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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionISOPparg (Mus musculus)6480464CTDMethamphetamine results in decreased expression of PPARG proteinPMID:18946735
Ppargincreases activityISOPparg (Mus musculus)6480464CTDMethamphetamine results in increased activity of PPARG proteinPMID:17019405
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDMethamphetamine results in increased expression of PPARG proteinPMID:17019405
Ppargincreases response to substanceISOPparg (Mus musculus)6480464CTDPPARG protein results in increased susceptibility to MethamphetaminePMID:17019405
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide promotes the reaction [PPARG protein results in increased susceptibility to Methamphetamine]; [pioglitazone co-treated with alitretinoin] inhibits the reaction [PPARG protein results in increased susceptibility to Methamphetamine]; ciglitazone inhibits the reaction [PPARG protein results in increased susceptibility to Methamphetamine]; Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of PPARG protein]; pioglitazone inhibits the reaction [PPARG protein results in increased susceptibility to Methamphetamine]PMID:17019405 PMID:18946735
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