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of RNA polymerase II transcription regulator complex and chromatin. Predicted to be active in nucleus. Biomarker of hypothyroidism. Orthologous to human NCOA1 (nuclear receptor coactivator 1); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SRC-1; steroid receptor coactivator 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,952,090 - 33,229,829 (-)NCBIGRCr8
mRatBN7.2627,232,609 - 27,507,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,232,611 - 27,475,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,524,867 - 27,768,734 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,840,748 - 28,084,625 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,318,440 - 27,562,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,677,563 - 28,931,844 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,677,540 - 28,931,843 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,483,476 - 38,734,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4627,224,396 - 27,473,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1627,229,075 - 27,336,790 (-)NCBI
Celera626,704,021 - 26,946,167 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
9-cis-retinoic acid  (ISO)
Acetyl tributyl citrate  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
androst-4-ene-3,17-dione  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butamben  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
ciglitazone  (ISO)
clemizole  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
daidzein  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Dicyclohexyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
econazole  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzacamene  (EXP)
estrone  (ISO)
ethanol  (ISO)
flavonol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
galangin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
guggulsterone  (ISO)
GW 4064  (ISO)
hexestrol  (ISO)
irinotecan  (ISO)
isopimpinellin  (ISO)
isoxazoles  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
Meclizine  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP,ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
miconazole  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (ISO)
Nonylphenol  (ISO)
omeprazole  (ISO)
ormeloxifene  (EXP)
oxaliplatin  (EXP)
oxiconazole  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraformaldehyde macromolecule  (ISO)
pazopanib  (ISO)
permethrin  (ISO)
Phenoxybenzamine  (ISO)
phenytoin  (ISO)
phthalic acid  (ISO)
pimecrolimus  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
PK-11195  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolines  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
topotecan  (EXP)
trimegestone  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Auger AP, etal., Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7551-5.
2. Sex differences and synchronous development of steroid receptor coactivator-1 and synaptic proteins in the hippocampus of postnatal female and male C57BL/6 mice. Bian C, etal., Steroids. 2012 Jan;77(1-2):149-56. Epub 2011 Nov 9.
3. Changes in the content of steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid hormone receptors in the rat brain during the estrous cycle. Camacho-Arroyo I, etal., J Steroid Biochem Mol Biol. 2005 Feb;94(1-3):267-72. Epub 2005 Feb 17.
4. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
5. Expression of estrogen receptor co-regulators SRC-1, RIP140 and NCoR and their interaction with estrogen receptor in rat uterus, under the influence of ormeloxifene. Daverey A, etal., J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):93-101. Epub 2009 May 19.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome. Green AR, etal., Breast Cancer Res Treat. 2007 Sep 28;.
8. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
9. Thyroid hormone exerts site-specific effects on SRC-1 and NCoR expression selectively in the neonatal rat brain. Iannacone EA, etal., Mol Cell Endocrinol. 2002 Jan 15;186(1):49-59.
10. Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. Igarashi-Migitaka J, etal., Eur J Endocrinol. 2005 Oct;153(4):595-604.
11. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
12. Expression of estrogen receptor coregulators in normal and malignant human endometrium. Kershah SM, etal., Gynecol Oncol. 2004 Jan;92(1):304-13.
13. Expression of androgen receptor coregulators in prostate cancer. Linja MJ, etal., Clin Cancer Res. 2004 Feb 1;10(3):1032-40.
14. Expression of nuclear hormone receptors, their coregulators and type I iodothyronine 5'-deiodinase gene in mammary tissue of nonlactating and postlactating rats. Macejova D, etal., Life Sci. 2005 Sep 30;77(20):2584-93.
15. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status. Martinez de Arrieta C, etal., Endocrinology. 2000 May;141(5):1693-8.
16. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. McInerney EM, etal., Genes Dev. 1998 Nov 1;12(21):3357-68.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1. Miard S, etal., Aging Cell. 2009 Aug;8(4):449-59. Epub 2009 May 22.
19. Expression and hormonal regulation of coactivator and corepressor genes. Misiti S, etal., Endocrinology. 1998 May;139(5):2493-500.
