Ppargc1a (PPARG coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (PPARG coactivator 1 alpha) Rattus norvegicus
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
RGD ID: 620925
Description: Enables several functions, including alpha-tubulin binding activity; nuclear estrogen receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; cellular response to organic cyclic compound; and regulation of smooth muscle cell proliferation. Located in apical dendrite; cytosolic ribosome; and neuronal cell body. Part of euchromatin. Used to study several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and sciatic neuropathy. Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); obesity; placental insufficiency; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
Previously known as: LRPGC1; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1-alpha; PGC-1alpha; PGC-1v; PGCvf; PGCvf-1; PGCvf1; PPAR gamma coactivator 1alpha variant form-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1; Ppargc1a-vf1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKY
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (IEP)
acute kidney failure  (ISO)
age related macular degeneration  (ISS)
Albuminuria  (ISO)
Alzheimer's disease  (IDA,ISO)
amblyopia  (IEP)
amyotrophic lateral sclerosis  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (IEP,ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISS)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IDA,ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IDA)
congenital hypothyroidism  (IEP)
congestive heart failure  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IDA,IEP)
dilated cardiomyopathy  (IDA)
Diseases of the Aged  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,IMP,ISO)
fatty liver disease  (IDA,IEP,ISO)
Fetal Growth Retardation  (IEP)
genetic disease  (ISO)
glucose intolerance  (ISO)
heart disease  (IDA)
Huntington's disease  (IDA,IEP,ISO)
hyperglycemia  (IDA,IEP,ISO)
hyperthyroidism  (IEP)
Insulin Resistance  (IEP,ISO)
Kearns-Sayre syndrome  (ISO)
kidney cancer  (ISO)
kidney failure  (IDA)
Kidney Reperfusion Injury  (IDA)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (IEP)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (ISO)
nephrotic syndrome  (IEP)
neuronal ceroid lipofuscinosis 1  (ISO)
non-alcoholic fatty liver disease  (IDA,ISO)
obesity  (IDA,IEP,ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
placental insufficiency  (IEP)
prediabetes syndrome  (IEP)
primary biliary cholangitis  (IEP)
pulmonary emphysema  (ISO)
renal fibrosis  (IEP)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (IEP)
Sleep Initiation and Maintenance Disorders  (ISO)
Spinal Cord Injuries  (IDA)
Takotsubo Cardiomyopathy  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IDA,IEP,ISO)
Ventricular Dysfunction, Right  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1D-myo-inositol 1-phosphate  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,6-dioxoheptanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (EXP,ISO)
acarbose  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
adenosine  (ISO)
adenosine 5'-monophosphate  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP,ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (EXP)
aminoguanidine  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP,ISO)
benfotiamine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP,ISO)
Betanin  (EXP)
bezafibrate  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
bupivacaine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butan-2-one  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (EXP,ISO)
calycosin  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
carvedilol  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
chicoric acid  (EXP)
CHIR 99021  (ISO)
chlormidazole  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholate  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clenbuterol  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cortisone  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
D-glucurono-6,3-lactone  (ISO)
dapagliflozin  (EXP)
decanoic acid  (ISO)
dehydroepiandrosterone  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dihydrofolic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (EXP,ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
farnesol  (EXP)
fenofibrate  (ISO)
fenoterol  (ISO)
fenpyroximate  (ISO)
ferulic acid  (EXP,ISO)
flavonoids  (ISO)
fluoxastrobin  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
galactose  (EXP)
gamma-hexachlorocyclohexane  (ISO)
Genipin  (ISO)
Geniposide  (ISO)
ginsenoside Rg2  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
GW 1929  (ISO)
GW 501516  (ISO)
haloperidol  (ISO)
harmine  (ISO)
hemin  (EXP)
herbicide  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
ICI 118551  (ISO)
imidacloprid  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inositol  (EXP)
inulin  (ISO)
ionomycin  (EXP)
iprodione  (EXP)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isoxazoles  (ISO)
kaempferol  (ISO)
ketotifen  (ISO)
kresoxim-methyl  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
Licarin A  (ISO)
limonene  (ISO)
linagliptin  (EXP,ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
losartan  (EXP)
lovastatin  (ISO)
luzindole  (ISO)
LY294002  (EXP,ISO)
mabuterol  (ISO)
Magnolol  (EXP)
malic acid  (ISO)
malonic acid  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
melatonin  (EXP,ISO)
meldonium  (EXP,ISO)
