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Gene: Ppargc1a (PPARG coactivator 1 alpha) Rattus norvegicus
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Description: Exhibits several functions, including alpha-tubulin binding activity; promoter-specific chromatin binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; cellular response to organic cyclic compound; and regulation of smooth muscle cell proliferation. Localizes to several cellular components, including cytosolic ribosome; mitochondrion; and nuclear euchromatin. Used to study several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and sciatic neuropathy. Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); placental insufficiency; primary biliary cirrhosis; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (20S)-ginsenoside Rg3.
Type: protein-coding
Also known as: peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1-alpha; PGC-1alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1
Homo sapiens (human) : PPARGC1A (PPARG coactivator 1 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppargc1a (PPARG coactivator 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPARGC1A (PPARG coactivator 1 alpha)
Canis lupus familiaris (dog) : PPARGC1A (PPARG coactivator 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppargc1a (PPARG coactivator 1 alpha)
Sus scrofa (pig) : PPARGC1A (PPARG coactivator 1 alpha)
Chlorocebus sabaeus (African green monkey) : PPARGC1A (PPARG coactivator 1 alpha)
Heterocephalus glaber (naked mole-rat) : Ppargc1a (PPARG coactivator 1 alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ppargc1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620925
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.