20. Developmental expression profiles and distinct regional estrogen responsiveness suggest a novel role for the steroid receptor coactivator SRC-1 as discriminative amplifier of estrogen signaling in the rat brain. Mitev YA, etal., FASEB J. 2003 Mar;17(3):518-9. Epub 2003 Jan 22.
21. Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes. Molenda-Figueira HA, etal., Endocrinology. 2008 Oct;149(10):5272-9. Epub 2008 Jun 19.
22. Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats. Molenda-Figueira HA, etal., Horm Behav. 2006 Sep;50(3):383-92.
23. The human glucocorticoid receptor: molecular basis of biologic function. Nicolaides NC, etal., Steroids. 2010 Jan;75(1):1-12. Epub 2009 Oct 7.
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Rochette-Egly C and Germain P, Nucl Recept Signal. 2009 May 8;7:e005.
29. Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions. Trousson A, etal., J Steroid Biochem Mol Biol. 2007 May;104(3-5):305-11. Epub 2007 Mar 23.
30. Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors. Wang L, etal., Arch Biochem Biophys. 2004 Aug 1;428(1):92-8.
31. The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300. Wang XL, etal., J Biol Chem. 2004 Aug 13;279(33):34191-200. Epub 2004 May 27.
32. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
33. Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex. Yousefi B, etal., Thyroid. 2005 Apr;15(4):314-9.
34. Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats. Zhang D, etal., Brain Res. 2011 Mar 25;1382:88-97. Epub 2011 Jan 15.
35. Expression of steroid receptor coactivator-1 was regulated by postnatal development but not ovariectomy in the hippocampus of rats. Zhang D, etal., Dev Neurosci. 2011;33(1):57-63. Epub 2011 Jan 11.
Additional References at PubMed
PMID:9223431   PMID:10207113   PMID:10934189   PMID:11891224   PMID:12039952   PMID:12089347   PMID:12446761   PMID:12917342   PMID:14534427   PMID:15155786   PMID:15219413   PMID:15367689  
PMID:15456935   PMID:15564339   PMID:15641800   PMID:15681609   PMID:15831516   PMID:15919756   PMID:16109736   PMID:16148126   PMID:16723356   PMID:17218095   PMID:17363140   PMID:17786964  
PMID:18063853   PMID:18563714   PMID:18798693   PMID:19423554   PMID:20685850   PMID:24550004   PMID:26223010   PMID:26482332   PMID:29263093  


Genomics

Comparative Map Data
Ncoa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,952,090 - 33,229,829 (-)NCBIGRCr8
mRatBN7.2627,232,609 - 27,507,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,232,611 - 27,475,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,524,867 - 27,768,734 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,840,748 - 28,084,625 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,318,440 - 27,562,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,677,563 - 28,931,844 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,677,540 - 28,931,843 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,483,476 - 38,734,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4627,224,396 - 27,473,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1627,229,075 - 27,336,790 (-)NCBI
Celera626,704,021 - 26,946,167 (-)NCBICelera
Cytogenetic Map6q14NCBI
NCOA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,491,254 - 24,770,702 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,491,254 - 24,770,702 (+)EnsemblGRCh38hg38GRCh38
GRCh37224,714,123 - 24,993,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,660,850 - 24,847,075 (+)NCBINCBI36Build 36hg18NCBI36
Build 34224,718,996 - 24,905,219NCBI
Celera224,648,250 - 24,833,882 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,545,896 - 24,731,418 (+)NCBIHuRef
CHM1_1224,736,919 - 24,923,129 (+)NCBICHM1_1
T2T-CHM13v2.0224,525,913 - 24,805,480 (+)NCBIT2T-CHM13v2.0
Ncoa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,297,362 - 4,569,452 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,297,362 - 4,527,182 (-)EnsemblGRCm39 Ensembl
