PPARA (peroxisome proliferator activated receptor alpha) - Rat Genome Database
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Gene: PPARA (peroxisome proliferator activated receptor alpha) Sus scrofa
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Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
RGD ID: 14213069
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); MDM2/MDM4 family protein binding (ortholog); NFAT protein binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); heart development (ortholog); lipid localization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH bezafibrate; cisplatin; clofibrate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: peroxisome proliferative activated receptor alpha; peroxisome proliferator-activated receptor alpha; PPARALPHA
Orthologs:
Homo sapiens (human) : PPARA (peroxisome proliferator activated receptor alpha)  HGNC  Alliance
Mus musculus (house mouse) : Ppara (peroxisome proliferator activated receptor alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppara (peroxisome proliferator activated receptor alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppara (peroxisome proliferator activated receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPARA (peroxisome proliferator activated receptor alpha)
Canis lupus familiaris (dog) : PPARA (peroxisome proliferator activated receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppara (peroxisome proliferator activated receptor alpha)
Chlorocebus sabaeus (African green monkey) : PPARA (peroxisome proliferator activated receptor alpha)
Heterocephalus glaber (naked mole-rat) : Ppara (peroxisome proliferator activated receptor alpha)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,708 - 3,366,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (ISO)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Diabetic Cardiomyopathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
hydrocephalus  (ISO)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (ISO)
hypertensive encephalopathy  (ISO)
Hypertensive Nephropathy  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
periodontitis  (ISO)
Phelan-McDermid syndrome  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (ISO)
cell differentiation  (IBA)
cellular response to starvation  (IEA)
circadian regulation of gene expression  (IEA)
enamel mineralization  (IEA)
epidermis development  (IEA)
fatty acid metabolic process  (IBA)
heart development  (ISO)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IEA)
lipid localization  (ISO)
lipoprotein metabolic process  (ISO)
negative regulation of appetite  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cholesterol storage  (IBA)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (IEA)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IBA)
negative regulation of leukocyte cell-cell adhesion  (IEA)
negative regulation of macrophage derived foam cell differentiation  (IEA)
negative regulation of neuron death  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
negative regulation of protein binding  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of sequestering of triglyceride  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (IEA)
positive regulation of gluconeogenesis  (IEA)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of viral genome replication  (ISO)
regulation of cellular ketone metabolic process  (ISO)
regulation of circadian rhythm  (IEA)
regulation of fatty acid metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (IBA)
regulation of lipid storage  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipid  (IBA)
response to organic cyclic compound  (ISO)
steroid hormone mediated signaling pathway  (IEA)
wound healing  (IEA)

Cellular Component
nucleoplasm  (IEA)
nucleus  (ISO)

References
Additional References at PubMed
PMID:11483366   PMID:14687083   PMID:15650118   PMID:16339839   PMID:17272864   PMID:17318406   PMID:22204804   PMID:24671595   PMID:29550794  


Genomics

Comparative Map Data
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,708 - 3,366,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2246,150,521 - 46,243,756 (+)EnsemblGRCh38hg38GRCh38
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372246,546,458 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBINCBI36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBI
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBI
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBImm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
Cytogenetic Map7q34NCBI
RH 3.4 Map7922.4RGD
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12245,218,364 - 45,302,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensemblpanpan1.1panPan2
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)Ensembl
ChlSab1.11928,614,892 - 28,709,272 (+)NCBI
Ppara
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 4 2 1 2
Low 6 2 3 5 1 23 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000007   ⟹   ENSSSCP00000000007
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl53,300,708 - 3,366,361 (-)Ensembl
RefSeq Acc Id: NM_001044526   ⟹   NP_001037991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.153,302,755 - 3,321,091 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001037991   ⟸   NM_001044526
- UniProtKB: Q1W4T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000000007   ⟸   ENSSSCT00000000007
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000006 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000000007 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000007 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  NHR_like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  PPAR-alpha UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report ssc:397239 UniProtKB/TrEMBL
NCBI Gene PPARA ENTREZGENE
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS PROXISOMEPAR UniProtKB/TrEMBL
  PROXISOMPAAR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/TrEMBL
UniGene Ssc.15874 ENTREZGENE
UniProt F1SM76_PIG UniProtKB/TrEMBL
  Q1W4T0 ENTREZGENE, UniProtKB/TrEMBL
  Q5J6J4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91682 ENTREZGENE