mesalamine  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP,ISO)
metoprolol  (EXP)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
Morroniside  (ISO)
myo-inositol hexakisphosphate  (ISO)
N(6)-butyryl-cAMP  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naringin  (EXP)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitrites  (EXP)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
NMN zwitterion  (ISO)
NSC 23766  (ISO)
O-acetyl-L-carnitine  (ISO)
octadecanoic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
orientin  (ISO)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
peroxynitrous acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
Phytolaccoside E  (ISO)
picloram  (ISO)
picoxystrobin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium chloride  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propionic acid  (ISO)
propranolol  (ISO)
prostaglandin D2  (ISO)
prostaglandin I2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyridaben  (ISO)
pyridoxine  (EXP,ISO)
pyrroloquinoline quinone  (EXP,ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-homocysteine  (ISO)
Salmeterol xinafoate  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
SB 431542  (ISO)
SB-239063  (EXP)
selenium atom  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium hydrogensulfite  (EXP)
splitomicin  (EXP)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetradecanoic acid  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trichlopyr  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trilobatin  (EXP)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
ziram  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IEP)
adipose tissue development  (IEA,ISO)
androgen metabolic process  (IEP)
autophagy of mitochondrion  (IEP)
cellular response to caffeine  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to fatty acid  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to fructose stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to ionomycin  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to nitrite  (IEP)
cellular response to oxidative stress  (IEA,ISO,ISS)
cellular response to potassium ion  (IEP)
cellular response to resveratrol  (IEP)
cellular response to thyroid hormone stimulus  (IDA,IEP)
cellular response to transforming growth factor beta stimulus  (IDA)
cellular response to tumor necrosis factor  (IEP)
cerebellum development  (IEP)
circadian regulation of gene expression  (IEA,ISO,ISS)
DNA-templated transcription  (IEA)
energy homeostasis  (IEA,ISO,ISS)
fatty acid oxidation  (IEP)
flavone metabolic process  (IEP)
forebrain development  (IEP)
galactose metabolic process  (IEP)
gluconeogenesis  (IEA,IEP,ISO,ISS)
mitochondrion organization  (IEA,IEP,IMP,ISO)
negative regulation of glycolytic process  (IMP)
negative regulation of mitochondrial fission  (IMP)
negative regulation of neuron apoptotic process  (IEA,ISO,ISS)
negative regulation of protein phosphorylation  (IMP)
negative regulation of signaling receptor activity  (IMP)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
neuron apoptotic process  (IEA,ISO)
positive regulation of ATP biosynthetic process  (IEA,ISO,ISS)
positive regulation of cellular respiration  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of DNA-binding transcription factor activity  (IBA,IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of fatty acid oxidation  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of mitochondrial DNA metabolic process  (IEA,ISO)
positive regulation of mitochondrion organization  (ISO,ISS)
positive regulation of muscle tissue development  (IEA,ISO)
positive regulation of oxidative phosphorylation uncoupler activity  (IEA,ISO)
positive regulation of podocyte apoptotic process  (IMP)
positive regulation of progesterone biosynthetic process  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of circadian rhythm  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (ISO,ISS)
regulation of NMDA receptor activity  (IMP)
respiratory electron transport chain  (IEA,ISO,ISS)
response to activity  (IDA,IEP)
response to dehydroepiandrosterone  (IEP)
response to dietary excess  (IEA,ISO)
response to electrical stimulus  (IEP)
response to electrical stimulus involved in regulation of muscle adaptation  (IEP)
response to epinephrine  (IEP)
response to fructose  (IEP)
response to hypobaric hypoxia  (IEP)
response to hypoxia  (IEP)
response to ischemia  (IEP)
response to leucine  (IEP)
response to methionine  (IEP)
response to muscle activity  (IEA,IEP,ISO,ISS)
response to norepinephrine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to reactive oxygen species  (IEP)
response to starvation  (IEP)
response to thyroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
skeletal muscle atrophy  (IEP)

Cellular Component
apical dendrite  (IDA)
cytosol  (IEA,ISO)
cytosolic ribosome  (IDA)
euchromatin  (IDA)
neuronal cell body  (IDA)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)
PML body  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
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101. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
102. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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108. PGC-1{alpha} Attenuates Neointimal Formation via Inhibition of Vascular Smooth Muscle Cell Migration in the Injured Rat Carotid Artery. Qu A, etal., Am J Physiol Cell Physiol. 2009 Jun 24.