GRCm38124,247,362 - 4,477,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,247,362 - 4,477,182 (-)EnsemblGRCm38mm10GRCm38
MGSCv37124,247,362 - 4,484,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36124,257,424 - 4,491,127 (-)NCBIMGSCv36mm8
Celera124,179,857 - 4,348,692 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map122.05NCBI
Ncoa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,794,821 - 6,892,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554696,676,780 - 6,892,587 (+)NCBIChiLan1.0ChiLan1.0
NCOA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,755,028 - 102,031,268 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,759,056 - 102,035,245 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,485,068 - 24,764,135 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,581,645 - 24,859,488 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,733,117 - 24,859,488 (+)Ensemblpanpan1.1panPan2
NCOA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11718,880,676 - 19,124,300 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1718,880,383 - 19,122,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1718,777,980 - 19,021,230 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,302,445 - 19,397,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,153,592 - 19,396,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11718,890,805 - 19,134,195 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01718,899,937 - 19,143,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01718,940,197 - 19,183,703 (+)NCBIUU_Cfam_GSD_1.0
Ncoa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,234,427 - 63,471,108 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,368,462 - 7,465,615 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,368,393 - 7,605,754 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,999,253 - 114,250,298 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,997,214 - 114,251,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,230,135 - 121,286,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.23121,349,942 - 121,379,022 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,898,368 - 83,028,137 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,897,348 - 83,013,589 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604528,994,261 - 29,270,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247386,943,726 - 7,054,454 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247386,770,745 - 7,054,616 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ncoa1
992 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:195
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000068531
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
D6Rat89  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,392,666 - 27,392,902 (+)MAPPERmRatBN7.2
Rnor_6.0628,841,077 - 28,841,312NCBIRnor6.0
Rnor_5.0638,646,507 - 38,646,742UniSTSRnor5.0
RGSC_v3.4627,388,747 - 27,388,983RGDRGSC3.4
RGSC_v3.4627,388,748 - 27,388,983UniSTSRGSC3.4
RGSC_v3.1627,391,700 - 27,391,936RGD
Celera626,863,437 - 26,863,672UniSTS
FHH x ACI Map625.9999RGD
FHH x ACI Map625.9999UniSTS
Cytogenetic Map6q14UniSTS
D6Rat171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,261,609 - 27,261,739 (+)MAPPERmRatBN7.2
Rnor_6.0628,706,592 - 28,706,721NCBIRnor6.0
Rnor_5.0638,512,104 - 38,512,233UniSTSRnor5.0
RGSC_v3.4627,253,868 - 27,253,998RGDRGSC3.4
RGSC_v3.4627,253,869 - 27,253,998UniSTSRGSC3.4
RGSC_v3.1627,256,821 - 27,256,951RGD
Celera626,732,958 - 26,733,087UniSTS
SHRSP x BN Map625.1499RGD
SHRSP x BN Map625.1499UniSTS
Cytogenetic Map6q14UniSTS
D6Got21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,375,920 - 27,376,215 (+)MAPPERmRatBN7.2
Rnor_6.0628,823,943 - 28,824,237NCBIRnor6.0
Rnor_5.0638,629,373 - 38,629,667UniSTSRnor5.0
RGSC_v3.4627,371,915 - 27,372,210RGDRGSC3.4
RGSC_v3.4627,371,916 - 27,372,210UniSTSRGSC3.4
RGSC_v3.1627,374,869 - 27,375,163RGD
