Gene: Ppargc1a (PPARG coactivator 1 alpha) Rattus norvegicus
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Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Description: ENCODES a protein that exhibits alpha-tubulin binding; chromatin binding; estrogen receptor binding; INVOLVED IN adaptive thermogenesis; aging; androgen metabolic process; PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; Huntington's disease pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome; Alzheimer's disease; amblyopia; FOUND IN apical dendrite; cytoplasm; cytosol; INTERACTS WITH (-)-epigallocatechin 3-gallate; (2-trans,6-trans)-farnesol; (20S)-ginsenoside Rg3
AGR Description: Exhibits several functions, including alpha-tubulin binding activity, promoter-specific chromatin binding activity, and signaling receptor binding activity; involved in several processes, including brain development, cellular response to organic cyclic compound, and positive regulation of cellular metabolic process; localizes to the apical dendrite, intracellular organelle, and neuronal cell body; used to study several diseases, including colitis, diabetic retinopathy, fatty liver disease (multiple), glucose metabolism disease (multiple), and neurodegenerative disease (multiple); biomarker of several diseases, including Huntington's disease, abdominal obesity-metabolic syndrome, congenital hypothyroidism, eye disease (multiple), and glucose metabolism disease (multiple); orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
Merged Description: Exhibits several functions, including alpha-tubulin binding activity, promoter-specific chromatin binding activity, and signaling receptor binding activity; involved in several processes, including brain development, cellular response to organic cyclic compound, and positive regulation of cellular metabolic process; localizes to the apical dendrite, intracellular organelle, and neuronal cell body; used to study several diseases, including colitis, diabetic retinopathy, fatty liver disease (multiple), glucose metabolism disease (multiple), and neurodegenerative disease (multiple); biomarker of several diseases, including Huntington's disease, abdominal obesity-metabolic syndrome, congenital hypothyroidism, eye disease (multiple), and glucose metabolism disease (multiple); orthologous to human PPARGC1A (PPARG coactivator 1 alpha); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; Huntington's disease pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (2-trans,6-trans)-farnesol; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1-alpha; PGC-1alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1
Orthologs:
Homo sapiens (human) : PPARGC1A (PPARG coactivator 1 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppargc1a (PPARG coactivator 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPARGC1A (PPARG coactivator 1 alpha)
Canis lupus familiaris (dog) : PPARGC1A (PPARG coactivator 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppargc1a (PPARG coactivator 1 alpha)
Sus scrofa (pig) : PPARGC1A (PPARG coactivator 1 alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ppargc1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 620925
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.