109. Population stratification may bias analysis of PGC-1alpha as a modifier of age at Huntington disease motor onset. Ramos EM, etal., Hum Genet. 2012 Dec;131(12):1833-40. doi: 10.1007/s00439-012-1205-z. Epub 2012 Jul 25.
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112. GOA pipeline RGD automated data pipeline
113. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
114. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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123. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Santos JM and Kowluru RA, Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8791-8. Print 2011.
124. Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations. Schlagowski AI, etal., J Appl Physiol (1985). 2014 Feb 15;116(4):364-75. doi: 10.1152/japplphysiol.01177.2013. Epub 2013 Dec 12.
125. PGC1alpha plays a critical role in TWEAK-induced cardiac dysfunction. Shi J, etal., PLoS One. 2013;8(1):e54054. doi: 10.1371/journal.pone.0054054. Epub 2013 Jan 16.
126. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Shin JH, etal., Cell. 2011 Mar 4;144(5):689-702.
127. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Siddiqui A, etal., Free Radic Biol Med. 2012 Aug 15;53(4):993-1003. doi: 10.1016/j.freeradbiomed.2012.05.024. Epub 2012 Jun 15.
128. The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is dependent on reactive oxygen species. Silveira LR, etal., Biochim Biophys Acta. 2006 Sep;1763(9):969-76. Epub 2006 Jul 7.
129. Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development. Sinha RA, etal., Biochem Biophys Res Commun. 2010 Jul 2;397(3):548-52. doi: 10.1016/j.bbrc.2010.05.154. Epub 2010 May 31.
130. AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle. Smith BK, etal., J Physiol. 2013 Mar 15;591(Pt 6):1551-61. doi: 10.1113/jphysiol.2012.245944. Epub 2013 Jan 7.
131. A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. Soyal SM, etal., Hum Mol Genet. 2012 May 28.
132. Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction. Sullo N, etal., Am J Respir Cell Mol Biol. 2013 Feb;48(2):198-203. doi: 10.1165/rcmb.2012-0167OC. Epub 2012 Nov 9.
133. Bone marrow-derived mononuclear cell therapy alleviates left ventricular remodeling and improves heart function in rat-dilated cardiomyopathy. Sun CK, etal., Crit Care Med. 2009 Apr;37(4):1197-205.
134. Nandrolone attenuates aortic adaptation to exercise in rats. Sun M, etal., Cardiovasc Res. 2013 Mar 15;97(4):686-95. doi: 10.1093/cvr/cvs423. Epub 2013 Jan 20.
135. Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model. Sung PH, etal., Int Heart J. 2009 Mar;50(2):191-206.
136. Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue. Sutherland LN, etal., J Physiol. 2009 Apr 1;587(Pt 7):1607-17. doi: 10.1113/jphysiol.2008.165464. Epub 2009 Feb 16.
137. Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo. Suwa M, etal., J Appl Physiol (1985). 2006 Dec;101(6):1685-92. Epub 2006 Aug 10.
138. Neuropathology of Partial PGC-1alpha Deficiency Recapitulates Features of Mitochondrial Encephalopathies but Not of Neurodegenerative Diseases. Szalardy L, etal., Neurodegener Dis. 2013 Feb 13.
139. PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease. Taherzadeh-Fard E, etal., Mol Neurodegener. 2011 May 19;6(1):32.
140. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Tang DX, etal., Evid Based Complement Alternat Med. 2013;2013:480597. doi: 10.1155/2013/480597. Epub 2013 Feb 26.
141. Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Terada S, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):350-4.
142. Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. Thakran S, etal., J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
143. Decreased mRNA expression of PGC-1alpha and PGC-1alpha-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS. Thau N, etal., J Neuropathol Exp Neurol. 2012 Dec;71(12):1064-74. doi: 10.1097/NEN.0b013e318275df4b.