Celera626,846,830 - 26,847,124UniSTS
RH 3.4 Map6107.5UniSTS
RH 3.4 Map6107.5RGD
RH 2.0 Map6222.5RGD
Cytogenetic Map6q14UniSTS
D6Got22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,306,935 - 27,307,104 (+)MAPPERmRatBN7.2
Rnor_6.0628,751,750 - 28,751,922NCBIRnor6.0
Rnor_5.0638,557,127 - 38,557,299UniSTSRnor5.0
RGSC_v3.4627,299,768 - 27,299,941RGDRGSC3.4
RGSC_v3.4627,299,769 - 27,299,941UniSTSRGSC3.4
RGSC_v3.1627,302,722 - 27,302,894RGD
Celera626,778,484 - 26,778,656UniSTS
RH 3.4 Map6116.9UniSTS
RH 3.4 Map6116.9RGD
RH 2.0 Map6223.6RGD
Cytogenetic Map6q14UniSTS
D6Got18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,471,732 - 27,471,889 (-)MAPPERmRatBN7.2
mRatBN7.2627,471,732 - 27,471,889 (+)MAPPERmRatBN7.2
Rnor_6.0628,927,909 - 28,928,065NCBIRnor6.0
Rnor_6.0630,363,565 - 30,363,721NCBIRnor6.0
Rnor_5.0638,730,388 - 38,730,544UniSTSRnor5.0
Rnor_5.0639,528,946 - 39,529,102UniSTSRnor5.0
RGSC_v3.4627,469,991 - 27,470,147UniSTSRGSC3.4
RGSC_v3.4627,469,990 - 27,470,147RGDRGSC3.4
RGSC_v3.1627,472,944 - 27,473,100RGD
Celera626,942,236 - 26,942,392UniSTS
RH 3.4 Map6102.5UniSTS
RH 3.4 Map6102.5RGD
RH 2.0 Map6224.2RGD
Cytogenetic Map6q14UniSTS
AU046409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,261,597 - 27,261,766 (+)MAPPERmRatBN7.2
Rnor_6.0628,706,580 - 28,706,748NCBIRnor6.0
Rnor_5.0638,512,092 - 38,512,260UniSTSRnor5.0
RGSC_v3.4627,253,857 - 27,254,025UniSTSRGSC3.4
Celera626,732,946 - 26,733,114UniSTS
Cytogenetic Map6q14UniSTS
RH137721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,355,388 - 27,355,637 (+)MAPPERmRatBN7.2
Rnor_6.0628,802,879 - 28,803,127NCBIRnor6.0
Rnor_5.0638,608,309 - 38,608,557UniSTSRnor5.0
RGSC_v3.4627,350,973 - 27,351,221UniSTSRGSC3.4
Celera626,826,766 - 26,827,014UniSTS
RH 3.4 Map6114.0UniSTS
Cytogenetic Map6q14UniSTS
RH80592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,234,627 - 27,234,858 (+)MAPPERmRatBN7.2
Rnor_6.0628,679,581 - 28,679,811NCBIRnor6.0
Rnor_5.0638,485,494 - 38,485,724UniSTSRnor5.0
RGSC_v3.4627,226,412 - 27,226,642UniSTSRGSC3.4
Celera626,706,037 - 26,706,267UniSTS
Cytogenetic Map6q14UniSTS
Ncoa1Cpn_6027473879  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4627,473,879 - 27,473,879 (-)RGDRGSC3.4


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 20 4 19 4 8 10 74 35 34 11 8
Low 6 37 37 37 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000068531   ⟹   ENSRNOP00000061906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,232,611 - 27,475,664 (-)Ensembl
Rnor_6.0 Ensembl628,677,565 - 28,931,843 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091659   ⟹   ENSRNOP00000071037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,233,124 - 27,475,664 (-)Ensembl
Rnor_6.0 Ensembl628,677,540 - 28,862,159 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105343   ⟹   ENSRNOP00000095601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,237,445 - 27,475,664 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110405   ⟹   ENSRNOP00000095436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,233,873 - 27,475,664 (-)Ensembl
RefSeq Acc Id: NM_001395569   ⟹   NP_001382498
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,195,924 (-)NCBI
mRatBN7.2627,232,609 - 27,476,452 (-)NCBI
RefSeq Acc Id: XM_017594128   ⟹   XP_017449617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,195,438 (-)NCBI
mRatBN7.2627,234,747 - 27,475,786 (-)NCBI
Rnor_6.0628,677,563 - 28,931,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112177   ⟹   XP_038968105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,229,829 (-)NCBI
mRatBN7.2627,234,747 - 27,507,992 (-)NCBI
RefSeq Acc Id: XM_039112178   ⟹   XP_038968106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,179,784 (-)NCBI
mRatBN7.2627,234,747 - 27,460,314 (-)NCBI
RefSeq Acc Id: XM_039112179   ⟹   XP_038968107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,196,011 (-)NCBI
mRatBN7.2627,232,609 - 27,476,260 (-)NCBI
