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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:34919
Term: Phenylamil
Definition: A pyrazine that has formula C12H12ClN7O.
Chemical ID: MESH:C047088
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects response to substanceISOPparg (Mus musculus)6480464CTDPPARG protein affects the susceptibility to phenylamilPMID:20519739
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDphenylamil results in increased expression of PPARG mRNAPMID:20519739
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD[phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA; PPARG protein promotes the reaction [phenylamil results in increased expression of ADIPOQ mRNA]; PPARG protein promotes the reaction [phenylamil results in increased expression of AQP7 mRNA]; PPARG protein promotes the reaction [phenylamil results in increased expression of FABP4 mRNA]PMID:20519739
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