144. PGC-1alpha promotes recovery after acute kidney injury during systemic inflammation in mice. Tran M, etal., J Clin Invest. 2011 Oct;121(10):4003-14. doi: 10.1172/JCI58662. Epub 2011 Sep 1.
145. PGC1alpha Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress. Vazquez F, etal., Cancer Cell. 2013 Feb 12. pii: S1535-6108(13)00034-2. doi: 10.1016/j.ccr.2012.11.020.
146. Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats. Vlamings R, etal., Neurobiol Dis. 2012 Dec;48(3):488-94. doi: 10.1016/j.nbd.2012.07.006. Epub 2012 Jul 17.
147. Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat. Wadley GD, etal., Am J Physiol Endocrinol Metab. 2008 May;294(5):E861-9. doi: 10.1152/ajpendo.00037.2008. Epub 2008 Mar 4.
148. Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training. Wadley GD, etal., Am J Physiol Endocrinol Metab. 2013 Mar 5.
149. The role of PGC-1 and Apoepsilon4 in insomnia. Wang CC and Lung FW, Psychiatr Genet. 2012 Apr;22(2):82-7.
150. A single nucleotide polymorphism in the coding region of PGC-1alpha is a male-specific modifier of Huntington disease age-at-onset in a large European cohort. Weydt P, etal., BMC Neurol. 2014 Jan 2;14:1. doi: 10.1186/1471-2377-14-1.
151. The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease. Weydt P, etal., Mol Neurodegener. 2009 Jan 8;4:3. doi: 10.1186/1750-1326-4-3.
152. Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression. Wright DC, etal., J Biol Chem. 2007 Jan 5;282(1):194-9. Epub 2006 Nov 12.
153. Nandrolone normalizes determinants of muscle mass and fiber type after spinal cord injury. Wu Y, etal., J Neurotrauma. 2012 May 20;29(8):1663-75. Epub 2012 Apr 16.
154. PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy. Xiong S, etal., J Biol Chem. 2010 Jan 22;285(4):2474-87. doi: 10.1074/jbc.M109.065235. Epub 2009 Nov 23.
155. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1alpha expression. Xu W, etal., Exp Cell Res. 2011 May 1;317(8):1083-92. doi: 10.1016/j.yexcr.2010.10.006. Epub 2010 Oct 15.
156. The protective role of peroxisome proliferator-activated receptor gamma coactivator-1alpha in hyperthyroid cardiac hypertrophy. Xu W, etal., J Cell Physiol. 2012 Sep;227(9):3243-53. doi: 10.1002/jcp.24015.
157. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
158. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. Yang SJ, etal., PLoS One. 2011 Feb 23;6(2):e17057.
159. PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1. Yazawa T, etal., Mol Endocrinol. 2010 Mar;24(3):485-96. doi: 10.1210/me.2009-0352. Epub 2010 Feb 4.
160. Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Yoshizawa T, etal., Hypertension. 2013 Feb;61(2):341-51. doi: 10.1161/HYPERTENSIONAHA.111.00647. Epub 2013 Jan 7.
161. AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons. Yu L and Yang SJ, Neuroscience. 2010 Aug 11;169(1):23-38. doi: 10.1016/j.neuroscience.2010.04.063. Epub 2010 May 18.
162. Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1alpha-Sirt3 axis. Yu X, etal., Molecules. 2012 Sep 20;17(9):11216-28.
163. Activation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Yuan Y, etal., Kidney Int. 2012 Oct;82(7):771-89. doi: 10.1038/ki.2012.188. Epub 2012 May 30.
164. Novel Small-Molecule PGC-1alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice. Zhang LN, etal., Diabetes. 2012 Dec 18.
165. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Zhang M, etal., Mol Cell Endocrinol. 2012 Nov 5;363(1-2):122-30. doi: 10.1016/j.mce.2012.08.006. Epub 2012 Aug 16.
166. Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha). Zhang Y, etal., J Biol Chem. 2004 Dec 24;279(52):53963-71. Epub 2004 Oct 6.
167. The effect of overexpression of PGC-1alpha on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model. Zhao XY, etal., Hear Res. 2013 Feb;296:13-24. doi: 10.1016/j.heares.2012.11.007. Epub 2012 Nov 16.
168. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. Zheng Z, etal., Diabetes. 2010 Sep;59(9):2315-25. Epub 2010 Jun 21.
169. Age-related decline of the cytochrome c oxidase subunit expression in the auditory cortex of the mimetic aging rat model associated with the common deletion. Zhong Y, etal., Hear Res. 2012 Dec;294(1-2):40-8. doi: 10.1016/j.heares.2012.09.006. Epub 2012 Sep 27.
170. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Zhou L, etal., Hepatology. 2012 Nov 23. doi: 10.1002/hep.26167.
171. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. Zhu L, etal., PLoS One. 2009;4(1):e4182. doi: 10.1371/journal.pone.0004182. Epub 2009 Jan 14.
172. Diammonium glycyrrhizinate upregulates PGC-1alpha and protects against Abeta1-42-induced neurotoxicity. Zhu X, etal., PLoS One. 2012;7(4):e35823. Epub 2012 Apr 23.
Additional References at PubMed
PMID:10913342   PMID:12531492   PMID:12734114   PMID:12821652   PMID:14570700   PMID:14576981   PMID:14744933   PMID:15044597   PMID:15165993   PMID:15199055   PMID:15681609   PMID:15716268  
PMID:15733855   PMID:15967803   PMID:16014350   PMID:16271724   PMID:16352671   PMID:16488887   PMID:16720625   PMID:17239528   PMID:17273866   PMID:17284668   PMID:17476214   PMID:17488713  
PMID:17640976   PMID:17952069   PMID:18555842   PMID:18789599   PMID:18798693   PMID:18972406   PMID:18993053   PMID:19082571   PMID:19179292   PMID:19345188   PMID:19389810   PMID:19542216  
PMID:19651776   PMID:19686839   PMID:19698760   PMID:19766270   PMID:19773550   PMID:19774670   PMID:19774674   PMID:20086200   PMID:20143420   PMID:20359506   PMID:20385772   PMID:20457122  
PMID:20566846   PMID:20661474   PMID:20799369   PMID:20849372   PMID:21106753   PMID:21162799   PMID:21307617   PMID:21536107   PMID:21590341   PMID:21789886   PMID:21972093   PMID:21994947  
PMID:22064484   PMID:22234788   PMID:22237023   PMID:22342160   PMID:22354784   PMID:22461724   PMID:22533417   PMID:22738191   PMID:22899824   PMID:23117952   PMID:23139024   PMID:23212379  
PMID:23292098   PMID:23505321   PMID:23515531   PMID:23525105   PMID:23525500   PMID:23602251   PMID:23635713   PMID:23836911   PMID:23880578   PMID:23948478   PMID:23994518   PMID:24005768  
PMID:24084166   PMID:24096033   PMID:24562467   PMID:24726645   PMID:24898700   PMID:25118933   PMID:25333348   PMID:25402826   PMID:25572651   PMID:25675425   PMID:25824459   PMID:25853493  
PMID:25972379   PMID:26020641   PMID:26054747   PMID:26102301   PMID:26118953   PMID:26287659   PMID:26310573   PMID:26844631   PMID:27076782   PMID:27132229   PMID:27174562   PMID:27178364  
PMID:27302464   PMID:27453548   PMID:27526155   PMID:27793739   PMID:28467933   PMID:28482939   PMID:29383690   PMID:29543139   PMID:29604268   PMID:29901150   PMID:29913155   PMID:30221360  
PMID:30223807   PMID:30396162   PMID:30541949   PMID:30656723   PMID:30664159   PMID:30676864   PMID:31085594   PMID:31238070   PMID:31242648   PMID:31340436   PMID:31471878   PMID:31778153  
PMID:32114097   PMID:32121211   PMID:32305957   PMID:32323734   PMID:32529514   PMID:32851675   PMID:33008083   PMID:33245682   PMID:33268575   PMID:33576345   PMID:33625690   PMID:33661552  
PMID:33847873   PMID:34482051   PMID:34530866   PMID:34576046   PMID:34636198   PMID:35180801   PMID:35395161   PMID:35569770   PMID:35883637   PMID:36414561   PMID:36922709   PMID:37085803  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKY
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ppargc1a
2196 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:28
Interacting mature miRNAs:35
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21459,495,697 - 59,496,182 (+)MAPPERmRatBN7.2
Rnor_6.01463,169,863 - 63,170,347NCBIRnor6.0
Rnor_5.01463,269,140 - 63,269,624UniSTSRnor5.0
RGSC_v3.41464,352,392 - 64,352,876UniSTSRGSC3.4
Celera1458,590,965 - 58,591,449UniSTS
Cytogenetic Map14q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 41 1 1 7 8 42 35 2 4 7
Low 3 2 56 41 15 41 1 3 32 38 7 1
Below cutoff 3 1


Nucleotide Sequences
RefSeq Transcripts NM_031347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY237127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY382577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC227803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000006071   ⟹   ENSRNOP00000006071
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1459,421,542 - 59,512,656 (+)Ensembl
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105198   ⟹   ENSRNOP00000076568