RefSeq Acc Id: XM_039112180   ⟹   XP_038968108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,196,005 (-)NCBI
mRatBN7.2627,234,747 - 27,476,260 (-)NCBI
RefSeq Acc Id: XM_039112182   ⟹   XP_038968110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,196,005 (-)NCBI
mRatBN7.2627,234,747 - 27,476,260 (-)NCBI
RefSeq Acc Id: XM_039112184   ⟹   XP_038968112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,954,255 - 33,196,005 (-)NCBI
mRatBN7.2627,234,604 - 27,476,260 (-)NCBI
RefSeq Acc Id: XM_063261875   ⟹   XP_063117945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,952,090 - 33,196,005 (-)NCBI
RefSeq Acc Id: XP_017449617   ⟸   XM_017594128
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLM3 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061906   ⟸   ENSRNOT00000068531
RefSeq Acc Id: ENSRNOP00000071037   ⟸   ENSRNOT00000091659
RefSeq Acc Id: XP_038968107   ⟸   XM_039112179
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLM3 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968112   ⟸   XM_039112184
- Peptide Label: isoform X3
- UniProtKB: A6HAH8 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968105   ⟸   XM_039112177
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLM3 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968110   ⟸   XM_039112182
- Peptide Label: isoform X2
- UniProtKB: A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968108   ⟸   XM_039112180
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLM3 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968106   ⟸   XM_039112178
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLM3 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095436   ⟸   ENSRNOT00000110405
RefSeq Acc Id: ENSRNOP00000095601   ⟸   ENSRNOT00000105343
RefSeq Acc Id: NP_001382498   ⟸   NM_001395569
- UniProtKB: A6HAH8 (UniProtKB/TrEMBL),   A0A8I6APA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117945   ⟸   XM_063261875
- Peptide Label: isoform X1
Protein Domains
bHLH   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3Q3-F1-model_v2 AlphaFold D4A3Q3 1-1417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309046 AgrOrtholog
BioCyc Gene G2FUF-38275 BioCyc
Ensembl Genes ENSRNOG00000004068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068531.3 UniProtKB/TrEMBL
  ENSRNOT00000091659.2 UniProtKB/TrEMBL
  ENSRNOT00000105343.1 UniProtKB/TrEMBL
  ENSRNOT00000110405.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.140.410 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro DUF1518 UniProtKB/TrEMBL
  HLH_DNA-bd UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  NCOA1 UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa-typ UniProtKB/TrEMBL
  Nuc_rcpt_coact_Ncoa_int_sf UniProtKB/TrEMBL
  Nuclear_rcpt_coactivator UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
  SRC-1 UniProtKB/TrEMBL
KEGG Report rno:313929 UniProtKB/TrEMBL
NCBI Gene 313929 ENTREZGENE
PANTHER PTHR10684 UniProtKB/TrEMBL
  PTHR10684:SF1 UniProtKB/TrEMBL
Pfam DUF1518 UniProtKB/TrEMBL
  NCOA_u2 UniProtKB/TrEMBL
  Nuc_rec_co-act UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_11 UniProtKB/TrEMBL
  SRC-1 UniProtKB/TrEMBL
PhenoGen Ncoa1 PhenoGen
PIRSF Nuclear_receptor_coactivator UniProtKB/TrEMBL
PROSITE HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004068 RatGTEx
SMART DUF1518 UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
  Nuc_recept_coact UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A0G2JZG4_RAT UniProtKB/TrEMBL
  A0A8I6APA0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLM3 ENTREZGENE, UniProtKB/TrEMBL
  A6HAH8 ENTREZGENE, UniProtKB/TrEMBL
  D4A3Q3_RAT UniProtKB/TrEMBL
UniProt Secondary D4AB68 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ncoa1  nuclear receptor coactivator 1   Ncoa1_predicted  nuclear receptor coactivator 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ncoa1_predicted  nuclear receptor coactivator 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED