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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]]]PMID:32623698
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDFulvestrant inhibits the reaction [Diazinon results in increased expression of PPARG protein]; Fulvestrant inhibits the reaction [Diethylstilbestrol results in increased activity of PPARG protein]; Fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]; Fulvestrant inhibits the reaction [phoxim results in increased expression of PPARG protein]; Fulvestrant inhibits the reaction [terbufos results in increased expression of PPARG protein]; Fulvestrant inhibits the reaction [tolclofos-methyl results in increased expression of PPARG protein]PMID:22710028 PMID:26408789 PMID:33872936
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