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1459,426,456 - 59,512,656 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108897   ⟹   ENSRNOP00000086053
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1459,421,606 - 59,512,619 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116869   ⟹   ENSRNOP00000093101
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)Ensembl
RefSeq Acc Id: NM_031347   ⟹   NP_112637
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,421,606 - 59,512,656 (+)NCBI
Rnor_6.01463,095,827 - 63,186,819 (+)NCBI
Rnor_5.01463,182,479 - 63,286,252 (+)NCBI
RGSC_v3.41464,278,115 - 64,370,912 (+)RGD
Celera1458,516,257 - 58,607,916 (+)RGD
RefSeq Acc Id: XM_039092488   ⟹   XP_038948416
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,421,851 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092489   ⟹   XP_038948417
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,421,414 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092490   ⟹   XP_038948418
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,407,506 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092491   ⟹   XP_038948419
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21458,860,752 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092492   ⟹   XP_038948420
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,421,852 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092493   ⟹   XP_038948421
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,421,858 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092494   ⟹   XP_038948422
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21459,421,844 - 59,516,525 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112637   ⟸   NM_031347
- UniProtKB: Q9QYK2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006071   ⟸   ENSRNOT00000006071
RefSeq Acc Id: XP_038948419   ⟸   XM_039092491
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038948418   ⟸   XM_039092490
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948417   ⟸   XM_039092489
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948422   ⟸   XM_039092494
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038948416   ⟸   XM_039092488
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948420   ⟸   XM_039092492
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948421   ⟸   XM_039092493
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000086053   ⟸   ENSRNOT00000108897
RefSeq Acc Id: ENSRNOP00000093101   ⟸   ENSRNOT00000116869
RefSeq Acc Id: ENSRNOP00000076568   ⟸   ENSRNOT00000105198
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYK2-F1-model_v2 AlphaFold Q9QYK2 1-796 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699342
Promoter ID:EPDNEW_R9866
Type:multiple initiation site
Description:PPARG coactivator 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01463,095,778 - 63,095,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620925 AgrOrtholog
BioCyc Gene G2FUF-15584 BioCyc
Ensembl Genes ENSRNOG00000004473 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006071 ENTREZGENE
  ENSRNOP00000006071.4 UniProtKB/TrEMBL
  ENSRNOP00000076568.1 UniProtKB/TrEMBL
  ENSRNOP00000086053.1 UniProtKB/TrEMBL
  ENSRNOP00000093101.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006071 ENTREZGENE
  ENSRNOT00000006071.6 UniProtKB/TrEMBL
  ENSRNOT00000105198.1 UniProtKB/TrEMBL
  ENSRNOT00000108897.1 UniProtKB/TrEMBL
  ENSRNOT00000116869.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPARGC1A_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83516 UniProtKB/Swiss-Prot
PANTHER PTHR15528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15528:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppargc1a PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y905_RAT UniProtKB/TrEMBL
  A0A8I6A531_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ppargc1a  PPARG coactivator 1 alpha  Ppargc1a  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppargc1a  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Ppargc1a  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Ppargc1a  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha  Ppargc1  peroxisome proliferative activated receptor, gamma, coactivator 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ppargc1  peroxisome proliferative activated receptor, gamma, coactivator 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process regulates gluconeogenic genes by cAMP and glucocorticoids; induces liver carnitine palmitoyltransferase I gene expression by cAMP 633650